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Research Article

Molecular Aspects of Paracetamol-Induced Hepatotoxicity and its Mechanism-Based Prevention

N. P. E. Vermeulen Department of Pharmacochemistry Division of Molecular Toxicology, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081, HV Amsterdam, Netherlands
,
J. G. M. Bessems Department of Pharmacochemistry Division of Molecular Toxicology, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081, HV Amsterdam, Netherlands
&
R. Van De Straat Department of Pharmacochemistry Division of Molecular Toxicology, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081, HV Amsterdam, Netherlands
Pages 367-407 | Published online: 22 Sep 2008

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Azadeh Rasooli, Faezeh Fatemi, Kambiz Akbarzadeh, Salome Dini & Shabnam Bahremand. (2016) Synergistic Protective Activity of Deuterium Depleted Water (DDW) and Satureja rechingeri Essential Oil on Hepatic Oxidative Injuries Induced by Acetaminophen in Rats. Journal of Essential Oil Bearing Plants 19:5, pages 1086-1101.
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A. Dadkhah, F. Fatemi, M. Alipour, Z. Ghaderi, F. Zolfaghari & F. Razdan. (2015) Protective effects of Iranian Achillea wilhelmsii essential oil on acetaminophen-induced oxidative stress in rat liver. Pharmaceutical Biology 53:2, pages 220-227.
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S. Palani, S. Raja, R. Naresh & B. Senthil Kumar. (2010) Evaluation of nephroprotective, diuretic, and antioxidant activities of plectranthus amboinicus on acetaminophen-induced nephrotoxic rats. Toxicology Mechanisms and Methods 20:4, pages 213-221.
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S. Palani, S. Raja, R. Santhosh Kalash & B. Senthil Kumar. (2010) Evaluation of nephroprotective and antioxidant activity of Mahonia leschenaultia takeda on acetaminophen-induced toxicity in rat. Toxicological & Environmental Chemistry 92:4, pages 789-799.
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Joydeep Das, Jyotirmoy Ghosh, Prasenjit Manna & Parames C. Sil. (2010) Acetaminophen induced acute liver failure via oxidative stress and JNK activation: Protective role of taurine by the suppression of cytochrome P450 2E1. Free Radical Research 44:3, pages 340-355.
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J. E. Laine, S. Auriola, M. Pasanen & R. O. Juvonen. (2009) Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica 39:1, pages 11-21.
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J. C. Chang, C. C. Lin, S. J. Wu, D. L. Lin, S. S. Wang, C. L. Miaw & L. T. Ng. (2008) Antioxidative and Hepatoprotective Effects of Physalis peruviana Extract against Acetaminophen-Induced Liver Injury in Rats. Pharmaceutical Biology 46:10-11, pages 724-731.
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DiannL. Blanset, Junfeng (Jim) Zhang & MarkG. Robson. (2007) Probabilistic Estimates of Lifetime Daily Doses from Consumption of Drinking Water Containing Trace Levels of N,N-diethyl-meta-toluamide (DEET), Triclosan, or Acetaminophen and the Associated Risk to Human Health. Human and Ecological Risk Assessment: An International Journal 13:3, pages 615-631.
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Gabriele Sabbioni & Christopher R. Jones. (2002) Biomonitoring of arylamines and nitroarenes. Biomarkers 7:5, pages 347-421.
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Jos G. M. Bessems & Nico P. E. Vermeulen. (2001) Paracetamol (Acetaminophen)-Induced Toxicity: Molecular and Biochemical Mechanisms, Analogues and Protective Approaches. Critical Reviews in Toxicology 31:1, pages 55-138.
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Francis L. Martin & Andre E.M. McLean. (1998) Comparison of Paracetamol-Induced Hepatotoxicity in the Rat in vivo with Progression of Cell Injury in Vitro in Rat Liver Slices. Drug and Chemical Toxicology 21:4, pages 477-494.
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Steven D. Cohen & Edward A. Khairallah. (1997) Selective Protein Arylation and Acetaminophen-Induced Hepatotoxicity. Drug Metabolism Reviews 29:1-2, pages 59-77.
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J. N. M. Commandeur & N. P. E. Vermeulen. (1996) Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin. Xenobiotica 26:7, pages 667-680.
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J. G. M. Bessems, J. M. Te Koppele, P. A. Van Dijk, L. L. P. Van Stee, J. N. M. Commandeur & N. P. E. Vermeulen. (1996) Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol. Xenobiotica 26:6, pages 647-666.
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L. T. Burka, J. M. Sanders & H. B. Matthews. (1996) Comparative metabolism and disposition of ethoxyquin in rat and mouse. II. Metabolism. Xenobiotica 26:6, pages 597-611.
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F. M. Fouad, F. Shahidi & O. A. Mamer. (1995) Comparison of thermally oxidized lipids and acetaminophen with concurrent consumption of ethanol as inducers of liver cirrhosis. Journal of Toxicology and Environmental Health 46:2, pages 217-232.
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Sidney D. Nelson. (1995) Mechanisms of the Formation and Disposition of Reactive Metabolites That can Cause Acute Liver Injury. Drug Metabolism Reviews 27:1-2, pages 147-177.
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Urs A. Boelsterli. (1993) Specific Targets of Covalent Drug-Protein Interactions in Hepatocytes and Their Toxicological Significance in Drug-Induced Liver Injury. Drug Metabolism Reviews 25:4, pages 395-451.
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