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Research Article

Drug Metabolism in the Nasal Cavity: Relevance to Toxicology

Pages 173-205 | Published online: 22 Sep 2008

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Madelyn C. Huang, Cynthia J. Willson, Sridhar Jaligama, Gregory L. Baker, Alan W. Singer, Yu Cao, Jessica Pierfelice, Esra Mutlu, Brian Burback, Guanhua Xie, David E. Malarkey, Barney Sparrow, Kristen Ryan, Matthew Stout & Georgia K. Roberts. (2021) Whole-body inhalation exposure to 2-ethyltoluene for two weeks produced nasal lesions in rats and mice. Inhalation Toxicology 33:9-14, pages 334-346.
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Zachary Enlo-Scott, Erica Bäckström, Ian Mudway & Ben Forbes. (2021) Drug metabolism in the lungs: opportunities for optimising inhaled medicines. Expert Opinion on Drug Metabolism & Toxicology 17:5, pages 611-625.
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Jean-Marie Heydel, Philippe Faure & Fabrice Neiers. (2019) Nasal odorant metabolism: enzymes, activity and function in olfaction. Drug Metabolism Reviews 51:2, pages 224-245.
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Georgia K. Roberts, Cynthia J. Willson, Dorian S. Olivera, David E. Malarkey & Daniel L. Morgan. (2017) Comparative inhalation toxicity of ethyltoluene isomers in rats and mice. Inhalation Toxicology 29:12-14, pages 577-585.
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Varsha Dhamankar, Mahfoud Assem & Maureen D. Donovan. (2015) Gene expression and immunochemical localization of major cytochrome P450 drug-metabolizing enzymes in bovine nasal olfactory and respiratory mucosa. Inhalation Toxicology 27:14, pages 767-777.
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Puneet Chopra, Vijay Kanoje, Arvind Semwal & Abhijit Ray. (2008) Therapeutic potential of inhaled p38 mitogen-activated protein kinase inhibitors for inflammatory pulmonary diseases. Expert Opinion on Investigational Drugs 17:10, pages 1411-1425.
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Edward T Maggio. (2006) Intravail™: highly effective intranasal delivery of peptide and protein drugs. Expert Opinion on Drug Delivery 3:4, pages 529-539.
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V. J. Feron, J. H. E. Arts, C. F. Kuper, P. J. Slootweg & R. A. Woutersen. (2001) Health Risks Associated with Inhaled Nasal Toxicants. Critical Reviews in Toxicology 31:3, pages 313-347.
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S. MARINI. (1998) Xenobiotic-metabolizing enzymes in pig nasal and hepatic tissues. Xenobiotica 28:10, pages 923-935.
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D. W. Ayres, A. Barrow, N. L. Scully, G. C. Curtis & H. M. Hughes. (1996) Absorption, pharmacokinetics and metabolism of 14C-sumatriptan following intranasal administration to the rat. Xenobiotica 26:12, pages 1273-1282.
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