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Research Article

Cytochromes P450: Their Active-Site Structure and Mechanism of Oxidation

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Pages 325-387 | Published online: 22 Sep 2008

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Prajwal P Nandekar & Abhay T Sangamwar. (2012) Cytochrome P450 1A1-mediated anticancer drug discovery: in silico findings. Expert Opinion on Drug Discovery 7:9, pages 771-789.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Gilbert H. John, Shannon Walls, Ronald Keith, Jodi Goodfox-Jones, Kayleen Tucker & K. J. Abraham. (2001) The Presence of a Cytochrome P450-like Protein in the Human Intestinal Microflora Eubacterium aerofaciens. Microbial Ecology in Health and Disease 13:1, pages 3-8.
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Peter W. Stacpoole, George N. Henderson, Zimeng Yan, Rachel Cornett & Margaret O. James. (1998) Pharmacokinetics, Metabolism, and Toxicology of Dichloroacetate. Drug Metabolism Reviews 30:3, pages 499-539.
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Marcel J. De Groot & Nico P. E. Vermeulen. (1997) Modeling the Active Sites of Cytochrome P450s and Glutathione S-Transferases, two of the Most Important Biotransformation Enzymes. Drug Metabolism Reviews 29:3, pages 747-799.
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Slobodan Rendic & Frederick J. Di Carlo. (1997) Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors. Drug Metabolism Reviews 29:1-2, pages 413-580.
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Arnold R. Goeptar, Heleen Scheerens & Nico P. E. Vermeulen. (1995) Oxygen and Xenobiotic Reductase Activities of Cytochrome P450. Critical Reviews in Toxicology 25:1, pages 25-65.
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GrazynaD. Szklarz, RickL. Ornstein & JamesR. Halpert. (1994) Application of 3-Dimensional Homology Modeling of Cytochrome P450 2B1 for Interpretation of Site-Directed Mutagenesis Results. Journal of Biomolecular Structure and Dynamics 12:1, pages 61-78.
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Articles from other publishers (33)

Samuel Filipe Cardoso de Paula, Isac George Rosset & André Luiz Meleiro Porto. (2021) Hydroxylated steroids in C-7 and C-15 positions from progesterone bio-oxidation by the marine-derived fungus Penicillium oxalicum CBMAI 1996. Biocatalysis and Agricultural Biotechnology 37, pages 102167.
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Charleen G. Don & Martin Smieško. (2018) Out‐compute drug side effects: Focus on cytochrome P450 2D6 modeling. WIREs Computational Molecular Science 8:5.
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Michele Gottardi, Jonathan D. Tyzack, Andreas Bender & Nina Cedergreen. (2018) Can the inhibition of cytochrome P450 in aquatic invertebrates due to azole fungicides be estimated with in silico and in vitro models and extrapolated between species?. Aquatic Toxicology 201, pages 11-20.
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Arthur I. Cederbaum. (2015) Molecular mechanisms of the microsomal mixed function oxidases and biological and pathological implications. Redox Biology 4, pages 60-73.
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Tomoki Hoshi, Kazuhiro Yamada, Yuko Yoshizawa & Keimei Oh. (2015) Structure-activity relationship study for fungicidal activity of 1-(4-phenoxymethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1H-1,2,4-triazole derivatives against rice blast. Journal of Plant Protection Research 55:4.
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Arthur G. Roberts, Sara E. A. Sjögren, Nadezda Fomina, Kathy T. Vu, Adah Almutairi & James R. Halpert. (2011) NMR-Derived Models of Amidopyrine and Its Metabolites in Complexes with Rabbit Cytochrome P450 2B4 Reveal a Structural Mechanism of Sequential N-Dealkylation. Biochemistry 50:12, pages 2123-2134.
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K. H. M. Nazmul Hussain Nazir, Hirofumi Ichinose & Hiroyuki Wariishi. (2010) Molecular characterization and isolation of cytochrome P450 genes from the filamentous fungus Aspergillus oryzae. Archives of Microbiology 192:5, pages 395-408.
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Dmitry Korolev, Konstantin V. Balakin, Yuri Nikolsky, Eugene Kirillov, Yan A. Ivanenkov, Nikolay P. Savchuk, Andrey A. Ivashchenko & Tatiana Nikolskaya. (2003) Modeling of Human Cytochrome P450-Mediated Drug Metabolism Using Unsupervised Machine Learning Approach. Journal of Medicinal Chemistry 46:17, pages 3631-3643.
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Cristina Marques-Soares, Sylvie Dijols, Anne-Christine Macherey, Michael R. Wester, Eric F. Johnson, Patrick M. Dansette & Daniel Mansuy. (2003) Sulfaphenazole Derivatives as Tools for Comparing Cytochrome P450 2C5 and Human Cytochromes P450 2Cs:  Identification of a New High Affinity Substrate Common to Those Enzymes † . Biochemistry 42:21, pages 6363-6369.
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