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Research Article

The Role of Lipoic Acid in the Treatment of Diabetic Polyneuropathy

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Pages 1025-1054 | Published online: 22 Sep 2008

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Emrah Tekdemir, Arzu Tatlipinar, Dilek Özbeyli, Özge Tekdemir & Emrah Kınal. (2018) The effects of lipoic acid and methylprednisolone on nerve healing in rats with facial paralysis. Acta Oto-Laryngologica 138:6, pages 537-541.
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Ernest Adeghate, Erzsébet Fehér & Huba Kalász. (2015) Evaluating the Phase II drugs currently under investigation for diabetic neuropathy. Expert Opinion on Investigational Drugs 24:1, pages 1-15.
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Courtney E McIlduff & Seward B Rutkove. (2011) Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy. Therapeutics and Clinical Risk Management 7, pages 377-385.
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Hale Z. Toklu, Tayfun Hakan, Hasan Celik, Necat Biber, Can Erzik, Ayliz V. Ogunc, Dilek Akakin, Esra Cikler, Sule Cetinel, Mehmet Ersahin & Goksel Sener. (2010) Neuroprotective Effects of Alpha-Lipoic Acid in Experimental Spinal Cord Injury in Rats. The Journal of Spinal Cord Medicine 33:4, pages 401-409.
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Joseph L Evans & Bahija Jallal. (1999) Protein tyrosine phosphatases: their role in insulin action and potential as drug targets. Expert Opinion on Investigational Drugs 8:2, pages 139-160.
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Articles from other publishers (24)

Marwa Abdeltawab MohammedDoaa Mostafa GharibHoda Ramadan ReyadAlaa Aboud MohamedFadwa A. ElrobyHoda Sayed Mahmoud. (2021) Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury. Canadian Journal of Physiology and Pharmacology 99:5, pages 499-505.
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Muneeb U. Rehman, Adil Farooq Wali, Anas Ahmad, Sheeba Shakeel, Saiema Rasool, Rayeesa Ali, Shazada Mudasir Rashid, Hassan Madkhali, Majid Ahmad Ganaie & Rehan Khan. (2019) Neuroprotective Strategies for Neurological Disorders by Natural Products: An update. Current Neuropharmacology 17:3, pages 247-267.
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Tarek M. Saleh, Monique C. Saleh, Barry J. Connell, Inan Kucukkaya & Alaa S. Abd-El-Aziz. (2017) A novel synthetic chemical entity (UPEI-800) is neuroprotective in vitro and in an in vivo rat model of oxidative stress. Clinical and Experimental Pharmacology and Physiology 44:10, pages 993-1000.
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Longquan Xu, Sylvia Hiller, Stephen Simington, Volker Nickeleit, Nobuyo Maeda, Leighton R. James & Xianwen Yi. (2016) Influence of Different Levels of Lipoic Acid Synthase Gene Expression on Diabetic Nephropathy. PLOS ONE 11:10, pages e0163208.
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Khairy M.A. Zoheir, Amro A. Amara, S.F. Ahmad, Mahmoud A. Mohammad, Abdelkader E. Ashour, Gamaleldin I. Harisa & Adel R. Abd-Allah. (2014) Study of the therapeutic effects of Lactobacillus and α-lipoic acid against dimethylnitrosamine-induced liver fibrosis in rats. Journal of Genetic Engineering and Biotechnology 12:2, pages 135-142.
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Magdalena Dudek, Anna Bilska-Wilkosz, Joanna Knutelska, Szczepan Mogilski, Marek Bednarski, Małgorzata Zygmunt, Małgorzata Iciek, Jacek Sapa, Dominik Bugajski, Barbara Filipek & Lidia Włodek. (2013) Are anti-inflammatory properties of lipoic acid associated with the formation of hydrogen sulfide?. Pharmacological Reports 65:4, pages 1018-1024.
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Daniele Tomassoni, Francesco Amenta, Consuelo Amantini, Valerio Farfariello, Lorenzo Di Cesare Mannelli, Innocent Nwankwo, Carlotta Marini & Seyed Tayebati. (2013) Brain Activity of Thioctic Acid Enantiomers: In Vitro and in Vivo Studies in an Animal Model of Cerebrovascular Injury. International Journal of Molecular Sciences 14:3, pages 4580-4595.
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Daniele Tomassoni, Francesco Amenta, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Innocent E. Nwankwo, Alessandra Pacini & Seyed Khosrow Tayebati. (2013) Neuroprotective Activity of Thioctic Acid in Central Nervous System Lesions Consequent to Peripheral Nerve Injury. BioMed Research International 2013, pages 1-14.
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Vijayshree Yadav, Lynne Shinto & Dennis N. Bourdette. 2011. Multiple Sclerosis Therapeutics. Multiple Sclerosis Therapeutics 562 573 .
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Guido R.M.M. Haenen, Mariken J.T.J. Arts, Aalt Bast & Michael D. Coleman. (2006) Structure and activity in assessing antioxidant activity in vitro and in vivo. Environmental Toxicology and Pharmacology 21:2, pages 191-198.
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Jeffrey Mechanick. 2006. Nutritional Strategies for the Diabetic/Prediabetic Patient. Nutritional Strategies for the Diabetic/Prediabetic Patient 221 264 .
E. Hoitsma, J.P.H. Reulen, M. de Baets, M. Drent, F. Spaans & C.G. Faber. (2004) Small fiber neuropathy: a common and important clinical disorder. Journal of the Neurological Sciences 227:1, pages 119-130.
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Arie Gruzman, Adel Hidmi, Jehoshua Katzhendler, Abdalla Haj-Yehie & Shlomo Sasson. (2004) Synthesis and characterization of new and potent α-lipoic acid derivatives. Bioorganic & Medicinal Chemistry 12:5, pages 1183-1190.
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Aalt Bast & Guido R. M. M. Haenen. (2003) Lipoic acid: A multifunctional antioxidant. BioFactors 17:1-4, pages 207-213.
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Alexandra K Kiemer, Christian Müller & Angelika M Vollmar. (2002) Inhibition of LPS-induced nitric oxide and TNF-α production by α-lipoic acid in rat Kupffer cells and in RAW 264.7 murine macrophages. Immunology and Cell Biology 80:6, pages 550-557.
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Aalt Bast & Guido R.M.M Haenen. (2002) The toxicity of antioxidants and their metabolites. Environmental Toxicology and Pharmacology 11:3-4, pages 251-258.
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Joseph L. Evans, Catherine J. Heymann, Ira D. Goldfine & Laurence A. Gavin. (2002) Pharmacokinetics, Tolerability, and Fructosamine-Lowering Effect of a Novel, Controlled-Release Formulation of α-Lipoic Acid. Endocrine Practice 8:1, pages 29-35.
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Lester Packer, Anthony Diplock & Sharon Landvik. 2001. Handbook of Antioxidants. Handbook of Antioxidants.
Lester Packer, Klaus Kraemer & Gerald Rimbach. (2001) Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 17:10, pages 888-895.
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Lester Packer & Klaus Krämer. 2001. Nutraceuticals in Health and Disease Prevention. Nutraceuticals in Health and Disease Prevention.
Guido Haenen & Aalt Bast. 2001. Nutraceuticals in Health and Disease Prevention. Nutraceuticals in Health and Disease Prevention.
Joseph L. Evans & Ira D. Goldfine. (2000) α-Lipoic Acid: A Multifunctional Antioxidant That Improves Insulin Sensitivity in Patients with Type 2 Diabetes. Diabetes Technology & Therapeutics 2:3, pages 401-413.
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Savita Khanna, Sashwati Roy, Lester Packer & Chandan K. Sen. (1999) Cytokine-induced glucose uptake in skeletal muscle: redox regulation and the role of α-lipoic acid. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 276:5, pages R1327-R1333.
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