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Sarah Parisi & Carlo Finelli. (2021) Prognostic Factors and Clinical Considerations for Iron Chelation Therapy in Myelodysplastic Syndrome Patients. Journal of Blood Medicine 12, pages 1019-1030.
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Fatemeh Delavar Mendi, Amir Sh. Saljooghi, Mohammad Ramezani, Rafal Kruszynski, Morgane Poupon, Monika Kucerakova, Volker Huch, Pawel Socha, Maryam Babaei & Mona Alibolandi. (2021) Five new complexes with deferiprone and N,N-donor ligands: evaluation of cytotoxicity against breast cancer MCF-7 cell line and HSA-binding determination. Journal of Biomolecular Structure and Dynamics 39:13, pages 4845-4858.
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Alireza Ghaffarieh & Joseph B. Ciolino. (2021) Potential of Application of Iron Chelating Agents in Ophthalmic Diseases. Seminars in Ophthalmology 36:4, pages 157-161.
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Christina N Kontoghiorghe, Annita Kolnagou & George J Kontoghiorghes. (2013) Potential clinical applications of chelating drugs in diseases targeting transferrin-bound iron and other metals. Expert Opinion on Investigational Drugs 22:5, pages 591-618.
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Articles from other publishers (60)
Andrzej Mular, Karolina Piasta, Aleksandra Jedyńczuk, Karolina Kamińska, Evgenia Olshvang, Nils Metzler Nolte, Elżbieta Wojaczyńska, Henryk Kozłowski & Elżbieta Gumienna-Kontecka. (2024) The diversity and utility of arylthiazoline and aryloxazoline siderophores: Challenges of coordination chemistry, biological activity and selected applications. Coordination Chemistry Reviews 501, pages 215551.
Crossref
Crossref
George J. Kontoghiorghes. (2023) Drug Selection and Posology, Optimal Therapies and Risk/Benefit Assessment in Medicine: The Paradigm of Iron-Chelating Drugs. International Journal of Molecular Sciences 24:23, pages 16749.
Crossref
Crossref
Jessica C. O'Keeffe, Nikhil Singh & Monica A. Slavin. (2023) Approach to diagnostic evaluation and prevention of invasive fungal disease in patients prior to allogeneic hematopoietic stem cell transplant. Transplant Infectious Disease 25:S1.
Crossref
Crossref
George J. Kontoghiorghes. (2023) Iron Load Toxicity in Medicine: From Molecular and Cellular Aspects to Clinical Implications. International Journal of Molecular Sciences 24:16, pages 12928.
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Crossref
George J. Kontoghiorghes. (2023) The Vital Role Played by Deferiprone in the Transition of Thalassaemia from a Fatal to a Chronic Disease and Challenges in Its Repurposing for Use in Non-Iron-Loaded Diseases. Pharmaceuticals 16:7, pages 1016.
Crossref
Crossref
Giovanna De Simone, Romualdo Varricchio, Tommaso Francesco Ruberto, Alessandra di Masi & Paolo Ascenzi. (2023) Heme Scavenging and Delivery: The Role of Human Serum Albumin. Biomolecules 13:3, pages 575.
Crossref
Crossref
George J. Kontoghiorghes. (2023) Deferiprone and Iron–Maltol: Forty Years since Their Discovery and Insights into Their Drug Design, Development, Clinical Use and Future Prospects. International Journal of Molecular Sciences 24:5, pages 4970.
Crossref
Crossref
Zinnet Şevval Aksoyalp, Aybala Temel & Betul Rabia Erdogan. (2023) Iron in infectious diseases friend or foe?: The role of gut microbiota. Journal of Trace Elements in Medicine and Biology 75, pages 127093.
Crossref
Crossref
Yuhang Zhou & Jianming Luo. (2022) Relationship between Iron deposition and T lymphocytes in children with β-thalassemia with haematopoietic stem cell transplantation. Frontiers in Pediatrics 10.
Crossref
Crossref
Yi Li, Ying Yang & Yongfeng Yang. (2022) Multifaceted Roles of Ferroptosis in Lung Diseases. Frontiers in Molecular Biosciences 9.
Crossref
Crossref
George J. Kontoghiorghes. (2022) Deferiprone: A Forty-Year-Old Multi-Targeting Drug with Possible Activity against COVID-19 and Diseases of Similar Symptomatology. International Journal of Molecular Sciences 23:12, pages 6735.
Crossref
Crossref
Kenneth I. Ataga, Santosh L. Saraf & Vimal K. Derebail. (2022) The nephropathy of sickle cell trait and sickle cell disease. Nature Reviews Nephrology 18:6, pages 361-377.
Crossref
Crossref
Eliza Cinteza, Alin Nicolescu, Tatiana Ciomartan, Liana-Cătălina Gavriliu, Cristiana Voicu, Adelina Carabas, Monica Popescu & Irina Margarint. (2022) Disseminated Cunninghamella spp. Endocarditis in a Beta-Thalassemia Patient after Asymptomatic COVID-19 Infection. Diagnostics 12:3, pages 657.
Crossref
Crossref
Hina Ashraf, Tehmina Anjum, Saira Riaz, Tanzeela Batool, Shahzad Naseem & Guihua Li. (2022) Sustainable synthesis of microwave-assisted IONPs using Spinacia oleracea L. for control of fungal wilt by modulating the defense system in tomato plants. Journal of Nanobiotechnology 20:1.
Crossref
Crossref
Yi Yu, Yuan Yan, Fanglin Niu, Yajun Wang, Xueyi Chen, Guodong Su, Yuru Liu, Xiling Zhao, Lu Qian, Ping Liu & Yuyan Xiong. (2021) Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases. Cell Death Discovery 7:1.
Crossref
Crossref
Tubagus Djumhana Atmakusuma, Ralph Girson & Sukamto Koesnoe. (2021) Correlations between Iron Load and CD4 in Adult Transfusion-Dependent Beta Thalassemia. Anemia 2021, pages 1-5.
Crossref
Crossref
George Kontoghiorghes, Annita Kolnagou, Theodora Demetriou, Marina Neocleous & Christina Kontoghiorghe. (2021) New Era in the Treatment of Iron Deficiency Anaemia Using Trimaltol Iron and Other Lipophilic Iron Chelator Complexes: Historical Perspectives of Discovery and Future Applications. International Journal of Molecular Sciences 22:11, pages 5546.
Crossref
Crossref
Bruce E. Holbein, M. Trisha C. Ang, David S. Allan, Wangxue Chen & Christian Lehmann. 2021. Sustainable Agriculture Reviews 49. Sustainable Agriculture Reviews 49
251
311
.
Rodrigo Abreu, Lauren Essler, Pramod Giri & Frederick Quinn. (2020) Interferon-gamma promotes iron export in human macrophages to limit intracellular bacterial replication. PLOS ONE 15:12, pages e0240949.
Crossref
Crossref
Mario Caruffo, Dinka Mandakovic, Madelaine Mejías, Ignacio Chávez-Báez, Pablo Salgado, Daniela Ortiz, Liliana Montt, Javiera Pérez-Valenzuela, Francisca Vera-Tamargo, José Manuel Yánez, Jurij Wacyk & Rodrigo Pulgar. (2020) Pharmacological iron-chelation as an assisted nutritional immunity strategy against Piscirickettsia salmonis infection. Veterinary Research 51:1.
Crossref
Crossref
Márcia Lombardo, Breno Pannia Espósito, Felipe Rebello Lourenço & Telma Mary Kaneko. (2020) The application of pharmaceutical quality by design concepts to evaluate the antioxidant and antimicrobial properties of a preservative system including desferrioxamine. DARU Journal of Pharmaceutical Sciences 28:2, pages 635-646.
Crossref
Crossref
George Kontoghiorghes & Christina Kontoghiorghe. (2020) Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases. Cells 9:6, pages 1456.
Crossref
Crossref
Francesca Vinchi, Saskia Hell & Uwe Platzbecker. (2020) Controversies on the Consequences of Iron Overload and Chelation in MDS. HemaSphere 4:3, pages e357.
Crossref
Crossref
Malcom G P Page. (2019) The Role of Iron and Siderophores in Infection, and the Development of Siderophore Antibiotics. Clinical Infectious Diseases 69:Supplement_7, pages S529-S537.
Crossref
Crossref
E. Karaaslan. (2019) Anesthetic management of rhinoorbitocerebral mucormycosis; Focus on challenges. Journal de Mycologie Médicale 29:3, pages 219-222.
Crossref
Crossref
Sufia Islam, Mohammod Jobayer Chisti, Muniruddin Ahmed, Nafiza Anwar & Christian Lehmann. (2019) Bacterial Resistance in Pneumonia in Developing Countries—A Role for Iron Chelation. Tropical Medicine and Infectious Disease 4:2, pages 59.
Crossref
Crossref
Sumant Puri, Rohitashw Kumar, Isolde G. Rojas, Ornella Salvatori & Mira Edgerton. (2019)
Iron Chelator Deferasirox Reduces
Candida albicans
Invasion of Oral Epithelial Cells and Infection Levels in Murine Oropharyngeal Candidiasis
. Antimicrobial Agents and Chemotherapy 63:4.
Crossref
Crossref
Joseph William Holloway & Jianping WuJoseph William Holloway & Jianping Wu. 2019. Red Meat Science and Production. Red Meat Science and Production
71
123
.
Mozhdeh Sepaskhah, Iman Moezzi, Mohammad Ali Davarpanah & Fatemeh Sari Aslani. (2018) Primary Cutaneous Mucormycosis in a Beta-Thalassemia Patient. Indian Journal of Hematology and Blood Transfusion 34:4, pages 776-777.
Crossref
Crossref
Débora C Coraça-Huber, Stefanie Dichtl, Stephan Steixner, Michael Nogler & Günter Weiss. (2018) Iron chelation destabilizes bacterial biofilms and potentiates the antimicrobial activity of antibiotics against coagulase-negative Staphylococci. Pathogens and Disease 76:5.
Crossref
Crossref
Anushila Chatterjee & Mark R. O'Brian. (2018) Rapid evolution of a bacterial iron acquisition system. Molecular Microbiology 108:1, pages 90-100.
Crossref
Crossref
Taylor Thorburn, Maral Aali, Lisanne Kostek, Chloe LeTourneau-Paci, Patricia Colp, Juan Zhou, Bruce Holbein, David Hoskin & Christian Lehmann. (2017) Anti-inflammatory effects of a novel iron chelator, DIBI, in experimental sepsis. Clinical Hemorheology and Microcirculation 67:3-4, pages 241-250.
Crossref
Crossref
Chuang Guo, Zhao-Hui Yang, Shuai Zhang, Rui Chai, Han Xue, Yan-Hui Zhang, Jia-Yi Li & Zhan-You Wang. (2017) Intranasal Lactoferrin Enhances α-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1α Pathways in an Alzheimer’s Disease Mouse Model. Neuropsychopharmacology 42:13, pages 2504-2515.
Crossref
Crossref
Eline H. VerbonPauline L. TrapetIoannis A. StringlisSophie KruijsPeter A.H.M. BakkerCorné M.J. Pieterse. (2017) Iron and Immunity. Annual Review of Phytopathology 55:1, pages 355-375.
Crossref
Crossref
Nathaniel P. Endicott, Eries Lee & Timothy A. Wencewicz. (2017)
Structural Basis for Xenosiderophore Utilization by the Human Pathogen
Staphylococcus aureus
. ACS Infectious Diseases 3:7, pages 542-553.
Crossref
Crossref
Piu Saha, Beng San Yeoh, Rodrigo A. Olvera, Xia Xiao, Vishal Singh, Deepika Awasthi, Bhagawat C. Subramanian, Qiuyan Chen, Madhu Dikshit, Yanming Wang, Carole A. Parent & Matam Vijay-Kumar. (2017) Bacterial Siderophores Hijack Neutrophil Functions. The Journal of Immunology 198:11, pages 4293-4303.
Crossref
Crossref
Geoffrey A. Heinzl, Weiliang Huang, Wenbo Yu, Bennett J. Giardina, Yue Zhou, Alexander D. MacKerellJr.Jr., Angela Wilks & Fengtian Xue. (2016)
Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of
Pseudomonas aeruginosa
. Journal of Medicinal Chemistry 59:14, pages 6929-6942.
Crossref
Crossref
David G. Workman, Michael Hunter, Lynn G. Dover & David Tétard. (2016) Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents. Journal of Inorganic Biochemistry 160, pages 49-58.
Crossref
Crossref
Katharina Richter, Mahnaz Ramezanpour, Nicky Thomas, Clive A. Prestidge, Peter-John Wormald & Sarah Vreugde. (2016)
Mind “De GaPP”: in vitro efficacy of deferiprone and gallium-protoporphyrin against
Staphylococcus aureus
biofilms
. International Forum of Allergy & Rhinology 6:7, pages 737-743.
Crossref
Crossref
Jun-Kai Kao, Shih-Chung Wang, Li-Wei Ho, Shi-Wei Huang, Shu-Hao Chang, Rei-Cheng Yang, Yu-Yuan Ke, Chun-Ying Wu, Jiu-Yao Wang & Jeng-Jer Shieh. (2016) Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification. PLOS ONE 11:5, pages e0156713.
Crossref
Crossref
Christina N Kontoghiorghe & George J Kontoghiorghes. (2016) New developments and controversies in iron metabolism and iron chelation therapy. World Journal of Methodology 6:1, pages 1.
Crossref
Crossref
Christina Kontoghiorghe, Annita Kolnagou & George Kontoghiorghes. (2015) Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology. Molecules 20:11, pages 20841-20872.
Crossref
Crossref
Paolo Ascenzi, Alessandra di Masi, Loris Leboffe, Emanuela Frangipani, Marco Nardini, Cinzia Verde & Paolo Visca. 2015. Recent Advances in Microbial Oxygen-Binding Proteins. Recent Advances in Microbial Oxygen-Binding Proteins
127
176
.
Robert L. Bertrand. (2014) Lag phase-associated iron accumulation is likely a microbial counter-strategy to host iron sequestration: Role of the ferric uptake regulator (fur). Journal of Theoretical Biology 359, pages 72-79.
Crossref
Crossref
Fabrizia MinandriCarlo BonchiEmanuela FrangipaniFrancesco Imperi & Paolo Visca. (2014) Promises and failures of gallium as an antibacterial agent. Future Microbiology 9:3, pages 379-397.
Crossref
Crossref
Jirapas Sripetchwandee, Noppamas Pipatpiboon, Nipon Chattipakorn & Siriporn Chattipakorn. (2014) Combined Therapy of Iron Chelator and Antioxidant Completely Restores Brain Dysfunction Induced by Iron Toxicity. PLoS ONE 9:1, pages e85115.
Crossref
Crossref
Vip Viprakasit & Worapant Kriengsoontornkij. 2014. A worldwide yearly survey of new data in adverse drug reactions and interactions. A worldwide yearly survey of new data in adverse drug reactions and interactions
419
433
.
Ji-Hoi Moon, Cheul Kim, Hee-Su Lee, Sung-Woon Kim & Jin-Yong Lee. (2013) Antibacterial and antibiofilm effects of iron chelators against Prevotella intermedia. Journal of Medical Microbiology 62:9, pages 1307-1316.
Crossref
Crossref
Nathan J. Schloemer, Anne H. Lincoln, Theresa A. Mikhailov, Chelsea L. Collins, Jennifer R. Di Rocco, Sue C. Kehl & Michael J. Chusid. (2013) Fatal Disseminated Pythium insidiosum Infection in a Child With Diamond-Blackfan Anemia. Infectious Diseases in Clinical Practice 21:4, pages e24-e26.
Crossref
Crossref
Glen A. Kennedy, Kirk L. Morris, Elango Subramonpillai, Cameron Curley, Jason Butler & Simon Durrant. (2013)
A prospective phase
II
randomized study of deferasirox to prevent iatrogenic iron overload in patients undertaking induction/consolidation chemotherapy for acute myeloid leukaemia
. British Journal of Haematology 161:6, pages 794-801.
Crossref
Crossref
Paolo Visca, Carlo Bonchi, Fabrizia Minandri, Emanuela Frangipani & Francesco Imperi. (2013) The Dual Personality of Iron Chelators: Growth Inhibitors or Promoters?. Antimicrobial Agents and Chemotherapy 57:5, pages 2432-2433.
Crossref
Crossref
Rebecca L.C. Adams & Robert J. Bird. (2013) Safety and efficacy of deferasirox in the management of transfusion-dependent patients with myelodysplastic syndrome and aplastic anaemia: a perspective review. Therapeutic Advances in Hematology 4:2, pages 93-102.
Crossref
Crossref
Paula Manuela de Castro Cardoso Pereira & Ana Filipa dos Reis Baltazar Vicente. (2013) Meat nutritional composition and nutritive role in the human diet. Meat Science 93:3, pages 586-592.
Crossref
Crossref
Elena T. Zakharova, Valeria A. Kostevich, Alexey V. Sokolov & Vadim B. Vasilyev. (2012) Human apo-lactoferrin as a physiological mimetic of hypoxia stabilizes hypoxia-inducible factor-1 alpha. BioMetals 25:6, pages 1247-1259.
Crossref
Crossref
C. Lalayanni, P. Baliakas, A. Xochelli, C. Apostolou, M. Arabatzis, A. Velegraki & A. Anagnostopoulos. (2012) Outbreak of cutaneous zygomycosis associated with the use of adhesive tape in haematology patients. Journal of Hospital Infection 81:3, pages 213-215.
Crossref
Crossref
Shigeo Fuji, Markus Kapp & Hermann Einsele. (2012) Challenges to Preventing Infectious Complications, Decreasing Re-hospitalizations, and Reducing Cost Burden in Long-Term Survivors After Allogeneic Hematopoietic Stem Cell Transplantation. Seminars in Hematology 49:1, pages 10-14.
Crossref
Crossref
Tomáš Filipský, Přemysl Mladěnka, Kateřina Macáková, Radomír Hrdina, Luciano Saso, Fabio Marchetti & Claudio Pettinari. (2012) In vitro characteristics of 1-phenyl-3-methyl-4-acylpyrazol-5-ones iron chelators. Biochimie 94:1, pages 125-131.
Crossref
Crossref
R.H.B. Meyboom. 2012. A worldwide yearly survey of new data in adverse drug reactions and interactions. A worldwide yearly survey of new data in adverse drug reactions and interactions
367
375
.
Ellis J. Neufeld. (2010) Update on Iron Chelators in Thalassemia. Hematology 2010:1, pages 451-455.
Crossref
Crossref
Eugene D. Weinberg. (2010) The hazards of iron loading. Metallomics 2:11, pages 732.
Crossref
Crossref