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Hemoglobin
international journal for hemoglobin research
Volume 18, 1994 - Issue 3
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Original Article

A simplified procedure for sequencing amplified DNA containing the α2- or α1-Globin gene

T. P. Molchanova Laboratory of Protein Chemistry Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912-2100, USA
,
D. D. Pobedimskaya Laboratory of Protein Chemistry Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912-2100, USA
&
Yu. V. Postnikov Laboratory of Protein Chemistry Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912-2100, USA
Pages 251-255 | Received 13 Aug 1993, Accepted 28 Feb 1994, Published online: 07 Jul 2009

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Saeed Anwar, Jarin Taslem Mourosi, Md. Kamrul Hasan, Mohammad Jakir Hosen & Md. Faruque Miah. (2020) Umbilical Cord Blood Screening for the Detection of Common Deletional Mutations of α-Thalassemia in Bangladesh. Hemoglobin 44:3, pages 201-210.
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Dewi Megawati, Ita M. Nainggolan, Maria Swastika, Susi Susanah, Johanes C. Mose, Alida R. Harahap & Iswari Setianingsih. (2014) Severe α-Thalassemia Intermedia Due to a Compound Heterozygosity for the Highly Unstable Hb Adana (HBA2: c.179G>A) and a Novel Codon 24 (HBA2: c.75T>A) Mutation. Hemoglobin 38:2, pages 149-151.
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Ita M. Nainggolan, Alida Harahap & Iswari Setianingsih. (2010) Hydrops Fetalis Associated with Homozygosity for Hb Adana [α59(E8)Gly→Asp (α2)]. Hemoglobin 34:4, pages 394-401.
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John Old & Shirley Henderson. (2010) Molecular diagnostics for haemoglobinopathies. Expert Opinion on Medical Diagnostics 4:3, pages 225-240.
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Laurie A. Steiner, Jack Van Hoff, Ferdane Kutlar & Patrick G. Gallagher. (2007) Aplastic Crisis Revealing the Diagnosis of Hb Evans [α62(E11)Val→Met, GTG→ATG (α2)] in a Hispanic Kindred: Case Report and Review. Hemoglobin 31:4, pages 409-416.
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J. M. Old. (2007) Screening and genetic diagnosis of haemoglobinopathies. Scandinavian Journal of Clinical and Laboratory Investigation 67:1, pages 71-86.
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Gunçag Dinçol, Dedrey Elam, Abdullah Kutlar & Ferdane Kutlar. (2003) Hb Setif [α94(G1)Asp→Tyr (α2)] Detected in a Turkish Family. Hemoglobin 27:4, pages 249-252.
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Nélida I. Noguera, Fernando A. González, Rubén A. Dávoli, Angela C. Milani & Ana Villegas. (2001) A NOVEL SPLICE ACCEPTOR SITE MUTATION OF THE α2-GLOBIN GENE CAUSING α-THALASSEMIA. Hemoglobin 25:3, pages 311-315.
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J. Hitchen, A. McFarlane, J. Lafferty & M. A.M. Ali. (1998) Detection of α2- and α1- Globin Gene Variants by a Modified Cycle Sequencing Method. Hemoglobin 22:4, pages 373-376.
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T. P. Molchanova & T. H. J. Huisman. (1996) The Importance of the 3′ Untranslated Region for the Expression of the α-Globin Genes. Hemoglobin 20:1, pages 41-54.
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E. G. Kazanetz, J. Ye. Leonova, J. B. Wilson, S. K. McMillan, M. Walbrecht, J. Mi. de Pablos Gallego & T. H. J. Huisman. (1995) Hb ananosa or α2111(G18)Ala → Valβ (α2 Mutation) and Hb mulhacen or α2123(H6)Ala → Serβ2 (αl Mutation) are two silent stable variants detected by sequencing of amplified dna. Hemoglobin 19:1-2, pages 1-6.
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A. Gürgey, C. Altay, L.-H. Gu, J. Ye. Leonova, A. Delibalta, C. Öner & T. H. J. Huisman. (1995) HB Hakkari or α2β231(B13)LEU→ARG, A Severely Unstable Hemoglobin Variant Associated with Numerous Intra-Erythroblastic Inclusions and Erythroid Hyperplasia of the Bone Marrow. Hemoglobin 19:3-4, pages 165-172.
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J. T. Prchal, B. Adler, J. B. Wilson, E. Baysal, W.-B. Qin, T. P. Molchanova, D. D. Pobedimskaya, E. G. Kazanetz & T. H. J. Huisman. (1995) HB Bibba OR α2136(H19)LEU→PROβ2 in a Caucasian Family from Alabama. Hemoglobin 19:3-4, pages 151-164.
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Articles from other publishers (18)

Aubrey Milunsky & Jeff M. MilunskyJohn M. Old & Jan Traeger‐Synodinos. 2021. Genetic Disorders and the Fetus. Genetic Disorders and the Fetus 1002 1034 .
Rong He, Jennifer L. Oliveira, James D. Hoyer & David S. Viswanatha. 2018. Hematopathology. Hematopathology 712 760.e18 .
John M. Old. 2015. Genetic Disorders and the Fetus. Genetic Disorders and the Fetus 718 754 .
Siew Leng Kho, Kek Heng Chua, Elizabeth George & Jin Ai Mary Anne Tan. (2015) A novel gap-PCR with high resolution melting analysis for the detection of α-thalassaemia Southeast Asian and Filipino β0-thalassaemia deletion. Scientific Reports 5:1.
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Shakil H. Merchant, Jennifer L. Oliveira, James D. Hoyer & David S. Viswanatha. 2012. Hematopathology. Hematopathology 679 726 .
Cornelis L Harteveld & Douglas R Higgs. (2010) α-thalassaemia. Orphanet Journal of Rare Diseases 5:1.
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John M. Old. 2009. Genetic Disorders and the Fetus. Genetic Disorders and the Fetus 646 679 .
Martin H. Steinberg, Bernard G. Forget, Douglas R. Higgs & David J. WeatherallMartin H. Steinberg, Mary Fabry & John M. Old. 2010. Disorders of Hemoglobin. Disorders of Hemoglobin 658 686 .
Martin H. Steinberg, Bernard G. Forget, Douglas R. Higgs & David J. WeatherallMartin H. Steinberg. 2010. Disorders of Hemoglobin. Disorders of Hemoglobin 623 624 .
Peng Yue & John Moult. (2006) Identification and Analysis of Deleterious Human SNPs. Journal of Molecular Biology 356:5, pages 1263-1274.
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Peng Yue, Zhaolong Li & John Moult. (2005) Loss of Protein Structure Stability as a Major Causative Factor in Monogenic Disease. Journal of Molecular Biology 353:2, pages 459-473.
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Tse N Leung, Tze K Lau & Tony KH Chung. (2005) Thalassaemia screening in pregnancy. Current Opinion in Obstetrics & Gynecology 17:2, pages 129-134.
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J.M Old. (2003) Screening and genetic diagnosis of haemoglobin disorders. Blood Reviews 17:1, pages 43-53.
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D.J. Weatherall & J.B. Clegg. 2001. The Thalassaemia Syndromes. The Thalassaemia Syndromes 733 821 .
Titus H.J. Huisman. (1997) High performance liquid chromatographic analysis of human hemoglobins and their polypeptide chains: its use in the identification of variants. Analytica Chimica Acta 352:1-3, pages 187-200.
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John Old. (1996) Haemoglobinopathies. Prenatal Diagnosis 16:13, pages 1181-1186.
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D. D. Pobedimskaya, T. P. Molchanova, S. Streichman & T. H. J. Huisman. (2006) Compound heterozygosity for two α‐globin gene defects, Hb taybe (α1; 38 or 39 minus thr) and a poly a mutation (α2; AATAAA → AATAAG), results in a severe hemolytic anemia. American Journal of Hematology 47:3, pages 198-202.
Crossref
T. P. Molchanova, D. D. Pobedimskaya & T. H. J. Huisman. (1994) The differences in quantities of α2-and α1-globin gene variants in heterozygotes. British Journal of Haematology 88:2, pages 300-306.
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