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Hemoglobin
international journal for hemoglobin research
Volume 21, 1997 - Issue 3
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Original Article

Clinical and Hematological Response to Hydroxyurea in a Patient with Hb Leporbp-Thalassemia

P. Rigano Thalassemia Centre, Ospedale “V. Cervello”, 90146, Palermo, Italia
,
L. Manfré Department of Radiology, Ospedale Policlinico, 90146, Palermo, Italia
,
R. La Galla Department of Radiology, Ospedale Policlinico, 90146, Palermo, Italia
,
D. Renda Thalassemia Centre, Ospedale “V. Cervello”, 90146, Palermo, Italia
,
M. C. Renda Thalassemia Centre, Ospedale “V. Cervello”, 90146, Palermo, Italia
,
A. Calabrese Thalassemia Centre, Ospedale “V. Cervello”, 90146, Palermo, Italia
,
R. Calzolari Thalassemia Centre, Ospedale “V. Cervello”, 90146, Palermo, Italia
&
A. Maggio Thalassemia Centre, Ospedale “V. Cervello”, 90146, Palermo, Italia
 show all
Pages 219-226 | Received 25 Apr 1996, Accepted 13 Jan 1997, Published online: 07 Jul 2009

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Karim Bayanzay & Ramsha Khan. (2015) Meta-analysis on effectiveness of hydroxyurea to treat transfusion-dependent beta-thalassemia. Hematology 20:8, pages 469-476.
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Alice Pecoraro, Antonio Troia, Roberta Calzolari, Concetta Scazzone, Paolo Rigano, Adriana Martorana, Massimiliano Sacco, Aurelio Maggio & Rosalba Di Marzo. (2015) Efficacy of Rapamycin as Inducer of Hb F in Primary Erythroid Cultures from Sickle Cell Disease and β-Thalassemia Patients. Hemoglobin 39:4, pages 225-229.
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I. PANIGRAHI, A. DIXIT, S. ARORA, M. KABRA, M. MAHAPATRA, V.P. CHOUDHRY & R. SAXENA. (2005) Do alpha deletions influence hydroxyurea response in thalassemia intermedia?. Hematology 10:1, pages 61-63.
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Articles from other publishers (23)

S.G. Duque, F.R. Jureschke & R.G. Leal. (2019) Reversible paraparesis secondary to spinal cord compression in a patient with ß-thalassaemia. Neurología (English Edition) 34:4, pages 270-272.
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S.G. Duque, F.R. Jureschke & R.G. Leal. (2019) Compresión medular con paraparesia reversible en paciente con ß-talasemia. Neurología 34:4, pages 270-272.
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Serena Sclafani, Alice Pecoraro, Veronica Agrigento, Antonio Troia, Rosario Di Maggio, Massimiliano Sacco, Aurelio Maggio, Elena D'Alcamo & Rosalba Di Marzo. (2016) Study on Hydroxyurea Response in Hemoglobinopathies Patients Using Genetic Markers and Liquid Erythroid Cultures. Hematology Reports 8:4, pages 56-60.
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Khaled M. MusallamAli T. TaherMaria Domenica CappelliniVijay G. Sankaran. (2013) Clinical experience with fetal hemoglobin induction therapy in patients with β-thalassemia. Blood 121:12, pages 2199-2212.
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Paolo Rigano, Alice Pecoraro, Roberta Calzolari, Antonio Troia, Santina Acuto, Disma Renda, Gaetano Restivo Pantalone, Aurelio Maggio & Rosalba Di Marzo. (2010) Desensitization to hydroxycarbamide following long-term treatment of thalassaemia intermedia as observed in vivo and in primary erythroid cultures from treated patients. British Journal of Haematology 151:5, pages 509-515.
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George Atweh & Hassana Fathallah. (2010) Pharmacologic Induction of Fetal Hemoglobin Production. Hematology/Oncology Clinics of North America 24:6, pages 1131-1144.
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Roberta Calzolari, Alice Pecoraro, Vito Borruso, Antonio Troia, Santina Acuto, Aurelio Maggio & Rosalba Di Marzo. (2008) Induction of gamma-globin gene transcription by hydroxycarbamide in primary erythroid cell cultures from Lepore patients. British Journal of Haematology 141:5, pages 720-727.
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Saqib H. Ansari, Tahir S. Shamsi, Fahad J. Siddiqui, Muhammad Irfan, Kausar Perveen, Tasneem Farzana, Vinodh K. Panjwani, Ayesha Yousuf & Tabassum Mehboob. (2007) Efficacy of Hydroxyurea (HU) in Reduction of Pack Red Cell (PRC) Transfusion Requirement Among Children Having Beta-thalassemia Major: Karachi HU Trial (KHUT). Journal of Pediatric Hematology/Oncology 29:11, pages 743-746.
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Jackie Sloane-Stanley, Nigel A. Roberts, Nancy Olivieri, David J. Weatherall & William G. Wood. (2006) Globin gene expression in Hb Lepore-BAC transgenic mice. British Journal of Haematology 135:5, pages 735-737.
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Hassana Fathallah & George F. Atweh. (2006) DNA hypomethylation therapy for hemoglobin disorders: Molecular mechanisms and clinical applications. Blood Reviews 20:4, pages 227-234.
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Andrea Mancuso, Aurelio Maggio, Disma Renda, Rosalba Marzo & Paolo Rigano. (2006) Treatment with hydroxycarbamide for intermedia thalassaemia: decrease of efficacy in some patients during long-term follow up. British Journal of Haematology 133:1, pages 105-106.
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Ashutosh Lal & Elliott Vichinsky. (2004) The role of fetal hemoglobin–enhancing agents in thalassemia. Seminars in Hematology 41, pages 17-22.
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Mohamed BradaiMohand Tayeb AbadSerge PissardFatima LamraouiLaurent SkopinskiMariane de Montalembert. (2003) Hydroxyurea can eliminate transfusion requirements in children with severe β-thalassemia. Blood 102:4, pages 1529-1530.
Crossref
George F Atweh & Dimitris Loukopoulos. (2001) Pharmacological induction of fetal hemoglobin in sickle cell disease and β-thalassemia. Seminars in Hematology 38:4, pages 367-373.
Crossref
MARTIN H. STEINBERG & GRIFFIN P. RODGERS. (2001) Pharmacologic Modulation of Fetal Hemoglobin. Medicine 80:5, pages 328-344.
Crossref
D.J. Weatherall & J.B. Clegg. 2001. The Thalassaemia Syndromes. The Thalassaemia Syndromes 733 821 .
Carolyn Hoppe, Elliott Vichinsky, Bradley Lewis, Dru Foote & Lori Styles. (1999) Hydroxyurea and sodium phenylbutyrate therapy in thalassemia intermedia. American Journal of Hematology 62:4, pages 221-227.
Crossref
Nancy F. Olivieri. (1999) The β-Thalassemias. New England Journal of Medicine 341:2, pages 99-109.
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NANCY F. OLIVIERI, DAVID C. REES, GORDON D. GINDER, SWEE LAY THEIN, JOHN S. WAYE, LEBE CHANG, GARY M. BRITTENHAM & DAVID J. WEATHERALL. (1998) Elimination of Transfusions Through Induction of Fetal Hemoglobin Synthesis in Cooley's Anemiaa. Annals of the New York Academy of Sciences 850:1 COOLEY'S ANEM, pages 100-109.
Crossref
Ben R. Saxon, David Rees & Nancy F. Olivieri. (2001) Regression of extramedullary haemopoiesis and augmentation of fetal haemoglobin concentration during hydroxyurea therapy in β thalassaemia. British Journal of Haematology 101:3, pages 416-419.
Crossref
Griffin P. Rodgers. (1998) 9 Pharmacological therapy. Baillière's Clinical Haematology 11:1, pages 239-255.
Crossref
Nancy Olivieri. (1998) 5 Thalassaemia: clinical management. Baillière's Clinical Haematology 11:1, pages 147-162.
Crossref
Nancy F Olivieri, David C Rees, Gordon D Ginder, Swee Lay Thein, Gary M Brittenham, John S Waye & DJ Weatherall. (1997) Treatment of thalassaemia major with phenylbutyrate and hydroxyurea. The Lancet 350:9076, pages 491-492.
Crossref

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