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Research Article

Study on hydrophilic 5-fluorouracil release from hydrophobic poly(ϵ-caprolactone) cylindrical implants

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Pages 1068-1075 | Received 09 Oct 2010, Accepted 28 Jan 2011, Published online: 30 Mar 2011

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Michael Hrynyk, Jordon P Ellis, Fiona Haxho, Stephanie Allison, Joseph AM Steele, Samar Abdulkhalek, Ronald J Neufeld & Myron R Szewczuk. (2015) Therapeutic designed poly (lactic-co-glycolic acid) cylindrical oseltamivir phosphate-loaded implants impede tumor neovascularization, growth and metastasis in mouse model of human pancreatic carcinoma. Drug Design, Development and Therapy 9, pages 4573-4586.
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Weiluan Chen, Zhenghua Wu, Han Yang, Shengrong Guo, Dawei Li & Liang Cheng. (2014) In vitro and in vivo evaluation of injectable implants for intratumoral delivery of 5-fluorouracil. Pharmaceutical Development and Technology 19:2, pages 223-231.
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Adriana De Fátima Pereira, Leticia Gonçalves Resende Pereira, Leandro Augusto De Oliveira Barbosa, Sílvia Ligório Fialho, Bruno Gonçalves Pereira, Patrícia Santiago De Oliveira Patricio, Flávia Carmo Horta Pinto & Gisele Rodrigues Da Silva. (2013) Efficacy of methotrexate-loaded poly(ε-caprolactone) implants in Ehrlich solid tumor-bearing mice. Drug Delivery 20:3-4, pages 168-179.
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Matteo Di Luca, Clare Hoskins, Francesca Corduas, Rachel Onchuru, Adeolu Oluwasanmi, Davide Mariotti, Bice Conti & Dimitrios A. Lamprou. (2022) 3D printed biodegradable multifunctional implants for effective breast cancer treatment. International Journal of Pharmaceutics 629, pages 122363.
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Adam Kasiński, Monika Zielińska-Pisklak, Ewa Oledzka, Grzegorz Nałęcz-Jawecki, Agata Drobniewska & Marcin Sobczak. (2020) Hydrogels Based on Poly(Ether-Ester)s as Highly Controlled 5-Fluorouracil Delivery Systems—Synthesis and Characterization. Materials 14:1, pages 98.
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Faezeh Ghahreman, Dariush Semnani, Saied Nouri Khorasani, Jaleh Varshosaz, Shahla Khalili, Sajjad Mohammadi & Elham Kaviannasab. (2020) Polycaprolactone–Gelatin Membranes in Controlled Drug Delivery of 5-Fluorouracil. Polymer Science, Series A 62:6, pages 636-647.
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Barbara E. Souza & Jin-Chong Tan. (2020) Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework . CrystEngComm 22:27, pages 4526-4530.
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Barbara E. Souza, Annika F. Möslein, Kirill Titov, James D. Taylor, Svemir Rudić & Jin-Chong Tan. (2020) Green Reconstruction of MIL-100 (Fe) in Water for High Crystallinity and Enhanced Guest Encapsulation. ACS Sustainable Chemistry & Engineering 8:22, pages 8247-8255.
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Ling Li, Chao Li & Jianping Zhou. (2018) Effective sustained release of 5-FU-loaded PLGA implant for improving therapeutic index of 5-FU in colon tumor. International Journal of Pharmaceutics 550:1-2, pages 380-387.
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Richard Garrett, Eri Niiyama, Yohei Kotsuchibashi, Koichiro Uto & Mitsuhiro Ebara. (2015) Biodegradable Nanofiber for Delivery of Immunomodulating Agent in the Treatment of Basal Cell Carcinoma. Fibers 3:4, pages 478-490.
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Pei-Ting Ko, I-Chi Lee, Mei-Chin Chen & Shau-Wei Tsai. (2015) Polymer microneedles fabricated from PCL and PCL/PEG blends for transdermal delivery of hydrophilic compounds. Journal of the Taiwan Institute of Chemical Engineers 51, pages 1-8.
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Ralf Smeets, Anders Henningsen, Ole Jung, Max Heiland, Christian Hammächer & Jamal M Stein. (2014) Definition, etiology, prevention and treatment of peri-implantitis – a review. Head & Face Medicine 10:1.
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Kamal K. Gupta, Namrata Pal, Pradeep K. Mishra, Pradeep Srivastava, Sujata Mohanty & Pralay Maiti. (2014) 5-Florouracil-loaded poly(lactic acid)-poly(caprolactone) hybrid scaffold: Potential chemotherapeutic implant. Journal of Biomedical Materials Research Part A 102:8, pages 2600-2612.
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Na Zheng, Mingyao Zhou & Wen Lu. (2012) In vivo distribution of 5-Fluorouracil after peritumoral implantation using a biodegradable micro-device in tumor-bearing mice. European Journal of Drug Metabolism and Pharmacokinetics 38:3, pages 183-190.
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Ana Almeida, Bart Claeys, Jean Paul Remon & Chris Vervaet. 2012. Hot‐Melt Extrusion: Pharmaceutical Applications. Hot‐Melt Extrusion: Pharmaceutical Applications 43 69 .

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