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Research Article

Stability of sulforaphane for topical formulation

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Pages 494-502 | Received 27 Sep 2012, Accepted 17 Jan 2013, Published online: 23 Apr 2013

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Read on this site (4)

Lizhen Li, Peihua Ma, Satoru Nirasawa & Haijie Liu. (2023) Formation, immunomodulatory activities, and enhancement of glucosinolates and sulforaphane in broccoli sprouts: a review for maximizing the health benefits to human. Critical Reviews in Food Science and Nutrition 0:0, pages 1-31.
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Lucía Yepes-Molina & Micaela Carvajal. (2021) Nanoencapsulation of sulforaphane in broccoli membrane vesicles and their in vitro antiproliferative activity. Pharmaceutical Biology 59:1, pages 1488-1502.
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Xin Jiang, Ye Liu, Lixin Ma, Rui Ji, Yaqin Qu, Ying Xin & Guoyue Lv. (2018) Chemopreventive activity of sulforaphane. Drug Design, Development and Therapy 12, pages 2905-2913.
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Przemysław Zalewski, Robert Skibiński, Magdalena Paczkowska, Piotr Garbacki, Alicja Talaczyńska, Judyta Cielecka-Piontek & Anna Jelińska. (2016) Stability of cefozopran hydrochloride in aqueous solutions. Drug Development and Industrial Pharmacy 42:4, pages 572-577.
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Articles from other publishers (43)

Rachel S. Grady, Tinna Traustadóttir, Anthony F. Lagalante & Aimee L. Eggler. (2023) Bioavailable Sulforaphane Quantitation in Plasma by LC–MS/MS Is Enhanced by Blocking Thiols. Journal of Agricultural and Food Chemistry 71:34, pages 12875-12882.
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Liang Yan & Yachun Yan. (2023) Therapeutic potential of sulforaphane in liver diseases: a review. Frontiers in Pharmacology 14.
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Wei Zhu, Larry A. Lerno, Eleonora Cremonini, Patricia I. Oteiza, Angela Mastaloudis, Gail M. Bornhorst & Alyson E. Mitchell. (2023) Robust UHPLC-(ESI+)-MS/MS Method for Simultaneous Analysis of Glucoraphanin, Sulforaphane, and Sulforaphane Metabolites in Biological Samples. ACS Food Science & Technology 3:7, pages 1300-1310.
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Wen-wen Deng, Xue-ping Mei, Zi-jun Cheng, Tian-xiang gan, Xuan Tian, Jiang-nan Hu, Chuan-ru Zang, Bo Sun, Jing Wu, Yin Deng, Reza. A. Ghiladi, George H. Lorimer, Gizem Keceli & Jun Wang. (2023) Extraction of weak hydrophobic sulforaphane from broccoli by salting-out assisted hydrophobic deep eutectic solvent extraction. Food Chemistry 405, pages 134817.
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Marie‐Céline Frantz, Roger Rozot & Laurent Marrot. (2022) NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products. BioFactors 49:1, pages 32-61.
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Tamara Ramírez-Pavez, Andrea García-Peñaranda, Paula Garcia-Ibañez, Lucía Yepes-Molina, Micaela Carvajal, Antonio J. Ruiz-Alcaraz, Diego A. Moreno, Pilar García-Peñarrubia & María Martínez-Esparza. (2022) Potential of Sulforaphane and Broccoli Membrane Vesicles as Regulators of M1/M2 Human Macrophage Activity. International Journal of Molecular Sciences 23:19, pages 11141.
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Julia Huchthausen, Luise Henneberger, Sophia Mälzer, Beate NicolChris SparhamBeate I. Escher. (2022) High-Throughput Assessment of the Abiotic Stability of Test Chemicals in In Vitro Bioassays . Chemical Research in Toxicology 35:5, pages 867-879.
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Sotiris Kyriakou, Dimitrios T. Trafalis, Maria V. Deligiorgi, Rodrigo Franco, Aglaia Pappa & Mihalis I. Panayiotidis. (2022) Assessment of Methodological Pipelines for the Determination of Isothiocyanates Derived from Natural Sources. Antioxidants 11:4, pages 642.
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Lucía Yepes-Molina, María Isabel Pérez-Jiménez, María Martínez-Esparza, José A. Teruel, Antonio J. Ruiz-Alcaraz, Pilar García-Peñarrubia & Micaela Carvajal. (2022) Membrane Vesicles for Nanoencapsulated Sulforaphane Increased Their Anti-Inflammatory Role on an In Vitro Human Macrophage Model. International Journal of Molecular Sciences 23:4, pages 1940.
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Xiaolu Yu, Hongju He, Xuezhi Zhao, Guangmin Liu, Liping Hu, Bing Cheng & Yaqin Wang. (2021) Determination of 18 Intact Glucosinolates in Brassicaceae Vegetables by UHPLC-MS/MS: Comparing Tissue Disruption Methods for Sample Preparation. Molecules 27:1, pages 231.
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Wu Yuanfeng, Lv Chengzhi, Zou Ligen, Sun Juan, Song Xinjie, Zhang Yao & Mao Jianwei. (2021) Approaches for enhancing the stability and formation of sulforaphane. Food Chemistry 345, pages 128771.
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Valentina Citi, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Simone Brogi, Lorenzo Flori, Era Gorica, Lara Testai, Alma Martelli, Vincenzo Calderone, Giuseppe Caliendo & Beatrice Severino. (2021) Structure-activity relationships study of isothiocyanates for H2S releasing properties: 3-Pyridyl-isothiocyanate as a new promising cardioprotective agent. Journal of Advanced Research 27, pages 41-53.
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Alessia Panusa, Alessia Rosetti, Claudio Villani & Roberto Cirilli. (2020) Direct HPLC enantioseparation of chemopreventive chiral isothiocyanates sulforaphane and iberin on immobilized amylose-based chiral stationary phases under normal-phase, polar organic and aqueous conditions. Talanta 218, pages 121151.
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Roberto Cirilli, Francesca Romana Gallo, Giuseppina Multari, Giovanna Palazzino, Carlo Mustazza & Alessia Panusa. (2020) Study of solvent effect on the stability of isothiocyanate iberin, a breakdown product of glucoiberin. Journal of Food Composition and Analysis 92, pages 103515.
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Khea Wolff, Asha Jaja-Chimedza, Youjin Kim, Carrie Waterman, Alexander Poulev, Ilya Raskin & David Ribnicky. (2020) Moringa isothiocyanate-1 is bioaccessible and bioavailable as a stable unmodified compound. Phytochemistry Letters 38, pages 33-38.
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Ruheea Taskin Ruhee & Katsuhiko Suzuki. (2020) The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical. Antioxidants 9:6, pages 521.
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Shanyi Li, Yuqing Yang, Davit Sargsyan, Renyi Wu, Ran Yin, Hsiao-Chen Dina Kuo, Irene Yang, Lujing Wang, David Cheng, Christina N. Ramirez, Rasika Hudlikar, Yaoping Lu & Ah-Ng Kong. (2020) Epigenome, Transcriptome, and Protection by Sulforaphane at Different Stages of UVB-Induced Skin Carcinogenesis. Cancer Prevention Research 13:6, pages 551-562.
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Bruno M. Simões, Angélica Santiago-Gómez, Chiara Chiodo, Tiago Moreira, Daniel Conole, Scott Lovell, Denis Alferez, Rachel Eyre, Katherine Spence, Aida Sarmiento-Castro, Bertram Kohler, Ludivine Morisset, Marilena Lanzino, Sebastiano Andò, Elisabetta Marangoni, Andrew H. Sims, Edward W. Tate, Sacha J. Howell & Robert B. Clarke. (2020) Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer. Oncogene 39:25, pages 4896-4908.
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S. Zhang, D.Y. Ying, L.J. Cheng, M. Bayrak, H. Jegasothy, L. Sanguansri & M.A. Augustin. (2020) Sulforaphane in broccoli-based matrices: Effects of heat treatment and addition of oil. LWT 128, pages 109443.
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Mohammad M. Kamal, Sharmin Akter, Chin-Nu Lin & Sami Nazzal. (2020) Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems. Archives of Pharmacal Research 43:4, pages 371-384.
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Annie Langston-Cox, Dovile Anderson, Darren J. Creek, Kirsten Palmer, Euan M. Wallace & Sarah A. Marshall. (2020) Measuring Sulforaphane and Its Metabolites in Human Plasma: A High Throughput Method. Molecules 25:4, pages 829.
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Yan Xue Cai, Mary Ann Augustin, Hema Jegasothy, Ji Hui Wang & Netsanet Shiferaw Terefe. (2020) Mild heat combined with lactic acid fermentation: a novel approach for enhancing sulforaphane yield in broccoli puree. Food & Function 11:1, pages 779-786.
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Maria Chiara Cristiano, Francesca Froiio, Roberta Spaccapelo, Antonia Mancuso, Steven P. Nisticò, Betty P. Udongo, Massimo Fresta & Donatella Paolino. (2019) Sulforaphane-Loaded Ultradeformable Vesicles as A Potential Natural Nanomedicine for the Treatment of Skin Cancer Diseases. Pharmaceutics 12:1, pages 6.
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Christine A. Houghton. (2019) Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. Oxidative Medicine and Cellular Longevity 2019, pages 1-27.
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Tâmmila V Klug, Elena Collado, Ginés B Martínez‐Hernández, Francisco Artés & Francisco Artés‐Hernández. (2018) Effect of stevia supplementation of kale juice spheres on their quality changes during refrigerated shelf life. Journal of the Science of Food and Agriculture 99:5, pages 2384-2392.
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Vicente Hernández-Rabaza, Rosa López-Pedrajas & Inmaculada Almansa. (2019) Progesterone, Lipoic Acid, and Sulforaphane as Promising Antioxidants for Retinal Diseases: A Review. Antioxidants 8:3, pages 53.
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David Cheng, Linbo Gao, Shan Su, Davit Sargsyan, Renyi Wu, Ilya Raskin & Ah-Ng Kong. (2019) Moringa Isothiocyanate Activates Nrf2: Potential Role in Diabetic Nephropathy. The AAPS Journal 21:2.
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Ginés B Martínez‐Hernández, Tâmmila Venzke‐Klug, María del Mar Carrión‐Monteagudo, Francisco Artés Calero, José M López‐Nicolás & Francisco Artés‐Hernández. (2018) Effects of α ‐, β ‐ and maltosyl‐ β ‐cyclodextrins use on the glucoraphanin–sulforaphane system of broccoli juice . Journal of the Science of Food and Agriculture 99:2, pages 941-946.
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Tâmmila Venzke Klug, Ginés Benito Martínez-Hernández, Elena Collado, Francisco Artés & Francisco Artés-Hernández. (2018) Effect of Microwave and High-Pressure Processing on Quality of an Innovative Broccoli Hummus. Food and Bioprocess Technology 11:8, pages 1464-1477.
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Ian Edwin Cock. (2018) Is the pharmaceutical industry’s preoccupation with the monotherapy drug model stifling the development of effective new drug therapies?. Inflammopharmacology 26:3, pages 861-879.
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Karen Blohm-Mangone, Nichole B. Burkett, Shekha Tahsin, Paul B. Myrdal, Alhassan Aodah, Brenda Ho, Jaroslav Janda, Michelle McComas, Kathylynn Saboda, Denise J. Roe, Zigang Dong, Ann M. Bode, Emanuel F. PetricoinIIIIII, Valerie S. Calvert, Clara Curiel-Lewandrowski, David S. Alberts, Georg T. Wondrak & Sally E. Dickinson. (2018) Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice. Cancer Prevention Research 11:5, pages 265-278.
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Noelia Castillejo, Ginés Benito Martínez-Hernández, Antonio José Lozano-Guerrero, Juan Luis Pedreño-Molina, Perla A Gómez, Encarna Aguayo, Francisco Artés & Francisco Artés-Hernández. (2018) Microwave heating modelling of a green smoothie: Effects on glucoraphanin, sulforaphane and S -methyl cysteine sulfoxide changes during storage . Journal of the Science of Food and Agriculture 98:5, pages 1863-1872.
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Yuanfeng Wu, Yuke Shen, Xuping Wu, Ye Zhu, Jothame Mupunga, Wenna Bao, Jun Huang, Jianwei Mao, Shiwang Liu & Yuru You. (2018) Hydrolysis before Stir-Frying Increases the Isothiocyanate Content of Broccoli. Journal of Agricultural and Food Chemistry 66:6, pages 1509-1515.
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Mary K. Montes de Oca, Ross L. Pearlman, Sarah F. McClees, Rebecca Strickland & Farrukh Afaq. (2017) Phytochemicals for the Prevention of Photocarcinogenesis. Photochemistry and Photobiology 93:4, pages 956-974.
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Jed W. Fahey, Kristina L. Wade, Scott L. Wehage, Walter David Holtzclaw, Hua Liu, Paul Talalay, Edward Fuchs & Katherine K. Stephenson. (2017) Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency. Molecular Nutrition & Food Research 61:4, pages 1600766.
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Aixian Lan, Wenjun Li, Yao Liu, Zhaohui Xiong, Xinyan Zhang, Shanshan Zhou, Olesya Palko, Hao Chen, Mayanga Kapita, Justin R. Prigge, Edward E. Schmidt, Xin Chen, Zheng Sun & Xiaoxin Luke Chen. (2016) Chemoprevention of oxidative stress-associated oral carcinogenesis by sulforaphane depends on NRF2 and the isothiocyanate moiety. Oncotarget 7:33, pages 53502-53514.
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Chau Ong & Fawzy Elbarbry. (2016) A new validated HPLC method for the determination of sulforaphane: application to study pharmacokinetics of sulforaphane in rats. Biomedical Chromatography 30:7, pages 1016-1021.
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FengMing Lan, Qiang Pan, Huiming Yu & Xiao Yue. (2015) Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/β-catenin signaling in glioblastoma. Journal of Neurochemistry 134:5, pages 811-818.
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Tugba Boyunegmez Tumer, Patricio Rojas-Silva, Alexander Poulev, Ilya Raskin & Carrie Waterman. (2015) Direct and Indirect Antioxidant Activity of Polyphenol- and Isothiocyanate-Enriched Fractions from Moringa oleifera . Journal of Agricultural and Food Chemistry 63:5, pages 1505-1513.
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Neel M. Fofaria, Alok Ranjan, Sung-Hoon Kim & Sanjay K. Srivastava. 2015. Mechanism of the Anticancer Effect of Phytochemicals. Mechanism of the Anticancer Effect of Phytochemicals 111 137 .
Francis Berenbaum. (2014) Les brocolis protègent-ils de l’arthrose ?. Revue du Rhumatisme 81:4, pages 278-280.
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Francis Berenbaum. (2014) Does broccoli protect from osteoarthritis?. Joint Bone Spine 81:4, pages 284-286.
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Gina De Nicola, Patrick Rollin, Emanuela Mazzon & Renato Iori. (2014) Novel Gram-Scale Production of Enantiopure R-Sulforaphane from Tuscan Black Kale Seeds. Molecules 19:6, pages 6975-6986.
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