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Research Article

The influence of API concentration on the roller compaction process: modeling and prediction of the post compacted ribbon, granule and tablet properties using multivariate data analysis

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Pages 1470-1478 | Received 23 May 2014, Accepted 21 Aug 2014, Published online: 12 Sep 2014

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Pezhman Kazemi, Mohammad Hassan Khalid, Ana Pérez Gago, Peter Kleinebudde, Renata Jachowicz, Jakub Szlęk & Aleksander Mendyk. (2017) Effect of roll compaction on granule size distribution of microcrystalline cellulose–mannitol mixtures: computational intelligence modeling and parametric analysis. Drug Design, Development and Therapy 11, pages 241-251.
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Ana Pérez Gago & Peter Kleinebudde. (2017) MCC–mannitol mixtures after roll compaction/dry granulation: percolation thresholds for ribbon microhardness and granule size distribution. Pharmaceutical Development and Technology 22:6, pages 764-774.
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Tim Wenzel, Cordula Stillhart, Peter Kleinebudde & Anikó Szepes. (2017) Influence of drug load on dissolution behavior of tablets containing a poorly water-soluble drug: estimation of the percolation threshold. Drug Development and Industrial Pharmacy 43:8, pages 1265-1275.
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Maxwell Korang-Yeboah, Sohail Akhtar, Akhtar Siddiqui, Ziyaur Rahman & Mansoor A. Khan. (2016) Application of NIR chemometric methods for quantification of the crystalline fraction of warfarin sodium in drug product. Drug Development and Industrial Pharmacy 42:4, pages 584-594.
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E. Faulhammer, M. Llusa, P. R. Wahl, A. Paudel, S. Lawrence, S. Biserni, V. Calzolari & J. G. Khinast. (2016) Development of a design space and predictive statistical model for capsule filling of low-fill-weight inhalation products. Drug Development and Industrial Pharmacy 42:2, pages 221-230.
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Hongqin Yang, Xiaoxiang Liao, Feng Peng, Wan Wang, Yanxin Liu, Jin Yan & Hui Li. (2015) Monitoring of the manufacturing process for ambroxol hydrochloride tablet using NIR-chemometric methods: compression effect on content uniformity model and relevant process parameters testing. Drug Development and Industrial Pharmacy 41:11, pages 1877-1887.
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Articles from other publishers (11)

Eun Ji Kim, Ji Hyeon Kim, Min-Soo Kim, Seong Hoon Jeong & Du Hyung Choi. (2021) Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification. Pharmaceutics 13:6, pages 919.
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Guolin Shi, Longfei Lin, Yuling Liu, Gongsen Chen, Yuting Luo, Yanqiu Wu & Hui Li. (2021) Pharmaceutical application of multivariate modelling techniques: a review on the manufacturing of tablets. RSC Advances 11:14, pages 8323-8345.
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Naseem A. Charoo & Ziyaur Rahman. (2020) Integrating QbD Tools for Flexible Scale-Up Batch Size Selection for Solid Dosage Forms. Journal of Pharmaceutical Sciences 109:3, pages 1223-1230.
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Jiaqi Yu, Bing Xu, Kunfeng Zhang, Chenfeng Shi, Zhiqiang Zhang, Jing Fu & Yanjiang Qiao. (2019) Using a Material Library to Understand the Impacts of Raw Material Properties on Ribbon Quality in Roll Compaction. Pharmaceutics 11:12, pages 662.
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Ana Patricia Ferreira, John F. Gamble, Michael M. Leane, Hyunsoo Park, Dolapo Olusanmi & Mike Tobyn. (2018) Enhanced Understanding of Pharmaceutical Materials Through Advanced Characterisation and Analysis. AAPS PharmSciTech 19:8, pages 3462-3480.
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Natalia L. Calvo, Rubén M. Maggio & Teodoro S. Kaufman. (2018) Characterization of pharmaceutically relevant materials at the solid state employing chemometrics methods. Journal of Pharmaceutical and Biomedical Analysis 147, pages 538-564.
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Nidhi Raval, Vishakha Tambe, Rahul Maheshwari, Pran Kishore Deb & Rakesh K. Tekade. 2018. Dosage Form Design Considerations. Dosage Form Design Considerations 669 700 .
Claudia C. Corredor, Dongsheng Bu & Gary McGeorge. 2018. Multivariate Analysis in the Pharmaceutical Industry. Multivariate Analysis in the Pharmaceutical Industry 211 234 .
Ana Patricia Ferreira, Clare Frances Rawlinson-Malone, John Gamble, Sarah Nicholson & Mike Tobyn. 2018. Multivariate Analysis in the Pharmaceutical Industry. Multivariate Analysis in the Pharmaceutical Industry 235 267 .
Zelalem Ayenew Worku, Dinesh Kumar, João Victor Gomes, Yunliang He, Brian Glennon, Kiran A. Ramisetty, Åke C. Rasmuson, Peter O’Connell, Kieran H. Gallagher, Trevor Woods, Nalini R. Shastri & Anne-Marie Healy. (2017) Modelling and understanding powder flow properties and compactability of selected active pharmaceutical ingredients, excipients and physical mixtures from critical material properties. International Journal of Pharmaceutics 531:1, pages 191-204.
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Cordula Stillhart, Neil J. Parrott, Marc Lindenberg, Pascal Chalus, Darren Bentley & Anikó Szepes. (2017) Characterising Drug Release from Immediate-Release Formulations of a Poorly Soluble Compound, Basmisanil, Through Absorption Modelling and Dissolution Testing. The AAPS Journal 19:3, pages 827-836.
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