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Drug Development and Industrial Pharmacy Volume 19, 1993 - Issue 15
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Research Article

Prolonged release Matrix Pellets Prepared by Melt Pelletization I. Process Variables

L. Juul Thomsen Royal Danish School of Pharmacy, Dept. of Pharmaceutics, 2 Universitetsparken, DK-2100, Copenhagen, Denmark
,
T. Schæfer Royal Danish School of Pharmacy, Dept. of Pharmaceutics, 2 Universitetsparken, DK-2100, Copenhagen, Denmark
,
J. M. Sonnergaard Royal Danish School of Pharmacy, Dept. of Pharmaceutics, 2 Universitetsparken, DK-2100, Copenhagen, Denmark
&
H. G. Kristensen Royal Danish School of Pharmacy, Dept. of Pharmaceutics, 2 Universitetsparken, DK-2100, Copenhagen, Denmark
Pages 1867-1887 | Published online: 20 Oct 2008

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Read on this site (3)

B. Evrard, K. Amighi, D. Beten, L. Delattre & A. J. Moës. (1999) Influence of Melting and Rheological Properties of Fatty Binders on the Melt Granulation Process in a High-Shear Mixer. Drug Development and Industrial Pharmacy 25:11, pages 1177-1184.
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E. Nicholas Griffin & Paul J. Niebergall. (1999) Release Kinetics of a Controlled-Release Multiparticulate Dosage Form Prepared Using a Hot-Melt Fluid Bed Coating Method. Pharmaceutical Development and Technology 4:1, pages 117-124.
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F. Zhou, C. Vervaet, D. L. Massart, B. Massart & J. P. Remon. (1998) Optimization of the Processing of Matrix Pellets Based on the Combination of Waxes and Starch Using Experimental Design. Drug Development and Industrial Pharmacy 24:4, pages 353-358.
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Articles from other publishers (17)

Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini & Nadia Passerini. (2024) The use of polymorphic state modifiers in solid lipid microparticles: The role of structural modifications on drug release performance. European Journal of Pharmaceutical Sciences 192, pages 106650.
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Shigeru Itai. (2019) Development of Novel Functional Formulations Based on Pharmaceutical Technologies製剤技術を基盤とした新規機能性製剤の開発. YAKUGAKU ZASSHI 139:3, pages 419-435.
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Mohamed Mohamady Ghobashy, M. A. Elhady & A. Awadallah. (2017) Pellets of magnetized polyethylene (Fe3O4/PE) wax from gamma irradiated polyethylene: synthesis and characterization. International Journal of Plastics Technology 22:1, pages 1-9.
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Karin Becker, Sharareh Salar-Behzadi & Andreas Zimmer. (2015) Solvent-Free Melting Techniques for the Preparation of Lipid-Based Solid Oral Formulations. Pharmaceutical Research 32:5, pages 1519-1545.
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C. Eckert, M. Pein & J. Breitkreutz. (2014) Lean production of taste improved lipidic sodium benzoate formulations. European Journal of Pharmaceutics and Biopharmaceutics 88:2, pages 455-461.
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Ahmed Abd-Elbary, Mina Ibrahim Tadros & Ahmed Adel Alaa-Eldin. (2013) Sucrose Stearate-Enriched Lipid Matrix Tablets of Etodolac: Modulation of Drug Release, Diffusional Modeling and Structure Elucidation Studies. AAPS PharmSciTech 14:2, pages 656-668.
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Kai Shiino, Yasunori Iwao, Yukari Fujinami & Shigeru Itai. (2012) Preparation and evaluation of granules with pH-dependent release by melt granulation. International Journal of Pharmaceutics 431:1-2, pages 70-77.
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Harjoh Nurulaini & Tin Wui Wong. (2011) Design of In Situ Dispersible and Calcium Cross-Linked Alginate Pellets as Intestinal-Specific Drug Carrier by Melt Pelletization Technique. Journal of Pharmaceutical Sciences 100:6, pages 2248-2257.
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Anette Pauli-Bruns, Klaus Knop & Bernhard C. Lippold. (2010) Preparation of sustained release matrix pellets by melt agglomeration in the fluidized bed: Influence of formulation variables and modelling of agglomerate growth. European Journal of Pharmaceutics and Biopharmaceutics 74:3, pages 503-512.
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Mario Grassi, Dario Voinovich, Mariarosa Moneghini, Erica Franceschinis, Beatrice Perissutti & Jelena Filipovic-Grcic. (2003) Preparation and evaluation of a melt pelletised paracetamol/stearic acid sustained release delivery system. Journal of Controlled Release 88:3, pages 381-391.
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Jamila Hamdani, André J Moës & Karim Amighi. (2002) Development and evaluation of prolonged release pellets obtained by the melt pelletization process. International Journal of Pharmaceutics 245:1-2, pages 167-177.
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Dario Voinovich, Mariarosa Moneghini, Beatrice Perissutti & Erica Franceschinis. (2001) Melt pelletization in high shear mixer using a hydrophobic melt binder: influence of some apparatus and process variables. European Journal of Pharmaceutics and Biopharmaceutics 52:3, pages 305-313.
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Torben Schæfer. (2001) Growth mechanisms in melt agglomeration in high shear mixers. Powder Technology 117:1-2, pages 68-82.
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Sally Harding, Herbert Baumann, Torkel Gren & Anette Seo. (2000) NMR microscopy of the uptake, distribution and mobility of dissolution media in small, sub-millimetre drug delivery systems. Journal of Controlled Release 66:1, pages 81-99.
Crossref
F. Zhou, C. Vervaet & J.P. Remon. (1997) Influence of processing on the characteristics of matrix pellets based on microcrystalline waxes and starch derivatives. International Journal of Pharmaceutics 147:1, pages 23-30.
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Torben Schæfer & Christina Mathiesen. (1996) Melt pelletization in a high shear mixer. VIII. Effects of binder viscosity. International Journal of Pharmaceutics 139:1-2, pages 125-138.
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H.G. Kristensen. 1995. Advances in Pharmaceutical Sciences Volume 7. Advances in Pharmaceutical Sciences Volume 7 221 272 .

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