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Research Article

Effect of Cyclodextrins on Topical Drug Delivery to the Eye

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Pages 473-481 | Published online: 20 Oct 2008

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Tivadar Bíró, Alexandra Bocsik, Bisera Jurišić Dukovski, Ilona Gróf, Jasmina Lovrić, Ildikó Csóka, Mária A Deli & Zoltán Aigner. (2021) New Approach in Ocular Drug Delivery: In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations. Drug Design, Development and Therapy 15, pages 351-360.
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Tivadar Bíró, Gabriella Horvát, Mária Budai-Szűcs, Erzsébet Csányi, Edit Urbán, Andrea Facskó, Piroska Szabó-Révész, Ildikó Csóka & Zoltán Aigner. (2018) Development of prednisolone-containing eye drop formulations by cyclodextrin complexation and antimicrobial, mucoadhesive biopolymer. Drug Design, Development and Therapy 12, pages 2529-2537.
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Pingfei Li, Shu Wang, Haoyuan Chen, Shiming Zhang, Shihui Yu, Yuenan Li, Mengsuo Cui, Weisan Pan & Xinggang Yang. (2018) A novel ion-activated in situ gelling ophthalmic delivery system based on κ-carrageenan for acyclovir. Drug Development and Industrial Pharmacy 44:5, pages 829-836.
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Linda Duxfield, Rubab Sultana, Ruokai Wang, Vanessa Englebretsen, Samantha Deo, Ilva D. Rupenthal & Raida Al-Kassas. (2016) Ocular delivery systems for topical application of anti-infective agents. Drug Development and Industrial Pharmacy 42:1, pages 1-11.
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Maaly A. Halim Mohamed & Azza A. Mahmoud. (2011) Formulation of Indomethacin Eye Drops via Complexation with Cyclodextrins. Current Eye Research 36:3, pages 208-216.
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Zhidong Liu, Weisan Pan, Shufang Nie, Libo Zhang, Xinggang Yang & Jiawei Li. (2005) Preparation and Evaluation of Sustained Ophthalmic Gel of Enoxacin. Drug Development and Industrial Pharmacy 31:10, pages 969-975.
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Yeşim Aktaş, Nurşen Ünlü, Mehmet Orhan, Murat İrkeç & A. Atilla Hıncal. (2003) Influence of Hydroxypropyl β-Cyclodextrin on the Corneal Permeation of Pilocarpine. Drug Development and Industrial Pharmacy 29:2, pages 223-230.
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Thorsteinn Loftsson & Dorte Seir Petersen. (1998) Cyclodextrin Solubilization of ETH-615, a Zwitterionic Drug. Drug Development and Industrial Pharmacy 24:4, pages 365-370.
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Qiuxiang Wang, Aiwen Zhang, Lu Zhu, Xuewen Yang, Guihua Fang & Bo Tang. (2023) Cyclodextrin-based ocular drug delivery systems: A comprehensive review. Coordination Chemistry Reviews 476, pages 214919.
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Garima Rawat, Shital Kolhe, Dhwani Rana, Sagar Salave & Derajram Benival. (2023) Exploring the Therapeutic Potential of Cyclosporine for Ophthalmic Indications by Novel Carrier Systems. Critical Reviews™ in Therapeutic Drug Carrier Systems 40:5, pages 1-45.
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Luna Krstić, Pekka Jarho, Marika Ruponen, Arto Urtti, María J. González-García & Yolanda Diebold. (2022) Improved ocular delivery of quercetin and resveratrol: A comparative study between binary and ternary cyclodextrin complexes. International Journal of Pharmaceutics 624, pages 122028.
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Hay Marn Hnin, Einar Stefánsson, Thorsteinn Loftsson, Thanyada Rungrotmongkol & Phatsawee Jansook. (2022) Angiotensin converting enzyme inhibitors/cyclodextrin inclusion complexes: solution and solid-state characterizations and their thermal stability. Journal of Inclusion Phenomena and Macrocyclic Chemistry 102:3-4, pages 347-358.
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Manisha Prajapati & Thorsteinn Loftsson. (2022) Stabilization and solubilization of difluprednate in aqueous cyclodextrin solution and its characterization for ophthalmic delivery. Journal of Drug Delivery Science and Technology 69, pages 103106.
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Haley ShelleyManjusha AnnajiForrest T. SmithR. Jayachandra Babu. (2022) Difluprednate-Hydroxypropyl-β-Cyclodextrin-Based Ophthalmic Solution for Improved Delivery in a Porcine Eye Model. Journal of Ocular Pharmacology and Therapeutics 38:1, pages 92-101.
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Jeonghun Lee & Chulhee Kim. (2021) Cyclodextrin Molecules, Polymers and Nanomaterials. Macromolecular Research 29:11, pages 745-760.
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Phatsawee Jansook, Hay Marn Hnin, Thorsteinn Loftsson & Einar Stefánsson. (2021) Cyclodextrin-based formulation of carbonic anhydrase inhibitors for ocular delivery – A review. International Journal of Pharmaceutics 606, pages 120955.
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Marcela Tavares Luiz, Leonardo Delello Di Filippo, Renata Carolina Alves, Victor Hugo Sousa Araújo, Jonatas Lobato Duarte, Juliana Maldonado Marchetti & Marlus Chorilli. (2021) The use of TPGS in drug delivery systems to overcome biological barriers. European Polymer Journal 142, pages 110129.
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Bíró & Aigner. (2019) Current Approaches to Use Cyclodextrins and Mucoadhesive Polymers in Ocular Drug Delivery—A Mini-Review. Scientia Pharmaceutica 87:3, pages 15.
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K. Sivakumar, V. Komathi & M. Murali Krishnan. (2018) Dinitrophenylhydrazine: β-cyclodextrin inclusion complex as a novel fluorescent chemosensor probe for Ce4+. Research on Chemical Intermediates 44:9, pages 5301-5327.
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Osama Abd El-Aazeem Soliman, Elham Abdel Monem Mohamed, Marwa Salah El-Dahan & Nabil Abdullah Ali Khatera. (2016) Potential Use of Cyclodextrin Complexes for Enhanced Stability, Anti-inflammatory Efficacy, and Ocular Bioavailability of Loteprednol Etabonate. AAPS PharmSciTech 18:4, pages 1228-1241.
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