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ORIGINAL ARTICLE: CELLULAR AND MOLECULAR BIOLOGY

PTEN, pAKT, and pmTOR Expression and Subcellular Distribution in Primary Renal Cell Carcinomas and Their Metastases

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Pages 427-438 | Published online: 22 Jun 2011

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Gaetano Pezzicoli, Elisabetta Filoni, Angela Gernone, Laura Cosmai, Mimma Rizzo & Camillo Porta. (2021) Playing the Devil’s Advocate: Should We Give a Second Chance to mTOR Inhibition in Renal Clear Cell Carcinoma? – ie Strategies to Revert Resistance to mTOR Inhibitors. Cancer Management and Research 13, pages 7623-7636.
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Articles from other publishers (14)

Gaetano Pezzicoli, Federica Ciciriello, Vittoria Musci, Francesco Salonne, Anna Ragno & Mimma Rizzo. (2023) Genomic Profiling and Molecular Characterization of Clear Cell Renal Cell Carcinoma. Current Oncology 30:10, pages 9276-9290.
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Lei Han, Zeyong Huang, Yan Liu, Lijuan Ye, Dongqi Li, Zhihong Yao, Cao Wang, Ya Zhang, Hang Yang, Zunxian Tan, Jiadai Tang & Zuozhang Yang. (2021) MicroRNA-106a regulates autophagy-related cell death and EMT by targeting TP53INP1 in lung cancer with bone metastasis. Cell Death & Disease 12:11.
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Raviprakash Tumkur Sitaram, Maréne Landström, Göran Roos & Börje Ljungberg. (2021) Significance of PI3K signalling pathway in clear cell renal cell carcinoma in relation to VHL and HIF status. Journal of Clinical Pathology 74:4, pages 216-222.
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Demin Fan, Qiang Liu, Fei Wu, Na Liu, Hongyi Qu, Yijiao Yuan, Yong Li, Huayu Gao, Juntao Ge, Yue Xu, Hao Wang, Qingyong Liu & Zuohui Zhao. (2020) Prognostic significance of PI3K/AKT/ mTOR signaling pathway members in clear cell renal cell carcinoma. PeerJ 8, pages e9261.
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Steffen Rausch, Daniel Schollenberger, Joerg Hennenlotter, Viktoria Stühler, Stephan Kruck, Arnulf Stenzl & Jens Bedke. (2018) mTOR and mTOR phosphorylation status in primary and metastatic renal cell carcinoma tissue: differential expression and clinical relevance. Journal of Cancer Research and Clinical Oncology 145:1, pages 153-163.
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Hojung Lee. (2017) Phosphorylated mTOR Expression Profiles in Human Normal and Carcinoma Tissues. Disease Markers 2017, pages 1-8.
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Tsukasa Igawa. (2017) Role of protein phosphatases in genitourinary cancers. International Journal of Urology 24:1, pages 16-24.
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Huiqiang Wang, Bin Chen, Bo Duan, Jiaxin Zheng & Xinyi Wu. (2016) miR-205 suppresses cell proliferation, invasion, and metastasis via regulation of the PTEN/AKT pathway in renal cell carcinoma. Molecular Medicine Reports 14:4, pages 3343-3349.
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Ryogo Minamimoto, Noboru Nakaigawa, Yoji Nagashima, Jun Toyohara, Daiki Ueno, Kazuhiro Namura, Kazuhiko Nakajima, Masahiro Yao & Kazuo Kubota. (2016) Comparison of 11C-4DST and 18F-FDG PET/CT imaging for advanced renal cell carcinoma: preliminary study. Abdominal Radiology 41:3, pages 521-530.
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Ahmed Q. Haddad, Payal Kapur, Nirmish Singla, Jay D. Raman, Matthew T. Then, Philipp Nuhn, Alexander Buchner, Patrick Bastian, Christian Seitz, Shahrokh F. Shariat, Karim Bensalah, Nathalie Rioux-Leclercq, Arthur Sagalowsky, Yair Lotan & Vitaly Margulis. (2015) Validation of mammalian target of rapamycin biomarker panel in patients with clear cell renal cell carcinoma. Cancer 121:1, pages 43-50.
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MEILING WEN, BAOXIU LI, XIAOFEI CAO, CHENGYIN WENG, YONG WU, XISHENG FANG, XIAOSHI ZHANG & GUOLONG LIU. (2014) Clinical significance of aberrant mammalian target of rapamycin expression in stage IIIB colon cancer. Oncology Letters 8:3, pages 1080-1086.
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J Stebbing, L C Lit, H Zhang, R S Darrington, O Melaiu, B Rudraraju & G Giamas. (2013) The regulatory roles of phosphatases in cancer. Oncogene 33:8, pages 939-953.
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James L. Chen, Daniel E. Appelbaum, Masha Kocherginsky, Charles L. Cowey, Wendy Kimryn Rathmell, David F. McDermott & Walter M. Stadler. (2013) FDG ‐ PET as a predictive biomarker for therapy with everolimus in metastatic renal cell cancer . Cancer Medicine 2:4, pages 545-552.
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Qingqing Cai, Haixia Deng, Dan Xie, Tianxin Lin & Tongyu Lin. (2012) Phosphorylated AKT Protein Is Overexpressed in Human Peripheral T-cell Lymphomas and Predicts Decreased Patient Survival. Clinical Lymphoma Myeloma and Leukemia 12:2, pages 106-112.
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