91
Views
181
CrossRef citations to date
0
Altmetric
Original Article

Methylation of the O6 Position of Guanine in DNA is the Most Likely Initiating Event in Carcinogenesis by Methylating Agents

Pages 223-231 | Published online: 11 Jun 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Gerd Bobe, KathleenG. Barrett, RoycelynnA. Mentor-Marcel, Umberto Saffiotti, MatthewR. Young, NancyH. Colburn, PaulS. Albert, MauriceR. Bennink & Elaine Lanza. (2008) Dietary Cooked Navy Beans and Their Fractions Attenuate Colon Carcinogenesis in Azoxymethane-Induced Ob/Ob Mice. Nutrition and Cancer 60:3, pages 373-381.
Read now
Gary D. Stoner, Tong Chen, Laura A. Kresty, Robeena M. Aziz, Tiffany Reinemann & Ronald Nines. (2006) Protection Against Esophageal Cancer in Rodents With Lyophilized Berries: Potential Mechanisms. Nutrition and Cancer 54:1, pages 33-46.
Read now
Rajaram Gopalakrishnan, Ashok Gupta, Peter S. Carlton, Mark A. Morse & Gary D. Stoner. (2002) FUNCTIONAL ROLE OF CYTOCHROME P-450 2A3 IN N -NITROSOMETHYLBENZYLAMINE METABOLISM IN RAT ESOPHAGUS. Journal of Toxicology and Environmental Health, Part A 65:15, pages 1077-1091.
Read now
V. Oreffo, R. Singh, K. J. Rich, D. E. G. Shuker, P. Carthew, R. Cordero, J. H. M. Van Delft & P. B. Farmer. (2000) DNA adducts in relation to lung tumour outcome are not markers of susceptibility following a single dose treatment of SWR, BALB/c and C57BL/6J mice with N-nitrosodiethylamine. Biomarkers 5:5, pages 323-340.
Read now
Gustav Lehne, Erkki Elonen, Mark Baekelandt, Torben Skovsgaard & Curt Peterson. (1998) Challenging Drug Resistance in Cancer Therapy: Review of the First Nordic Conference on Chemoresistance in Cancer Treatment, October 9th and 10th, 1997. Acta Oncologica 37:5, pages 431-439.
Read now
F. Bianchini, E. Weiderpass, S. Kyrtopoulos, V. L. Souliotis, M. Henry-Amar, C. P. Wild & P. Boffetta. (1996) Detection of DNA methylation adducts in Hodgkin's disease patients treated with procarbazine. Biomarkers 1:4, pages 226-231.
Read now
Guizhou Hu, Chi Han, ChristopherP. Wild, Janet Hall & Junshi Chen. (1992) Lack of effects of selenium on N‐nitrosomethylbenzylamine‐induced tumorigenesis, DNA methylation, and oncogene expression in rats and mice. Nutrition and Cancer 18:3, pages 287-295.
Read now
Gerhard Fritz, Keizo Tano, Sankar Mitra & Bernd Kaina. (1991) Inducibility of the DNA Repair Gene Encoding O6-Methylguanine- DNA Methyltransferase in Mammalian Cells by DNA-Damaging Treatments. Molecular and Cellular Biology 11:9, pages 4660-4668.
Read now
Shigeki Miyamoto, Saraswati Sukumar, Raphael C. Guzman, Rebecca C. Osborn & Satyabrata Nandi. (1990) Transforming c-Ki-ras Mutation Is a Preneoplastic Event in Mouse Mammary Carcinogenesis Induced In Vitro by N-Methyl-N-Nitrosourea. Molecular and Cellular Biology 10:4, pages 1593-1599.
Read now
Zigang Dong & Alan M. Jeffrey. (1990) Mechanisms of Organ Specificity in Chemical Carcinogenesis. Cancer Investigation 8:5, pages 523-533.
Read now

Articles from other publishers (169)

Melisa Medina-Rivera, Samantha Phelps, Madhumita Sridharan, Jordan Becker, Natalie A Lamb, Charanya Kumar, Mark D Sutton, Anja Bielinsky, Lata Balakrishnan & Jennifer A Surtees. (2023) Elevated MSH2 MSH3 expression interferes with DNA metabolism in vivo . Nucleic Acids Research.
Crossref
Shayne Cox Gad & Dexter SullivanJr.Jr.. 2023. Drug Safety Evaluation. Drug Safety Evaluation 363 394 .
Paulina Prorok, Inga R. Grin, Bakhyt T. Matkarimov, Alexander A. Ishchenko, Jacques Laval, Dmitry O. Zharkov & Murat Saparbaev. (2021) Evolutionary Origins of DNA Repair Pathways: Role of Oxygen Catastrophe in the Emergence of DNA Glycosylases. Cells 10:7, pages 1591.
Crossref
Adrían Martínez-Limón, Giulia Calloni, Robert Ernst & R. Martin Vabulas. (2020) Flavin dependency undermines proteome stability, lipid metabolism and cellular proliferation during vitamin B2 deficiency. Cell Death & Disease 11:9.
Crossref
Bakhyt T. Matkarimov & Murat K. Saparbaev. 2020. Mechanisms of Genome Protection and Repair. Mechanisms of Genome Protection and Repair 77 100 .
Kwang-Il Park, Kwang-Youn Kim, Tae Woo Oh, Du-Seock Kang, Eung-Kyun Kim, Yong Ryoul Yang, Young-Kyo Seo, Jin-Yeul Ma & Pann-Ghill Suh. (2017) Phospholipase Cγ1 links inflammation and tumorigenesis in colitis-associated cancer. Oncotarget 9:5, pages 5752-5763.
Crossref
Pedro Hernandez, Konrad Gronke & Andreas Diefenbach. (2018) A catch-22: Interleukin-22 and cancer. European Journal of Immunology 48:1, pages 15-31.
Crossref
Marcus W. Stepp, Mark A. Doll, David J. Samuelson, Mary Ann G. Sanders, J. Christopher States & David W. Hein. (2017) Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism. BMC Cancer 17:1.
Crossref
Jian-Ru Guo, Zheng Li, Cai-Yun Wang, Christopher Wai Kei Lam, Qian-Qian Chen, Wei-Jia Zhang, Vincent Kam Wai Wong, Mei-Cun Yao & Wei Zhang. (2017) Profiling of ribonucleotides and deoxyribonucleotides pools in response to DNA damage and repair induced by methyl methanesulfonate in cancer and normal cells. Oncotarget 8:60, pages 101707-101719.
Crossref
Tobias Klemm, Anja Mannuß, Daniela Kobbe, Alexander Knoll, Oliver Trapp, Annika Dorn & Holger Puchta. (2017) The DNA translocase RAD 5A acts independently of the other main DNA repair pathways, and requires both its ATP ase and RING domain for activity in Arabidopsis thaliana . The Plant Journal 91:4, pages 725-740.
Crossref
Se-Lim Kim, Seong Hun Kim, Young Ran Park, Yu-Chuan Liu, Eun-Mi Kim, Hwan-Jeong Jeong, Yo Na Kim, Seung Young Seo, In Hee Kim, Seung Ok Lee, Soo Teik Lee & Sang-Wook Kim. (2017) Combined Parthenolide and Balsalazide Have Enhanced Antitumor Efficacy Through Blockade of NF-κB Activation. Molecular Cancer Research 15:2, pages 141-151.
Crossref
Takeshi Yoshikawa, Jianfeng Wu, Motoyuki Otsuka, Takahiro Kishikawa, Nobumi Suzuki, Akemi Takata, Motoko Ohno, Rei Ishibashi, Mari Yamagami, Ryo Nakagawa, Naoya Kato, Masaaki Miyazawa, Jiahuai Han & Kazuhiko Koike. (2017) Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis. Gastroenterology 152:3, pages 631-643.
Crossref
R. Grüber, J. Aranda, A. Bellili, I. Tuñón & E. Dumont. (2017) Free energy profiles for two ubiquitous damaging agents: methylation and hydroxylation of guanine in B-DNA. Physical Chemistry Chemical Physics 19:22, pages 14695-14701.
Crossref
Shayne Cox Gad. 2016. Drug Safety Evaluation. Drug Safety Evaluation 321 350 .
Maryanne C.S. Herzig, Jessica A. Zavadil, Karah Street, Kim Hildreth, Norman R. Drinkwater, Traci Reddick, Damon C. Herbert, Martha A. Hanes, C. Alex McMahan, Robert L. Reddick & Christi A. Walter. (2016) DNA Alkylating Agent Protects Against Spontaneous Hepatocellular Carcinoma Regardless of O6-Methylguanine-DNA Methyltransferase Status. Cancer Prevention Research 9:3, pages 245-252.
Crossref
Dennis Gillingham, Stefanie Geigle & O. Anatole von Lilienfeld. (2016) Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics. Chemical Society Reviews 45:9, pages 2637-2655.
Crossref
Yvonne P. Dragan. 2016. Hepatocellular Carcinoma. Hepatocellular Carcinoma 65 92 .
Maria Tintoré, Santiago Grijalvo, Ramon Eritja & Carme Fàbrega. (2015) Synthesis of oligonucleotides carrying fluorescently labelled O6-alkylguanine for measuring hAGT activity. Bioorganic & Medicinal Chemistry Letters 25:22, pages 5208-5211.
Crossref
Pallabi Mitra, Khadija Banu, Abhijit S. Deshmukh, Naidu Subbarao & Suman Kumar Dhar. (2015) Functional dissection of proliferating-cell nuclear antigens (1 and 2) in human malarial parasite Plasmodium falciparum: possible involvement in DNA replication and DNA damage response . Biochemical Journal 470:1, pages 115-129.
Crossref
Caitlyn W. Barrett, Vishruth K. Reddy, Sarah P. Short, Amy K. Motley, Mary K. Lintel, Amber M. Bradley, Tanner Freeman, Jefferson Vallance, Wei Ning, Bobak Parang, Shenika V. Poindexter, Barbara Fingleton, Xi Chen, Mary K. Washington, Keith T. Wilson, Noah F. Shroyer, Kristina E. Hill, Raymond F. Burk & Christopher S. Williams. (2015) Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. Journal of Clinical Investigation 125:7, pages 2646-2660.
Crossref
Shayne C. Gad, Charles B. Spainhour & Samantha E. Gad. 2015. Mammalian Toxicology. Mammalian Toxicology 341 393 .
SE LIM KIM, YU CHUAN LIU, SEUNG YOUNG SEO, SEONG HUN KIM, IN HEE KIM, SEUNG OK LEE, SOO TEIK LEE, DAE-GHON KIM & SANG WOOK KIM. (2015) Parthenolide induces apoptosis in colitis-associated colon cancer, inhibiting NF-κB signaling. Oncology Letters 9:5, pages 2135-2142.
Crossref
Toshiharu Sakurai, Hiroshi Kashida, Tomohiro Watanabe, Satoru Hagiwara, Tsunekazu Mizushima, Hideki Iijima, Naoshi Nishida, Hiroaki Higashitsuji, Jun Fujita & Masatoshi Kudo. (2014) Stress Response Protein Cirp Links Inflammation and Tumorigenesis in Colitis-Associated Cancer. Cancer Research 74:21, pages 6119-6128.
Crossref
Xin Li, Yuyan Gao, Ming Yang, Qi Zhao, Guangyu Wang, Yan mei Yang, Yue Yang, Hui Liu & Yanqiao Zhang. (2014) Identification of Gene Expression Changes from Colitis to CRC in the Mouse CAC Model. PLoS ONE 9:4, pages e95347.
Crossref
Syed Umesalma, Ponnuraj Nagendraprabhu & Ganapasam Sudhandiran. (2013) Antiproliferative and apoptotic-inducing potential of ellagic acid against 1,2-dimethyl hydrazine-induced colon tumorigenesis in Wistar rats. Molecular and Cellular Biochemistry 388:1-2, pages 157-172.
Crossref
Yasuhito Kokunai, Motomu Tsuji, Yuko Ito, Teruo Kurokawa, Yoshinori Otsuki & Shinichi Moriwaki. (2013) Immunohistochemical analysis of O6-methylguanine-DNA methyltransferase in human melanoma in comparison with skin squamous cell carcinoma. Medical Molecular Morphology 47:1, pages 8-13.
Crossref
Ahmet Yilmaz, Michael E. Davis & Weiqiang Zhao. (2014) Effect of the R406H Substitution on the Normal Function of CHEK2. Advances in Bioscience and Biotechnology 05:04, pages 386-392.
Crossref
Shun Matsuda, Ryo Matsuda, Yoko Matsuda, Shin-ya Yanagisawa, Masae Ikura, Tsuyoshi Ikura & Tomonari Matsuda. (2014) An Easy-to-use Genotoxicity Assay Using EGFP-MDC1-expressing Human Cells. Genes and Environment 36:1, pages 17-28.
Crossref
Amanda Tivnan & Kerrie Leanne McDonald. (2013) Current Progress for the Use of miRNAs in Glioblastoma Treatment. Molecular Neurobiology 48:3, pages 757-768.
Crossref
Takeshi Yoshikawa, Motoyuki Otsuka, Takahiro Kishikawa, Akemi Takata, Motoko Ohno, Chikako Shibata, Young Jun Kang, Haruhiko Yoshida & Kazuhiko Koike. (2013) Unique Haploinsufficient Role of the MicroRNA-Processing Molecule Dicer1 in a Murine Colitis-Associated Tumorigenesis Model. PLoS ONE 8:9, pages e71969.
Crossref
Yuyan Gao, Xin Li, Ming Yang, Qi Zhao, Xiaolong Liu, Guangyu Wang, Xiaolin Lu, Qi Wu, Jin Wu, Yanmei Yang, Yue Yang & Yanqiao Zhang. (2013) Colitis-accelerated colorectal cancer and metabolic dysregulation in a mouse model. Carcinogenesis 34:8, pages 1861-1869.
Crossref
Caitlyn W. Barrett, Kshipra Singh, Amy K. Motley, Mary K. Lintel, Elena Matafonova, Amber M. Bradley, Wei Ning, Shenika V. Poindexter, Bobak Parang, Vishruth K. Reddy, Rupesh Chaturvedi, Barbara M. Fingleton, Mary K. Washington, Keith T. Wilson, Sean S. Davies, Kristina E. Hill, Raymond F. Burk & Christopher S. Williams. (2013) Dietary Selenium Deficiency Exacerbates DSS-Induced Epithelial Injury and AOM/DSS-Induced Tumorigenesis. PLoS ONE 8:7, pages e67845.
Crossref
A. P. Iatsyshyna. (2013) MGMT expression: insights into its regulation. 1. Epigenetic factors. Biopolymers and Cell 29:2, pages 99-106.
Crossref
Sophie Couvé, Alexander A. Ishchenko, Olga S. Fedorova, Erlan M. Ramanculov, Jacques Laval & Murat Saparbaev. (2013) Direct DNA Lesion Reversal and Excision Repair in Escherichia coli . EcoSal Plus 5:2.
Crossref
C Taccioli, H Chen, Y Jiang, X P Liu, K Huang, K J Smalley, J L Farber, C M Croce & L Y Fong. (2011) Dietary zinc deficiency fuels esophageal cancer development by inducing a distinct inflammatory signature. Oncogene 31:42, pages 4550-4558.
Crossref
Kevin Anton, Joachim M. Baehring & Tina Mayer. (2012) Glioblastoma Multiforme. Hematology/Oncology Clinics of North America 26:4, pages 825-853.
Crossref
Junko Murai, Shar-yin N. Huang, Benu Brata Das, Thomas S. Dexheimer, Shunichi Takeda & Yves Pommier. (2012) Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells. Journal of Biological Chemistry 287:16, pages 12848-12857.
Crossref
Gunasekaran Sivagami, Venkatachalam Karthikkumar, Thangavel Balasubramanian & Namashivayam Nalini. (2012) The modulatory influence of p-methoxycinnamic acid, an active rice bran phenolic acid, against 1,2-dimethylhydrazine-induced lipid peroxidation, antioxidant status and aberrant crypt foci in rat colon carcinogenesis. Chemico-Biological Interactions 196:1-2, pages 11-22.
Crossref
Yun-Ching Chang, Jeng-Dong Hsu, Wea-Lung Lin, Yi-Ju Lee & Chau-Jong Wang. (2011) High incidence of acute promyelocytic leukemia specifically induced by N-nitroso-N-methylurea (NMU) in Sprague–Dawley rats. Archives of Toxicology 86:2, pages 315-327.
Crossref
Khalid S Al-Numair, Mostafa I Waly, Amanat Ali, Mohamed M Essa, Mohamed F Farhat & Mohamed A Alsaif. (2011) Dietary folate protects against azoxymethane-induced aberrant crypt foci development and oxidative stress in rat colon. Experimental Biology and Medicine 236:9, pages 1005-1011.
Crossref
Caitlyn W. Barrett, Barbara Fingleton, Amanda Williams, Wei Ning, Melissa A. Fischer, Mary K. Washington, Rupesh Chaturvedi, Keith T. Wilson, Scott W. Hiebert & Christopher S. Williams. (2011) MTGR1 Is Required for Tumorigenesis in the Murine AOM/DSS Colitis-Associated Carcinoma Model. Cancer Research 71:4, pages 1302-1312.
Crossref
Kimiko Ishiguro, Yong-Lian Zhu, Krishnamurthy Shyam, Philip G. Penketh, Raymond P. Baumann & Alan C. Sartorelli. (2010) Quantitative relationship between guanine O6-alkyl lesions produced by Onrigin™ and tumor resistance by O6-alkylguanine-DNA alkyltransferase. Biochemical Pharmacology 80:9, pages 1317-1325.
Crossref
Qingming Fang, Sreenivas Kanugula, Julie L. Tubbs, John A. Tainer & Anthony E. Pegg. (2010) Repair of O4-Alkylthymine by O6-Alkylguanine-DNA Alkyltransferases. Journal of Biological Chemistry 285:11, pages 8185-8195.
Crossref
Jeremy Dupaul-Chicoine, Garabet Yeretssian, Karine Doiron, Kirk S.B. Bergstrom, Christian R. McIntire, Philippe M. LeBlanc, Charles Meunier, Claire Turbide, Philippe Gros, Nicole Beauchemin, Bruce A. Vallance & Maya Saleh. (2010) Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases. Immunity 32:3, pages 367-378.
Crossref
Jianyong Wang & Tao Chen. (2009) Sequencing analysis of mutations induced by N ‐ethyl‐ N ‐nitrosourea at different sampling times in mouse bone marrow . Journal of Applied Toxicology 30:2, pages 133-141.
Crossref
Evandro Rocco Panico, Christopher Ede, Michael Schildmann, Kirsten Anke Schürer & Wilfried Kramer. (2009) Genetic evidence for a role of Saccharomyces cerevisiae Mph1 in recombinational DNA repair under replicative stress . Yeast 27:1, pages 11-27.
Crossref
Karina Acevedo‐Torres, Sharon Fonseca‐Williams, Sylvette Ayala‐Torres & Carlos A. Torres‐Ramos. (2009) Requirement of the Saccharomyces cerevisiae APN1 gene for the repair of mitochondrial DNA alkylation damage . Environmental and Molecular Mutagenesis 50:4, pages 317-327.
Crossref
Nabil Matmati, Hiroshi Kitagaki, David Montefusco, Bidyut K. Mohanty & Yusuf A. Hannun. (2009) Hydroxyurea Sensitivity Reveals a Role for ISC1 in the Regulation of G2/M. Journal of Biological Chemistry 284:13, pages 8241-8246.
Crossref
Sheeno P. Thyparambil, Ricky D. Edmondson & Yvonne P. Dragan. 2010. Hepatocellular Carcinoma. Hepatocellular Carcinoma 55 107 .
Manana Melikishvili, Joseph J. Rasimas, Anthony E. Pegg & Michael G. Fried. (2008) Interactions of Human O 6 -Alkylguanine-DNA Alkyltransferase (AGT) with Short Double-Stranded DNAs . Biochemistry 47:52, pages 13754-13763.
Crossref
D. W. Rosenberg, C. Giardina & T. Tanaka. (2008) Mouse models for the study of colon carcinogenesis. Carcinogenesis 30:2, pages 183-196.
Crossref
Bryan W. Davies & Graham C. Walker. (2008) A Highly Conserved Protein of Unknown Function Is Required by Sinorhizobium meliloti for Symbiosis and Environmental Stress Protection . Journal of Bacteriology 190:3, pages 1118-1123.
Crossref
Ryohei YokoiMorimichi HayashiToru TamuraKazuo KobayashiJunji KurodaHiroshi KusamaHiroshi Kagami & Tamao Ono. (2008) Embryonic mortality and intrauterine growth retardation (IUGR) associated with placental alterations in pregnant rats treated with methyl methanesulfonate (MMS) at the peri-implantation stage. The Journal of Toxicological Sciences 33:5, pages 585-598.
Crossref
Ryohei YOKOISatoshi SUDAKazuo KOBAYASHIJunji KURODAHiroshi KUSAMAHiroshi KAGAMI & Tamao ONO. (2007) DIFFERENTIAL SUSCEPTIBILITY OF RAT EMBRYOS TO METHYL METHANESULFONATE DURING THE PREGASTRULATION PERIOD. The Journal of Toxicological Sciences 32:5, pages 495-503.
Crossref
Masaki Odahara, Takayuki Inouye, Tomomichi Fujita, Mitsuyasu Hasebe & Yasuhiko Sekine. (2007) Involvement of mitochondrial-targeted RecA in the repair of mitochondrial DNA in the moss, Physcomitrella patens. Genes & Genetic Systems 82:1, pages 43-51.
Crossref
Jun Zhang, Brigid Stirling, Stephane T. Temmerman, Chi A. Ma, Ivan J. Fuss, Jonathan M.J. Derry & Ashish Jain. (2006) Impaired regulation of NF-κB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice. Journal of Clinical Investigation 116:11, pages 3042-3049.
Crossref
Steven S. Smith & Roderich E. Schwarz. (2006) Gastric DNA damage through tobacco chewing: In vitro mechanistic studies of DNA nitrite attack. Cancer Letters 235:2, pages 221-228.
Crossref
Florian R. Greten & Michael Karin. 2006. Apoptosis and Cancer Therapy. Apoptosis and Cancer Therapy 445 461 .
Masanori Mazaki, Keiko Kataoka, Takemi Kinouchi, Usanee Vinitketkumnuen, Masami Yamada, Takehiko Nohmi, Tomomi Kuwahara, Shigeru Akimoto & Yoshinari Ohnishi. (2006) Inhibitory effects of caraway (Carum carvi L.) and its component on N-methyl-N'-nitro-N-nitrosoguanidine-induced mutagenicity. The Journal of Medical Investigation 53:1-2, pages 123-133.
Crossref
James M. Allan & Lois B. Travis. (2005) Mechanisms of therapy-related carcinogenesis. Nature Reviews Cancer 5:12, pages 943-955.
Crossref
Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood, Roger A. Schultz & Tom Ellenberger. 2005. DNA Repair and Mutagenesis. DNA Repair and Mutagenesis 9 69 .
Jennifer L. Ariazi, Jill D. Haag & Michael N. Gould. (2005) Methylguanine methyltransferase activity deficiency in immature rat mammary epithelial cells parallels increased carcinogenic susceptibility. Molecular Carcinogenesis 44:3, pages 193-201.
Crossref
Adam B. Salmon, Shin Murakami, Andrzej Bartke, John Kopchick, Kyoko Yasumura & Richard A. Miller. (2005) Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. American Journal of Physiology-Endocrinology and Metabolism 289:1, pages E23-E29.
Crossref
Masafumi Miyazaki, Eika Sugawara, Teruki Yoshimura, Hiroshi Yamazaki & Tetsuya Kamataki. (2005) Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 581:1-2, pages 165-171.
Crossref
Kristina Schoonjans, Laurent Dubuquoy, Joseph Mebis, Elisabeth Fayard, Olivia Wendling, Céline Haby, Karel Geboes & Johan Auwerx. (2005) Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation. Proceedings of the National Academy of Sciences 102:6, pages 2058-2062.
Crossref
Florian R. Greten, Lars Eckmann, Tim F. Greten, Jin Mo Park, Zhi-Wei Li, Laurence J. Egan, Martin F. Kagnoff & Michael Karin. (2004) IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer. Cell 118:3, pages 285-296.
Crossref
K Anke Schürer, Christian Rudolph, Helle D Ulrich & Wilfried Kramer. (2004) Yeast MPH1 Gene Functions in an Error-Free DNA Damage Bypass Pathway That Requires Genes From Homologous Recombination, but Not From Postreplicative Repair . Genetics 166:4, pages 1673-1686.
Crossref
Barbara Oesch‐Bartlomowicz, Kai Janssen, Oliver Wiss & Franz Oesch. (2004) Guanine 6‐ O ‐Methylation Pattern within the Dioxin Responsive Element of the CYP1A1 Enhancer Shows Two Critical Guanines for AhR/ARNT Binding . Chemistry & Biodiversity 1:3, pages 473-480.
Crossref
Heidrun Ellinger-Ziegelbauer, Barry Stuart, Brad Wahle, Werner Bomann & Hans-Jürgen Ahr. (2004) Characteristic Expression Profiles Induced by Genotoxic Carcinogens in Rat Liver. Toxicological Sciences 77:1, pages 19-34.
Crossref
E. S. Gilbert, M. Stovall, M. Gospodarowicz, F. E. van Leeuwen, M. Andersson, B. Glimelius, T. Joensuu, C. F. Lynch, R. E. Curtis, E. Holowaty, H. Storm, E. Pukkala, M. B. van't Veer, J. F. FraumeniJr.Jr., J. D. BoiceJr.Jr., E. A. Clarke & L. B. Travis. (2003) Lung Cancer after Treatment for Hodgkin's Disease: Focus on Radiation Effects. Radiation Research 159:2, pages 161-173.
Crossref
Kishore Guda, Hongyi Cui, Sanjeev Garg, Mei Dong, Prashant R. Nambiar, Luke E.K. Achenie & Daniel W. Rosenberg. (2003) Multistage gene expression profiling in a differentially susceptible mouse colon cancer model. Cancer Letters 191:1, pages 17-25.
Crossref
Michael Chang, Mohammed Bellaoui, Charles Boone & Grant W. Brown. (2002) A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proceedings of the National Academy of Sciences 99:26, pages 16934-16939.
Crossref
Alison J Rattray, Brenda K Shafer, Carolyn B McGill & Jeffrey N Strathern. (2002) The Roles of REV3 and RAD57 in Double-Strand-Break-Repair-Induced Mutagenesis of Saccharomyces cerevisiae . Genetics 162:3, pages 1063-1077.
Crossref
Brian Plosky, Leona Samson, Bevin P Engelward, Barry Gold, Brenda Schlaen, Themistocles Millas, Michael Magnotti, Jonathan Schor & David A Scicchitano. (2002) Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes. DNA Repair 1:8, pages 683-696.
Crossref
Stanton L. Gerson. (2002) Clinical Relevance of MGMT in the Treatment of Cancer . Journal of Clinical Oncology 20:9, pages 2388-2399.
Crossref
Henry Pitot & Daniel Loeb. 2002. Fundamentals of Oncology, Revised and Expanded. Fundamentals of Oncology, Revised and Expanded 41 106 .
Donghui Li. 2002. Pancreatic Cancer. Pancreatic Cancer 3 13 .
L. Y. Y. Fong, V. T. Nguyen & J. L. Farber. (2001) Esophageal Cancer Prevention in Zinc-Deficient Rats: Rapid Induction of Apoptosis by Replenishing Zinc. JNCI Journal of the National Cancer Institute 93:20, pages 1525-1533.
Crossref
Ronald B Walter, Huang-Mo Sung, Gabe W Intano & Christi A Walter. (2001) Characterization of O6-methylguanine-DNA-methyltransferase (O6-MGMT) activity in Xiphophorus fishes. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 493:1-2, pages 11-22.
Crossref
Jürgen Scheller, Anke Schürer, Christian Rudolph, Stefan Hettwer & Wilfried Kramer. (2000) MPH1 , A Yeast Gene Encoding a DEAH Protein, Plays a Role in Protection of the Genome From Spontaneous and Chemically Induced Damage . Genetics 155:3, pages 1069-1081.
Crossref
Kunihiro Kawabata, Takuji Tanaka, Tomohiro Yamamoto, Jun Ushida, Akira Hara, Akira Murakami, Kouichi Koshimizu, Hajime Ohigashi, Gray D. Stoner & Hideki Mori. (2005) Suppression of N ‐Nitrosomethylbenzylamine‐induced Rat Esophageal Tumorigenesis by Dietary Feeding of 1′‐Acetoxychavicol Acetate . Japanese Journal of Cancer Research 91:2, pages 148-155.
Crossref
Kenjiro Asagoshi, Takao Yamada, Hiroaki Terato, Yoshihiko Ohyama, Yoshiaki Monden, Tsuyoshi Arai, Susumu Nishimura, Hiroyuki Aburatani, Tomas Lindahl & Hiroshi Ide. (2000) Distinct Repair Activities of Human 7,8-Dihydro-8-oxoguanine DNA Glycosylase and Formamidopyrimidine DNA Glycosylase for Formamidopyrimidine and 7,8-Dihydro-8-oxoguanine. Journal of Biological Chemistry 275:7, pages 4956-4964.
Crossref
Ramesh K. Wali, Susan Skarosi, John Hart, Yingchun Zhang, M.eileen Dolan, Robert C. Moschel, Lan Nguyen, Reba Mustafi, Thomas A. Brasitus & Marc Bissonnette. (1999) Inhibition of O6 -methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats. Carcinogenesis 20:12, pages 2355-2360.
Crossref
Aya Masaoka, Hiroaki Terato, Mutsumi Kobayashi, Akiko Honsho, Yoshihiko Ohyama & Hiroshi Ide. (1999) Enzymatic Repair of 5-Formyluracil. Journal of Biological Chemistry 274:35, pages 25136-25143.
Crossref
Yoshihito Ohba, Masaaki Kai & Kiyoshi Zaitsu. (1998) Simultaneous determination of 7-methylguanine and O6-methylguanine in DNA by liquid chromatography with postcolumn fluorescence derivatization using 3,4-dimethoxyphenylglyoxal. Analytica Chimica Acta 365:1-3, pages 233-239.
Crossref
Alexandros Papanikolaou, Ronald C. Shank, Don A. Delker, Andrew Povey, Donald P. Cooper & Daniel W. Rosenberg. (1998) Initial Levels of Azoxymethane-Induced DNA Methyl Adducts Are Not Predictive of Tumor Susceptibility in Inbred Mice. Toxicology and Applied Pharmacology 150:1, pages 196-203.
Crossref
N. Takebe, S.-C. Zhao, D. Banerjee & J. R. Bertino. 1998. Gene Therapy. Gene Therapy 153 181 .
M. Hall & R.T. Johnson. (1996) The role of DNA repair in the prevention of cancer. Molecular Aspects of Medicine 17:3, pages 235-383.
Crossref
Nobuyuki Ito, Ryohei Hasegawa, Katsumi Imaida, Masao Hirose, Makoto Asamoto & Tomoyuki Shirai. (1995) Concepts in multistage carcinogenesis. Critical Reviews in Oncology/Hematology 21:1-3, pages 105-133.
Crossref
Elizabeth W. Newcomb, William Bayona & Sobha Pisharody. (2006) N ‐methylnitrosourea—lnduced Ki‐ ras codon 12 mutations: Early events in mouse thymic lymphomas . Molecular Carcinogenesis 13:2, pages 89-95.
Crossref
Stanton L. Gerson & James K.V. Willson. (1995) O 6 -Alkylguanine-DNA Alkyltransferase: A Target for the Modulation of Drug Resistance. Hematology/Oncology Clinics of North America 9:2, pages 431-450.
Crossref
Javed Musarrat, Jasna Arezina, Shahab Uddin & Altaf A. Wani. (1995) Induction and processing of promutagenic 04-ethylthymine lesion in specific gene segments of plasmid DNA. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1260:3, pages 276-284.
Crossref
Ewa Śledziewska-Gójska. (1995) Inactivation of O6-methylguanine-DNA methyltransferase in vivo by SN2 alkylating agents. Mutation Research/DNA Repair 336:1, pages 61-67.
Crossref
Pertti Kaihovaara, Katja S. Salmela, Risto P. Roine, Timo U. Kosunen & Mikko Salaspuro. (2006) Purification and Characterization of Helicobacter pylori Alcohol Dehydrogenase . Alcoholism: Clinical and Experimental Research 18:5, pages 1220-1225.
Crossref
Teresa Roldán‐Arjona, Francisco L. Luque‐Romero, Rafael R. Ariza, Juan Jurado & Carmen Pueyo. (2006) Influence of DNA repair by ada and ogt alkytransferases on the mutational specificity of alkylating agents . Molecular Carcinogenesis 9:4, pages 200-209.
Crossref
K. Mineura, I. Izumi, K. Watanabe, M. Kowada, K. Kohda & M. Ikenaga. (1994) Potential of O6-methylguanine or O6-benzylguanine in the enhancement of chloroethylnitrosourea cytotoxicity on brain tumours. Acta Neurochirurgica 128:1-4, pages 13-20.
Crossref
K. Sankaranarayana. (1994) Working paper no. 6 Estimation of genetic risks of exposure to chemical mutagens: relevance of data on spontaneous mutations and of experience with ionizing radiation. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 304:1, pages 139-158.
Crossref
M. Salaspuro. 1994. Helicobacter pylori. Helicobacter pylori 232 242 .
M. Salaspuro. 1994. Toward a Molecular Basis of Alcohol Use and Abuse. Toward a Molecular Basis of Alcohol Use and Abuse 185 195 .
G C HardI S RodgersK P BaetckeW L RichardsR E McGaughyL R Valcovic. (1993) Hazard evaluation of chemicals that cause accumulation of alpha 2u-globulin, hyaline droplet nephropathy, and tubule neoplasia in the kidneys of male rats.. Environmental Health Perspectives 99, pages 313-349.
Crossref
Luba L. DumencoEsther AllayKathleen NortonStanton L. Gerson. (1993) The Prevention of Thymic Lymphomas in Transgenic Mice by Human O 6 -Alkylguanine-DNA Alkyltransferase . Science 259:5092, pages 219-222.
Crossref
Peter G. Foiles, Lisa A. Peterson, Lisa M. Miglietta & Zeev Ronai. (1992) Analysis of mutagenic activity and ability to induce replication of polyoma DNA sequences by different model metabolites of the carcinogenic tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Mutation Research/Genetic Toxicology 279:2, pages 91-101.
Crossref
Thomas E. Spratt & Hannah De los Santos. (2002) Reaction of O6-alkylguanine-DNA alkyltransferase with O6-methylguanine analogs: evidence that the oxygen of O6-methylguanine is protonated by the protein to effect methyl transfer. Biochemistry 31:14, pages 3688-3694.
Crossref
Yi Wang, Tomohisa Kato, Hitoshi Ayaki, Kanji Ishizaki, Keizo Tano, Sankar Mitra & Mituo Ikenaga. (1992) Correlation between DNA methylation and expression of O6-methylguanine-DNA methyltransferase gene in cultured human tumor cells. Mutation Research/DNA Repair 273:2, pages 221-230.
Crossref
Seigou Usuki, Akihiko Maekawa, Ho‐il Kang, Seigo Shumiya & Sumi Nagase. (2005) High Susceptibility of Analbuminemic Rats to Neurogenic Tumor Induction by Transplacental Administration of N‐Ethyl‐N‐nitrosourea. Japanese Journal of Cancer Research 83:2, pages 146-152.
Crossref
Susumu Shiota, Mathew A. Von Wronski, Keizo Tano, Darell D. Bigner, Thomas P. Brent & Sankar Mitra. (2002) Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in E. coli. Biochemistry 31:7, pages 1897-1903.
Crossref
Nasir K. Alvi & Gary M. Williams. (1992) Restriction fragment pattern analysis of HPRT mutations induced in rat-liver epithelial cells by alkylating and arylating agents. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 265:2, pages 283-295.
Crossref
V.L. Souliotis, V. Zongza, V. Nikolopoulou & G.J. Dimitriadis. (1992) Measurement of O6-methylguanine-type adducts in DNA and O6-alkylguanine-DNA-alkyltransferase repair activity in normal and neoplastic human tissues. Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 101:1-2, pages 269-275.
Crossref
Toshiaki Ogiu, Hiroko Fukami & Mayumi Nishimura. (1992) DNA strand breaks and death of thymocytes induced byN-methyl-N-nitrosourea. Journal of Cancer Research and Clinical Oncology 118:1, pages 23-29.
Crossref
Keizo Tano, Susumu Shiota, Joanna S. Remack, Thomas P. Brent, Darell D. Bigner & Sankar Mitra. (1991) The origin of O6-methylguanine-DNA methyltransferase in Chinese hamster overy cells transfected with human DNA. Mutation Research/DNA Repair 255:2, pages 175-182.
Crossref
Gerd Bochert, Thomas Platzek, Ute Rahm & Diether Neubert. (1991) Embryotoxicity induced by alkylating agents: 6. DNA adduct formation induced by methylnitrosourea in mouse embryos. Archives of Toxicology 65:5, pages 390-395.
Crossref
S C RossiM D Topal. (1991) Mutagenic frequencies of site-specifically located O6-methylguanine in wild-type Escherichia coli and in a strain deficient in ada-methyltransferase. Journal of Bacteriology 173:3, pages 1201-1207.
Crossref
H. W. Rüdiger. 1991. Ecogenetics. Ecogenetics 205 215 .
Charles J. LinkJr.Jr. & Vilhelm A. Bohr. 1991. Molecular and Clinical Advances in Anticancer Drug Resistance. Molecular and Clinical Advances in Anticancer Drug Resistance 209 232 .
David A. Scicchitano & Philip C. Hanawalt. (1990) Lack of sequence-specific removal of N-methylpurines from cellular DNA. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 233:1-2, pages 31-37.
Crossref
Ngee Wah Tan & Benjamin F. L. Li. (2002) Interaction of oligonucleotides containing 6-O-methylguanine with human DNA (cytosine-5-)-methyltransferase. Biochemistry 29:39, pages 9234-9240.
Crossref
Debasish BHATTACHARYYA, Robert S. FOOTE, Amy M. BOULDEN & Sankar MITRA. (2005) Physicochemical studies of human O 6 ‐methylguanine‐DNA methyltransferase . European Journal of Biochemistry 193:2, pages 337-343.
Crossref
Douglas F. Fix, David R. Koehler & Barry W. Glickman. (1990) Uracil-DNA glycosylase activity affects the mutagenicity of ethyl methanesulfonate: Evidence for an alternative pathway of alkylation mutagenesis. Mutation Research Letters 244:2, pages 115-121.
Crossref
Jeffrey M. Voigt & Michael D. Topal. (2002) O6-Methylguanine in place of guanine causes asymmetric single-strand cleavage of DNA by some restriction enzymes. Biochemistry 29:6, pages 1632-1637.
Crossref
A. E. Pegg. 1990. Chemical Carcinogenesis and Mutagenesis II. Chemical Carcinogenesis and Mutagenesis II 103 131 .
Shinya Shibutani, Robert Gentles & Francis Johnson. 1990. Nitroarenes. Nitroarenes 135 147 .
Matthew O. Sikpi, Larry C. Waters, Kenneth H. Kraemer, R. Julian Preston & Sankar Mitra. (2006) N ‐methyl‐ N ‐nitrosourea‐lnduced mutations in a shuttle plasmid replicated in human cells . Molecular Carcinogenesis 3:1, pages 30-36.
Crossref
Michael J. Horsfall, Alasdair J. E. Gordon, Philip A. Burns, Maria Zielenska, Gabrielle M. E. van der Vliet & Barry W. Glickman. (2008) Mutational specificity of alkylating agents and the influence of DNA repair. Environmental and Molecular Mutagenesis 15:2, pages 107-122.
Crossref
Alain Barbin & Helmut Bartsch. (1989) Nucleophilic selectivity as a determinant of carcinogenic potency (TD50) in rodents: a comparison of mono- and bi-functional alkylating agents and vinyl chloride metabolites. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 215:1, pages 95-106.
Crossref
Nikolai M. Mironov, Christopher P. Wild, Ghyslaine Martel-Planche, Peter F. Swann & Ruggero Montesano. (1989) Measurement of the removal of O6-methylguanine and O4-methylthymine from oligodeoxynucleotides using an immunoprecipitation technique. Analytical Biochemistry 183:1, pages 74-79.
Crossref
Willie J. Washington, Robert S. Foote, William C. Dunn, Walderico M. Generoso & Sankar Mitra. (1989) Age-dependent modulation of tissue-specific repair activity for 3-methyladenine and O6-methylguanine in DNA in inbred mice. Mechanisms of Ageing and Development 48:1, pages 43-52.
Crossref
Erwin Eder, Christoph Deininger & Wolfgang Kütt. (1989) Genotoxicity of monofunctional methanesulphonates in the SOS chromotest as a function of alkylation mechanisms. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 211:1, pages 51-64.
Crossref
Bhalchandra A. Diwan & Jerry M. Rice. 1989. The Pathobiology of Neoplasia. The Pathobiology of Neoplasia 149 171 .
B. Singer. 1989. DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells. DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells 1 17 .
Michael J. Horsfall, Marco J. Zeilmaker, Georges R. Mohn & Barry W. Glickman. (2006) Mutational specificities of environmental carcinogens in the lac l gene of Escherichia coli . II: A host‐mediated approach to N ‐nitroso‐ N, N ‐dimethylamine and endogenous mutagenesis in vivo . Molecular Carcinogenesis 2:2, pages 107-115.
Crossref
Samin Hirani‐Hojatti, Jamie R. Milligan, Asya Kovnat, Ken Brown & Michael C. Archer. (2006) Activation of the c‐Ha‐ ras ‐1 proto‐oncogene by methylation in vitro with α‐acetoxy‐ N ‐nitrosodimethylamine . Molecular Carcinogenesis 2:2, pages 101-106.
Crossref
John H. Weisburger, R. Conrad Jones, William S. Barnes & Anthony E. Pegg. (2005) Mechanisms of Differential Strain Sensitivity in Gastric Carcinogenesis. Japanese Journal of Cancer Research 79:12, pages 1304-1310.
Crossref
L.Y.Y. Fong, T. Cheung & Y.S. Ho. (1988) Effect of nutritional zinc-deficiency on O6-alkylguanine-DNA-methyl-transferase activities in rat tissues. Cancer Letters 42:3, pages 217-223.
Crossref
H.W. Theilmann, C.H. Schröder & A.W. Hsie. (1988) Formation and removal of DNA adducts after treatment of Chinese hamster ovary cells with N-methyl- and N-ethyl-N-nitrosourea. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 202:1, pages 235-250.
Crossref
Izumi Arita, Kouichi Tatsumi, Akira Tachibana, Mariko Toyoda & Hiraku Takebe. (1988) Instability of Mex− phenotype in human lymphoblastoid cell lines. Mutation Research Letters 208:3-4, pages 167-172.
Crossref
Willie J. Washington, William C. DunnJr.Jr., Walderico M. Generoso & Sankar Mitra. (1988) Tissue-specific variation in repair activity for 3-methyladenine in DNA in two stocks of mice. Mutation Research Letters 207:3-4, pages 165-169.
Crossref
Stuart H. Yuspa & Miriam C. Poirier. 1988. 25 70 .
A.T. Fong, J.D. Hendricks, R.H. Dashwood, S. Van Winkle & G.S. Bailey. (1988) Formation and persistence of ethylguanines in liver DNA of rainbow trout (Salmo gairdneri) treated with diethylnitrosamine by water exposure. Food and Chemical Toxicology 26:8, pages 699-704.
Crossref
Weiling Xue & Robert M. Carlson. (1988) Separation characteristics of alkylated guanines in high-performance liquid chromatography. Journal of Chromatography A 447, pages 81-90.
Crossref
P. Karran & J. Hall. 1988. Nucleic Acids and Molecular Biology. Nucleic Acids and Molecular Biology 188 197 .
M. Zielenska, J. B. Guttenplan & D. Beranek. (1988) Different mutational profiles induced by N-nitroso-N-ethylurea: Effects of dose and error-prone DNA repair and correlations with DNA adducts. Environmental and Molecular Mutagenesis 11:4, pages 473-485.
Crossref
B W GlickmanM J HorsfallA J GordonP A Burns. (1987) Nearest neighbor affects G:C to A:T transitions induced by alkylating agents.. Environmental Health Perspectives 76, pages 29-32.
Crossref
David A. Scicchitano & Anthony E. Pegg. (1987) Inhibition of O6-alkylguanine-DNA-alkyltransferase by metals. Mutation Research Letters 192:3, pages 207-210.
Crossref
B D Preston, B Singer & L A Loeb. (1987) Comparison of the relative mutagenicities of O-alkylthymines site-specifically incorporated into phi X174 DNA.. Journal of Biological Chemistry 262:28, pages 13821-13827.
Crossref
Katherine K. Richardson, Renae M. Crosby, Frank C. Richardson & Thomas R. Skopek. (1987) DNA base changes induced following in vivo exposure of unadapted, adapted or Ada− Escherichia coli to N-methyl-N′-nitro-N-nitrosoguanidine. Molecular and General Genetics MGG 209:3, pages 526-532.
Crossref
Kanji Ishizaki, Tohru Tsujimura, Chikau Fujio, Zhang Yangpei, Hideo Yawata, Yusaku Nakabeppu, Mutsuo Sekiguchi & Mituo Ikenaga. (1987) Expression of the truncated E. coliO6-methylguanine methyltransferase gene in repair-deficient human cells and restoration of cellular resistance to alkylating agents. Mutation Research/DNA Repair Reports 184:2, pages 121-128.
Crossref
Heinz Walter Thielmann, Lutz Edler, Max Roland Burkhardt & Ernst Gustav Jung. (1987) DNA repair synthesis in fibroblast strains from patients with actinic keratosis, squamous cell carcinoma, basal cell carcinoma, or malignant melanoma after treatment with ultraviolet light, N-acetoxy-2-acetyl-aminofluorene, methyl methanesulfonate, and N-methyl-N-nitrosourea. Journal of Cancer Research and Clinical Oncology 113:2, pages 171-186.
Crossref
J. Doniger, V. Notario & J.A. DiPaolo. (1987) Carcinogens with diverse mutagenic activities initiate neoplastic guinea pig cells that acquire the same N-ras point mutation.. Journal of Biological Chemistry 262:8, pages 3813-3819.
Crossref
C. Elizabeth Castro. 1987. Nutritional Toxicology. Nutritional Toxicology 129 155 .
Harry L. Duran & Altaf A. Wani. (1987) Site-specific gap-misrepair mutagenesis by O4-ethylthymine. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 908:1, pages 60-69.
Crossref
F.C. Richardson, R.O. BeauchampJr.Jr. & J.A. Swenberg. (1987) Properties and biological consequences of alkylpyrimidine deoxyribonucleosides. Pharmacology & Therapeutics 34:2, pages 181-213.
Crossref
Anthony E. Pegg & M. Eileen Dolan. (1987) Properties and assay of mammalian O6-alkyguanine-DNA alkyltransferase. Pharmacology & Therapeutics 34:2, pages 167-179.
Crossref
Ivo Schmerold & Alfred Spath. (1986) Induction of rat liver O6-alkylguanine-DNA alkyltransferase by bleomycin. Chemico-Biological Interactions 60:3, pages 297-304.
Crossref
Heinz Walter Thielmann, Lutz Edler & Susanne Friemel. (1986) Xeroderma pigmentosum patients from Germany: repair capacity of 45 XP fibroblast strains of the Mannheim XP Collection as measured by colony-forming ability and unscheduled DNA synthesis following treatment with methyl methanesulfonate and N-methyl-N-nitrosourea. Journal of Cancer Research and Clinical Oncology 112:3, pages 245-257.
Crossref
M. Wiessler. (1986) DNA adducts by N-nitroso compounds. Journal of Cancer Research and Clinical Oncology 112:2, pages 81-84.
Crossref
Frederica Perera. (2006) New Approaches in Risk Assessment for Carcinogens. Risk Analysis 6:2, pages 195-201.
Crossref
S. G. Sedgwick. 1986. Accuracy in Molecular Processes. Accuracy in Molecular Processes 233 289 .
Elizabeth C. Miller. 1986. Biological Reactive Intermediates III. Biological Reactive Intermediates III 1029 1037 .
Helmut Zarbl, Saraswati Sukumar, Anne L. Arthur, Dionisio Martin-Zanca & Mariano Barbacid. 1986. Mechanisms of DNA Damage and Repair. Mechanisms of DNA Damage and Repair 385 397 .
C. P. Wild, D. Umbenhauer, B. Chapot & R. Montesano. (2004) Monitoring of individual human exposure to aflatoxins (AF) and N‐nitrosamines (NNO) by immunoassays. Journal of Cellular Biochemistry 30:2, pages 171-179.
Crossref
Alain Barbin, Francoise Besson, Marie-Hélène Perrard, Jean-Claude Béréziat, John Kaldor, Georges Michel & Helmut Bartsch. (1985) Induction of specific base-pair substitutions in E. coli trpA mutants by chloroenthylene oxide, a carcinogenic vinyl chloride metabolite. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 152:2-3, pages 147-156.
Crossref
J A Swenberg, F C Richardson, J A Boucheron & M C Dyroff. (1985) Relationships between DNA adduct formation and carcinogenesis.. Environmental Health Perspectives 62, pages 177-183.
Crossref
A E Pegg, M E Dolan, D Scicchitano & K Morimoto. (1985) Studies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria.. Environmental Health Perspectives 62, pages 109-114.
Crossref
M.Eileen Dolan, Christopher D. Corsico & Anthony E. Pegg. (1985) Exposure of HeLa cells to 06-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents. Biochemical and Biophysical Research Communications 132:1, pages 178-185.
Crossref
R. Montesano, R. Becker, J. Hall, A. Likhachev, S.H. Lu, D. Umbenhauer & C.P. Wild. (1985) Repair of DNA alkylation adducts in mammalian cells. Biochimie 67:9, pages 919-928.
Crossref
Helmut Zarbl, Saraswati Sukumar, Anne V. Arthur, Dionisio Martin-Zanca & Mariano Barbacid. (1985) Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature 315:6018, pages 382-385.
Crossref
Richard A. Becker, Shih Shin Lu, Henriette Brésil, Ronald C. Shank & Ruggero Montesano. (1985) DNA ethylation in target and non-target organs of hamsters and rats treated with diethylnitrosamine. Cancer Letters 26:1, pages 17-24.
Crossref
R. B. Setlow. 1985. Assessment of Risk from Low-Level Exposure to Radiation and Chemicals. Assessment of Risk from Low-Level Exposure to Radiation and Chemicals 251 260 .
R. B. Setlow. 1985. Epidemiology and Quantitation of Environmental Risk in Humans from Radiation and Other Agents. Epidemiology and Quantitation of Environmental Risk in Humans from Radiation and Other Agents 375 381 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.