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Original Article

Use of Recombinant Human Interleukin-2 in Conjunction with Bone Marrow Transplantation as a Model for Control of Minimal Residual Disease in Malignant Hematological Disorders: I. Treatment of Murine Leukemia in Conjunction with Allogeneic Bone Marrow Transplantation and IL-2-Activated Cell-Mediated Immunotherapy

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Pages 19-26 | Published online: 11 Jun 2009

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Read on this site (2)

Michael Y Shapira, Igor B Resnick, Panagiotis D Tsirigotis & Shimon Slavin. (2006) Biological response modifiers as adjuncts to stem cell transplantation. Expert Opinion on Biological Therapy 6:5, pages 467-483.
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Bryon D. Johnson, Carrie A. Hanke & Robert L. Truitt. (1996) The Graft-Versus-Leukemia Effect of Post-transplant Donor Leukocyte Infusion. Leukemia & Lymphoma 23:1-2, pages 1-9.
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Articles from other publishers (46)

Shimon Slavin. (2023) Immunotherapy with cure potential of multi-drug resistant hematologic malignancies using IL-2 preactivated intentionally mismatched donor lymphocyte. Journal of Cancer Research and Clinical Oncology 149:11, pages 9277-9284.
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Scott S Graves, Maura H Parker & Rainer Storb. (2018) Animal Models for Preclinical Development of Allogeneic Hematopoietic Cell Transplantation. ILAR Journal 59:3, pages 263-275.
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Mi-Sun Choi, Ji-Young Lim, Byung-Sik Cho, Yoo-Jin Kim, Nack-Gyun Chung, Dae Chul Jeong, Hyewon Youn, Chulbom Lee, Eun Young Choi & Chang-Ki Min. (2011) The role of regulatory T cells during the attenuation of graft-versus-leukemia activity following donor leukocyte infusion in mice. Leukemia Research 35:12, pages 1549-1556.
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Shimon Slavin, Aliza Ackerstein, Reuven Or, Michael Y. Shapira, Benjamin Gesundheit, Nadir Askenasy & Shoshana Morecki. (2010) Immunotherapy in high-risk chemotherapy-resistant patients with metastatic solid tumors and hematological malignancies using intentionally mismatched donor lymphocytes activated with rIL-2: a phase I study. Cancer Immunology, Immunotherapy 59:10, pages 1511-1519.
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Edwin P. Alyea. (2008) Modulating graft-versus-host disease to enhance the graft-versus-leukemia effect. Best Practice & Research Clinical Haematology 21:2, pages 239-250.
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Ji-Young LimBo-Gyeong KimSeol-Kyung MoonChang-Ki Min. (2008) Enhancement of Graft-versus-leukemia Effects by Mesenchymal Stem Cells in Mixed Chimerisim after a Murine Non-myeloablative Hematopoietic Stem Cell Transplantation. The Korean Journal of Hematology 43:4, pages 219.
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Fariba EsmaeiliTaki TiraihiMansoureh MovahedinSeyed Javad Mowla. (2006) Selegiline Induces Neuronal Phenotype and Neurotrophins Expression in Embryonic Stem Cells. Rejuvenation Research 9:4, pages 475-484.
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Iris Yung, Lola Weiss, Ali Abdul-Hai, Judith Kasir, Shoshana Reich & Shimon Slavin. (2005) Induction of Early Post-Transplant Graft-versus-Leukemia Effects Using Intentionally Mismatched Donor Lymphocytes and Elimination of Alloantigen-Primed Donor Lymphocytes for Prevention of Graft-versus-Host Disease. Cancer Research 65:21, pages 9735-9740.
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Shimon Slavin. (2005) Allogeneic Cell-Mediated Immunotherapy at the Stage of Minimal Residual Disease following High-Dose Chemotherapy Supported by Autologous Stem Cell Transplantation. Acta Haematologica 114:4, pages 214-220.
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L Weiss, S Reich, O Mandelboim & S Slavin. (2004) Murine B-cell leukemia lymphoma (BCL1) cells as a target for NK cell-mediated immunotherapy. Bone Marrow Transplantation 33:11, pages 1137-1141.
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Shimon Slavin, Shoshana Morecki, Lola Weiss, Michael Y Shapira, Igor Resnick & Reuven Or. (2004) Nonmyeloablative stem cell transplantation: reduced-intensity conditioning for cancer immunotherapy—from bench to patient bedside. Seminars in Oncology 31:1, pages 4-21.
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Beverly A. Teicher. 2004. Anticancer Drug Development Guide. Anticancer Drug Development Guide 243 258 .
Shimon Slavin. (2018) Graft-versus-Host Disease, the Graft-versus-Leukemia Effect, and Mixed Chimerism following Nonmyeloablative Stem Cell Transplantation. International Journal of Hematology 78:3, pages 195-207.
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M Y Shapira, R Or, I B Resnick, M Bitan, A Ackerstein, S Samuel, S Elad, I Zilberman, S Miron & S Slavin. (2003) A new minimally ablative stem cell transplantation procedure in high-risk patients not eligible for nonmyeloablative allogeneic bone marrow transplantation. Bone Marrow Transplantation 32:6, pages 557-561.
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Shimon Slavin, Shoshana Morecki, Lola Weiss & Reuven Or. (2003) Immunotherapy of hematologic malignancies and metastatic solid tumors in experimental animals and man. Critical Reviews in Oncology/Hematology 46:2, pages 139-163.
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Igor Espinoza-Delgado & Dan L. Longo. 2003. Allogeneic Stem Cell Transplantation. Allogeneic Stem Cell Transplantation 83 99 .
Shimon SlavinShoshana MoreckiLola WeissReuven Or. (2002) Donor Lymphocyte Infusion: The Use of Alloreactive and Tumor-Reactive Lymphocytes for Immunotherapy of Malignant and Nonmalignant Diseases in Conjunction with Allogeneic Stem Cell Transplantation. Journal of Hematotherapy & Stem Cell Research 11:2, pages 265-276.
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I. Nir, L. Weiss & S. Slavin. 2002. Melatonin After Four Decades. Melatonin After Four Decades 407 409 .
C Ferrá, M Rodríguez-Luaces, D Gallardo, M Encuentra, GA Martín-Henao, J Peris, I Ancín, J Sarrá, JJ Berlanga, J García & A Grañena. (2001) Individually adjusted prophylactic donor lymphocyte infusions after CD34-selected allogeneic peripheral blood stem cell transplantation. Bone Marrow Transplantation 28:10, pages 963-968.
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Shimon Slavin. (2001) Immunotherapy of cancer with alloreactive lymphocytes. The Lancet Oncology 2:8, pages 491-498.
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Shimon Slavin, Arnon Nagler, Michael Shapira, Soumya Panigrahi, Simcha Samuel & Arnon Or. (2001) Non-myeloablative allogeneic stem cell transplantation focusing on immunotherapy of life-threatening malignant and non-malignant diseases. Critical Reviews in Oncology/Hematology 39:1-2, pages 25-29.
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Shoshana Morecki, Elena Yacovlev, Yael Gelfand, Ifat Uzi & Shimon Slavin. (2001) Cell Therapy With Preimmunized Effector Cells Mismatched for Minor Histocompatible Antigens in the Treatment of a Murine Mammary Carcinoma. Journal of Immunotherapy 24:2, pages 114-121.
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Arnon Nagler, Aliza Ackerstein, Reuven Or, Elizabeth Naparstek & Shimon Slavin. (2000) Adoptive immunotherapy with haploidentical allogeneic peripheral blood lymphocytes following autologous bone marrow transplantation. Experimental Hematology 28:11, pages 1225-1231.
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Shimon Slavin. (2000) New strategies for bone marrow transplantation. Current Opinion in Immunology 12:5, pages 542-551.
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H. Sefrioui, A. D. Billiau & M. Waer. (2000) GRAFT-VERSUS-LEUKEMIA EFFECT IN MINOR ANTIGEN MISMATCHED CHIMERAS GIVEN DELAYED DONOR LEUCOCYTE INFUSION: IMMUNOREGULATORY ASPECTS AND ROLE OF DONOR T AND ASGM1-POSITIVE CELLS1. Transplantation 70:2, pages 348-353.
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Stephen Mackinnon. (2000) Who may benefit from donor leucocyte infusions after allogeneic stem cell transplantation?. British Journal of Haematology 110:1, pages 12-17.
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Shoshana MoreckiShimon Slavin. (2000) Toward Amplification of a Graft-Versus-Leukemia Effect While Minimizing Graft-Versus-Host Disease. Journal of Hematotherapy & Stem Cell Research 9:3, pages 355-366.
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John BarrettShoshana Morecki, Gabor Varadi, Elizabeth Naparstek, Rami Ben-Yosef, Shimon Slavin, Arnon Nagler & Reuven Or. 2000. Allogeneic Immunotherapy for Malignant Diseases. Allogeneic Immunotherapy for Malignant Diseases.
Shimon Slavin & Arnon Nagler. 2000. Cancer and Autoimmunity. Cancer and Autoimmunity 409 421 .
S. Slavin, A. Nagler, E. Naparstek, G. Varadi, R. Ben-Yosef & R. Or. 2000. Transplantation in Hematology and Oncology. Transplantation in Hematology and Oncology 112 117 .
Urania Vourka-Karussis, Aliza Ackerstein, Thea Pugatsch & Shimon Slavin. (1999) Allogeneic cell-mediated immunotherapy for eradication of minimal residual disease. Experimental Hematology 27:3, pages 461-469.
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David L. Porter & Joseph H. Antin. (1998) INFUSION OF DONOR PERIPHERAL BLOOD MONONUCLEAR CELLS TO TREAT RELAPSE AFTER TRANSPLANTATION FOR CHRONIC MYELOGENOUS LEUKEMIA. Hematology/Oncology Clinics of North America 12:1, pages 123-150.
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S. Slavin & A. Nagler. (1998) Immunotherapy in conjunction with autologous and allogeneic blood or marrow transplantation in lymphoma. Annals of Oncology 9, pages S31-S39.
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A. NaglerA. AckersteinR. OrE. NaparstekS. Slavin. (1997) Immunotherapy With Recombinant Human Interleukin-2 and Recombinant Interferon-α in Lymphoma Patients Postautologous Marrow or Stem Cell Transplantation. Blood 89:11, pages 3951-3959.
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Stephen Mackinnon. (1997) 11 Donor leukocyte infusions. Bailli?re's Clinical Haematology 10:2, pages 357-367.
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Beverly A. Teicher. 1997. Anticancer Drug Development Guide. Anticancer Drug Development Guide 183 196 .
David L. Porter & Joseph H. Antin. 1997. Blood Stem Cell Transplantation. Blood Stem Cell Transplantation 57 85 .
A.R. Perry & S. Mackinnon. (1996) Adoptive immunotherapy post bone-marrow transplantation. Blood Reviews 10:4, pages 237-241.
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Robin Foa, Alessandro Cignetti & Anna Guarini. (2012) Acute Leukaemia. Clinical Immunotherapeutics 6:3, pages 238-249.
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Amos Toren, Aliza Ackerstein, Shimon Slavin & Arnon Nagler. (1995) Role of interleukin-2 in human hematological malignancies. Medical Oncology 12:3, pages 177-186.
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J. Nemunaitis, C. Rosenfeld, R. Collins, P. Pallansch, L. Pineiro, S. Ohr, D. Waxman, M. Stone, J. Fay, W. Miller & Luis Piñeiro. (2003) Allogeneic transplantation combining mobilized blood and bone marrow in patients with refractory hematologic malignancies. Transfusion 35:8, pages 666-673.
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E. Naparstek, R. Or, A. Nagler, G. Cividalli, D. Engelhard, M. Aker, Z. Gimon, N. Manny, T. Sacks, Z. Tochner, L. Weiss, S. Samuel, C. Brautbar, G. Hale, H. Waldmann, S. M. Steinberg & S. SLAVIN. (2008) T‐cell‐depleted allogeneic bone marrow transplantation for acute leukaemia using Campath‐1 antibodies and post‐transplant administration of donor's peripheral blood lymphocytes for prevention of relapse. British Journal of Haematology 89:3, pages 506-515.
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Esperanza B. Papadopoulos, Marc Ladanyi, David Emanuel, Stephen Mackinnon, Farid Boulad, Matthew H. Carabasi, Hugo Castro-Malaspina, Barrett H. Childs, Alfred P. Gillio, Trudy N. Small, James W. Young, Nancy A. Kernan & Richard J. O'Reilly. (1994) Infusions of Donor Leukocytes to Treat Epstein-Barr Virus-Associated Lymphoproliferative Disorders after Allogeneic Bone Marrow Transplantation. New England Journal of Medicine 330:17, pages 1185-1191.
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GEOFF HALE & HERMAN WALDMANN. (1994) CAMPATH-1 Monoclonal Antibodies in Bone Marrow Transplantation. Journal of Hematotherapy 3:1, pages 15-31.
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Pierre Tiberghien & Patrick Hervé. (1992) Perspectives in marrow graft T-cell depletion in allogeneic matched related bone marrow transplantation. Transfusion Science 13:4, pages 443-454.
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Simcha Samuel, Arnon Nagler, Reuven Or & Shimon Slavin. (1992) Effects of interleukin 2 on engraftment following autologous bone marrow transplantation (ABMT) in dogs. Leukemia Research 16:10, pages 967-972.
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