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Cancer Investigation Volume 11, 1993 - Issue 1
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Original Article

Mutational Status of Codons 12 and 13 of the N- and K-ras Genes in Tissue and Cell Lines Derived from Primary and Metastatic Prostate Carcinomas

Robert G. Pergolizzi Department of Research, Medicine North Shore University Hospital-Cornell University Medical College Manhasset, New York, 11030; Department of Laboratories, Medicine, North Shore University Hospital-Cornell University Medical College Manhasset, New York, 11030; Department of Pediatrics, Medicine, North Shore University Hospital-Cornell University Medical College Manhasset, New York, 11030
,
Willi Kreis Department of Medicine, North Shore University Hospital-Cornell University Medical College Manhasset, New York, 11030
,
Cheryl Rottach Department of Medicine, North Shore University Hospital-Cornell University Medical College Manhasset, New York, 11030
,
Myron Susin Department of Laboratories, Medicine, North Shore University Hospital-Cornell University Medical College Manhasset, New York, 11030
&
John D. Broome Department of Laboratories, Medicine, North Shore University Hospital-Cornell University Medical College Manhasset, New York, 11030
Pages 25-32 | Published online: 11 Jun 2009

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Atike Bahcivan, Mehmet Gamsizkan, Sinem Kantarcioglu Coskun, Sengul Cangur, Alpaslan Yuksel, Aysegul Ceyhan & Binnur Onal. (2020) KRAS, BRAF, PIK3CA mutation frequency of radical prostatectomy samples and review of the literature. The Aging Male 23:5, pages 1627-1641.
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Hoda Yeganehjoo, Russell DeBose-Boyd, Brian K. McFarlin & Huanbiao Mo. (2017) Synergistic Impact of d-δ-Tocotrienol and Geranylgeraniol on the Growth and HMG CoA Reductase of Human DU145 Prostate Carcinoma Cells. Nutrition and Cancer 69:4, pages 682-691.
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Michael V. Viola. (1993) Genetic Changes in Prostate Carcinoma Cells. Cancer Investigation 11:1, pages 92-93.
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Marcelo Ehrlich & Eran Bacharach. (2021) Oncolytic Virotherapy: The Cancer Cell Side. Cancers 13:5, pages 939.
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Suruchi Aggarwal, Minu Singh, Ashok Kumar & Tapas Mukhopadhyay. (2015) SRD5A2 gene expression inhibits cell migration and invasion in prostate cancer cell line via F-actin reorganization. Molecular and Cellular Biochemistry 408:1-2, pages 15-23.
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Man Kit Siu, Wassim Abou-Kheir, Juan Juan Yin, Yung-Sheng Chang, Ben Barrett, Florent Suau, Orla Casey, Wei-Yu Chen, Lei Fang, Paul Hynes, Yao-Yu Hsieh, Yen-Nien Liu, Jiaoti Huang & Kathleen Kelly. (2014) Loss of EGFR signaling-regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance. Oncotarget 5:11, pages 3770-3784.
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Meng Fu, Wei Zhang, Ling Shan, Jian Song, Donghao Shang, Jianming Ying & Jimao Zhao. (2014) Mutation status of somatic EGFR and KRAS genes in Chinese patients with prostate cancer (PCa). Virchows Archiv 464:5, pages 575-581.
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MASANORI HATASHITA, MASAHIKO TANIGUCHI, KIMIYE BABA, KEN KOSHIBA, TAKEFUMI SATO, YUTAKA JUJO, RYUTA SUZUKI & SACHIKO HAYASHI. (2014) Sinodielide A exerts thermosensitizing effects and induces apoptosis and G2/M cell cycle arrest in DU145 human prostate cancer cells via the Ras/Raf/MAPK and PI3K/Akt signaling pathways. International Journal of Molecular Medicine 33:2, pages 406-414.
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Sun-Hye LeeTae-Gyun WooSu-Jin LeeJin-Sik KimNam-Chul HaBum-Joon Park. (2013) Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system. Oncotarget 4:12, pages 2523-2531.
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Aditi Gupta, Wei Cao, Kavitha Sadashivaiah, Wantao Chen, Abraham Schneider & Meenakshi A. Chellaiah. (2013) Promising Noninvasive Cellular Phenotype in Prostate Cancer Cells Knockdown of Matrix Metalloproteinase 9. The Scientific World Journal 2013, pages 1-13.
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Eun-Jin Yun, Kaijie Wu, Yuh-Shyan Tsai, Daxing Xie & Jer-Tsong Hsieh. 2013. Prostate Cancer. Prostate Cancer 275 293 .
Fatma Silan, Yener Gultekin, Sinem Atik, Davran Kilinc, Cabir Alan, Fazilet Yildiz, Ahmet Uludag & Ozturk Ozdemir. (2011) Combined point mutations in codon 12 and 13 of KRAS oncogene in prostate carcinomas. Molecular Biology Reports 39:2, pages 1595-1599.
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Faris Farassati, Weihong Pan, Farnaz Yamoutpour, Susann Henke, Mark Piedra, Silke Frahm, Said Al-Tawil, Wells I. Mangrum, Luis F. Parada, Samuel D. Rabkin, Robert L. Martuza & Andreas Kurtz. (2008) Ras Signaling Influences Permissiveness of Malignant Peripheral Nerve Sheath Tumor Cells to Oncolytic Herpes. The American Journal of Pathology 173:6, pages 1861-1872.
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Anna Moshnikova, Judson Frye, Jerry W. Shay, John D. Minna & Andrei V. Khokhlatchev. (2006) The Growth and Tumor Suppressor NORE1A Is a Cytoskeletal Protein That Suppresses Growth by Inhibition of the ERK Pathway*. Journal of Biological Chemistry 281:12, pages 8143-8152.
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Lamia Benbrahim-Tallaa, Robert A. Waterland, Miroslav Styblo, William E. Achanzar, Mukta M. Webber & Michael P. Waalkes. (2005) Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicology and Applied Pharmacology 206:3, pages 288-298.
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David G. Bostwick, Harry B. Burke, Daniel Djakiew, Susan Euling, Shuk-mei Ho, Joseph Landolph, Howard Morrison, Babasaheb Sonawane, Tiffany Shifflett, David J. Waters & Barry Timms. (2004) Human prostate cancer risk factors. Cancer 101:S10, pages 2371-2490.
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Roxane Tenta, Despina Tiblalexi, Evangelia Sotiriou, Peter Lembessis, Menelaos Manoussakis & Michael Koutsilieris. (2003) Bone microenvironment‐related growth factors modulate differentially the anticancer actions of zoledronic acid and doxorubicin on PC‐3 prostate cancer cells. The Prostate 59:2, pages 120-131.
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Keith BuppMonica J. Roth. (2003) Targeting a Retroviral Vector in the Absence of a Known Cell-Targeting Ligand. Human Gene Therapy 14:16, pages 1557-1564.
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Gary R. Hudes. (2002) Signaling Inhibitors in the Treatment of Prostate Cancer. Investigational New Drugs 20:2, pages 159-172.
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Zhi Wang, Ching-Ping Tseng, Rey-Chen Pong, Hong Chen, John D. McConnell, Nora Navone & Jer-Tsong Hsieh. (2002) The Mechanism of Growth-inhibitory Effect of DOC-2/DAB2 in Prostate Cancer. Journal of Biological Chemistry 277:15, pages 12622-12631.
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Allen C. Gao & John T. Isaacs. 2002. The Molecular Basis of Human Cancer. The Molecular Basis of Human Cancer 365 378 .
Jian Zhou, Jessica Scholes & Jer-Tsong Hsieh. 2002. Prostate Cancer: New Horizons in Research and Treatment. Prostate Cancer: New Horizons in Research and Treatment 215 226 .
Adrie van Bokhoven, Marileila Varella‐Garcia, Christopher Korch, Daphne Hessels & Gary J. Miller. (2001) Widely used prostate carcinoma cell lines share common origins. The Prostate 47:1, pages 36-51.
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Deepika Rajesh, Kathleen Schell & A. K. Verma. (1999) Ras Mutation, Irrespective of Cell Type and p53 Status, Determines a Cell’s Destiny to Undergo Apoptosis by Okadaic Acid, an Inhibitor of Protein Phosphatase 1 and 2A . Molecular Pharmacology 56:3, pages 515-525.
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Rajani K. Ravi, Martin McMahon, Zang Yangang, Jerry R. Williams, Larry E. Dillehay, Barry D. Nelkin & Mack Mabry. (1999) Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells. Journal of Cellular Biochemistry 72:4, pages 458-469.
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Y.Z. Wang & Y.C. Wong. (1997) Oncogenes and tumor suppressor genes in prostate cancer: a review. Urologic Oncology: Seminars and Original Investigations 3:2, pages 41-46.
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Larry V. Blount & David B. Cooke. (1996) Point mutations in theKi-ras2 gene of codon 12 in the Dunning R-3327 prostatic adenocarcinoma system. The Prostate 28:1, pages 44-50.
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Kim T. Ow, Hedy Mameghan, Alistair Lochhead, Richard Fisher, Jia L. Yang, Jill Mameghan, Stephen Andersen & Pamela J. Russell. (1995) The prognostic significance of tumor-associated markers p53, HER-2/neu, c-myc, v-H-ras, PCNA and EGFr of local and distant recurrence in localized human prostatic adenocarcinoma. Urologic Oncology: Seminars and Original Investigations 1:4, pages 144-152.
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Tsuneo Masui, Tomoyuki Shirai, Katsumi Imaida, Masao Hirose, Mitsuru Futakuchi, Masae Tatematsu & Nobuyuki Ito. (2006) Ki‐ ras mutations with frequent normal allele loss versus absence of p53 mutations in rat prostate and seminal vesicle carcinomas induced with 3,2′‐dimethyl‐4‐aminobiphenyl . Molecular Carcinogenesis 13:1, pages 21-26.
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