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Review Article

Edatrexate, an Antifolate with Antitumor Activity: A Review

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Pages 36-45 | Published online: 11 Jun 2009

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Shabnam Jeibouei, Mohammad Esmael Akbari, Alireza Kalbasi, Amir Reza Aref, Mohammad Ajoudanian, Alireza Rezvani & Hakimeh Zali. (2019) Personalized medicine in breast cancer: pharmacogenomics approaches. Pharmacogenomics and Personalized Medicine 12, pages 59-73.
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Nicole Hagner & Markus Joerger. (2010) Cancer chemotherapy: targeting folic acid synthesis. Cancer Management and Research 2, pages 293-301.
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Philip Kuriakose, David R. Gandara & Edith A. Perez. (2002) Phase I Trial of Edatrexate in Advanced Breast and Other Cancers. Cancer Investigation 20:4, pages 473-479.
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Godefridus J Peters & Stephen P Ackland. (1996) Leading Article: Oncologic, Endocrine & Metabolic: New antimetabolites in preclinical and clinical development. Expert Opinion on Investigational Drugs 5:6, pages 637-679.
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Galal H. Elgemeie & Reham A. Mohamed-Ezzat. 2022. New Strategies Targeting Cancer Metabolism. New Strategies Targeting Cancer Metabolism 143 220 .
Tianfeng Gao, Congying Zhang, Xiaowei Shi, Ran Guo, Kai Zhang, Jianmin Gu, Lin Li, Shuolei Li, Qianqian Zheng, Mengyu Cui, Miao Cui, Xingmei Gao, Yi Liu & Lei Wang. (2019) Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents. European Journal of Medicinal Chemistry 178, pages 329-340.
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SarahA Mubaraki. (2019) Oral mucositis in children associated with hematopoietic stem cells transplant. Saudi Journal of Oral Sciences 6:2, pages 47.
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Balaraman Selvakumar & Kuppanagounder P. Elango. (2019) Synthesis of Non-Glutamate-Type Pyrrolo[2,3-d]Pyrimidines via Direct Aminocarbonylation of Aryl Halides Using Solid Co 2 (CO) 8 as a CO Source and Their Antibacterial Activity . Journal of Chemical Research 41:4, pages 230-234.
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Douglas E. Peterson, Kerstin ?hrn, Joanne Bowen, Monica Fliedner, Judith Lees, Charles Loprinzi, Takehiko Mori, Anthony Osaguona, Dianna S. Weikel, Sharon Elad & Rajesh V. Lalla. (2012) Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy. Supportive Care in Cancer 21:1, pages 327-332.
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Ana Maria Gonzalez-Angulo, Flavia Morales-Vasquez & Gabriel N. Hortobagyi. 2007. Breast Cancer Chemosensitivity. Breast Cancer Chemosensitivity 1 22 .
Jackie Walling. (2006) From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates. Investigational New Drugs 24:1, pages 37-77.
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W. Thomas Purcell & David S. Ettinger. (2003) Novel antifolate drugs. Current Oncology Reports 5:2, pages 114-125.
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Gerardo Colon-Otero, Robert D. Niedringhaus, Shauna H. Hillman, Susan Geyer, Jeffrey Sloan, James E. Krook, Harold E. Windschitl, Randolph S. Marks, Martin Wiesenfeld, Loren K. Tschetter & James J. Jett. (2001) A Phase II Trial of Edatrexate, Vinblastine, Adriamycin, Cisplastin, and Filgrastim (EVAC/G-CSF) in Patients With Non?Small-Cell Carcinoma of the Lungs. American Journal of Clinical Oncology 24:6, pages 551-555.
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Larry H. Matherly. 2001. 131 162 .
Andre Rosowsky, Joel E. Wright, Chitra M. Vaidya, Ronald A. Forsch & Henry Bader. (2000) Analogues of the Potent Nonpolyglutamatable Antifolate N α -(4-Amino-4-deoxypteroyl)- N δ -hemiphthaloyl- l -ornithine (PT523) with Modifications in the Side Chain, p -Aminobenzoyl Moiety, or 9,10-Bridge:  Synthesis and in Vitro Antitumor Activity . Journal of Medicinal Chemistry 43:8, pages 1620-1634.
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Richard Gorlick. 2000. Methotrexate. Methotrexate 9 29 .
Hedy L. Kindler, Chandra P. Belani, James E. Herndon, Nicholas J. Vogelzang, Yasunosuke Suzuki & Mark R. Green. (1999) Edatrexate (10-ethyl-deaza-aminopterin) (NSC #626715) with or without leucovorin rescue for malignant mesothelioma. Cancer 86:10, pages 1985-1991.
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J.R. Rigas, M.G. Kris, V.A. Miller, K.M.W. Pisters, R.T. Heelan, S.C. Grant, D.W. Fennelly, Ting-Chao Chou & F.M. Sirotnak. (1999) Phase I study of the sequential administration of edatrexate and paclitaxel in patients with advanced solid tumors. Annals of Oncology 10:5, pages 601-603.
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Richard Gorlick & Joseph R. Bertino. 1999. Antifolate Drugs in Cancer Therapy. Antifolate Drugs in Cancer Therapy 37 57 .
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Martin J. Edelman, David R. Gandara, Edith A. Perez, Derrick Lau, Ignacio Lauder, Corrine Turrell, Margaret Uhrich & Frederick Meyers. (1998) Phase I trial of edatrexate plus carboplatin in advanced solid tumors: amelioration of dose-limiting mucositis by ice chip cryotherapy. Investigational New Drugs 16:1, pages 69-75.
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Gerrit Jansen & Rob Pieters. (1998) The role of impaired transport in (pre)clinical resistance to methotrexate: insights on new antifolates. Drug Resistance Updates 1:3, pages 211-218.
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Jacques Galipeau, Ely Benaim, Harold T. Spencer, Raymond L. Blakley & Brian P. Sorrentino. (1997) A Bicistronic Retroviral Vector for Protecting Hematopoietic Cells Against Antifolates and P-Glycoprotein Effluxed Drugs. Human Gene Therapy 8:15, pages 1773-1783.
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Robert Dreicer, Kathleen J. Propert, Timothy Kuzel, John M. Kirkwood, Peter J. O'Dwyer & Patrick J. Loehrer. (1997) A Phase II Trial of Edatrexate in Patients with Advanced Renal Cell Carcinoma. American Journal of Clinical Oncology 20:3, pages 251-253.
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Martina C. Hum & Barton A. Kamen. (1996) Folate, antifolates, and folate analogs in Pediatric Oncology. Investigational New Drugs 14:1, pages 101-111.
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Chris H. Takimoto. (1996) New Antifolates: Pharmacology and Clinical Applications. The Oncologist 1:1-2, pages 68-81.
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Michael J. Spinella, Kevin E. Brigle, Esteban E. Sierra & I. David Goldman. (1995) Distinguishing between Folate Receptor-α-mediated Transport and Reduced Folate Carrier-mediated Transport in L1210 Leukemia Cells. Journal of Biological Chemistry 270:14, pages 7842-7849.
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Colin Paul Spears. (1995) Clinical Resistance to Antimetabolites. Hematology/Oncology Clinics of North America 9:2, pages 397-414.
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Ting-Chao Chou, Glenys M. Otter & Francis M. Sirotnak. (1995) Schedule-dependent synergism of taxol or taxotere with edatrexate against human breast cancer cells in vitro. Cancer Chemotherapy and Pharmacology 37:3, pages 222-228.
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George deStevens, V. Zingel, C. Leschke, W. Schunack, Paul D. Hoeprich, Richard M. Schultz, P. K. Mehrotra, Sanjay Batra, A. P. Bhaduri, Anil K. Saxena & Mridula SaxenaRichard M. Schultz. 1995. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques 129 157 .
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D.F. MooreJrJr, R. Pazdur, J.L. Abbruzzese, J.A. Ajani, D.W. Dubovsky, J.L. WadeIIIIII, R.J. Belt, C. Mangold, B. Bready & R.J. Winn. (1994) Phase II trial of edatrexate in patients with advanced pancreatic adenocarcinoma. Annals of Oncology 5:3, pages 286-287.
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Jacques Jolivet, Gerrit Jansen, Godefridus J. Peters, Marie-France Pinard & Jan H. Schornagel. (1994) Leucovorin rescue of human cancer and bone marrow cells following edatrexate or methotrexate. Biochemical Pharmacology 47:4, pages 659-665.
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Edith A. Perez, Frank M. Hack, Lauri M. Webber & Ting-Chao Chou. (1993) Schedule-dependent synergism of edatrexate and cisplatin in combination in the A549 lung-cancer cell line as assessed by median-effect analysis. Cancer Chemotherapy and Pharmacology 33:3, pages 245-250.
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