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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 27, 2010 - Issue 8
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Research Article

INFLUENCE OF CIRCADIAN TIME OF HYPERTENSION TREATMENT ON CARDIOVASCULAR RISK: RESULTS OF THE MAPEC STUDY

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Pages 1629-1651 | Received 25 May 2010, Accepted 06 Jul 2010, Published online: 20 Sep 2010

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Cigdem Ileri, Zekeriya Dogan, Beste Ozben, Latife Bircan, Aycan Acet & Taner Sen. (2023) The Impact of Timing of Fixed Dose Triple Antihypertensive Combinations on Ambulatory Blood Pressure Monitoring Parameters. Clinical and Experimental Hypertension 45:1.
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Ramón G. Hermida-Ayala, Artemio Mojón, José R. Fernández, Michael H. Smolensky & Ramón C. Hermida. (2022) Ingestion-time differences in the pharmacodynamics of dual-combination hypertension therapies: Systematic review and meta-analysis of published human trials. Chronobiology International 39:4, pages 493-512.
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Ramón C. Hermida, Ramón G. Hermida-Ayala, Artemio Mojón, Michael H. Smolensky & José R. Fernández. (2021) Systematic review and quality evaluation of published human ingestion-time trials of blood pressure-lowering medications and their combinations. Chronobiology International 38:10, pages 1460-1476.
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Ramón C. Hermida, Ramón G. Hermida-Ayala, Michael H. Smolensky, Artemio Mojón & José R. Fernández. (2020) Ingestion-time – relative to circadian rhythms – differences in the pharmacokinetics and pharmacodynamics of hypertension medications. Expert Opinion on Drug Metabolism & Toxicology 16:12, pages 1159-1173.
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Reinhold Kreutz, Sverre E. Kjeldsen, Michel Burnier, Krzysztof Narkiewicz, Suzanne Oparil & Giuseppe Mancia. (2020) Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project. Blood Pressure 29:3, pages 135-136.
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José R. Fernández, Artemio Mojón & Ramón C. Hermida. (2020) Chronotherapy of hypertension: advantages of 48-h ambulatory blood pressure monitoring assessments in MAPEC and Hygia Chronotherapy Trial. Chronobiology International 37:5, pages 739-750.
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Fabio Fabbian, Michael H. Smolensky, Ruana Tiseo, Marco Pala, Roberto Manfredini & Francesco Portaluppi. (2013) Dipper and Non-Dipper Blood Pressure 24-Hour Patterns: Circadian Rhythm–Dependent Physiologic and Pathophysiologic Mechanisms. Chronobiology International 30:1-2, pages 17-30.
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