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Original Article

Dhea Replacement in Women with Adrenal Insufficiency—Pharmacokinetics, Bioconversion and Clinical Effects on Well-Being, Sexuality and Cognition

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Pages 505-511 | Published online: 07 Jul 2009

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C. Peixoto, C. G. Carrilho, J. A. Barros, T. T. S. B. Ribeiro, L. M. Silva, A. E. Nardi, A. Cardoso & A. B. Veras. (2017) The effects of dehydroepiandrosterone on sexual function: a systematic review. Climacteric 20:2, pages 129-137.
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Dubravka Svob Strac, Josipa Vlainic, Janko Samardzic, Julija Erhardt & Zeljka Krsnik. (2016) Effects of acute and chronic administration of neurosteroid dehydroepiandrosterone sulfate on neuronal excitability in mice. Drug Design, Development and Therapy 10, pages 1201-1215.
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Marcus K. Taylor, Genieleah A. Padilla, Katherine E. Stanfill, Amanda E. Markham, Jasmine Y. Khosravi, Michael D. Dial Ward & Matthew M. Koehler. (2012) Effects of dehydroepiandrosterone supplementation during stressful military training: A randomized, controlled, double-blind field study. Stress 15:1, pages 85-96.
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Articles from other publishers (52)

Dingfeng Li. (2022) Quality of Life in Patients with Adrenal Insufficiency. Endocrinology and Metabolism Clinics of North America 51:4, pages 741-753.
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Heitor O. Santos, Flávio A. Cadegiani & Scott C. Forbes. (2022) Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review. Clinical Therapeutics 44:8, pages 1129-1149.
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Javier García-Sánchez, Mayra Alejandra Mafla-España, María Dolores Torregrosa & Omar Cauli. (2022) Androstenedione and Follicle-Stimulating Hormone Concentration Predict the Progression of Frailty Syndrome at One Year Follow-Up in Patients with Localized Breast Cancer Treated with Aromatase Inhibitors. Biomedicines 10:7, pages 1634.
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Gillian Bennett, Leanne Cussen & Michael W. O’Reilly. (2022) The role for long-term use of dehydroepiandrosterone in adrenal insufficiency. Current Opinion in Endocrinology, Diabetes & Obesity 29:3, pages 284-293.
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Rafaela S. C. Takeshita, Renata S. Mendonça, Fred B. Bercovitch & Michael A. Huffman. (2019) Developmental changes in the endocrine stress response in orangutans (Pongo pygmaeus). Journal of Comparative Physiology B 189:6, pages 659-672.
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Candace M. Hogue. (2019) The protective impact of a mental skills training session and motivational priming on participants’ psychophysiological responses to performance stress. Psychology of Sport and Exercise 45, pages 101574.
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Winnie Ho & Maralyn Druce. (2018) Quality of life in patients with adrenal disease: A systematic review. Clinical Endocrinology 89:2, pages 119-128.
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Kwangsung Park & Noel N. Kim. 2018. Textbook of Female Sexual Function and Dysfunction. Textbook of Female Sexual Function and Dysfunction 107 125 .
Irina Bancos, Stefanie Hahner, Jeremy Tomlinson & Wiebke Arlt. (2015) Diagnosis and management of adrenal insufficiency. The Lancet Diabetes & Endocrinology 3:3, pages 216-226.
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Jitske Tiemensma, Cornelie D Andela, Ad A Kaptein, Johannes A Romijn, Roos C van der Mast, Nienke R Biermasz & Alberto M Pereira. (2014) Psychological morbidity and impaired quality of life in patients with stable treatment for primary adrenal insufficiency: cross-sectional study and review of the literature. European Journal of Endocrinology 171:2, pages 171-182.
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Jonathan Bertin, Alain Y. Dury, Johanne Ouellet, Georges Pelletier & Fernand Labrie. (2014) Localization of the Androgen‐Synthesizing Enzymes, Androgen Receptor, and Sex Steroids in the Vagina: Possible Implications for the Treatment of Postmenopausal Sexual Dysfunction. The Journal of Sexual Medicine 11:8, pages 1949-1961.
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John E. Morley. (2013) Scientific overview of hormone treatment used for rejuvenation. Fertility and Sterility 99:7, pages 1807-1813.
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Bruno Allolio, Wiebke Arlt & Stefanie Hahner. 2012. Testosterone. Testosterone 437 458 .
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Sonia L. Davison & Susan R. Davis. (2011) Androgenic hormones and aging — The link with female sexual function. Hormones and Behavior 59:5, pages 745-753.
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Seong Ju LeeWoo Sik ChungHana Yoon. (2011) The Clinical Effect of Androgen Replacement Therapy for Female Sexual Dysfunction. The Ewha Medical Journal 34:2, pages 33.
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Katherine Shaio Sandhu, Arnold Melman & Magdy S. Mikhail. (2011) Impact of Hormones on Female Sexual Function and Dysfunction. Female Pelvic Medicine & Reconstructive Surgery 17:1, pages 8-16.
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Abdulmaged M. Traish, Ella Botchevar & Noel N. Kim. (2010) Biochemical Factors Modulating Female Genital Sexual Arousal Physiology. The Journal of Sexual Medicine 7:9, pages 2925-2946.
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Abdulmaged M. Traish. (2010) Role of androgens in modulating male and female sexual function. Hormone Molecular Biology and Clinical Investigation 4:1.
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Shalender Bhasin, Rajan Singh, Ravi Jasuja & Thomas W. Storer. 2010. Osteoporosis in Men. Osteoporosis in Men 335 348 .
Sybil Crawford, Nanette Santoro, Gail A. Laughlin, Mary Fran Sowers, Daniel McConnell, Kim Sutton-Tyrrell, Gerson Weiss, Marike Vuga, John Randolph & Bill Lasley. (2009) Circulating Dehydroepiandrosterone Sulfate Concentrations during the Menopausal Transition. The Journal of Clinical Endocrinology & Metabolism 94:8, pages 2945-2951.
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Mary Panjari, Robin J. Bell, Fiona Jane, Jenny Adams, Corallee Morrow & Susan R. Davis. (2009) The safety of 52 weeks of oral DHEA therapy for postmenopausal women. Maturitas 63:3, pages 240-245.
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Abdulmaged M. Traish, Robert J. Feeley & Andre T. Guay. (2009) Testosterone Therapy in Women with Gynecological and Sexual Disorders: A Triumph of Clinical Endocrinology from 1938 to 2008. The Journal of Sexual Medicine 6:2, pages 334-351.
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Mark V. Flinn, Michael P. Muehlenbein & Davide Ponzi. (2009) Evolution of neuroendocrine mechanisms linking attachment and life history: The social neuroendocrinology of middle childhood. Behavioral and Brain Sciences 32:1, pages 27-28.
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Nicole Maninger, Owen M. Wolkowitz, Victor I. Reus, Elissa S. Epel & Synthia H. Mellon. (2009) Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Frontiers in Neuroendocrinology 30:1, pages 65-91.
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Donna Kritz-Silverstein, Denise Von Mühlen, Gail A. Laughlin & Ricki Bettencourt. (2008) Effects of Dehydroepiandrosterone Supplementation on Cognitive Function and Quality of Life: The DHEA and Well-Ness (DAWN) Trial. Journal of the American Geriatrics Society 56:7, pages 1292-1298.
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F. Gueugnon, C. Gondcaille, S. Leclercq, J. Bellenger, S. Bellenger, M. Narce, T. Pineau, F. Bonnetain & S. Savary. (2007) Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene (ABCD2) independently of PPARα in rodents. Biochimie 89:11, pages 1312-1321.
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Abdulmaged Traish, Andre T. Guay, Richard F. Spark & the Testosterone Therapy in Women Study Group. (2007) COMMENTARY: Are the Endocrine Society's Clinical Practice Guidelines on Androgen Therapy in Women Misguided? A Commentary. The Journal of Sexual Medicine 4:5, pages 1223-1235.
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S. Andrade, S.L. Silveira, R. Gomez, H.M.T. Barros & M.F.M. Ribeiro. (2007) Gender differences of acute and chronic administration of dehydroepiandrosterone in rats submitted to the forced swimming test. Progress in Neuro-Psychopharmacology and Biological Psychiatry 31:3, pages 613-621.
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P. Corvi Mora, M. Cirri & P. Mura. (2006) Differential scanning calorimetry as a screening technique in compatibility studies of DHEA extended release formulations. Journal of Pharmaceutical and Biomedical Analysis 42:1, pages 3-10.
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Benjamin Campbell. (2006) Adrenarche and the evolution of human life history. American Journal of Human Biology 18:5, pages 569-589.
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Wiebke Arlt. (2006) Dehydroepiandrosterone replacement therapy. Current Opinion in Endocrinology and Diabetes 13:3, pages 291-305.
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Karen K. Miller, Thilo Deckersbach, Scott L. Rauch, Alan J. Fischman, Kelly A. Grieco, David B. Herzog & Anne Klibanski. (2004) Testosterone administration attenuates regional brain hypometabolism in women with anorexia nervosa. Psychiatry Research: Neuroimaging 132:3, pages 197-207.
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Wiebke Arlt. (2004) Dehydroepiandrosterone and ageing. Best Practice & Research Clinical Endocrinology & Metabolism 18:3, pages 363-380.
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Michael Ritsner, Rachel Maayan, Anatoly Gibel, Rael D Strous, Ilan Modai & Abraham Weizman. (2004) Elevation of the cortisol/dehydroepiandrosterone ratio in schizophrenia patients. European Neuropsychopharmacology 14:4, pages 267-273.
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Wattana Leowattana. (2004) DHEAS as a new diagnostic tool. Clinica Chimica Acta 341:1-2, pages 1-15.
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Ricardo Munarriz, Noel N. Kim, Abdul Traish & Irwin Goldstein. 2004. Male and Female Sexual Dysfunction. Male and Female Sexual Dysfunction 275 285 .
S. Genedani, G. Rasio, P. Cortelli, F. Antonelli, D. Guidolin, M. Galantucci, K. Fuxe & L. F. Agnati. (2004) Studies on homocysteine and dehydroepiandrosterone sulphate plasma levels in alzheimer’s disease patients and in Parkinson’s disease patients. Neurotoxicity Research 6:4, pages 327-332.
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M. Schumacher, C. Ibanez, F. Robert, L. M. Garcia-Segura, R. J. M. Franklin & R. C. Melcangi. 2004. Endocrine Aspects of Successful Aging: Genes, Hormones and Lifestyles. Endocrine Aspects of Successful Aging: Genes, Hormones and Lifestyles 101 127 .
Shi‐Fang Lu, Qianxing Mo, Shan Hu, Carrie Garippa & Neal G. Simon. (2003) Dehydroepiandrosterone upregulates neural androgen receptor level and transcriptional activity. Journal of Neurobiology 57:2, pages 163-171.
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P. Corvi Mora, M. Cirri, B. Allolio, F. Carli & P. Mura. (2003) Enhancement of Dehydroepiandrosterone Solubility and Bioavailability by Ternary Complexation with α‐Cyclodextrin and Glycine. Journal of Pharmaceutical Sciences 92:11, pages 2177-2184.
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Ketan K. Dhatariya & K. Sreekumaran Nair. (2003) Dehydroepiandrosterone: Is There a Role for Replacement?. Mayo Clinic Proceedings 78:10, pages 1257-1273.
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M. Schumacher, S. Weill-Engerer, P. Liere, F. Robert, R.J.M. Franklin, L.M. Garcia-Segura, J.J. Lambert, W. Mayo, R.C. Melcangi, A. Parducz, U. Suter, C. Carelli, E.E. Baulieu & Y. Akwa. (2003) Steroid hormones and neurosteroids in normal and pathological aging of the nervous system. Progress in Neurobiology 71:1, pages 3-29.
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A. M. Isidori, G. A. Kaltsas, L. Perry, J. M. Burrin, G. M. Besser & J. P. Monson. (2003) The effect of growth hormone replacement therapy on adrenal androgen secretion in adult onset hypopituitarism. Clinical Endocrinology 58:5, pages 601-611.
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Henry Lardy, Ashok Marwah & Padma Marwah. (2002) Transformations of DHEA and its metabolites by rat liver. Lipids 37:12, pages 1187-1191.
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Ma Clara M. Padero, Shalender Bhasin & Theodore C. Friedman. (2002) Androgen Supplementation in Older Women: Too Much Hype, Not Enough Data. Journal of the American Geriatrics Society 50:6, pages 1131-1140.
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Jos H.H. Thijssen. (2002) Relations of androgens and selected aspects of human behavior. Maturitas 41, pages 47-54.
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Abdulmaged M Traish, Noel Kim, Kweonsik Min, Ricardo Munarriz & Irwin Goldstein. (2002) Role of androgens in female genital sexual arousal: receptor expression, structure, and function. Fertility and Sterility 77, pages 11-18.
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David LeonardiAlan P. MintzAnton DotsonJhoanna Mukai. (2001) Hormone Modulation, Low Glycemic Nutrition, and Exercise Instruction: Effects on Disease Risk and Quality of Life. Journal of Anti-Aging Medicine 4:4, pages 357-371.
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