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Original Article

Studies on Methotrexate Effects on Testicular Steroidogenesis in Rats

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Pages 247-262 | Published online: 07 Jul 2009

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A. K. Saxena, S. DHUNGEL, S. BHATTACHARYA, C. B. JHA & A. K. SRIVASTAVA. (2004) EFFECT OF CHRONIC LOW DOSE OF METHOTREXATE ON CELLULAR PROLIFERATION DURING SPERMATOGENESIS IN RATS. Archives of Andrology 50:1, pages 33-35.
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Articles from other publishers (20)

Emad H.M. Hassanein, Wafaa R. Mohamed, Rasha M. Hussein & El-Shaimaa A. Arafa. (2023) Edaravone alleviates methotrexate-induced testicular injury in rats: Implications on inflammation, steroidogenesis, and Akt/p53 signaling. International Immunopharmacology 117, pages 109969.
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Medhat Taha, Sara T. Elazab, Abdullah A. Saati, Gomaa S. Ahmed, Tourki A. S. Baokbah, Khaled Fathy, Ibrahim El-Shenbaby, Omer Abdelbagi, Mahmoud A. E. Hassan, Mohie Mahmoud Ibrahim & Alaa. M. Badawy. (2022) Zamzam Water Ameliorates Gentamicin-Induced Testicular Toxicity in a Rat Model via Targeting Sperm Parameters, Testicular Tissue Oxidative Insult, Inflammation, Apoptosis, and Pituitary-Gonadal Axis. Toxics 11:1, pages 2.
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Karima El-Sayed, Dina A. Ali, Shymaa Ahmed Maher, Dalia Ghareeb, Samy Selim, Sarah Albogami, Eman Fayad & Eman Kolieb. (2022) Prophylactic and Ameliorative Effects of PPAR-γ Agonist Pioglitazone in Improving Oxidative Stress, Germ Cell Apoptosis and Inflammation in Gentamycin-Induced Testicular Damage in Adult Male Albino Rats. Antioxidants 11:2, pages 191.
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Dina F. Mansour, Dalia O. Saleh, Omar A. Ahmed-Farid, Mona Rady, Rofanda M. Bakeer & Ingy M. Hashad. (2021) Ginkgo biloba extract (EGb 761) mitigates methotrexate-induced testicular insult in rats: Targeting oxidative stress, energy deficit and spermatogenesis. Biomedicine & Pharmacotherapy 143, pages 112201.
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Shatha G. Felemban, Maha A. Aldubayan, Ahmad H. Alhowail & Ibtesam S. Almami. (2020) Vitamin B17 Ameliorates Methotrexate-Induced Reproductive Toxicity, Oxidative Stress, and Testicular Injury in Male Rats. Oxidative Medicine and Cellular Longevity 2020, pages 1-11.
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Samy MakaryMohamed AbdoEreny Fekry. (2018) Oxidative stress burden inhibits spermatogenesis in adult male rats: testosterone protective effect. Canadian Journal of Physiology and Pharmacology 96:4, pages 372-381.
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C Mary Schooling. (2017) Tachykinin neurokinin 3 receptor antagonists: a new treatment for cardiovascular disease?. The Lancet 390:10095, pages 709-711.
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Anne Grosen, Jens Kelsen, Christian Lodberg Hvas, Emanuelle Bellaguarda & Stephen B. Hanauer. (2017) The Influence of Methotrexate Treatment on Male Fertility and Pregnancy Outcome After Paternal Exposure. Inflammatory Bowel Diseases 23:4, pages 561-569.
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J V Zhao & C M Schooling. (2016) Homocysteine-reducing B vitamins and ischemic heart disease: a separate-sample Mendelian randomization analysis. European Journal of Clinical Nutrition 71:2, pages 267-273.
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Krishna Prahlad Maremanda & G.B. Jena. (2017) Methotrexate-induced germ cell toxicity and the important role of zinc and SOD1: Investigation of molecular mechanisms. Biochemical and Biophysical Research Communications 483:1, pages 596-601.
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Erma Z. Drobnis & Ajay K. NangiaErma Z. Drobnis & Ajay K. Nangia. 2017. Impacts of Medications on Male Fertility. Impacts of Medications on Male Fertility 179 210 .
Mehmet Fatih Sönmez, Kübra Tuğçe Çilenk, Derya Karabulut, Sunay Ünalmış, Erkan Deligönül, İsmet Öztürk & Emin Kaymak. (2016) Protective effects of propolis on methotrexate-induced testis injury in rat. Biomedicine & Pharmacotherapy 79, pages 44-51.
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Jessica A. Morgan, Satish B. Cheepala, Yao Wang, Geoff Neale, Masashi Adachi, Deepa Nachagari, Mark Leggas, Wenchen Zhao, Kelli Boyd, Raman Venkataramanan & John D. Schuetz. (2012) Deregulated Hepatic Metabolism Exacerbates Impaired Testosterone Production in Mrp4-deficient Mice. Journal of Biological Chemistry 287:18, pages 14456-14466.
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Sritulasi Karri & Vanithakumari G. (2011) Effect of methotrexate and leucovorin on female reproductive tract of albino rats. Cell Biochemistry and Function 29:1, pages 1-21.
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Jana Jurcovicova, Karol Svik, Sona Scsukova, Katarina Bauerova, Jozef Rovensky & Maria Stancikova. (2009) Methotrexate treatment ameliorated testicular suppression and anorexia related leptin reduction in rats with adjuvant arthritis. Rheumatology International 29:10, pages 1187-1191.
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H. Serati Nouri, Y. Azarmi & M. Movahedin. (2009) Effect of growth hormone on testicular dysfunction induced by methotrexate in rats. Andrologia 41:2, pages 105-110.
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P. Sreedhar Reddy, T. Pushpalatha & P. Sreenivasula Reddy. (2006) Reduction of spermatogenesis and steroidogenesis in mice after fentin and fenbutatin administration. Toxicology Letters 166:1, pages 53-59.
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WenChieh Chen, Diane Thiboutot & Christos C. Zouboulis. (2002) Cutaneous Androgen Metabolism: Basic Research and Clinical Perspectives. Journal of Investigative Dermatology 119:5, pages 992-1007.
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&NA;. (2002) RE: ORGAN SPARING SURGERY FOR MALIGNANT GERM CELL TUMOR OF THE TESTIS. The Journal of Urology, pages 1111-1112.
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. (2002) RE: ORGAN SPARING SURGERY FOR MALIGNANT GERM CELL TUMOR OF THE TESTIS: Reply by Authors. Journal of Urology 168:3, pages 1111-1112.
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