47
Views
21
CrossRef citations to date
0
Altmetric
Original Article

Studies on Methotrexate Effects on Testicular Steroidogenesis in Rats

, &
Pages 247-262 | Published online: 07 Jul 2009

References

  • Witty L. A., Steiner F., Curfmann M., Webb D., Wheat LJ. Disseminated histoplasmosis in patients receiving low dose methotrexate therapy for psoriasis. Arch Derm 1992; 128: 91–93
  • Owen ET., Cohen ML. Methotrexate in Reiter's disease. Ann Rheum Dis 1979; 38: 48–50
  • Gianini ET., Cohen JP. Treatment of dermatomyositis with methotrexate and prednisone. Arch Dermatol 1980; 115: 1251–1252
  • Tannenbaum H. Combined therapy with methotrexate and prednisone in polyarteritis nodosa. Can Med Assoc J 1980; 123: 893–894
  • Bohan A., Peter J. B., Bowman RL., Pearson CM. A computer assisted analysis of 153 patients with polymyositis and dermatomyositis. Medicine 1977; 56: 255–286
  • Hanno R., Gruber G. G., Owen LG., Callen JP. Methotrexate in psoriasis: a brief review of indications, usage and complication of methotrexate therapy. J Am Acad Dermatol 1980; 2: 171–174
  • Capizzi RL., Bertino JR. Methotrexate therapy of Wegener's granulomatosis. Ann Intnl Med 1971; 74: 74–79
  • Wong GV., Hersh EM. Methotrexate in the therapy of cyclitis. Trans Am Acad Ophthal Otolaryn 1965; 1: 279–293
  • Lacher M. J. Spontaneous remission or response to methotrexate in sarcoidosis. Ann Intl Med 1968; 69: 1247–1248
  • Bannwarth B., Labat L., Moride Y., Schaeverbeke T. Methotrexate in rheumatoid arthritis. An update. Drugs 1994; 47: 25–30
  • Mathur R., Bhasin RC. Methotrexate as a steroid sparing drug in bronchial asthma. Lung India 1992; 10: 57–60
  • Sussman A., Leonard JM. Psoriasis, methotrexate and oligospermia. Arch Dermatol 1980; 116: 215–217
  • Takeda M., Hosaka M., Kitajima N., Noguchi K., Fujii H., Oshima H., Harada M. Effects of anticancer agents on rat prostate. Evaluation of organ weight histological finding and 5 alpha - reductase activities. Hinyokika Kiyo 1985; 31: 71–80
  • Koehler M., Waldherr R., Ludwig R., Heinrich U., Brandeis WE. Effects of methotrexate on rabbit testes. Part 1: Morphological changes. Pediatr Hematol Oncol 1986a; 3: 325–334
  • Koehler M., Heinrich U., Ludwig R., Waldherr R., Brandeis WE. Effects of methotrexate on rabbit testes. Part 2 : Hormonal changes. Pediatr Hematol Oncol 1986b; 3: 335–341
  • Black DJ., Livingston RB. Antineoplastic drugs in 1990 - Review. Part I. Drugs 1990; 39: 489–501
  • Bertino J. R., Levitta M., McCullough JL., Chabner B. New approaches to chemotherapy with folate antagonists. Use of leucovorin “rescue” and enzymatic folate depletion. Ann NY Acad Sci 1971; 186: 486–495
  • Tishler M., Caspi D., Fishel B., Yaron M. The effects of leucovorin (Folinic acid) on methotrexate therapy in rheumatoid arthritis patients. Arthritis Rheum 1988; 31: 906–908
  • Folch J., Lees M., Sloans-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497–509
  • Mangold H. K. Thin layer chromatography, E. Stahl. Academic Press, New York 1965; 137–139
  • Hanel HK., Dam H. Determination of small amount of total cholesterol by the Tsehugaeff reaction with a note on the determination of lathosterol. Acta Chem Scand 1955; 9: 677–682
  • Bergmeyer H. U. Steroid dehydrogenase. Methods of Enzymatic Analysis, HU. Bergmeyer. Academic Press, New York 1974; Vol 1: 476–477
  • Zar J. H. Biostatistical analysis. Prentice Hall Inc., USA 1974
  • Wing T. Y., Ewing L.L, Zirkin BR. Effects of luteinizing hormone withdrawal on Leydig cell smooth endoplasmic reticulum and steroidogenic reactions which converts pregnenolone to testosterone. Endocrinology 1984; 115: 2290–2296
  • Badri SNP, Vanithakumari G, Malini T. Studies on methotrexate effects on pituitary-testicular hormone axis. J Pharm Pharmacol Commun (Communicated). 1999
  • Andersen JM., Dietschy JM. Relative importance of high and low density lipoproteins in the regulation of cholesterol synthesis in the adrenal gland, ovary and testis of the rat. J Biol Chem 1978; 253: 9024–9031
  • Hou J. W., Collins DC., Schleicher RL. Sources of cholesterol for testosterone biosynthesis in murine Leydig cells. Endocrinology 1990; 127: 2047–2055
  • Morris MD., Chaikoff IL. The origin of cholesterol in liver, adrenal gland and testis of the rat. J Biol Chem 1959; 234: 1095–1097
  • Freeman DA., Ascoli M. Studies on the source of cholesterol used for steroid biosynthesis in cultured Leydig tumour cells. J Biol Chem 1982; 257: 1423–1438
  • Schreiber J. R., Weinstein DB., Hsueh AJW. Lipoproteins stimulate androgen production by cultured rat testis cells. J Steroid Biochem 1982; 16: 39–43
  • Aarsaether N., Berge R. K., Aarstand A., Svardal A., Ueland PM. Effects of methotrexate on long chain fatty acid metabolism in liver of rats fed a standard or a defined, choline deficient diet. Biochim Biophys Acta 1988; 958: 70–80
  • Mori H., Christensen AK. Morphometric analysis of Leydig cells in the normal rat testis. J Cell Biol 1980; 84: 340–354
  • Bartke A. Effects of prolactin and luteinizing hormone on the cholesterol stores in the mouse testis. J Endocr 1971; 49: 317–323
  • Oshima M., Carpenter MP. The lipid composition of the prepubertal and adult rat testis. Biochim Biophys Acta 1968; 152: 479–497
  • Payne A., Chase D., O'Shaugnessy PJ. Regulation of steroidogenesis in Leydig cells. Cellular Regulation of Secretion and Release, M. Conn. Academic Press, New York 1982; 355–408
  • Freeman D. A. Plasma membrane cholesterol: removal and insertion into the membrane and utilisation as substrate for steroidogenesis. Endocrinology 1989; 124: 2524–2527
  • Badri SNP, Vanithakumari G, Malini T. Effects of methotrexate and its antidote, leucovorin on spermatogenesis in rats. Toxicol Appl Pharmacol (Communicated) 1999
  • Hall P. F. Testicular steroid synthesis: organization and regulation. The Physiology of Reproduction, E Knobil, J. Neill. Raven Press, New York 1988; 975–998
  • Payne A. H. Hormonal regulation of cytochrome P450 enzymes, cholesterol side-chain cleavage and 17α-hydroxylase/C17–20 lyase in Leydig cells. Biol Reprod 1990; 42: 399–404
  • Miller W. L. Molecular biology of steroid hormone synthesis. Endocr Rev 1988; 9: 295–318
  • Shaw M. J., Georgopoulos LE., Payne AH. Synergistic effect of follicle stimulating hormone and luteinizing hormone on testicular Δ5-3β-hydroxysteroid dehydrogenase-isomerase : application of a new method for the separation of testicular compartments. Endocrinology 1979; 104: 912–918
  • Bogovich K., Payne AH. Purification of rat testicular microsomal 17-ketosteroid reductase. Evidence that 17-ketosteroid reductase and 17β hydroxysteroid dehydrogenase are distinct enzymes. J Biol Chem 1980; 255: 5552–5559

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.