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Annals of Medicine Volume 45, 2013 - Issue 5-6
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Review Article

Laboratory testing of rivaroxaban in routine clinical practice: When, how, and which assays

Edelgard Lindhoff-LastDivision of Angiology and Hemostaseology, Department of Internal Medicine, University Hospital Frankfurt, Frankfurt, GermanyCorrespondence[email protected]
,
Jack AnsellDepartment of Medicine, Lenox Hill Hospital, New York, NY, USA
,
Theodore SpiroBayer HealthCare Pharmaceuticals Inc., Montville, NJ, USA
&
Meyer Michel SamamaCochin-Broca-Hôtel-Dieu University Hospital, Paris, France;Biomnis Laboratories Clinical Research, Ivry-sur-Seine, France
Pages 423-429 | Received 23 Nov 2012, Accepted 29 Apr 2013, Published online: 07 Jun 2013

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B Kim, S Jang, YJ Lee, N Park, YU Cho & CJ Park. (2019) The rivaroxaban-adjusted normalized ratio: use of the prothrombin time to monitor the therapeutic effect of rivaroxaban. British Journal of Biomedical Science 76:3, pages 122-128.
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Hugo ten Cate, Yvonne MC Henskens & Marcus D Lancé. (2017) Practical guidance on the use of laboratory testing in the management of bleeding in patients receiving direct oral anticoagulants. Vascular Health and Risk Management 13, pages 457-467.
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Gualtiero Palareti & Daniela Poli. (2016) The challenges and limitations of widespread direct oral anticoagulant treatment: practical suggestions for their best use. Expert Review of Cardiovascular Therapy 14:2, pages 163-176.
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Sylvia Haas, Christoph Bode, Bo Norrving & Alexander GG Turpie. (2014) Practical guidance for using rivaroxaban in patients with atrial fibrillation: balancing benefit and risk. Vascular Health and Risk Management 10, pages 101-114.
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Antoni Martínez-Rubio, George Andrei Dan & Juan Carlos Kaski. (2014) Rivaroxaban and stroke prevention in patients with atrial fibrillation: new evidence. Expert Review of Cardiovascular Therapy 12:8, pages 933-947.
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Bita Divsalar, Tahereh Kalantari, Soheila Mohebbi, Ardeshir Bahmanimehr, Amin Shahsavani & Afshin Borhani-Haghighi. (2023) Comparison of Commercial Low Molecular Weight Heparin and Homemade Anti-Xa Calibrators to a Commercial Specific Anti-Xa Calibrator for Plasma Rivaroxaban Quantification by Anti-Xa Oral Anticoagulant Plasma Concentration Chromogenic Assay. Laboratory Medicine 54:4, pages 400-405.
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Alireza Ghodsi, Leila Etemad, Bita Dadpour, Babak Mostafazadeh & Mohammad Moshiri. (2021) Conservative management of massive rivaroxaban overdose: A case report and literature review. Clinical Case Reports 9:11.
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Shaul Lin, Ron Hoffman, Omri Nabriski, Daniel Moreinos & Paul M. H. Dummer. (2021) Management of patients receiving novel antithrombotic treatment in endodontic practice: Review and clinical recommendations. International Endodontic Journal 54:10, pages 1754-1768.
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Xu Wu, Liping Wang, Yan Peng, Fang Wu, Jiumei Cao, Xiaohong Chen, Wanwan Wu, Huinan Yang, Mengmeng Xing, Yiming Zhu, Yijue Shi & Songlin Zhuang. (2020) Quantitative analysis of direct oral anticoagulant rivaroxaban by terahertz spectroscopy. The Analyst 145:11, pages 3909-3915.
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Junwoo Bae, Hyunwoo Kim, Woosun Kim, Suhee Kim, Jinho Park, Dong‐In Jung & Dohyeon Yu. (2019) Therapeutic monitoring of rivaroxaban in dogs using thromboelastography and prothrombin time. Journal of Veterinary Internal Medicine 33:3, pages 1322-1330.
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Hai-Di Wu, Hong-Yan Cao, Zi-Kai Song, Shuo Yang, Ming-Long Tang, Yang Liu & Ling Qin. (2019) Considerations for routine coagulation monitoring with rivaroxaban: A case report and review of the literature. World Journal of Clinical Cases 7:3, pages 382-388.
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Jen-Hung Huang, Yung-Kuo Lin, Cheng-Chih Chung, Ming-Hsiung Hsieh, Wan-Chun Chiu & Yi-Jen Chen. (2018) Factors That Determine the Prothrombin Time in Patients With Atrial Fibrillation Receiving Rivaroxaban. Clinical and Applied Thrombosis/Hemostasis 24:9_suppl, pages 188S-193S.
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Zikai Song, Haidi Wu, Hongyan Cao, Shuo Yang, Minglong Tang & Ling Qin. (2018) Routine coagulation test abnormalities caused by rivaroxaban. Medicine 97:45, pages e13104.
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I. Thom, G. Cameron, D. Robertson & H. G. Watson. (2018) Measurement of rivaroxaban concentrations demonstrates lack of clinical utility of a PT, dPT and APTT test in estimating levels. International Journal of Laboratory Hematology 40:4, pages 493-499.
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P. Bahrmann & M. Christ. (2017) Antikoagulation bei Vorhofflimmern im AlterAnticoagulation in geriatric patients with atrial fibrillation. Herz 43:3, pages 214-221.
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Neethu Menon, Ravi Sarode & Ayesha Zia. (2018) Rivaroxaban dose adjustment using thrombin generation in severe congenital protein C deficiency and warfarin-induced skin necrosis. Blood Advances 2:2, pages 142-145.
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J.‐D. Studt, L. Alberio, A. Angelillo‐Scherrer, L.M. Asmis, P. Fontana, W. Korte, A. Mendez, P. Schmid, H. Stricker, D.A. Tsakiris, W.A. Wuillemin & M. Nagler. (2017) Accuracy and consistency of anti‐Xa activity measurement for determination of rivaroxaban plasma levels. Journal of Thrombosis and Haemostasis 15:8, pages 1576-1583.
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Fanny Ofek, Samuel Bar Chaim, Nirit Kronenfeld, Tomer Ziv-Baran & Matitiahu Berkovitch. (2017) International Normalized Ratio Is Significantly Elevated With Rivaroxaban and Apixaban Drug Therapies: A Retrospective Study. Clinical Therapeutics 39:5, pages 1003-1010.
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R. B. Zotz & L. Weißbach. (2017) Monitoring von NOAKMonitoring of NOAC. Medizinische Klinik - Intensivmedizin und Notfallmedizin 112:2, pages 92-98.
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Edelgard Lindhoff-Last. (2017) Direct oral anticoagulants (DOAC) – Management of emergency situations. Hämostaseologie 37:04, pages 257-266.
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Annemarie Bluecher, Sascha Meyer dos Santos, Nerea Ferreirós, Sandra Labocha, Isabel Maria Rodrigues Meyer dos Santos, Bettina Picard-Willems, Sebastian Harder & Oliver C. Singer. (2017) Microfluidic coagulation assay for monitoring anticoagulant therapy in acute stroke patients. Thrombosis and Haemostasis 117:03, pages 519-528.
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Béatrice Le-Roy, Barbara Foucher, Amélie Lagarde, Cyril Mounier & Fabien Bévalot. (2016) Dosage plasmatique de quatre anticoagulants directs par UHPLC/DAD. Toxicologie Analytique et Clinique 28:4, pages 278-285.
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Jerrold H. Levy. (2016) Discontinuation and Management of Direct-Acting Anticoagulants for Emergency Procedures. The American Journal of Medicine 129:11, pages S47-S53.
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Jerrold H. Levy. (2016) Discontinuation and management of direct-acting anticoagulants for emergency procedures. The American Journal of Emergency Medicine 34:11, pages 14-18.
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Jean Amiral, Claire Dunois, Cédric Amiral & Jerard Seghatchian. (2016) Anti-Xa bioassays for the laboratory measurement of direct Factor Xa inhibitors in plasma, in selected patients. Transfusion and Apheresis Science 55:2, pages 249-261.
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Sean G. Yates, Sabra Smith, William Tharpe, Yu-Min Shen & Ravi Sarode. (2016) Can an anti-Xa assay for low-molecular-weight heparin be used to assess the presence of rivaroxaban?. Transfusion and Apheresis Science 55:2, pages 212-215.
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Vicky K. Yang, Suzanne M. Cunningham, John E. Rush & Armelle de Laforcade. (2016) The use of rivaroxaban for the treatment of thrombotic complications in four dogs. Journal of Veterinary Emergency and Critical Care 26:5, pages 729-736.
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Flavio Egger, Federica Targa, Ivan Unterholzner, Russell P. Grant, Markus Herrmann & Christian J. Wiedermann. (2016) Medication Error When Switching from Warfarin to Rivaroxaban Leading to Spontaneous Large Ecchymosis of the Abdominal and Chest Wall. Clinics and Practice 6:3, pages 873.
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Philipp Bahrmann, Fred Harms, Christian Martin Schambeck, Martin Wehling & Jürgen Flohr. (2016) Neue orale Antikoagulanzien zur Prophylaxe von SchlaganfällenNew oral anticoagulants for prophylaxis of stroke. Zeitschrift für Gerontologie und Geriatrie 49:3, pages 216-226.
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Henry A. Spiller, James B. Mowry, Alfred AleguasJr.Jr., Jill R.K. Griffith, Robert Goetz, Mark L. Ryan, Stacey Bangh, Wendy Klein-Schwartz, Scott Schaeffer & Marcel J. Casavant. (2016) An Observational Study of the Factor Xa Inhibitors Rivaroxaban and Apixaban as Reported to Eight Poison Centers. Annals of Emergency Medicine 67:2, pages 189-195.
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Carmela E. Corallo, Louise Grannell & Huyen Tran. (2015) Postoperative Bleeding After Administration of a Single Dose of Rivaroxaban to a Patient Receiving Antiretroviral Therapy. Drug Safety - Case Reports 2:1.
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Lucia Terzuoli, Antonella Silvietti, Carlo Scapellato, Brunetta Porcelli & Roberto Cappelli. (2015) Determinazione dei farmaci anticoagulanti orali diretti in regime di urgenzaDetermination of direct oral anticoagulant drugs in emergency. La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine 11:3, pages 157-164.
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Sotiris Antoniou. (2015) Rivaroxaban for the treatment and prevention of thromboembolic disease. Journal of Pharmacy and Pharmacology 67:8, pages 1119-1132.
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Shanshan Du, Job Harenberg, Sandra Krämer, Roland Krämer, Martin Wehling & Christel Weiss. (2015) Measurement of Non–Vitamin K Antagonist Oral Anticoagulants in Patient Plasma Using Heptest-STAT Coagulation Method. Therapeutic Drug Monitoring 37:3, pages 375-380.
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Hein Than, Joanna Bao Ern Loh, Christina Lai Lin Sum & Heng Joo Ng. (2015) Clinical utility of anti-Xa monitoring and differential sensitivity of prothrombin time assays: an illustrated case report. Journal of Clinical Pathology 68:4, pages 318-319.
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Jeffrey I. Weitz & Charles V. PollackJrJr. (2017) Practical management of bleeding in patients receiving non-vitamin K antagonist oral anticoagulants. Thrombosis and Haemostasis 114:12, pages 1113-1126.
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Simon McRae. (2014) Treatment options for venous thromboembolism: lessons learnt from clinical trials. Thrombosis Journal 12:1.
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Jerrold H. Levy, Alex C. Spyropoulos, Charles M. Samama & James Douketis. (2014) Direct Oral Anticoagulants. JACC: Cardiovascular Interventions 7:12, pages 1333-1351.
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L.‐A. Linkins & K. Moffat. (2014) Monitoring the anticoagulant effect after a massive rivaroxaban overdose. Journal of Thrombosis and Haemostasis 12:9, pages 1570-1571.
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Ariane Sümnig, Anne Grotevendt, Antje Westphal, Michael Fiene, Andreas Greinacher & Thomas Thiele. (2014) Acquired Hemophilia With Inhibitors Presenting as an Emergency. Deutsches Ärzteblatt international.
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Sebastian Harder. (2014) Pharmacokinetic and pharmacodynamic evaluation of rivaroxaban: considerations for the treatment of venous thromboembolism. Thrombosis Journal 12:1, pages 22.
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Wolfgang Mueck, Jan Stampfuss, Dagmar Kubitza & Michael Becka. (2013) Clinical Pharmacokinetic and Pharmacodynamic Profile of Rivaroxaban. Clinical Pharmacokinetics 53:1, pages 1-16.
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Meyer Michel Samama. (2013) Coagulation Assays in Patients with New Oral Anticoagulants (NOACs): Why? When?. Drug Development Research 74:8, pages 582-586.
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Sean Yates & Ravi Sarode. (2013) Novel thrombin and factor Xa inhibitors. Current Opinion in Hematology 20:6, pages 552-557.
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