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Clinical Study

Plasma Indoleamine 2,3-Dioxygenase and Arginase Type I May Contribute to Decreased Blood T-Cell Count in Hemodialysis Patients

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Pages 1118-1122 | Received 08 May 2012, Accepted 06 Jul 2012, Published online: 17 Aug 2012

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Ismael Dale Cotrim Guerreiro da Silva, Dirce Maria Lobo Marchioni, Antonio Augusto Ferreira Carioca, Valquiria Bueno & Gisele Wally Braga Colleoni. (2021) May critical molecular cross-talk between indoleamine 2,3-dioxygenase (IDO) and arginase during human aging be targets for immunosenescence control?. Immunity & Ageing 18:1.
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Thomas Bernd Dschietzig, Karl-Heinz Kellner, Katrin Sasse, Felix Boschann, Robert Klüsener, Jana Ruppert, Franz Paul Armbruster, Dragic Bankovic, Andreas Meinitzer, Veselin Mitrovic & Christoph Melzer. (2019) Plasma Kynurenine Predicts Severity and Complications of Heart Failure and Associates with Established Biochemical and Clinical Markers of Disease. Kidney and Blood Pressure Research 44:4, pages 765-776.
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Rongyi Chen, Jiachang Hu, Fangfang Xiang, Xiao Tan, Bo Shen, Zhonghua Liu, Wenlv Lv, Xiaoqiang Ding, Xuesen Cao & Jianzhou Zou. (2017) Decreased percentage of peripheral naïve T cells is independently associated with ischemic stroke in patients on hemodialysis. International Urology and Nephrology 49:11, pages 2051-2060.
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Shuxin Liu, Lichao Wang, Chunxiu Hu, Xin Huang, Hong Liu, Qiuhui Xuan, Xiaohui Lin, Xiaojun Peng, Xin Lu, Ming Chang & Guowang Xu. (2017) Plasma metabolomics profiling of maintenance hemodialysis based on capillary electrophoresis - time of flight mass spectrometry. Scientific Reports 7:1.
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Yuanhan Chen, Zhen Xie, Chenggen Xiao, Min Zhang, Zhilian Li, Jianteng Xie, Yusheng Zhang, Xingchen Zhao, Pengfei Zeng, Liyi Mo, Xinling Liang & Wei Shi. (2017) Peripheral kynurenine/tryptophan ratio is not a reliable marker of systemic indoleamine 2,3-dioxygenase: A lesson drawn from patients on hemodialysis. Oncotarget 8:15, pages 25261-25269.
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Theodoros Eleftheriadis, Georgios Pissas, Maria Sounidaki, Konstantina Tsogka, Nikolaos Antoniadis, Georgia Antoniadi, Vassilios Liakopoulos & Ioannis Stefanidis. (2016) Indoleamine 2,3-dioxygenase, by degrading L-tryptophan, enhances carnitine palmitoyltransferase I activity and fatty acid oxidation, and exerts fatty acid-dependent effects in human alloreactive CD4+ T-cells. International Journal of Molecular Medicine 38:5, pages 1605-1613.
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THEODOROS ELEFTHERIADIS, GEORGIOS PISSAS, GEORGIA ANTONIADI, KONSTANTINA TSOGKA, MARIA SOUNIDAKI, VASSILIOS LIAKOPOULOS & IOANNIS STEFANIDIS. (2016) Indoleamine 2,3-dioxygenase downregulates T-cell receptor complex ζ-chain and c-Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T-cells. Molecular Medicine Reports 13:1, pages 925-932.
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Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Vassilios Liakopoulos & Ioannis Stefanidis. (2015) Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4 + T cells . Immunology 146:2, pages 292-300.
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Theodoros Eleftheriadis, Georgios Pissas, Efi Yiannaki, Dimitra Markala, Spyridon Arampatzis, Georgia Antoniadi, Vassilios Liakopoulos & Ioannis Stefanidis. (2013) Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells. Human Immunology 74:12, pages 1501-1509.
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Theodoros Eleftheriadis, Efi Yiannaki, Vassilios Liakopoulos, Georgia Antoniadi, Georgios Pissas, Grammati Galaktidou & Ioannis Stefanidis. (2013) Serum osteoprotegerin is markedly increased and may contribute to decreased blood T cell count in hemodialysis patients. International Urology and Nephrology 45:6, pages 1671-1677.
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Lisa Christiansson, Stina Söderlund, Emma Svensson, Satu Mustjoki, Mats Bengtsson, Bengt Simonsson, Ulla Olsson-Strömberg & Angelica S. I. Loskog. (2013) Increased Level of Myeloid-Derived Suppressor Cells, Programmed Death Receptor Ligand 1/Programmed Death Receptor 1, and Soluble CD25 in Sokal High Risk Chronic Myeloid Leukemia. PLoS ONE 8:1, pages e55818.
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