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Renal Failure Volume 34, 2012 - Issue 10
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Laboratory Study

Losartan Alleviates Renal Fibrosis by Down-Regulating HIF-1α and Up-Regulating MMP-9/TIMP-1 in Rats with 5/6 Nephrectomy

Wencheng FuDepartment of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
,
Yunman WangDepartment of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
,
Zhouhui JinDepartment of Nephrology, Liqun Hospital, Shanghai, PR China
,
Hao WangDepartment of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
,
Weiwei ChengDepartment of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
,
Haishan ZhouDepartment of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
,
Peihao YinDepartment of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
&
Wen PengDepartment of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR ChinaCorrespondence[email protected]
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Pages 1297-1304 | Received 14 May 2012, Accepted 14 Aug 2012, Published online: 24 Sep 2012

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Jingjing Li, Kan Chen, Sainan Li, Jiao Feng, Tong Liu, Fan Wang, Rong Zhang, Shizan Xu, Yuqing Zhou, Shunfeng Zhou, Yujing Xia, Jie Lu, Yingqun Zhou & Chuanyong Guo. (2016) Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy. Drug Design, Development and Therapy 10, pages 619-630.
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S. L. Della Penna, M. I. Rosón, J. E. Toblli & B. E. Fernández. (2015) Role of angiotensin II and oxidative stress in renal inflammation by hypernatremia: Benefits of atrial natriuretic peptide, losartan, and tempol. Free Radical Research 49:4, pages 383-396.
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Articles from other publishers (15)

Junju Zou, Xiaotao Zhou, Yuerong Ma & Rong Yu. (2022) Losartan ameliorates renal interstitial fibrosis through metabolic pathway and Smurfs-TGF-β/Smad. Biomedicine & Pharmacotherapy 149, pages 112931.
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Terumasa Hashimoto, Keita Shibata, Kazuo Honda & Koji Nobe. (2021) Acetic acid treatment causes renal inflammation and chronic kidney disease in mice. Journal of Pharmacological Sciences 146:3, pages 160-168.
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Xiaoli Du, Qianqian Tao, Hongxia Du, Zhenbang Zhao, Yu Dong, Shuang He, Rui Shao, Yule Wang, Wenrun Han, Xintong Wang & Yan Zhu. (2021) Tengdan Capsule Prevents Hypertensive Kidney Damage in SHR by Inhibiting Periostin-Mediated Renal Fibrosis. Frontiers in Pharmacology 12.
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Seiko Yamakoshi, Takahiro Nakamura, Nobuyoshi Mori, Chihiro Suda, Masahiro Kohzuki & Osamu Ito. (2021) Effects of exercise training on renal interstitial fibrosis and renin–angiotensin system in rats with chronic renal failure. Journal of Hypertension 39:1, pages 143-152.
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Yufeng Jiang, Yaohan Zhu, Timing Zhen, Jie Li, Kaichen Xing, Liqun He & Sibo Zhu. (2020) Transcriptomic analysis of the mechanisms of alleviating renal interstitial fibrosis using the traditional Chinese medicine Kangxianling in a rat model. Scientific Reports 10:1.
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Jiqiang Wu, Yao Chu, Zhenxiu Jiang & Qin Yu. (2019) Losartan protects against intermittent hypoxia-induced peritubular capillary loss by modulating the renal renin–angiotensin system and angiogenesis factors. Acta Biochimica et Biophysica Sinica 52:1, pages 38-48.
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Zhen-Zhen Qiu, Ji-Ming He, Hao-Xiang Zhang, Zuo-Hua Yu, Zhi-Wei Zhang & Hao Zhou. (2019) Renoprotective effects of pirfenidone on chronic renal allograft dysfunction by reducing renal interstitial fibrosis in a rat model. Life Sciences 233, pages 116666.
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Chongxiang Xiong, Yingjie Guan, Xiaoxu Zhou, Lirong Liu, Michelle A. Zhuang, Wei Zhang, Yunhe Zhang, Monica V. Masucci, George Bayliss, Ting C. Zhao & Shougang Zhuang. (2019) Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis. The FASEB Journal 33:7, pages 8249-8262.
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Hailun Li, Zhuan Yan, Qingping Xiong, Xiaoling Chen, Yongtao Lin, Yong Xu, Lin Bai, Wei Jiang, Donghui Zheng & Changying Xing. (2019) Renoprotective effect and mechanism of polysaccharide from Polyporus umbellatus sclerotia on renal fibrosis. Carbohydrate Polymers 212, pages 1-10.
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Yuejiang Jiao, Hongwei Jiang, Haibo Lu, Yiping Yang, Yanfang Zhang, Kun Zhang & Hui Liu. (2018) Deficiency of hypoxia inducible factor‑1α promoted progression of diabetic nephropathy with hypertension. Experimental and Therapeutic Medicine.
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Junsuke Hirono, Haruka Sanaki, Kana Kitada, Haruka Sada, Atsushi Suzuki, Laurensius K. Lie, Eri Segi-Nishida, Kimie Nakagawa & Hiroshi Hasegawa. (2018) Expression of tissue inhibitor of metalloproteinases and matrix metalloproteinases in the ischemic brain of photothrombosis model mice. NeuroReport 29:3, pages 174-180.
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Rashmi Shukla, Nidhi Pandey, Somanshu Banerjee & Yamini B. Tripathi. (2017) Effect of extract of Pueraria tuberosa on expression of hypoxia inducible factor-1α and vascular endothelial growth factor in kidney of diabetic rats. Biomedicine & Pharmacotherapy 93, pages 276-285.
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Hyung Eun Yim, Kee Hwan Yoo, In Sun Bae & Young Sook Hong. (2017) Early Treatment With Enalapril and Later Renal Injury in Programmed Obese Adult Rats. Journal of Cellular Physiology 232:2, pages 447-455.
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Hyosang Kim, Chung Baek, Raymond Lee, Jai Chang, Won Yang & Sang Lee. (2017) Anti-Fibrotic Effect of Losartan, an Angiotensin II Receptor Blocker, Is Mediated through Inhibition of ER Stress via Up-Regulation of SIRT1, Followed by Induction of HO-1 and Thioredoxin. International Journal of Molecular Sciences 18:2, pages 305.
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Zhifeng Dong, Penglong Wu, Yongguang Li, Yuan shen, Ping Xin, Shuai Li, Zhihua Wang, Xiaoyan Dai, Wei Zhu & Meng Wei. (2014) Myocardial infarction worsens glomerular injury and microalbuminuria in rats with pre-existing renal impairment accompanied by the activation of ER stress and inflammation. Molecular Biology Reports 41:12, pages 7911-7921.
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