3,885
Views
44
CrossRef citations to date
0
Altmetric
REVIEW

Guidelines for Diagnosis and Management of Beta-Thalassemia Intermedia

, , , &
Pages 583-596 | Received 07 May 2014, Accepted 19 Jun 2014, Published online: 23 Sep 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Mohammadreza Saeidnia, Pooria Fazeli, Arghavan Farzi, Maryam Atefy Nezhad, Mojtaba Shabani-Borujeni, Mehran Erfani, Gholamhossein Tamaddon & Mehran Karimi. (2023) An Expert Overview on Therapies in Non-Transfusion-Dependent Thalassemia: Classical to Cutting Edge in Treatment. Hemoglobin 47:2, pages 56-70.
Read now
Wenqian Cai, Qian Xiong, Jing Tong, Xiang Dai, Bin Zhou, Shanshan Shen & Xijiang Hu. (2021) Prevalence and genetic analysis of thalassemia in neonates in Wuhan area: a national megacity in central China. The Journal of Maternal-Fetal & Neonatal Medicine 34:14, pages 2240-2247.
Read now
Zahra Mohammadi, Reza Mohammadi, Sezaneh Haghpanah, Mohamad Moghadam, Reza Pazhoomand & Mehran Karimi. (2020) Association of Exon 14 of the SOX6 Gene Sequence Variations with Response to Hydroxyurea Therapy in Patients Carrying Non Transfusion-Dependent Thalassemia. Hemoglobin 44:6, pages 406-410.
Read now
Mehran Karimi, Fatemeh Amirmoezi, Sezaneh Haghpanah, Seyedpouria Ostad, Mehrzad Lotfi, Sepideh Sefidbakht & Shahed Rezaian. (2017) Correlation of serum ferritin levels with hepatic MRI T2 and liver iron concentration in nontransfusion beta-thalassemia intermediate patients: A contemporary issue. Pediatric Hematology and Oncology 34:5, pages 292-297.
Read now

Articles from other publishers (39)

Kasper Munch Lauridsen, Helle Pilgaard Kristiansen & Anne Winther-Larsen. (2023) Pediatric reference intervals of the hemoglobin fractions HbA2, HbF and HbA0using High-Performance Liquid Chromatography and Capillary Electrophoresis. Clinica Chimica Acta, pages 117557.
Crossref
Hayder M. Al-Kuraishy, Mohamed H. Mazhar Ashour, Hebatallah M. Saad & Gaber El-Saber Batiha. (2023) COVID-19 and β-thalassemia: in lieu of evidence and vague nexus. Annals of Hematology.
Crossref
Udani Gamage, Kesari Warnakulasuriya, Sonali Hansika & Gayathri N. Silva. (2023) CRISPR Gene Therapy: A Promising One-Time Therapeutic Approach for Transfusion-Dependent β-Thalassemia—CRISPR-Cas9 Gene Editing for β-Thalassemia. Thalassemia Reports 13:1, pages 51-69.
Crossref
Na Li, Bowen Wu, Jifeng Wang, Yumeng Yan, Peng An, Yuezhen Li, Yuning Liu, Yanfei Hou, Xiaoqing Qing, Lili Niu, Xiang Ding, Zhensheng Xie, Mengmeng Zhang, Xiaojing Guo, Xiulan Chen, Tanxi Cai, Jianming Luo, Fudi Wang & Fuquan Yang. (2023) Differential proteomic patterns of plasma extracellular vesicles show potential to discriminate β-thalassemia subtypes. iScience 26:2, pages 106048.
Crossref
Antony P. Martin, Enrico Ferri Grazzi, Claudia Mighiu, Manoj Chevli, Farrukh Shah, Louise Maher, Anum Shaikh, Aliah Sagar, Hayley Hubberstey, Bethany Franks, Juan M. Ramos-Goñi, Mark Oppe & Derek Tang. (2022) Health state utilities for beta-thalassemia: a time trade-off study. The European Journal of Health Economics 24:1, pages 27-38.
Crossref
Hadi Darvishi-Khezri, Aily Aliasgharian, Mohammad Naderisorki, Mehrnoush Kosaryan, Mobin Ghazaiean, Hanie Fallah, Mohammad Zahedi & Hossein Karami. (2022) Ferritin thresholds for cardiac and liver hemosiderosis in β-thalassemia patients: a diagnostic accuracy study. Scientific Reports 12:1.
Crossref
Հ․ Ա. Գրիգորյան, Լ․ Ս․ Հակոբյան, Լ. Մ. Քրմոյան, Ս․ Հ․ Դանելյան & Լ․ Հ․ Վաղարշակյան. (2022) Թալասեմիաների ընդհանուր բնութագիրը. Medical Science of Armenia, pages 20-30.
Crossref
Valeria Filippi, Hubertina Reina, Cecile Monod & Gwendolin Manegold-Brauer. (2022) Extramedullary haematopoiesis presenting as an adnexal mass in a patient with β-thalassaemia. BMJ Case Reports 15:6, pages e249422.
Crossref
Giovanna De Simone, Alberto Quattrocchi, Benedetta Mancini, Alessandra di Masi, Clara Nervi & Paolo Ascenzi. (2022) Thalassemias: from gene to therapy. Molecular Aspects of Medicine 84, pages 101028.
Crossref
Na Li, Peng An, Jifeng Wang, Tingting Zhang, Xiaoqing Qing, Bowen Wu, Lang Sun, Xiang Ding, Lili Niu, Zhensheng Xie, Mengmeng Zhang, Xiaojing Guo, Xiulan Chen, Tanxi Cai, Jianming Luo, Fudi Wang & Fuquan Yang. (2022) Plasma proteome profiling combined with clinical and genetic features reveals the pathophysiological characteristics of β-thalassemia. iScience 25:4, pages 104091.
Crossref
Shuang-Ping Ma, Xu-Xia Gao, Guo-Qiang Zhou, Hao-Kun Zhang, Jing-Min Yang, Wen-Juan Wang, Xian-Min Song, Hong-Yan Chen & Da-Ru Lu. (2022) Reactivation of γ-globin expression using a minicircle DNA system to treat β-thalassemia. Gene 820, pages 146289.
Crossref
Keivan Moradi, Reza Alibakhshi, Samaneh Shafieenia & Azam Azimi. (2022) Problem of borderline hemoglobin A2 levels in an Iranian population with a high prevalence of α- and β-thalassemia carriers. Egyptian Journal of Medical Human Genetics 23:1.
Crossref
Meichun Wang, Meixia Huang & Yijin Hong. (2021) Psychological intervention in children with transfusion‐dependent β‐thalassaemia. Vox Sanguinis 117:3, pages 386-392.
Crossref
Keivan Moradi, Aboozar Mohammadi & Mohsen Kazeminia. (2021) In silico prediction of HBD gene variants in the Iranian population. Egyptian Journal of Medical Human Genetics 22:1.
Crossref
Mehran Karimi, Tahereh Zarei, Ardeshir Bahmanimehr, Azam Aramesh, Saeed Daryanoush & Sezaneh Haghpanah. (2021) Long-term safety and efficacy of hydroxyurea in patients with non-transfusion-dependent β-thalassemia: a comprehensive single-center experience. Annals of Hematology 100:12, pages 2901-2907.
Crossref
Fangfang Wang, Ling Ling & Duonan Yu. (2021) MicroRNAs in β-thalassemia. The American Journal of the Medical Sciences 362:1, pages 5-12.
Crossref
Alexandros Makis, Ersi Voskaridou, Ioannis Papassotiriou & Eleftheria Hatzimichael. (2021) Novel Therapeutic Advances in β-Thalassemia. Biology 10:6, pages 546.
Crossref
Yunhao Liang, Xinhua Zhang, Yongqiong Liu, Liren Wang, Yuhua Ye, Xuemei Tan, Jiajie Pu, Qianqian Zhang, Xiuqin Bao, Xiaofeng Wei, Dongzhi Li, Ryo Kurita, Yukio Nakamura, Dali Li & Xiangmin Xu. (2021) GATA zinc finger domain‐containing protein 2A ( GATAD2A ) deficiency reactivates fetal haemoglobin in patients with β‐thalassaemia through impaired formation of methyl‐binding domain protein 2 (MBD2)‐containing nucleosome remodelling and deacetylation (NuRD) complex . British Journal of Haematology 193:6, pages 1220-1227.
Crossref
Xiuqin Bao, Xinhua Zhang, Liren Wang, Zhongju Wang, Jin Huang, Qianqian Zhang, Yuhua Ye, Yongqiong Liu, Diyu Chen, Yangjin Zuo, Qifa Liu, Peng Xu, Binbin Huang, Jianpei Fang, Jinquan Lao, Xiaoqin Feng, Yafeng Li, Ryo Kurita, Yukio Nakamura, Weiwei Yu, Cunxiang Ju, Chunbo Huang, Narla Mohandas, Dali Li, Cunyou Zhao & Xiangmin Xu. (2021) Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia. The American Journal of Human Genetics 108:4, pages 709-721.
Crossref
Gilda Cennamo, Daniela Montorio, Giuliano Mazzella, Paolo Ricchi, Silvia Costantini, Anna Spasiano, Aldo Filosa, Maria Rosaria Storino, Francesca Aquila, Fausto Tranfa & Michela Grosso. (2021) Retinal and Choriocapillaris Vascular Changes in Patients Affected by Different Clinical Phenotypes of β-Thalassemia: An Optical Coherence Tomography Angiography Study. Biology 10:4, pages 276.
Crossref
Yuanjun Wu, Yanli Ji, Bingmei Dai, Faliang Guo, Yong Wu, Ziyi He, Chunyan Mo, Shujie Wu & Yingming Hu. (2020) A case of hyperhaemolysis syndrome in a pregnant Chinese woman with β‐thalassemia during perinatal transfusion. Transfusion Medicine 31:1, pages 24-29.
Crossref
Fan Jiang, Liandong Zuo, Dongzhi Li, Jian Li, Xuewei Tang, Guilan Chen, Jianying Zhou, Hang Lu & Can Liao. (2020) Molecular epidemiology and hematologic characterization of δβ-thalassemia and hereditary persistence of fetal hemoglobin in 125,661 families of greater Guangzhou area, the metropolis of southern China. BMC Medical Genetics 21:1.
Crossref
Stamatia Theodoridou, Angeliki Balassopoulou, Effrossyni Boutou, Evangelia-Eleni Delaki, Eleni Yfanti, Timoleon-Achilleas Vyzantiadis, Evangelia Vetsiou, Ersi Voskaridou & Efthymia Vlachaki. (2020) Coinheritance of Triplicated Alpha-Globin Gene and Beta-Thalassemia Mutations in Adulthood: Ten Years of Referrals in Northern Greece. Journal of Pediatric Hematology/Oncology 42:8, pages e762-e764.
Crossref
Mehran Karimi, Sezaneh Haghpanah, Azita Azarkeivan, Zohreh Zahedi, Tahereh Zarei, Maryam Akhavan Tavakoli, Asghar Bazrafshan, Afshan Shirkavand & Vincezo De Sanctis. (2020) Prevalence and mortality in β‐thalassaemias due to outbreak of novel coronavirus disease (COVID‐19): the nationwide Iranian experience. British Journal of Haematology 190:3.
Crossref
Mehran Karimi, Tahereh Zarei, Sezaneh Haghpanah, Azita Azarkeivan, Christos Kattamis, Vassilis Ladis, Antonios Kattamis, Yurdanur Kilinc, Shahina Daar, Saif Alyaarubi, Doaa Khater, Yasser Wali, Mohamed Elshinawy, Ali Almadhani, Mohamed Yassin, Ashraf T. Soliman, Duran Canatan, Maha Obiedat, Hala Al-Rimawi, Demetris Mariannis, Constantinos Christodoulides, Soteroula Christou, Ploutarchos Tzoulis, Saveria Campisi, Salvatore Di Maio & Vincenzo De Sanctis. (2019) Evaluation of endocrine complications in beta-thalassemia intermedia (β-TI): a cross-sectional multicenter study. Endocrine 69:1, pages 220-227.
Crossref
Rashail Faraon, Mahmoud Daraghmah, Fekri Samarah & Mahmoud A. Srour. (2019) Molecular characterization of β-thalassemia intermedia in the West Bank, Palestine. BMC Hematology 19:1.
Crossref
Mehran Karimi, Sezaneh Haghpanah, Parisa Pishdad, Zohreh Zahedi, Shirin Parand & Sanaz Safaei. (2019) Frequency of silent brain lesions and aspirin protection evaluation over 3 years follow-up in beta thalassemia patients. Annals of Hematology 98:10, pages 2267-2271.
Crossref
Dejian Pang, Xuan Shang, Decheng Cai, Fei Zhu, Yi Cheng, Jianmei Zhong, Sheng Yi, Qianqian Zhang & Xiangmin Xu. (2019) Thalassaemia intermedia caused by coinheritance of a β‐thalassaemia mutation and a de novo duplication of α‐globin genes in the paternal allele . British Journal of Haematology 186:4, pages 620-624.
Crossref
Tammy YN Tong, Timothy J Key, Kezia Gaitskell, Timothy J Green, Wenji Guo, Thomas A Sanders & Kathryn E Bradbury. (2019) Hematological parameters and prevalence of anemia in white and British Indian vegetarians and nonvegetarians in the UK Biobank. The American Journal of Clinical Nutrition 110:2, pages 461-472.
Crossref
Maria Mendoza Rincon & Wendy Chan. (2018) Massive hemothorax in extramedullary hematopoiesis. Visual Journal of Emergency Medicine 13, pages 35-36.
Crossref
Chingiz Asadov, Zohra Alimirzoeva, Tahira Mammadova, Gunay Aliyeva, Shahla Gafarova & Jeyhun Mammadov. (2018) β-Thalassemia intermedia: a comprehensive overview and novel approaches. International Journal of Hematology 108:1, pages 5-21.
Crossref
Omid R. Zekavat, Ayda Bahmanjahromi, Sezaneh Haghpanah, Sara Ebrahimi & Nader Cohan. (2018) The Zinc and Copper Levels in Thalassemia Major Patients, Receiving Iron Chelation Therapy. Journal of Pediatric Hematology/Oncology 40:3, pages 178-181.
Crossref
Özlem Tüfekçi, Berna Atabay, Meral Türker, Şebnem Yilmaz Bengoa, Salih Gözmen, Tuba Karapinar, Hale Ören & Gülersu İrken. (2017) Evaluation of the Clinical and Laboratory Characteristics of Previously Followed-up Thalassemia Intermedia Patients to Provide Them Better Care in the Future. Journal of Pediatric Hematology/Oncology 39:6, pages 440-444.
Crossref
Satheesh Chonat & Charles T. Quinn. 2017. Gene and Cell Therapies for Beta-Globinopathies. Gene and Cell Therapies for Beta-Globinopathies 59 87 .
Alexandros Makis, Eleftheria Hatzimichael, Ioannis Papassotiriou & Ersi Voskaridou. (2016) 2017 Clinical trials update in new treatments of β‐thalassemia. American Journal of Hematology 91:11, pages 1135-1145.
Crossref
Hee Won Chueh. (2016) Treatment and Management of Late Complications in Hereditary Hemolytic Anemia. Clinical Pediatric Hematology-Oncology 23:1, pages 1-7.
Crossref
Chaowen Yu, Juan Zhang, Zhaojian Yuan, Hao Liu, Xingbin Wang, Ming Wang & Lin Zou. (2015) A novel method for quantification of human hemoglobin from dried blood spots by use of tandem mass spectrometry. Analytical and Bioanalytical Chemistry 407:26, pages 8121-8127.
Crossref
Seyyed Mehdi Khoshfetrat, Mitra Ranjbari, Mohsen Shayan, Masoud A. Mehrgardi & Abolfazl Kiani. (2015) Wireless Electrochemiluminescence Bipolar Electrode Array for Visualized Genotyping of Single Nucleotide Polymorphism. Analytical Chemistry 87:16, pages 8123-8131.
Crossref
Amin Abolhasani Foroughi, Hosein Ghaffari, Sezaneh Haghpanah, Masoume Nazeri, Roghieh Ghaffari, Marzieh Bardestani & Mehran Karimi. (2015) Comparative Study of Radiographic and Laboratory Findings Between Beta Thalassemia Major and Beta Thalassemia Intermedia Patients With and Without Treatment by Hydroxyurea. Iranian Red Crescent Medical Journal 17:2.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.