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Pediatric Hematology and Oncology Volume 3, 1986 - Issue 2
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Original Article

Pharmacokinetics of Methotrexate and 7-Hydroxy-Methotrexate after High-Dose (33.6 g/m2) Methotrexate Therapy

Lars Slørdal Department of Pharmacology, Institute of Medical Biology; Department of Pediatrics, Institute of Clinical Medicine, University of Tromsø, N-9000, Tromsø, Norway
,
Svein Kolmannskog Department of Pharmacology, Institute of Medical Biology; Department of Pediatrics, Institute of Clinical Medicine, University of Tromsø, N-9000, Tromsø, Norway
,
Per S. Prytz Department of Pharmacology, Institute of Medical Biology; Department of Pediatrics, Institute of Clinical Medicine, University of Tromsø, N-9000, Tromsø, Norway
,
Peter Johan Moe Department of Pediatrics, University of Trondheim, N-7000, Trondheim, Norway
&
Jarle Aarbakke Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9000, Tromsø, Norway
Pages 127-134 | Received 17 Dec 1985, Accepted 13 Feb 1986, Published online: 09 Jul 2009

Citations (18)

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Ole-Martin Fuskevåg, Christel Kristiansen,Randi Olsen,Jarle Aarbakke,Sigurd Lindal. (2000) Microvascular Perturbations in Rats Receiving the Maximum Tolerated Dose of Methotrexate or Its Major Metabolite 7-Hydroxymethotrexate. Ultrastructural Pathology 24:5, pages 325-332.
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Joseph D. Borsi, Erling Sagen, Civ Ing, Inge Romslo & Peter J. Moe. (1990) Pharmacokinetics and Metabolism of Methotrexate: An Example for the Use of Clinical Pharmacology in Pediatric Oncology. Pediatric Hematology and Oncology 7:1, pages 13-33.
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Lars Slørdal, Svein Kolmannskog, Peter Johan Moe, Per S. Prytz & Jarle Aarbakke. (1987) High-Dose Methotrexate Therapy (6‐8 G/M2) in Childhood Malignancies: Clinical Tolerability and Pharmacokinetics. Pediatric Hematology and Oncology 4:1, pages 33-42.
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Articles from other publishers (15)

Lars Slørdal, Georg Sager, Nils-Erik Huseby & Jarle Aarbakke. (1988) Distribution of 7-hydroxymethotrexate in human blood. Journal of Pharmacy and Pharmacology 40:1, pages 50-52.
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M. Joerger, A. D. R. Huitema, H. J. G. D. Van Den Bongard, P. Baas, J. H. Schornagel, J. H. M. Schellens & J. H. Beijnen. (2005) Determinants of the elimination of methotrexate and 7‐hydroxy‐methotrexate following high‐dose infusional therapy to cancer patients. British Journal of Clinical Pharmacology 62:1, pages 71-80.
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E. Groninger, J.H. Proost & S.S.N. de Graaf. (2004) Pharmacokinetic studies in children with cancer. Critical Reviews in Oncology/Hematology 52:3, pages 173-197.
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Eivind Smeland, Ole Martin Fuskevåg, Kirsten Nymann, John Sigurd Svendsen, Randi Olsen, Sigurd Lindal, Roy M. Bremnes & Jarle Aarbakke. (1996) High-dose 7-hydroxymethotrexate: Acute toxicity and lethality in a rat model. Cancer Chemotherapy and Pharmacology 37:5, pages 415-422.
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Eivind Smeland, Roy M. Bremnes, Anders Andersen, Ragnhild J�ger, Tor J. Eide, Nils-E Huseby & Jarle Aarbakke. (1994) Renal and hepatic toxicity after high-dose 7-hydroxymethotrexate in the rat. Cancer Chemotherapy and Pharmacology 34:2, pages 119-124.
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R. M. Bremnes, E. Smeland, N.‐E. Huseby, T. J. Eide & J. Aarbakke. (2009) Acute Hepatotoxicity after High‐Dose Methotrexate Administration to Rats. Pharmacology & Toxicology 69:2, pages 132-139.
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Roy M. Bremnes, Eivind Smeland, Nils P. Willassen, Erik Wist & Jarle Aarbakke. (1991) Inhibition of 7-hydroxymethotrexate formation by amsacrine. Cancer Chemotherapy and Pharmacology 28:5, pages 377-383.
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Joseph D. Borsi, Erling Sagen, Inge Romslo, Lars Sl�rdal & Peter J. Moe. (1990) 7-Hydroxymethotrexate concentrations in serum and cerebrospinal fluid of children with acute lymphoblastic leukemia. Cancer Chemotherapy and Pharmacology 27:2, pages 164-167.
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Joseph D. Borsi, Erling Sagen, Inge Romslo & Peter J. Moe. (2006) Comparative study on the pharmacokinetics of 7‐hydroxy‐methotrexate after administration of methotrexate in the dose range of 0.5‐33.6 g/m 2 to children with acute lymphoblastic leukemia . Medical and Pediatric Oncology 18:3, pages 217-224.
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L. Slørdal, R. Jæger, J. Kjæve & J. Aarbakke. (2009) Pharmacokinetics of 7‐Hydroxy‐methotrexate and Methotrexate in the Rat. Pharmacology & Toxicology 63:2, pages 81-84.
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Lars Slørdal, Georg Sager & Jarle Aarbakke. (1988) PHARMACOKINETIC INTERACTIONS WITH METHOTREXATE: IS 7-HYDROXY-METHOTREXATE THE CULPRIT?. The Lancet 331:8585, pages 591-592.
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Lars Slørdal, Georg Sager, Ragnhild Jæger & Jarle Aarbakke. (1988) Interactions with the protein binding of 7-hydroxy-methotrexate in human serum in vitro. Biochemical Pharmacology 37:4, pages 607-611.
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Joseph D. Borsi & Peter Johan Moe. (1987) Systemic clearance of methotrexate in the prognosis of acute lymphoblastic leukemia in children. Cancer 60:12, pages 3020-3024.
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Joseph D. Borsi & Peter Johan Moe. (1987) A comparative study on the pharmacokinetics of methotrexate in a dose range of 0.5 g to 33.6 g/m2 in children with acute lymphoblastic leukemia. Cancer 60:1, pages 5-13.
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Lars Slørdal & Jarle Aarbakke. (1987) Effect of anticancer drugs on drug metabolism. Pharmacology & Therapeutics 35:1-2, pages 217-226.
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