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Pediatric Hematology and Oncology Volume 4, 1987 - Issue 1
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Original Article

High-Dose Methotrexate Therapy (6‐8 G/M2) in Childhood Malignancies: Clinical Tolerability and Pharmacokinetics

Lars Slørdal Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9000, Tromsø, Norway
,
Svein Kolmannskog Department of Pediatrics, Institute of Clinical Medicine, University Hospital of Tromsø, N-9000, Tromsø, Norway
,
Peter Johan Moe Department of Pediatrics, University Hospital of Trondheim, N-7000, Trondheim, Norway
,
Per S. Prytz Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9000, Tromsø, Norway
&
Jarle Aarbakke Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9000, Tromsø, Norway
Pages 33-42 | Received 23 Sep 1986, Accepted 18 Nov 1986, Published online: 09 Jul 2009

Citations (11)

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Ole-Martin Fuskevåg, Christel Kristiansen,Randi Olsen,Jarle Aarbakke,Sigurd Lindal. (2000) Microvascular Perturbations in Rats Receiving the Maximum Tolerated Dose of Methotrexate or Its Major Metabolite 7-Hydroxymethotrexate. Ultrastructural Pathology 24:5, pages 325-332.
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Charlotte Rask, Freidoun Albertioni, Soeren M. Bentzen, Henrik Schroeder & Curt Peterson. (1998) Clinical and Pharmacokinetic Risk Factors for High-dose Methotrexate-induced Toxicity in Children with Acute Lymphoblastic Leukemia: A Logistic Regression Analysis. Acta Oncologica 37:3, pages 277-284.
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Articles from other publishers (9)

E. Groninger, J.H. Proost & S.S.N. de Graaf. (2004) Pharmacokinetic studies in children with cancer. Critical Reviews in Oncology/Hematology 52:3, pages 173-197.
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Frank G. H. Hill, Sue Richards, Brenda Gibson, Ian Hann, John Lilleyman, Sally Kinsey, Christopher Mitchell, Christine J. Harrison & Osborn B. Eden. (2003) Successful treatment without cranial radiotherapy of children receiving intensified chemotherapy for acute lymphoblastic leukaemia: results of the risk‐stratified randomized central nervous system treatment trial MRC UKALL XI (ISRC TN 16757172). British Journal of Haematology 124:1, pages 33-46.
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Shigeyuki Kitamura, Keiko Nakatani, Kazumi Sugihara & Shigeru Ohta. (1999) Strain differences of the ability to hydroxylate methotrexate in rats. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 122:3, pages 331-336.
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A. FABBRI, E. MOTTA, S. FERRARI, C. LONGHI, E. MARCHI, G. BACCI, E. FIGUS & G. MARCHESINI MD. (2009) High‐dose methotrexate treatment and liver function in patients with osteosarcoma. Journal of Internal Medicine 236:2, pages 209-214.
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Vaskar Saha & Tim Eden. (1993) An odyssey in search of a cure: The evolution of treatment of childhood acute lymphoblastic leukemia in the United Kingdom. The Indian Journal of Pediatrics 60:4, pages 525-538.
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Joseph D. Borsi, Erling Sagen, Inge Romslo, Lars Sl�rdal & Peter J. Moe. (1990) 7-Hydroxymethotrexate concentrations in serum and cerebrospinal fluid of children with acute lymphoblastic leukemia. Cancer Chemotherapy and Pharmacology 27:2, pages 164-167.
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Joseph D. Borsi, Erling Sagen, Inge Romslo & Peter J. Moe. (2006) Comparative study on the pharmacokinetics of 7‐hydroxy‐methotrexate after administration of methotrexate in the dose range of 0.5‐33.6 g/m 2 to children with acute lymphoblastic leukemia . Medical and Pediatric Oncology 18:3, pages 217-224.
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L. Slørdal, R. Jæger, J. Kjæve & J. Aarbakke. (2009) Pharmacokinetics of 7‐Hydroxy‐methotrexate and Methotrexate in the Rat. Pharmacology & Toxicology 63:2, pages 81-84.
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Joseph D. Borsi & Peter Johan Moe. (1987) Systemic clearance of methotrexate in the prognosis of acute lymphoblastic leukemia in children. Cancer 60:12, pages 3020-3024.
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