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Pediatric Hematology and Oncology Volume 11, 1994 - Issue 4
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Original Article

Early Discharge Of Pediatric Febrile Neutropenic Cancer Patients By Substitution Of Oral For Intravenous Antibiotics

R. C. Lau Division of Haematology/Oncology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada
,
J. J. Doyle Division of Haematology/Oncology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada
,
M. H. Freedman Division of Haematology/Oncology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada
,
S. M. King Division of Infectious Diseases, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada
&
S. E. Richardson Department of Microbiology, Hospital for Sick Children and University of Toronto, Toronto, Canada
Pages 417-421 | Received 21 Sep 1993, Accepted 10 Dec 1993, Published online: 09 Jul 2009

Citations (38)

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Michael L. N. Willoughby. (1994) Editorial: Early Discharge in Febrile Neutropenia. Pediatric Hematology and Oncology 11:6, pages 571-573.
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Articles from other publishers (37)

Utsav Nepal, Vijay Kumar Panthi, Namindra Prasad Chaudhary & Samip Chaudhary. (2022) A Validated RP-HPLC Method for Simultaneous Determination of Cefixime and Clavulanic Acid Powder in Pediatric Oral Suspension. International Journal of Analytical Chemistry 2022, pages 1-10.
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Jessica E. Morgan, Jemma Cleminson, Karl Atkin, Lesley A. Stewart & Robert S. Phillips. (2016) Systematic review of reduced therapy regimens for children with low risk febrile neutropenia. Supportive Care in Cancer 24:6, pages 2651-2660.
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Aditi Vedi & Richard Cohn. (2013) Oral versus intravenous antibiotics in treatment of paediatric febrile neutropenia. Journal of Paediatrics and Child Health 49:3, pages 170-178.
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L. Kwofie, B. L. Rapoport, H. Fickl, P. W. A. Meyer, P. Rheeder, H. Hlope, R. Anderson & G. R. Tintinger. (2011) Evaluation of circulating soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) to predict risk profile, response to antimicrobial therapy, and development of complications in patients with chemotherapy-associated febrile neutropenia: a pilot study. Annals of Hematology 91:4, pages 605-611.
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Vincas Urbonas, Audronė Eidukaitė & Indrė Tamulienė. (2012) The Diagnostic Value of Interleukin-6 and Interleukin-8 for Early Prediction of Bacteremia and Sepsis in Children With Febrile Neutropenia and Cancer. Journal of Pediatric Hematology/Oncology 34:2, pages 122-127.
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R. Dommett, J. Geary, S. Freeman, J. Hartley, M. Sharland, A. Davidson, R. Tulloh, M. Taj, S. Stoneham & J.C. Chisholm. (2009) Successful introduction and audit of a step-down oral antibiotic strategy for low risk paediatric febrile neutropaenia in a UK, multicentre, shared care setting. European Journal of Cancer 45:16, pages 2843-2849.
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Esther M. te Poele, Wim J.E. Tissing, Willem A. Kamps & Eveline S.J.M. de Bont. (2009) Risk assessment in fever and neutropenia in children with cancer: What did we learn?. Critical Reviews in Oncology/Hematology 72:1, pages 45-55.
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Ajay Gupta, Chetanya Swaroop, Sandeep Agarwala, Ravindra Mohan Pandey & Sameer Bakhshi. (2009) Randomized Control Trial Comparing Oral Amoxicillin-clavulanate and Ofloxacin With Intravenous Ceftriaxone and Amikacin as Outpatient Therapy in Pediatric Low-risk Febrile Neutropenia. Journal of Pediatric Hematology/Oncology 31:9, pages 635-641.
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Christoph Härtel, Maresa Deuster, Thomas Lehrnbecher & Christian Schultz. (2007) Current approaches for risk stratification of infectious complications in pediatric oncology. Pediatric Blood & Cancer 49:6, pages 767-773.
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Julia C. Chisholm & Rachel Dommett. (2006) The evolution towards ambulatory and day-case management of febrile neutropenia. British Journal of Haematology 135:1, pages 3-16.
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Tohru Masaoka. (2004) Economic Issues: Toward a Cost‐Effective Approach to the Management of Febrile Neutropenia in Japan. Clinical Infectious Diseases 39:s1, pages S68-S69.
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Guy Leverger. (2004) Antibiothérapie ambulatoire chez les enfants neutropéniques fébriles. La Presse Médicale 33:5, pages 330-337.
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CRAIG A. MULLEN. (2003) Ciprofloxacin in treatment of fever and neutropenia in pediatric cancer patients. The Pediatric Infectious Disease Journal 22:12, pages 1138-1142.
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Wanda Salzer, Seth M. Steinberg, David J. Liewehr, Alison Freifeld, Frank M. Balis & Brigitte C. Widemann. (2003) Evaluation and Treatment of Fever in the Non-Neutropenic Child With Cancer. Journal of Pediatric Hematology/Oncology 25:8, pages 606-612.
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Julie R. Park, James Coughlin, Douglas Hawkins, Debra L. Friedman, Jane L. Burns & Thomas Pendergrass. (2002) Ciprofloxacin and amoxicillin as continuation treatment of febrile neutropenia in pediatric cancer patients. Medical and Pediatric Oncology 40:2, pages 93-98.
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Mark T Holdsworth, Jeff Hanrahan, Bernadette Albanese & Jami Frost. (2003) Outpatient Management of Febrile Neutropenia in Children with Cancer. Pediatric Drugs 5:7, pages 443-455.
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Mark T Holdsworth, Jeff Hanrahan, Bernadette Albanese & Jami Frost. (2003) Outpatient Management of Febrile Neutropenia in Children with Cancer. Pediatric Drugs 5:7, pages 443-455.
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Elmar Orudjev & Beverly J. Lange. (2002) Evolving concepts of management of febrile neutropenia in children with cancer. Medical and Pediatric Oncology 39:2, pages 77-85.
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Walter T. Hughes, Donald Armstrong, Gerald P. Bodey, Eric J. Bow, Arthur E. Brown, Thierry Calandra, Ronald Feld, Philip A. Pizzo, Kenneth V. I. Rolston, Jerry L. Shenep & Lowell S. Young. (2002) 2002 Guidelines for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer. Clinical Infectious Diseases 34:6, pages 730-751.
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Craig A. Mullen. (2001) Which children with fever and neutropenia can be safely treated as outpatients?. British Journal of Haematology 112:4, pages 832-837.
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J. L. Shenep, P. M. Flynn, D. K. Baker, S. V. Hetherington, M. M. Hudson, W. T. Hughes, C. C. Patrick, P. K. Roberson, J. T. Sandlund, V. M. Santana, J. W. Sixbey & K. S. Slobod. (2001) Oral Cefixime Is Similar to Continued Intravenous Antibiotics in the Empirical Treatment of Febrile Neutropenic Children with Cancer. Clinical Infectious Diseases 32:1, pages 36-43.
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Elio Castagnola, Dimitri Paola, Raffaella Giacchino & Claudio Viscoli. (2000) Clinical and Laboratory Features Predicting a Favorable Outcome and Allowing Early Discharge in Cancer Patients with Low-Risk Febrile Neutropenia: A Literature Review. Journal of Hematotherapy & Stem Cell Research 9:5, pages 645-649.
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Robert J. Klaassen, Upton Allen & John J. Doyle. (2000) Randomized Placebo-Controlled Trial of Oral Antibiotics in Pediatric Oncology Patients at Low-Risk With Fever and Neutropenia. Journal of Pediatric Hematology/Oncology 22:5, pages 405-411.
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Jerry L. Shenep. (2000) Outpatient management of the neutropenic child with unexplained fever. Seminars in Pediatric Infectious Diseases 11:2, pages 105-112.
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G. Höffken, R. Pasold, K. H. Pflüger, J. Finke, A. A. Fauser, H. Szelenyi & J. Wagner. (1999) An open, randomized, multicentre study comparing the use of low-dose ceftazidime or cefotaxime, both in combination with netilmicin, in febrile neutropenic patients. Journal of Antimicrobial Chemotherapy 44:3, pages 367-376.
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Marin H. Kollef. (1999) EPIDEMIOLOGY AND RISK FACTORS FOR NOSOCOMIAL PNUEMONIA. Clinics in Chest Medicine 20:3, pages 653-670.
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Brenda K. Shelton. (1999) Sepsis. Seminars in Oncology Nursing 15:3, pages 209-221.
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Alison Freifeld, Donna Marchigiani, Thomas Walsh, Stephen Chanock, Linda Lewis, John Hiemenz, Sharon Hiemenz, Jeanne E. Hicks, Vee Gill, Seth M. Steinberg & Philip A. Pizzo. (1999) A Double-Blind Comparison of Empirical Oral and Intravenous Antibiotic Therapy for Low-Risk Febrile Patients with Neutropenia during Cancer Chemotherapy. New England Journal of Medicine 341:5, pages 305-311.
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Louise Hooker & Janice Kohler. (1999) Safety, efficacy, and acceptability of home intravenous therapy administered by parents of pediatric oncology patients. Medical and Pediatric Oncology 32:6, pages 421-426.
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Edward B Rubenstein, Linda S. Elting, Charlotte C. Sun & Kenneth V. I. Rolston. 1999. Clinical Applications of Cytokines and Growth Factors. Clinical Applications of Cytokines and Growth Factors 159 177 .
Jerry L. Shenep. (1998) Antimicrobial therapy in the immunocompromised host. Seminars in Pediatric Infectious Diseases 9:4, pages 330-338.
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Viscoli Castagnola. (2001) Planned progressive antimicrobial therapy in neutropenic patients. British Journal of Haematology 102:4, pages 879-888.
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J. Cooke. (1998) Cost issues in sequential therapy. Journal of Infection 37, pages 45-50.
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A. Engel, E. Mack, P. Kern & W. V. Kern. (1998) An analysis of interleukin-8, interleukin-6 and C-Reactive protein serum concentrations to predict fever, gram-negative bacteremia and complicated infection in neutropenic cancer patients. Infection 26:4, pages 213-221.
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Shelley Anne Diamond & Beverley Jane Hales. (1997) Strategies for controlling antibiotic use in a tertiary-care paediatric hospital. Paediatrics & Child Health 2:3, pages 181-186.
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Kenneth V. I. Rolston & Edward B. Rubenstein. (2017) Early Empiric Antibiotic Therapy for Febrile Neutropenia Patients at Low Risk. Cancer Control 3:4, pages 366-374.
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Kenneth V.I. Rolston, Edward B. Rubenstein & Alison Freifeld. (1996) EARLY EMPIRIC ANTIBIOTIC THERAPY FOR FEBRILE NEUTROPENIA PATIENTS AT LOW RISK. Infectious Disease Clinics of North America 10:2, pages 223-237.
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