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Original Article

The Acid Sphingomyelinase Inhibitor SR33557 Counteracts TNF-α-Mediated Potentiation of IL-1β-Induced NF-κB Activation in the Insulin-Producing Cell Line RINm5F

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Pages 241-254 | Received 21 Jan 2000, Accepted 22 Apr 2000, Published online: 07 Jul 2009

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Florian Lang, Susanne Ullrich & Erich Gulbins. (2011) Ceramide formation as a target in beta-cell survival and function. Expert Opinion on Therapeutic Targets 15:9, pages 1061-1071.
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Dariush MokhtariAndreea BarbuIlir Mehmeti, Chantal Vercamer & Nils Welsh. (2009) Overexpression of the nuclear factor-κB subunit c-Rel protects against human islet cell death in vitro. American Journal of Physiology-Endocrinology and Metabolism 297:5, pages E1067-E1077.
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Maryline Moulin, Stéphane Carpentier, Thierry Levade & André-Patrick Arrigo. (2007) Potential roles of membrane fluidity and ceramide in hyperthermia and alcohol stimulation of TRAIL apoptosis. Apoptosis 12:9, pages 1703-1720.
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Yasumasa Kato, Shigeyuki Ozawa, Mamoru Tsukuda, Eiro Kubota, Kaoru Miyazaki, Yves St‐Pierre & Ryu‐Ichiro Hata. (2007) Acidic extracellular pH increases calcium influx‐triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase‐9 expression in mouse metastatic melanoma. The FEBS Journal 274:12, pages 3171-3183.
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S. Lépine, H. Le Stunff, B. Lakatos, J.C. Sulpice & F. Giraud. (2006) ATP-induced apoptosis of thymocytes is mediated by activation of P2X7 receptor and involves de novo ceramide synthesis and mitochondria. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1761:1, pages 73-82.
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Anjaneyulu Kowluru. (2005) Novel regulatory roles for protein phosphatase-2A in the islet β cell. Biochemical Pharmacology 69:12, pages 1681-1691.
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Scott A. Summers & Don H. Nelson. (2005) A Role for Sphingolipids in Producing the Common Features of Type 2 Diabetes, Metabolic Syndrome X, and Cushing’s Syndrome. Diabetes 54:3, pages 591-602.
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Sandrine Lépine, Boris Lakatos, Marie-Pierre Courageot, Hervé Le Stunff, Jean-Claude Sulpice & Françoise Giraud. (2004) Sphingosine Contributes to Glucocorticoid-Induced Apoptosis of Thymocytes Independently of the Mitochondrial Pathway. The Journal of Immunology 173:6, pages 3783-3790.
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Murielle Mimeault, Nicole Pommery & Jean-Pierre Hénichart. (2003) Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines. International Journal of Cancer 106:1, pages 116-124.
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Murielle Mimeault. (2002) New advances on structural and biological functions of ceramide in apoptotic/necrotic cell death and cancer. FEBS Letters 530:1-3, pages 9-16.
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Andreea Barbu, Nils Welsh & Johan Saldeen. (2002) Cytokine-induced apoptosis and necrosis are preceded by disruption of the mitochondrial membrane potential (Δψm) in pancreatic RINm5F cells: prevention by Bcl-2. Molecular and Cellular Endocrinology 190:1-2, pages 75-82.
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Johan Saldeen, John C Lee & Nils Welsh. (2001) Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis. Biochemical Pharmacology 61:12, pages 1561-1569.
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