The Acid Sphingomyelinase Inhibitor SR33557 Counteracts TNF-α-Mediated Potentiation of IL-1β-Induced NF-κB Activation in the Insulin-Producing Cell Line RINm5F

References

• Bendtzen K, Mandrup-Poulsen T, Nerup J, Nielsen J H, Din-Arello C. A., Svenson M. Cytotoxicity of human pi 7 interleukin-1 for pancreatic islets of Langerhans. Science 1986; 232: 1545–1547
   PubMed Web of Science ®Google Scholar
• Nerup J, Mandrup-Poulsen T, Mølvig J, Helqvist S, Wogensen L, Egeberg J. Mechanisms of pancreatic p-cell destruction in type I diabetes. Diabetes Care 1988; 11(Suppl 1)16–23
   PubMedGoogle Scholar
• Southern C, Schulster D, Green I C. Inhibition of insulin secretion by interleukin-1 β and tumour necrosis factor-α via an L-arginine-dependent nitric oxide generating mechanism. FEBS Lett 1990; 276: 42–44
   PubMed Web of Science ®Google Scholar
• Welsh N, Eizirik D L, Bendtzen K, Sandler S. Interleukin-1 β-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology 1991; 129: 3167–3173
   PubMed Web of Science ®Google Scholar
• Corbett J A, Wang J L, Hughes J H, Wolf B A, Sweetland M A, Lancaster J. R., Jr, McDaniel M L. Nitric oxide and cyclic GMP formation induced by interleukin 1 β in islets of Langerhans. Evidence for an effector role of nitric oxide in islet dysfunction. Biochem J 1992; 287(Pt 1)229–235
   PubMedGoogle Scholar
• Eizirik D L, Flodstrom M, Karlsen E A, Welsh N. The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic β cells. Diabelologia 1996; 39: 875–890
   PubMed Web of Science ®Google Scholar
• Takamura T, Kato I, Kimura N, Nakazawa T, Yonekura H, Takasawa S, Okamoto H. Transgenic mice overex-pressing type 2 nitric-oxide synthase in pancreatic β cells develop insulin-dependent diabetes without insulitis. J Biol Chem 1998; 273: 2493–2496
   PubMed Web of Science ®Google Scholar
• Saldeen J, Welsh N. Interleukin-1β induced activation of NF-αB in insulin producing RINm5F cells is prevented by the protease inhibitor Na-p-tosyl-L-lysine chloromethylke-tone. Biochem Biophys Res Commun 1994; 203: 149–155
   PubMed Web of Science ®Google Scholar
• Machleidt T, Wiegmann K, Henkel T, Schütze S, Baeuerle P, Krönke M. Sphingomyelinase activates proteolytic IαB-α degradation in a cell-free system. J Biol Chem 1994; 269: 13760–13765
   PubMed Web of Science ®Google Scholar
• Jin D Y, Chae H Z, Rhee S G, Jeang K T. Regulatory role for a novel human thioredoxin peroxidase in NF-αB activation. J Biol Chem 1997; 272: 30952–30961
   PubMed Web of Science ®Google Scholar
• Lee F S, Hagler J, Chen Z J, Maniatis T. Activation of the IkappaB a kinase complex by MEKK1, a kinase of the JNK pathway. Cell 1997; 88: 213–222
   PubMed Web of Science ®Google Scholar
• Diaz-Guerra M J, Bodelon O G, Velasco M, Whelan R, Parker P J, Bosca L. Up-regulation of protein kinase C-epsi-lon promotes the expression of cytokine-inducible nitric oxide synthase in RAW 264.7 cells. J Biol Chem 1996; 271: 32028–32033
   PubMedGoogle Scholar
• Lozano J, Berra E, Municio M M, Diaz-Meco M T, Dominguez I, Sanz L, Moscat J. Protein kinase C α, isoform is critical for αB-dependent promoter activation by sphingomyelinase. J Biol Chem 1994; 269: 19200–19202
   PubMed Web of Science ®Google Scholar
• Zandi E, Rothwarf D M, Delhase M, Hayakawa M, Karin M. The IKinase complex (IKK) contains two kinase subunits, IKKαd IKKβecessary for IKB phosphorylation and NF-KB activation. Cell 1997; 91: 243–252
   PubMed Web of Science ®Google Scholar
• Welsh N. Interleukin-1 β-induced ceramide and dia-cylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F. J Biol Chem 1996; 271: 8307–8312
   PubMed Web of Science ®Google Scholar
• Kolesnick R N, Golde D W. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 1994; 77: 325–328
   PubMed Web of Science ®Google Scholar
• Kolesnick R N. Sphingomyelin and derivatives as cellular signals. Prog Lipid Res 1991; 30: 1–38
   PubMed Web of Science ®Google Scholar
• Spiegel S, Foster D, Kolesnick R N. Signal transduction through lipid second messengers. Curr Opin Cell Biol 1996; 8: 159–167
   PubMed Web of Science ®Google Scholar
• Ji L, Zhang G, Uematsu S, Akahori Y, Hirabayashi Y. Induction of apoptotic DNA fragmentation and cell death by natural ceramide. FEBS Lett 1995; 358: 211–214
   PubMed Web of Science ®Google Scholar
• Jaffrezou J P, Herbert J M, Levade T, Gau M N, Chatelain P, Laurent G. Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein. J Biol Chem 1991; 266: 19585–19864
   Web of Science ®Google Scholar
• Svenson M, Bendtzen K. Inhibitor of interleukin 1 in normal human urine. Different effects on mouse thymocytes and on a murine T-cell line. Scand J Immunol 1988; 27: 593–599
   PubMed Web of Science ®Google Scholar
• Andersson A. Isolated mouse pancreatic in culture: effects of serum and different culture media on the insulin production of the islets. Diabetologia 1978; 14: 397–404
   PubMed Web of Science ®Google Scholar
• Robinson B S, Hii C S, Poulos A, Ferrante A. Effect of tumor necrosis factor-α on the metabolism of arachidonic acid in human neutrophils. J Lipid Res 1996; 37: 1234–1245
   PubMed Web of Science ®Google Scholar
• Bradford M M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248–251
   PubMed Web of Science ®Google Scholar
• Dignam J D, Lebovitz R M, Roeder R G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 1983; 11: 1475–1489
   PubMed Web of Science ®Google Scholar
• Laird P W, Zijderveld A, Linders K, Rudnicki M A, Jaenisch R, Berns A. Simplified mammalian DNA isolation procedure. Nucleic Acids Res 1991; 19: 4293
   PubMed Web of Science ®Google Scholar
• Saldeen I, Welsh N. Nicotinamide-induced apoptosis in insulin producing cells is associated with cleavage of poly (ADP-ribose) polymerase. Mol Cell Endocrinol 1998; 139: 99–107
   PubMed Web of Science ®Google Scholar
• Stephens L A, Thomas H E, Ming L, Grell M, Darwiche R, Volodin L, Kay T. W. Tumor necrosis factor-alpha-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic beta cells. Endocrinology 1999; 140: 3219–27
   PubMed Web of Science ®Google Scholar
• Stamler J S, Singel D J, Loscalzo J. Biochemistry of nitric oxide and its redox-activated forms. Science 1992; 258: 1898–1902
   PubMed Web of Science ®Google Scholar
• Tepper A, de Vries E, van Blitterswijk W J, Borst J. Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis. J Clin Invest 1999; 103: 971–978
   PubMed Web of Science ®Google Scholar
• Major C D, Zhi-Yong G., Wolf B A. Activation of the sphingomyelinase/ceramide signal transduction pathway in insulin-secreting β-cells. Diabetes 1999; 48: 1372–1380
   PubMed Web of Science ®Google Scholar
• Kowluru A, Metz S A. Ceramide-activated protein phosphatase-2A activity in insulin-secreting cells. FEBS Lett 1997; 418: 179–182
   PubMed Web of Science ®Google Scholar
• Ninomiya-Tsuji J, Kishimoto K, Hihama A, Lnoue J I, Cao Z, Matsumoto K. The kinase TAK1 can activate the NIK-IKB as well as the MAP kinase cascade in the IL-1 signaling pathway. Nature 1999; 398: 252–256
   PubMed Web of Science ®Google Scholar
• Nagata S. Apoptosis by death factor. Cell 1997; 88: 355–365
   PubMed Web of Science ®Google Scholar
• Wang Y M, Seibenhener M L, Vandenplas M. L., Wooten M W. Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-KB/JNK kinase and cell survival. J Neurosci Res 1999; 55: 293–302
   PubMed Web of Science ®Google Scholar
• Heitmeier M R, Scarim A L, Corbett J A. Interferon-y increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1. J Biol Chem 1997; 272: 13697–13704
   PubMed Web of Science ®Google Scholar
• Huwiler A, Pfeilschifter J, Van den Bosch H. Nitric-oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells. J Biol Chem 1999; 274: 7190–7195
   PubMed Web of Science ®Google Scholar
• Sjöholm Å. Ceramide inhibits pancreatic β-cell insulin production and mitogenesis and mimics the actions of interleukin-1 β. FEBS Lett 1995; 367: 283–286
   PubMedGoogle Scholar
• Nokin P, Clinet M, Polster P, Beaufort P, Meysmans L, Gou-Gat J., Chatelain P. SR33557, a novel calcium-antagonist: interactions with [3H]-(+/-)-nitrendipine and [H)-(-)-desmethoxy-verapamil binding sites in cerebral membranes. Naunvn Schmeidebergs Arch Pharmacol 1989; 339: 31–36
   PubMed Web of Science ®Google Scholar
• Mizuno N, Yoshitomi H, Ishida H, Kuromi H, Kawaki J, Seino Y, Seino S. Altered bcl-2 and bax expression and intracellular Ca2+ signaling in apoptosis of pancreatic cells and the impairment of glucose-induced insulin secretion. Endocrinology 1998; 139: 1429–1439
   PubMed Web of Science ®Google Scholar
• Leist M, Single B, Castoldi A F, Kuhne S, Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med 1997; 185: 1481–1486
   PubMed Web of Science ®Google Scholar