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Research Article

Long pentraxin 3 (PTX3) in the light of its structure, mechanism of action and clinical implications

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Pages 119-128 | Received 06 Mar 2011, Accepted 04 Aug 2011, Published online: 11 Oct 2011

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L. Watson, P. Brogan, I. Peart, C. Landes, N. Barnes & G. Cleary. (2014) Diagnosis and Assessment of Disease Activity in Takayasu Arteritis: A Childhood Case Illustrating the Challenge. Case Reports in Rheumatology 2014, pages 1-6.
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Yuki Shimada, Yu Funakubo Asanuma, Kazuhiro Yokota, Yoshihiro Yoshida, Hiroshi Kajiyama, Kojiro Sato, Yuji Akiyama & Toshihide Mimura. (2013) Pentraxin 3 is associated with disease activity but not atherosclerosis in patients with systemic lupus erythematosus. Modern Rheumatology.
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