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Original Article

Multiple Epitopes on Cartilage Type II Collagen are Accessible for Antibody Binding in vivo

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Pages 27-34 | Received 07 Nov 1990, Accepted 12 Mar 1991, Published online: 07 Jul 2009

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Rikard Holmdahl, Vivianne Malmström & Eero Vuorio. (1993) Autoimmune Recognition of Cartilage Collagens. Annals of Medicine 25:3, pages 251-264.
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Articles from other publishers (32)

Jeevithan Elango, Camilo Zamora-Ledezma, Baolin Ge, Chunyu Hou, Zhilin Pan, Bin Bao, Carlos Pérez Albacete Martínez, José Manuel Granero Marín, José Eduardo Maté Sánchez de Val, Chunling Bao & Wenhui Wu. (2022) Paradoxical Duel Role of Collagen in Rheumatoid Arthritis: Cause of Inflammation and Treatment. Bioengineering 9:7, pages 321.
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Changrong Ge, Dongmei Tong, Erik Lönnblom, Bibo Liang, Weiwei Cai, Cecilia Fahlquist‐Hagert, Taotao Li, Alf Kastbom, Inger Gjertsson, Doreen Dobritzsch & Rikard Holmdahl. (2022) Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis. Arthritis & Rheumatology 74:6, pages 961-971.
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Sukayna Fadlallah, Hadi Hussein, Mary-Ann Jallad, Marwa Shehab, Abdo R. Jurjus, Ghassan M. Matar & Elias A. Rahal. (2021) Effect of Epstein-Barr Virus DNA on the Incidence and Severity of Arthritis in a Rheumatoid Arthritis Mouse Model. Frontiers in Immunology 12.
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C Hagert, R Siitonen, X-G Li, H Liljenbäck, A Roivainen & R Holmdahl. (2019) Rapid spread of mannan to the immune system, skin and joints within 6 hours after local exposure. Clinical and Experimental Immunology 196:3, pages 383-391.
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Kutty Selva Nandakumar, Mattias Collin, Kaisa E. Happonen, Susanna L. Lundström, Allyson M. Croxford, Bingze Xu, Roman A. Zubarev, Merrill J. Rowley, Anna M. Blom, Christian Kjellman & Rikard Holmdahl. (2018) Streptococcal Endo-β-N-Acetylglucosaminidase Suppresses Antibody-Mediated Inflammation In Vivo. Frontiers in Immunology 9.
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Anne D. Christensen, Claus Haase, Andrew D. Cook & John A. Hamilton. (2016) K/BxN Serum-Transfer Arthritis as a Model for Human Inflammatory Arthritis. Frontiers in Immunology 7.
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M. S. Drutskaya, G. A. Efimov, R. V. Zvartsev, A. A. Chashchina, D. M. Chudakov, S. V. Tillib, A. A. Kruglov & S. A. Nedospasov. (2014) Experimental models of arthritis in which pathogenesis is dependent on TNF expression. Biochemistry (Moscow) 79:12, pages 1349-1357.
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Ingrid Lindh, Omri Snir, Erik Lönnblom, Hüseyin Uysal, Ida Andersson, Kutty Nandakumar, Michel Vierboom, Bert 't Hart, Vivianne Malmström & Rikard Holmdahl. (2014) Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice. Arthritis Research & Therapy 16:4, pages R143.
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Karin Stenfeldt, Cathrine Johansson, Per-Olof Eriksson & Sten Hellström. (2013) Collagen Type II Is Produced in Healing Pars Tensa of Perforated Tympanic Membranes. Otology & Neurotology 34:7, pages e88-e92.
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Kutty Selva Nandakumar, Mattias CollinKaisa E. Happonen, Allyson M. Croxford, Susanna L. LundströmRoman A. ZubarevMerrill J. Rowley, Anna M. Blom & Rikard Holmdahl. (2013) Dominant suppression of inflammation by glycan-hydrolyzed IgG. Proceedings of the National Academy of Sciences 110:25, pages 10252-10257.
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Allyson M. Croxford, Senga Whittingham, Donald McNaughton, Kutty Selva Nandakumar, Rikard Holmdahl & Merrill J. Rowley. (2013) Type II collagen–specific antibodies induce cartilage damage in mice independent of inflammation. Arthritis & Rheumatism 65:3, pages 650-659.
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Kutty Selva Nandakumar. 2012. Antibody-Mediated Drug Delivery Systems. Antibody-Mediated Drug Delivery Systems 407 426 .
Allyson M. Croxford, Kutty Selva Nandakumar, Rikard Holmdahl, Mark J. Tobin, Don McNaughton & Merrill J. Rowley. (2011) Chemical changes demonstrated in cartilage by synchrotron infrared microspectroscopy in an antibody-induced murine model of rheumatoid arthritis. Journal of Biomedical Optics 16:6, pages 066004.
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Hüseyin Uysal, Kutty Selva Nandakumar, Christoph Kessel, Sabrina Haag, Stefan Carlsen, Harald Burkhardt & Rikard Holmdahl. (2010) Antibodies to citrullinated proteins: molecular interactions and arthritogenicity. Immunological Reviews 233:1, pages 9-33.
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S TURNER, N P M BAKKER, B A 't HART, P J L HOLT & K MORGAN. (1994) Identification of antibody epitopes in the CB-11 peptide of bovine type II collagen recognized by sera from arthritis-susceptible and -resistant rhesus monkeys. Clinical and Experimental Immunology 96:2, pages 275-280.
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Kutty Selva Nandakumar, Estelle Bajtner, Leigh Hill, Beate Böhm, Merrill J. Rowley, Harald Burkhardt & Rikard Holmdahl. (2008) Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation. Arthritis & Rheumatism 58:1, pages 184-196.
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Kutty Selva Nandakumar, Mattias Collin, Arne Olsén, Falk Nimmerjahn, Anna M. Blom, Jeffrey V. Ravetch & Rikard Holmdahl. (2007) Endoglycosidase treatment abrogates IgG arthritogenicity: Importance of IgG glycosylation in arthritis. European Journal of Immunology 37:10, pages 2973-2982.
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Kutty Selva Nandakumar & Rikard Holmdahl. 2007. Arthritis Research. Arthritis Research 215 223 .
Levon M Khachigian. (2006) Collagen antibody-induced arthritis. Nature Protocols 1:5, pages 2512-2516.
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Kutty Selva Nandakumar & Rikard Holmdahl. (2005) Efficient promotion of collagen antibody induced arthritis (CAIA) using four monoclonal antibodies specific for the major epitopes recognized in both collagen induced arthritis and rheumatoid arthritis. Journal of Immunological Methods 304:1-2, pages 126-136.
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Jinan Li, Annelii Ny, Göran Leonardsson, Kutty Selva Nandakumar, Rikard Holmdahl & Tor Ny. (2005) The Plasminogen Activator/Plasmin System Is Essential for Development of the Joint Inflammatory Phase of Collagen Type II-Induced Arthritis. The American Journal of Pathology 166:3, pages 783-792.
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Kutty Selva Nandakumar, Lars Svensson & Rikard Holmdahl. (2003) Collagen Type II-Specific Monoclonal Antibody-Induced Arthritis in Mice. The American Journal of Pathology 163:5, pages 1827-1837.
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Verdrengh, Kum, Chow & Tarkowski. (1999) The effect of site-specific monoclonal antibodies directed to toxic shock syndrome toxin-1 in experimental Staphylococcus aureus arthritis. Clinical and Experimental Immunology 118:2, pages 268-270.
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Stefan Schulte, Christine Unger, John A. Mo, Olaf Wendler, Eva Bauer, Svenja Frischholz, Klaus von der Mark, Joachim R. Kalden, Rikard Holmdahl & Harald Burkhardt. (1998) Arthritis-related B Cell Epitopes in Collagen II Are Conformation-dependent and Sterically Privileged in Accessible Sites of Cartilage Collagen Fibrils. Journal of Biological Chemistry 273:3, pages 1551-1561.
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Andrew P. Cope & Grete Sonderstrup. (1998) Evaluating candidate autoantigens in rheumatoid arthritis. Springer Seminars in Immunopathology 20:1-2, pages 23-39.
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Robert Karlsson, John A. Mo & Rikard Holmdahl. (1995) Binding of autoreactive mouse anti-type II collagen antibodies derived from the primary and the secondary immune response investigated with the biosensor technique. Journal of Immunological Methods 188:1, pages 63-71.
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Hendrik Schulze‐Koops, Harald Burkhardt, JÜRgen Heesemann, Klaus Von Der Mark & Frank Emmrich. (2005) Characterization of the binding region for the yersinia enterocolitica adhesin yada on types i and ii collagen . Arthritis & Rheumatism 38:9, pages 1283-1289.
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J. A. MO, A. SCHEYNIUS, S. NILSSON & R. HOLMDAHL. (2006) Germline‐Encoded IgG Antibodies Bind Mouse Cartilage In Vivo: Epitope‐ and Idiotype‐Specific Binding and Inhibition . Scandinavian Journal of Immunology 39:2, pages 122-130.
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John A. Mo, Constantin A. Bona & Rikard Holmdahl. (1993) Variable region gene selection of immunoglobulin G-expressing B cells with specificity for a defined epitope on type II collagen. European Journal of Immunology 23:10, pages 2503-2510.
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C. VINGSBO, P. LARSSON, M. ANDERSSON & R. HOLMDAHL. (2006) Association of Pepsin with Type II Collagen (CII) Breaks Control of CII Autoimmunity and Triggers Development of Arthritis in Rats. Scandinavian Journal of Immunology 37:3, pages 337-342.
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J.‐P. BOUVET, B. FRANC, A. ZYAD & J. COUDERC. (2006) Resistance to Collagen‐Induced Arthritis in Biozzi Mice is Not Associated With a Defect in Autoantibodies to Accessible Epitopes on Cartilage Collagen. Scandinavian Journal of Immunology 35:6, pages 677-680.
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R. Holmdahl. 1992. Rheumatoid Arthritis. Rheumatoid Arthritis 180 201 .

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