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Original Article

Multiple Epitopes on Cartilage Type II Collagen are Accessible for Antibody Binding in vivo

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Pages 27-34 | Received 07 Nov 1990, Accepted 12 Mar 1991, Published online: 07 Jul 2009

References

  • Wooley P H, Luthra H S, Stuart J M, David C S. Type II collagen induced arthritis in mice. I. Major histocompatibility complex (I‐region) linkage and antibody correlates. J. Exp Med. 1981; 154: 688–700
  • Holmdahl R, Jansson L, Gullberg D, Rubin K, Forsberg P O, Klareskog L. Incidence of arthritis and autoreactivity of anti‐collagen antibodies after immunization of DBA/1 mice with heterologous and autologous collagen II. Clin exp Immunol. 1985; 62: 639–646
  • Holmdahl R, Jansson L, Larsson E, Rubin K, Klareskog L. Homologous type II collagen induces chronic and progressive arthritis in mice. Arthritis Rheum. 1986; 29: 106–113
  • Boissier M C, Feng X Z, Carlioz A, Roudier R, Fournier C. Experimental autoimmune arthritis in mice. I. Homologous type II collagen is responsible for self‐perpetuating chronic polyarthritis. Annals Rheum Dis. 1987; 46: 691–700
  • Holmdahl R, Rubin K, Klareskog L, Larsson E, Wigzell H. Characterization of the antibody response in mice with type II collagen‐induced arthritis, using monoclonal anti‐type II collagen antibodies. Arthritis Rheum. 1986; 29: 400–410
  • Holmdahl R, Anderson M, Tarkowski A. Origin of the autoreactive anti‐type II collagen response. I: Frequency of specific and multispecific B cells in primed murine lymph nodes. Immunology. 1987; 61: 369–374
  • Franzen A, Heinegárdh D, Solursh M. Evidence for sequential appearance of cartilage matrix proteins in developing mouse limbs and in cultures of mouse mesenchymal cells. Differentiation. 1987; 36: 199–210
  • Heinegárdh D, Paulsson M. Cartilage. Meth Enzymol. 1987; 145: 336–363
  • Klareskog L, Johnell O, Hulth A, Holmdahl R, Rubin K. Reactivity of monoclonal anti‐type II collagen antibodies with cartilage and synovial tissue in rheumatoid arthritis and osteoarthritis. Arthritis Rheum. 1986; 29: 730–738
  • Linsenmayer T F, Hendrix M J C. Monoclonal antibodies to connective tissue macromolecules: Type II collagen. Biochem Biophys Res Com. 1980; 92: 440–446
  • Thorogood P, Bee J, Vonder Mark K. Transient expression of collagen type II at epitheliomesenchymal interfaces during morphogenesis of the cartilaginous neurocranium. Dev Biol. 1986; 116: 497–509
  • Vondermark K, vonder Mark H, Timpl R, Trelstad R. Immuno‐fluorescent localization of collagen types I, II, and III in the embryonic chick eye. Dev Biol. 1979; 59: 75–85
  • Vonder Mark H, vonder Mark K, Gay S. Study of different collagen synthesis during development of the chick embryo by immunofluorescens. I. Preparation of collagen type I and type II specific antibodies and their application to early stages of the chick embryo. Deli Biol. 1976; 48: 237–249
  • Kerwar S S, Englert M E, McReynolds R A, Landes M J, Lloyd J M, Oronsky A L, Wilson F J. Type II collagen‐induced arthritis. Studies with purified anticollagen immunoglobulin. Arthritis Rheum. 1983; 26: 1120–1131
  • Jonsson R, Karlsson A L, Holmdahl R. Demonstration of immune‐reactive sites on cartilage after in vivo administration of biotinylated anti‐type II collagen antibodies. J Histochem Cytochem. 1989; 31: 265–268
  • Holmdahl R, Klareskog L, Anderson M, Hansen C. High antibody response to autologous type II collagen is restricted to H‐2q. Immunogenetics. 1986; 24: 84–89
  • Jonsson R, Tarkowski A, Klareskog L. A demineralization procedure for immunohistopathological use. J Immunol Meth. 1986; 88: 109–114
  • Hsu S M, Raine L, Fanger H. Use of avidin‐biotin‐peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabelled antibody (PAP) procedures. J Histochem Cytochem. 1981; 29: 577
  • Holmdahl R, Bailey C, Enander I, Mayer R, Klareskog L, Moran T, Bona C. Origin of the autoreactive anti type II collagen response. I. I. Specificities, isotypes and usage of V gene families of anti type II collagen autoantibodies. J Immunol. 1989; 142: 1881–1886
  • Burkhardt H, Holmdahl R, Deutzmann R, Wiedemann H, Vonder Mark H, Goodman S, vonder Mark K. Identification of a major antigenic epitope on CNBr fragment II of type II collagen recognized by murine autoreactive B cells. Eur J Immunol. 1991; 21: 49–54
  • Heinz H P, Rubin K, Laurell A B, Loos M. Common epitopes in Clq and collagen type II. Mol Immunol. 1989; 26: 163–169
  • Stuart J M, Dixon F J. Serum transfer of collagen induced arthritis in mice. J Exp Med. 1983; 158: 378–392
  • Holmdahl R, Jansson L, Larsson A, Jonsson R. Arthritis in DBA/I mice induced with passively transferred type II collagen immune serum. Immunohistopathology and serum levels of anti‐type II collagen autoantibodies. Scand J. Immunol. 1990; 31: 147–157
  • Morgan K, Clague R B, Shaw M J, Firth S A, Twose T M, Holt P J L. Native type II collagen‐induced arthritis in the rat. The effect of complement depletion by cobra venom factor. Arthritis Rheum. 1981; 24: 1356–1362
  • Watson W C, Brown P S, Pitcock J A, Townes A S. Passive transfer studies with type II collagen antibody in B10.D2/old and new line and C57BL/6 normal and beige (Chediak‐Higashi) strains: Evidence of important roles for C5 and multiple inflammatory cell types in the development of erosive arthritis. Arthritis Rheum. 1987; 30: 460–465
  • Clague R B, Moore L J. IgG and IgM antibody to native type II collagen in rheumatoid arthritis serum and synovial fluid. Evidence for the presence of collagen‐anticollagen immune complexes in synovial fluid. Arthritis Rheum. 1984; 27: 1370–1377
  • Jasin H E. Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum. 1985; 28: 241–248
  • Tarkowski A, Klareskog L, Carlsten H, Herberts P, Koopman W J. Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis. Arthritis Rheum. 1989; 32: 1087–1092
  • Qin Y, Sun D, Goto M, Meyermann R, Wekerle H. Resistance to experimental autoimmune encephalomyelitis induced by neonatal tolerization to myelin basic protein: clonal elimination vs. regulation of autoaggressive lymphocytes. Eur J Immunol. 1989; 19: 373–380

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