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Original Article

Low Dose Streptozotocin Causes Diabetes in Severe Combined Immunodeficient (Scid) Mice Without Immune Cell Infiltration of the Pancreatic Islets

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Pages 83-92 | Received 14 May 1994, Published online: 07 Jul 2009

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Maria N. Povydysh, Maria V. Titova, Igor M. Ivanov, Andrey G. Klushin, Dmitry V. Kochkin, Boris A. Galishev, Elena V. Popova, Dmitry Yu. Ivkin, Vladimir G. Luzhanin, Marina V. Krasnova, Natalia V. Demakova & Alexander M. Nosov. (2021) Effect of Phytopreparations Based on Bioreactor-Grown Cell Biomass of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus on Carbohydrate and Lipid Metabolism in Type 2 Diabetes Mellitus. Nutrients 13:11, pages 3811.
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Catharina de Barros Pimentel Villaça, Carolina Cavalcante Paula, Caroline Cruz Oliveira, Eloisa Aparecida Vilas‐Boas, Junia Carolina Santos‐Silva, Sérgio Ferreira Oliveira, Fernando Abdulkader, Sandra Mara Ferreira & Fernanda Ortis. (2021) Beneficial effects of physical exercise for β‐cell maintenance in a type 1 diabetes mellitus animal model. Experimental Physiology 106:7, pages 1482-1497.
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Tatiane M. Preisser, Vanessa P. da Cunha, Mariana P. Santana, Vanessa B. Pereira, Denise C. Cara, Bianca M. Souza & Anderson Miyoshi. (2021) Recombinant Lactococcus lactis Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model. Journal of Diabetes Research 2021, pages 1-15.
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Yoshio Osada, Tomohiro Fujiyama, Naoto Kamimura, Tsukushi Kaji, Susumu Nakae, Katsuko Sudo, Kenji Ishiwata & Tamotsu Kanazawa. (2017) Dual genetic absence of STAT6 and IL-10 does not abrogate anti-hyperglycemic effects of Schistosoma mansoni in streptozotocin-treated diabetic mice. Experimental Parasitology 177, pages 1-12.
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Christine N. Metz, LaQueta K. Hudson & Valentin A. Pavlov. 2017. Principles of Diabetes Mellitus. Principles of Diabetes Mellitus 215 238 .
Yeray Brito-Casillas, Carlos Melián & Ana María Wägner. (2016) Study of the pathogenesis and treatment of diabetes mellitus through animal models. Endocrinología y Nutrición 63:7, pages 345-353.
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Yeray Brito-Casillas, Carlos Melián & Ana María Wägner. (2016) Study of the pathogenesis and treatment of diabetes mellitus through animal models. Endocrinología y Nutrición (English Edition) 63:7, pages 345-353.
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Christine N. Metz, LaQueta K. Hudson & Valentin A. Pavlov. 2016. Principles of Diabetes Mellitus. Principles of Diabetes Mellitus 1 25 .
Sity Aishah Mansur, Aleksandra Mieczkowska, Béatrice Bouvard, Peter R. Flatt, Daniel Chappard, Nigel Irwin & Guillaume Mabilleau. (2015) Stable Incretin Mimetics Counter Rapid Deterioration of Bone Quality in Type 1 Diabetes Mellitus. Journal of Cellular Physiology 230:12, pages 3009-3018.
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Xiaoxia Liu, Sophie Turban, Roderick N. Carter, Shakil Ahmad, Lynne Ramage, Scott P. Webster, Brian R. Walker, Jonathan R. Seckl & Nicholas M. Morton. (2014) β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction. Frontiers in Endocrinology 5.
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Zunaira Z Chaudhry, David L Morris, Dan R Moss, Emily K Sims, Yien Chiong, Tatsuyoshi Kono & Carmella Evans-Molina. (2013) Streptozotocin is equally diabetogenic whether administered to fed or fasted mice. Laboratory Animals 47:4, pages 257-265.
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L C da Rosa, F Chiuso-Minicucci, S F G Zorzella-Pezavento, T G D França, L L W Ishikawa, P M Colavite, B Balbino, L C B Tavares, C L Silva, C Marques, M R V Ikoma & A Sartori. (2013) Bacille Calmette–Guérin/DNAhsp65 prime-boost is protective against diabetes in non-obese diabetic mice but not in the streptozotocin model of type 1 diabetes. Clinical and Experimental Immunology 173:3, pages 430-437.
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Aileen JF King. (2012) The use of animal models in diabetes research. British Journal of Pharmacology 166:3, pages 877-894.
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M C Deeds, J M Anderson, A S Armstrong, D A Gastineau, H J Hiddinga, A Jahangir, N L Eberhardt & Y C Kudva. (2011) Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models. Laboratory Animals 45:3, pages 131-140.
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Qingguo RuanShi-Jun ZhengScott PalmerRuaidhri J. CarmodyYouhai H. Chen. (2010) Roles of Bcl-3 in the Pathogenesis of Murine Type 1 Diabetes. Diabetes 59:10, pages 2549-2557.
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Katherine Motyl & Laura R. McCabe. (2009) Streptozotocin, Type I Diabetes Severity and Bone. Biological Procedures Online 11:1, pages 296-315.
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Shiva Reddy, Robert B. Elliott, Mike Chang, Tim Hsu, Jessica A. Rodrigues, Linzi Qiao & Elizabeth Robinson. (2008) Newly Weaned Nonobese Diabetic Mice Show Heightened Early Diabetes Sensitivity to Multiple Low Doses of Streptozotocin Than Nondiabetes-Prone CD-1 Mice. Pancreas 37:1, pages e8-e19.
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A. A. Spasov, M. P. Samokhina, I. A. Kheyfets, J. L. Dugina, A. V. Martyushev-Poklad, S. A. Sergeeva & O. I. Epstein. (2007) Study of antidiabetic activity of a new ultralow-dose antibody preparation on the model of streptozotocin diabetes in rats. Bulletin of Experimental Biology and Medicine 144:1, pages 46-48.
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Sergiu Botolin & Laura R. McCabe. (2007) Bone Loss and Increased Bone Adiposity in Spontaneous and Pharmacologically Induced Diabetic Mice. Endocrinology 148:1, pages 198-205.
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D. A. Rees & J. C. Alcolado. (2005) Animal models of diabetes mellitus. Diabetic Medicine 22:4, pages 359-370.
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Shayne C. Barlow, Will Langston, Kametra M. Matthews, John H. ChidlowJrJr & Christopher G. Kevil. (2004) CD18 Deficiency Protects against Multiple Low-Dose Streptozotocin-Induced Diabetes. The American Journal of Pathology 165:6, pages 1849-1852.
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Ludwig, Kretschmer, Caspar, Bojunga, Oldenburg, Schumm‐Draeger, Stegmüller, Von Minckwitz, Usadel & Kusterer. (2001) In vivo microscopy of murine islets of Langerhans: increased adhesion of transferred lymphocytes to islets depends on macrophage‐derived cytokines in a model of organ‐specific insulitis . Immunology 98:1, pages 111-115.
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S. Reddy, M. Young, C.A. Poole & J.M. Ross. (1998) Loss of Glucose Transporter-2 Precedes Insulin Loss in the Nonobese Diabetic and the Low-Dose Streptozotocin Mouse Models: A Comparative Immunohistochemical Study by Light and Confocal Microscopy. General and Comparative Endocrinology 111:1, pages 9-19.
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W.-T Lu, J.-H Juang, B.Ray-Sea Hsu & H.-S Huang. (1998) Effects of High or Low Dose of Streptozocin on Pancreatic Islets in C57BL/6 and C.B17-SCID Mice. Transplantation Proceedings 30:2, pages 609-610.
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