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Autoimmunity Volume 26, 1997 - Issue 2
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Original Article

Cytokines in the Evolution of Graves' Ophthalmopathy

Neena Natt Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, 55905
,
S. Rebecca Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, 55905
&
M. D. Bahn Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, 55905
Pages 129-136 | Received 15 Nov 1996, Accepted 12 Mar 1997, Published online: 07 Jul 2009

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Read on this site (3)

Leendert van Steensel & Willem A. Dik. (2010) The Orbital Fibroblast: A Key Player and Target for Therapy in Graves’ Ophthalmopathy. Orbit 29:4, pages 202-206.
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Janusz Myśliwiec, Adam Krętowski, Agnieszka Stępień & Ida Kinalska. (2004) Serum Levels of Soluble TNFα Receptors (sTNFR1 and sTNFR2) During Corticosteroid Treatment in Patients with Graves' Ophthalmopathy. Immunological Investigations 33:1, pages 61-68.
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Masayo Yamada, Audrey Wu Li & Jack R. Wall. (2000) Thyroid-Associated Ophthalmopathy: Clinical Features, Pathogenesis, and Management. Critical Reviews in Clinical Laboratory Sciences 37:6, pages 523-549.
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Articles from other publishers (39)

Laura Paniagua, Manuel F. Bande, Jose M. Abalo-Lojo & Francisco Gonzalez. (2023) Computer aided volumetric assessment of orbital structures in patients with Graves' orbitopathy: correlation with serum thyroid antiperoxidase antibodies and disease activity. International Ophthalmology 43:9, pages 3377-3384.
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Dhanesh Amarnani, Angie V. Sanchez, Lindsay L. Wong, Brandon V. Duffy, Leslie Ramos, Suzanne K. Freitag, Diane R. Bielenberg, Leo A. Kim & Nahyoung Grace Lee. (2020) Characterization of a Murine Model of Oxazolone-Induced Orbital Inflammation. Translational Vision Science & Technology 9:8, pages 26.
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Christine M. Longo & Paul J. Higgins. (2019) Molecular biomarkers of Graves' ophthalmopathy. Experimental and Molecular Pathology 106, pages 1-6.
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Shirin Hamed Azzam, Swan Kang, Mario Salvi & Daniel G Ezra. (2018) Tocilizumab for thyroid eye disease. Cochrane Database of Systematic Reviews 2018:11.
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Edina Kishazi, Marianne Dor, Simone Eperon, Aurélie Oberic, Natacha Turck & Mehrad Hamedani. (2018) Differential profiling of lacrimal cytokines in patients suffering from thyroid-associated orbitopathy. Scientific Reports 8:1.
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Erika Galgoczi, Florence Jeney, Annamaria Gazdag, Annamaria Erdei, Monika Katko, Domonkos M Nagy, Bernadett Ujhelyi, Zita Steiber, Ferenc Gyory, Eszter Berta & Endre V Nagy. (2016) Cell density-dependent stimulation of PAI-1 and hyaluronan synthesis by TGF-β in orbital fibroblasts. Journal of Endocrinology 229:2, pages 187-196.
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Meritxell Arenas, Sebastià Sabater, Pedro Lara Jiménez, Àngels Rovirosa, Albert Biete, Victoria Linares, Montse Belles & Julià Panés. (2016) Radiotherapy for Graves’ disease. The possible role of low-dose radiotherapy. Reports of Practical Oncology & Radiotherapy 21:3, pages 213-218.
Crossref
Kah Hie Wong, Shi Song Rong, Kelvin K. L. Chong, Alvin L. Young, Chi Pui Pang & Li Jia Chen. (2015) Genetic Associations of Interleukin-related Genes with Graves’ Ophthalmopathy: a Systematic Review and Meta-analysis. Scientific Reports 5:1.
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Sara Salehi Hammerstad & Yaron Tomer. 2015. Graves' Disease. Graves' Disease 21 37 .
Shannon J. C. Shan & Raymond S. Douglas. (2014) The Pathophysiology of Thyroid Eye Disease. Journal of Neuro-Ophthalmology 34:2, pages 177-185.
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Bernadett UjhelyiPeter GogolakAnnamaria ErdeiValeria NagyErzsebet BalazsEva RajnavolgyiAndras BertaEndre V. Nagy. (2012) Graves' Orbitopathy Results in Profound Changes in Tear Composition: A Study of Plasminogen Activator Inhibitor-1 and Seven Cytokines. Thyroid 22:4, pages 407-414.
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Delu Song, Renyan Wang, Yong Zhong, Weiye Li, Hui Li & Fangtian Dong. (2011) Locally produced insulin-like growth factor-1 by orbital fibroblasts as implicative pathogenic factor rather than systemically circulated IGF-1 for patients with thyroid-associated ophthalmopathy. Graefe's Archive for Clinical and Experimental Ophthalmology 250:3, pages 433-440.
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Bernadett Ujhelyi, Peter Gogolak, Annamaria Erdei, Valeria Nagy, Erzsebet Balazs, Eva Rajnavolgyi, Andras Berta & Endre V Nagy. (2011) Graves’ orbitopathy results in profound changes in tear composition; a study of Plasminogen activator inhibitor-1 (PAI-1) and seven cytokines. Thyroid, pages 111229135013004.
Crossref
M Anvari, O Khalilzadeh, A Esteghamati, S A Esfahani, A Rashidi, A Etemadi, M Mahmoudi & A A Amirzargar. (2009) Genetic susceptibility to Graves’ ophthalmopathy: the role of polymorphisms in proinflammatory cytokine genes. Eye 24:6, pages 1058-1063.
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Omid Khalilzadeh, Mehdi Anvari, Fatemeh Momen-Heravi, Alireza Esteghamati, Armin Rashidi, Mahdi Mahmoudi, Behrouz Nikbin & Aliakbar Amirzargar. (2009) Gene polymorphisms of interleukin-4, interleukin-10 and transforming growth factor-beta in Graves’ disease. Clinical and Experimental Medicine 10:2, pages 123-128.
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Seema KumarReagan SchieferMichael J. CoenenRebecca S. Bahn. (2010) A Stimulatory Thyrotropin Receptor Antibody (M22) and Thyrotropin Increase Interleukin-6 Expression and Secretion in Graves' Orbital Preadipocyte Fibroblasts. Thyroid 20:1, pages 59-65.
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A Reagan Schiefer & Rebecca S Bahn. 2010. Ocular Disease. Ocular Disease 433 437 .
Omid Khalilzadeh, Mehdi Anvari, Alireza Esteghamati, Mahdi Mahmoudi, Maryam Tahvildari, Armin Rashidi, Farideh Khosravi & Aliakbar Amirzargar. (2009) Graves' ophthalmopathy and gene polymorphisms in interleukin-1α, interleukin-1β, interleukin-1 receptor and interleukin-1 receptor antagonist. Clinical & Experimental Ophthalmology 37:6, pages 614-619.
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G.E. Krassas & A. Gogakos. (2006) Thyroid-associated Ophthalmopathy in Juvenile Graves' Disease- Clinical, Endocrine and Therapeutic Aspects. Journal of Pediatric Endocrinology and Metabolism 19:10.
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Katarzyna Komosińska-Vassev, Katarzyna Winsz-Szczotka, Krystyna Olczyk & Ewa M. Koźma. (2006) Alterations in serum glycosaminoglycan profiles in Graves' patients. Clinical Chemistry and Laboratory Medicine (CCLM) 44:5.
Crossref
S. Kloprogge, L. Kowal, J. Wall & A.G. Frauman. (2018) The Clinicopathologic Basis of Graves' Ophthalmopathy: A Review. European Journal of Ophthalmology 15:3, pages 315-323.
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Bellur S. Prabhakar, Rebecca S. Bahn & Terry J. Smith. (2003) Current Perspective on the Pathogenesis of Graves’ Disease and Ophthalmopathy. Endocrine Reviews 24:6, pages 802-835.
Crossref
Seema Kumar & Rebecca S. Bahn. (2003) Relative Overexpression of Macrophage-Derived Cytokines in Orbital Adipose Tissue from Patients with Graves’ Ophthalmopathy. The Journal of Clinical Endocrinology & Metabolism 88:9, pages 4246-4250.
Crossref
Rebecca S. Bahn. (2003) Pathophysiology of Graves’ Ophthalmopathy: The Cycle of Disease. The Journal of Clinical Endocrinology & Metabolism 88:5, pages 1939-1946.
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Janusz Myśliwiec, Adam Krętowski, Agnieszka Stępień, Katarzyna Mirończuk & Ida Kinalska. (2003) Interleukin 18 and transforming growth factor β1 in the serum of patients with Graves' ophthalmopathy treated with corticosteroids. International Immunopharmacology 3:4, pages 549-552.
Crossref
Yuji HiromatsuHiroo KakuIkuyo MiyakeShiro MurayamaEri Soejima. (2002) Role of Cytokines in the Pathogenesis of Thyroid-Associated Ophthalmopathy. Thyroid 12:3, pages 217-221.
Crossref
Tomasz Bednarczuk, Yuji Hiromatsu, Yoichi Inoue, Kazuhiko Yamamoto, Jack R. Wall & Janusz Nauman. (2002) T-Cell–Mediated Immunity in Thyroid-Associated Ophthalmopathy. Thyroid 12:3, pages 209-215.
Crossref
Ildikó Molnár, Csaba Balázs, Gyula Szegedi & Sándor Sipka. (2002) Inhibition of type 2,5′-deiodinase by tumor necrosis factor alpha, interleukin-6 and interferon gamma in human thyroid tissue. Immunology Letters 80:1, pages 3-7.
Crossref
Soma C. JyonouchiRosanee W. ValyaseviDebra A. HarteneckCharyl M. DuttonRebecca S. Bahn. (2001) Interleukin-6 Stimulates Thyrotropin Receptor Expression in Human Orbital Preadipocyte Fibroblasts from Patients with Graves' Ophthalmopathy. Thyroid 11:10, pages 929-934.
Crossref
George J. Kahaly, Wibke Müller-Forell, Gregor J. Förster, Susanne Pitz, Hans Peter Rösier & Wolf J. Mann. 2001. Thyroid Eye Disease. Thyroid Eye Disease 137 162 .
Yuji Hiromatsu & Tomasz Bednarczukt. 2001. Thyroid Eye Disease. Thyroid Eye Disease 45 65 .
Marian Ludgate & Kerry Starkey. (2000) Progress in our understanding of the pathogenesis of Graves ophthalmopathy. Current Opinion in Endocrinology & Diabetes 7:5, pages 270-274.
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P. J. Hunt, S. E. Marshall, A. P. Weetman, J. I. Bell, J. A. H. Wass & K. I. Welsh. (2000) Cytokine Gene Polymorphisms in Autoimmune Thyroid Disease. The Journal of Clinical Endocrinology & Metabolism 85:5, pages 1984-1988.
Crossref
Yuji Hiromatsu, Dame Yang, Tomasz Bednarczuk, Ikuyo Miyake, Kyohei Nonaka & Yoichi Inoue. (2000) Cytokine Profiles in Eye Muscle Tissue and Orbital Fat Tissue from Patients with Thyroid-Associated Ophthalmopathy*. The Journal of Clinical Endocrinology & Metabolism 85:3, pages 1194-1199.
Crossref
R. A. Ajjan, P. F. Watson & A. P. Weetman. 2000. Graves’ Disease. Graves’ Disease 79 93 .
Rebecca S. Bahn. 2000. Graves’ Disease. Graves’ Disease 249 256 .
Ronald E. Warwar. (1999) New insights into pathogenesis and potential therapeutic options for Graves orbitopathy. Current Opinion in Opthalmology 10:5, pages 358-361.
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DAMU YANG, YUJI HIROMATSU, TOMOAKI HOSHINO, YOICHI INOUE, KYOGO ITOH & KYOHEI NONAKA. (1999) Dominant Infiltration of TH 1-type CD4 + T Cells at the Retrobulbar Space of Patients with Thyroid-Associated Ophthalmopathy . Thyroid 9:3, pages 305-310.
Crossref
REBECCA S. BAHN. (1998) Cytokines in Thyroid Eye Disease: Potential for Anticytokine Therapy. Thyroid 8:5, pages 415-418.
Crossref

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