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Autoimmunity Volume 27, 1998 - Issue 4
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Original Article

Iodine is Essential for Human T Cell Recognition of Human Thyroglobulin

Linda Rasooly Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Baltimore, MD, 21205-2196
,
Noel R. Rose Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205-2196; Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Baltimore, MD, 21205-2196
,
Ali M. Saboori Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205-2196
,
Paul W. Ladenson Endocrinology and Metabolic Diseases, John Hopkins Hospital, Baltimore, MD, 21205
&
C. Lynne Burek Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205-2196; Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Baltimore, MD, 21205-2196; Department of Pathology, 648 Ross Research Building/720 Rutland Avenue, Baltimore, MD, 21205-2196
Pages 213-219 | Received 04 Aug 1997, Published online: 07 Jul 2009

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S. Nazarpour, F. Ramezani Tehrani, M. Simbar & F. Azizi. (2016) Thyroid autoantibodies and the effect on pregnancy outcomes. Journal of Obstetrics and Gynaecology 36:1, pages 3-9.
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Kazuki Morohoshi, Michiko Osone, Katsumi Yoshida, Yoshinori Nakagawa, Saeko Hoshikawa, Hiroshi Ozaki, Yurie Takahashi, Sadayoshi Ito & Kouki Mori. (2011) The sphingosine 1-phosphate receptor modulator FTY720 prevents iodide-induced autoimmune thyroiditis in non-obese diabetic mice. Autoimmunity 44:6, pages 490-495.
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Ingrid M Outschoorn, William H Hoffman, Ingrid M Outschoorn, William H Hoffman, Noel R Rose, Ingrid M Outschoorn, William H Hoffman, Noel R Rose, C. Lynne Burek, Ingrid M Outschoorn, William H Hoffman, Noel R Rose & C. Lynne Burek. (2007) Heritability of levels of autoantibodies to thyroid antigens using the method of plotting regression of offspring on midparent (ROMP). Autoimmunity 40:5, pages 366-371.
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George Carayanniotis. (2003) The Cryptic Self in Thyroid Autoimmunity: The Paradigm of Thyroglobulin. Autoimmunity 36:6-7, pages 423-428.
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Articles from other publishers (41)

Claudia Teti, Marta Panciroli, Elena Nazzari, Giampaola Pesce, Stefano Mariotti, Antonella Olivieri & Marcello Bagnasco. (2021) Iodoprophylaxis and thyroid autoimmunity: an update. Immunologic Research 69:2, pages 129-138.
Crossref
Τ. Giassa, I. Mamali, Ε. Gaki, G. Kaltsas, G. Kouraklis, Κ. Β. Markou & T. Karatzas. (2018) Iodine intake and chronic autoimmune thyroiditis: a comparative study between coastal and mainland regions in Greece. Hormones 17:4, pages 565-571.
Crossref
KP Aravindan. (2017) Papillary thyroid cancer: Why the increase and what can be done?. Indian Journal of Cancer 54:3, pages 491.
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Peter Manoharan C, Himagirish K Rao, Achu Jacob Philip, Rahul Raj C.L, Gautham P.J & Varun Varun. (2016) THYROID AUTOIMMUNITY IN AN IODINE-REPLETE POPULATION: A RESEARCH ARTICLE. Journal of Evidence Based Medicine and Healthcare 3:40, pages 2002-2006.
Crossref
Y. R. Yan, Y. Liu, H. Huang, Q. G. Lv, X. L. Gao, J. Jiang & N. W. Tong. (2014) Iodine nutrition and thyroid diseases in Chengdu, China: an epidemiological study. QJM 108:5, pages 379-385.
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Sandra M. McLachlan & Basil Rapoport. (2014) Breaking Tolerance to Thyroid Antigens: Changing Concepts in Thyroid Autoimmunity. Endocrine Reviews 35:1, pages 59-105.
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Patrizio CaturegliAlessandra De RemigisKelly ChuangMarieme DembeleAkiko IwamaShintaro Iwama. (2013) Hashimoto's Thyroiditis: Celebrating the Centennial Through the Lens of the Johns Hopkins Hospital Surgical Pathology Records. Thyroid 23:2, pages 142-150.
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Rania Ahmed, Safa Al-Shaikh & Mohammed Akhtar. (2012) Hashimoto Thyroiditis. Advances in Anatomic Pathology 19:3, pages 181-186.
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Kathryn Haskins & Anne Cooke. (2011) CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes. Current Opinion in Immunology 23:6, pages 739-745.
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Su He Wang & James R. Baker. 2011. Immunoendocrinology: Scientific and Clinical Aspects. Immunoendocrinology: Scientific and Clinical Aspects 443 455 .
Nam H. Cho, Hoon Sung Choi, Kyung Won Kim, Hyung‐Lae Kim, Soo‐Youn Lee, Sung Hee Choi, Soo Lim, Young Joo Park, Do Joon Park, Hak C. Jang & Bo Youn Cho. (2010) Interaction between cigarette smoking and iodine intake and their impact on thyroid function. Clinical Endocrinology 73:2, pages 264-270.
Crossref
C. Lynne Burek. (2010) Autoimmune thyroiditis research at Johns Hopkins University. Immunologic Research 47:1-3, pages 207-215.
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C. Lynne Burek & Monica V. Talor. (2009) Environmental triggers of autoimmune thyroiditis. Journal of Autoimmunity 33:3-4, pages 183-189.
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H. Hadj-Kacem, S. Rebuffat, M. Mnif-Féki, S. Belguith-Maalej, H. Ayadi & S. Péraldi-Roux. (2009) Autoimmune thyroid diseases: genetic susceptibility of thyroid-specific genes and thyroid autoantigens contributions. International Journal of Immunogenetics 36:2, pages 85-96.
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Yun-Ju Lai, Shih-Yi Lin, Wayne Huey-Herng Sheu & I-Te Lee. (2009) Graves Disease After Thyroid Hormone Treatment for Thyroid Nodule. The Endocrinologist 19:2, pages 73-74.
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George Carayanniotis & Yi-chi M. Kong. 2009. Comprehensive Handbook of Iodine. Comprehensive Handbook of Iodine 315 322 .
Radovan Bílek & Václav Zamrazil. 2009. Comprehensive Handbook of Iodine. Comprehensive Handbook of Iodine 55 64 .
C. Lynne Burek & Noel R. Rose. (2008) Autoimmune thyroiditis and ROS. Autoimmunity Reviews 7:7, pages 530-537.
Crossref
Yushu Li, Di Teng, Zhongyan Shan, Xiaochun Teng, Haixia Guan, Xiaohui Yu, Chenling Fan, Wei Chong, Fan Yang, Hong Dai, Xiaolan Gu, Yang Yu, Jinyuan Mao, Dong Zhao, Jia Li, Yanyan Chen, Rong Yang, Chenyang Li & Weiping Teng. (2008) Antithyroperoxidase and Antithyroglobulin Antibodies in a Five-Year Follow-Up Survey of Populations with Different Iodine Intakes. The Journal of Clinical Endocrinology & Metabolism 93:5, pages 1751-1757.
Crossref
Rajni B. Sharma, C. Lynne Burek, Daniela Cihákova, Dolores B. Njoku & Noel R. Rose. 2008. Autoimmune Diseases in Endocrinology. Autoimmune Diseases in Endocrinology 35 75 .
George Carayanniotis. (2007) Recognition of Thyroglobulin by T Cells: The Role of Iodine. Thyroid 17:10, pages 963-973.
Crossref
Labrini PapanastasiouIoannis-Anastasios VatalasDemetrios A. KoutrasGeorge Mastorakos. (2007) Thyroid Autoimmunity in the Current Iodine Environment. Thyroid 17:8, pages 729-739.
Crossref
Haiyan S. Li & George Carayanniotis. (2007) Induction of Goitrous Hypothyroidism by Dietary Iodide in SJL Mice. Endocrinology 148:6, pages 2747-2752.
Crossref
Haiyan S. Li, Hong Y. Jiang & George Carayanniotis. (2007) Modifying effects of iodine on the immunogenicity of thyroglobulin peptides. Journal of Autoimmunity 28:4, pages 171-176.
Crossref
J G Barin, M V Talor, R B Sharma, N R Rose & C L Burek. (2005) Iodination of murine thyroglobulin enhances autoimmune reactivity in the NOD.H2h4 mouse. Clinical and Experimental Immunology 142:2, pages 251-259.
Crossref
Rajni B. Sharma, Judy D. Alegria, Monica V. Talor, Noel R. Rose, Patrizio Caturegli & C. Lynne Burek. (2005) Iodine and IFN-γ Synergistically Enhance Intercellular Adhesion Molecule 1 Expression on NOD.H2h4 Mouse Thyrocytes. The Journal of Immunology 174:12, pages 7740-7745.
Crossref
Zhongtian Jin, Kouki Mori, Keisei Fujimori, Saeko Hoshikawa, Jun-ichi Tani, Jo Satoh, Sadayoshi Ito, Susumu Satomi & Katsumi Yoshida. (2004) Experimental autoimmune thyroiditis in nonobese diabetic mice lacking interferon regulatory factor-1. Clinical Immunology 113:2, pages 187-192.
Crossref
Vincent GeenenGherardo Mazziotti & Marian Elizabeth Ludgate. 2004. Immunoendocrinology in Health and Disease. Immunoendocrinology in Health and Disease 461 490 .
Fabrizio Gentile, Marisa Conte & Silvestro Formisano. (2004) Thyroglobulin as an autoantigen: what can we learn about immunopathogenicity from the correlation of antigenic properties with protein structure?. Immunology 112:1, pages 13-25.
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Stelios Fountoulakis & Agathocles Tsatsoulis. (2004) On the pathogenesis of autoimmune thyroid disease: a unifying hypothesis. Clinical Endocrinology 60:4, pages 397-409.
Crossref
Yang D. Dai, Varada P. Rao & George Carayanniotis. (2002) Enhanced Iodination of Thyroglobulin Facilitates Processing and Presentation of a Cryptic Pathogenic Peptide. The Journal of Immunology 168:11, pages 5907-5911.
Crossref
J Guo, Y Wang, B Rapoport & S M Mclachlan. (2000) Evidence for antigen presentation to sensitized T cells by thyroid peroxidase (TPO)-specific B cells in mice injected with fibroblasts co-expressing TPO and MHC class II. Clinical and Experimental Immunology 119:1, pages 38-46.
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Noel R. Rose, Raphael Bonita & C.Lynne Burek. (2002) Iodine: an environmental trigger of thyroiditis. Autoimmunity Reviews 1:1-2, pages 97-103.
Crossref
A M Saboori, N R Rose & C L Burek. (1998) Iodination of human thyroglobulin (Tg) alters its immunoreactivity. II. Fine specificity of a monoclonal antibody that recognizes iodinated Tg. Clinical and Experimental Immunology 113:2, pages 303-308.
Crossref
A M Saboori, N R Rose, H S Bresler, M Vladut-Talor & C L Burek. (1998) Iodination of human thyroglobulin (Tg) alters its immunoreactivity. I. Iodination alters multiple epitopes of human Tg. Clinical and Experimental Immunology 113:2, pages 297-302.
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Peter A. Graham, Raymond F. Nachreiner, Kent R. Refsal & Anne L. Provencher-Bolliger. (2001) Lymphocytic Thyroiditis. Veterinary Clinics of North America: Small Animal Practice 31:5, pages 915-933.
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Javier I. Torréns & Henry B. Burch. (2001) SERUM THYROGLOBULIN MEASUREMENT. Endocrinology and Metabolism Clinics of North America 30:2, pages 429-467.
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C. Ruwhof & H.A. Drexhage. (2001) Iodine and Thyroid Autoimmune Disease in Animal Models. Thyroid 11:5, pages 427-436.
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Linda Rasooly & Noel R. Rose. 2000. Nutrition and Immunology. Nutrition and Immunology 355 361 .
N.R Rose. (1999) Reflections on tolerance, self-tolerance and Felix Milgrom. Transplantation Proceedings 31:3, pages 1460-1463.
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Noel R. Rose. 1999. The Decade of Autoimmunity. The Decade of Autoimmunity 19 24 .

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