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Autoimmunity Volume 27, 1998 - Issue 4
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Original Article

Iodine is Essential for Human T Cell Recognition of Human Thyroglobulin

Linda Rasooly Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Baltimore, MD, 21205-2196
,
Noel R. Rose Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205-2196; Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Baltimore, MD, 21205-2196
,
Ali M. Saboori Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205-2196
,
Paul W. Ladenson Endocrinology and Metabolic Diseases, John Hopkins Hospital, Baltimore, MD, 21205
&
C. Lynne Burek Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205-2196; Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Baltimore, MD, 21205-2196; Department of Pathology, 648 Ross Research Building/720 Rutland Avenue, Baltimore, MD, 21205-2196
Pages 213-219 | Received 04 Aug 1997, Published online: 07 Jul 2009

References

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  • Sundick R. S., Herdegen D., Brown T. R., Bagchi N. Thyroiditis induced by dietary iodine may be due to the increased immunogenicity of highly iodinated thyroglobulin. The thyroid and autoimmunity, H. A. Drexhage, W. M. Wiersinga. Elsevier Science Publishers. 1986; 213
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  • Akasu F., Morita T., Resetkova E., Yoshikawa N., Cara-Yon P., Volpe R. Sensitization of T lymphocytes to thyroglobulin and thyroperoxidase in autoimmune thyroid diseases. Autoimmunity 1993; 14: 261–268
  • Saboori A. M, Rose N. R., Butscher W. G., Burek C. L. Modification of a nonincinerative method for determination of iodine in iodoproteins. Anal Biochem 1993; 214: 335–8
  • Kong Y. C, McCormick D. J., Wan Q., Motte R. W., Fuller B. E., Giraldo A. A., David C. S. Primary hormonogenic sites as conserved autoepitopes on thyroglobulin in murine autoimmune thyroiditis. Secondary role of iodination. Journal of Immunology 1995; 155: 5847–54

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