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Original Article

Increased Density of Jejunal γδ+ T Cells in Patients Having Normal Mucosa - Marker of Operative Autoimmune Mechanisms?

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Pages 179-187 | Received 11 May 1998, Published online: 07 Jul 2009

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Luca Elli, Federica Branchi, Reena Sidhu, Stefano Guandalini, Asaad Assiri, Firas Rinawi, Raanan Shamir, Prasenjit Das & Govind K Makharia. (2017) Small bowel villous atrophy: celiac disease and beyond. Expert Review of Gastroenterology & Hepatology 11:2, pages 125-138.
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Sari Iltanen, Immo Rantala, Pekka Laippala, Kati Holm, Jukka Partanen & Markku Maki. (1999) Expression of HSP-65 in Jejunal Epithelial Cells in Patients Clinically Suspected of Coeliac Disease. Autoimmunity 31:2, pages 125-132.
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Pekka Collin. (1999) New diagnostic findings in coeliac disease. Annals of Medicine 31:6, pages 399-405.
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Chiara Maria Trovato, Monica Montuori, Francesco Valitutti, Beatrice Leter, Salvatore Cucchiara & Salvatore Oliva. (2019) The Challenge of Treatment in Potential Celiac Disease. Gastroenterology Research and Practice 2019, pages 1-6.
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Alina Popp & Markku Mäki. (2019) Gluten-Induced Extra-Intestinal Manifestations in Potential Celiac Disease—Celiac Trait. Nutrients 11:2, pages 320.
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Zsolt Szakács, Péter Mátrai, Péter Hegyi, Imre Szabó, Áron Vincze, Márta Balaskó, Bernadett Mosdósi, Patrícia Sarlós, Mária Simon, Katalin Márta, Alexandra Mikó, Dániel Pécsi, Alexandra Demcsák & Judit Bajor. (2017) Younger age at diagnosis predisposes to mucosal recovery in celiac disease on a gluten-free diet: A meta-analysis. PLOS ONE 12:11, pages e0187526.
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Henna Pekki, Kalle Kurppa, Markku Mäki, Heini Huhtala, Harri Sievänen, Kaija Laurila, Pekka Collin & Katri Kaukinen. (2015) Predictors and Significance of Incomplete Mucosal Recovery in Celiac Disease After 1 Year on a Gluten-Free Diet. American Journal of Gastroenterology 110:7, pages 1078-1085.
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Ilan Bank & Victoria Marcu-Malina. (2013) Quantitative Peripheral Blood Perturbations of γδ T Cells in Human Disease and Their Clinical Implications. Clinical Reviews in Allergy & Immunology 47:3, pages 311-333.
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Anna Tavakkoli & Benjamin Lebwohl. 2014. Celiac Disease. Celiac Disease 107 122 .
Benjamin Lebwohl, Alberto Rubio-Tapia, Asaad Assiri, Catherine Newland & Stefano Guandalini. (2012) Diagnosis of Celiac Disease. Gastrointestinal Endoscopy Clinics of North America 22:4, pages 661-677.
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Valérie Abadie, Valentina Discepolo & Bana Jabri. (2012) Intraepithelial lymphocytes in celiac disease immunopathology. Seminars in Immunopathology 34:4, pages 551-566.
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S. Husby, S. Koletzko, I.R. Korponay-Szabó, M.L. Mearin, A. Phillips, R. Shamir, R. Troncone, K. Giersiepen, D. Branski, C. Catassi, M. Lelgeman, M. Mäki, C. Ribes-Koninckx, A. Ventura & K.P. Zimmer. (2012) European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease. Journal of Pediatric Gastroenterology & Nutrition 54:1, pages 136-160.
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Alberto Rubio-Tapia, Mussarat W Rahim, Jacalyn A See, Brian D Lahr, Tsung-Teh Wu & Joseph A Murray. (2010) Mucosal Recovery and Mortality in Adults With Celiac Disease After Treatment With a Gluten-Free Diet. American Journal of Gastroenterology 105:6, pages 1412-1420.
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M Borrelli, M Maglio, M Agnese, F Paparo, S Gentile, B Colicchio, A Tosco, R Auricchio & R Troncone. (2010) High density of intraepithelial γδ lymphocytes and deposits of immunoglobulin (Ig)M anti-tissue transglutaminase antibodies in the jejunum of coeliac patients with IgA deficiency. Clinical and Experimental Immunology 160:2, pages 199-206.
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T.T. Salmi, P. Collin, T. Reunala, M. Mäki & K. Kaukinen. (2010) Diagnostic methods beyond conventional histology in coeliac disease diagnosis. Digestive and Liver Disease 42:1, pages 28-32.
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Jonas F Ludvigsson, Lena Brandt & Scott M Montgomery. (2009) Symptoms and signs in individuals with serology positive for celiac disease but normal mucosa. BMC Gastroenterology 9:1.
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Mariantonia MaglioFiorella FlorianMonica VecchietRenata AuricchioFrancesco PaparoRaffaella SpadaroDelia ZanziLuciano RapacciuoloAdriana FranzeseDaniele SblatteroRoberto MarzariRiccardo Troncone. (2009) Majority of Children With Type 1 Diabetes Produce and Deposit Anti-Tissue Transglutaminase Antibodies in the Small Intestine. Diabetes 58:7, pages 1578-1584.
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Antonella Tosco, Maria Maglio, Francesco Paparo, Luciano Rapacciuolo, Anna Sannino, Erasmo Miele, Maria Vittoria Barone, Renata Auricchio & Riccardo Troncone. (2008) Immunoglobulin A Anti-tissue Transglutaminase Antibody Deposits in the Small Intestinal Mucosa of Children With No Villous Atrophy. Journal of Pediatric Gastroenterology & Nutrition 47:3, pages 293-298.
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S. LOHI, K. MUSTALAHTI, K. KAUKINEN, K. LAURILA, P. COLLIN, H. RISSANEN, O. LOHI, E. BRAVI, M. GASPARIN, A. REUNANEN & M. MÄKI. (2007) Increasing prevalence of coeliac disease over time. Alimentary Pharmacology & Therapeutics 26:9, pages 1217-1225.
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A. CARROCCIO, G. CAMPISI, G. IACONO, O. LO. IACONO, E. MARESI, L. DI PRIMA, D. COMPILATO, F. BARBARIA, A. ARINI, C. DI LIBERTO, G. PIRRONE, A. CRAXÌ & V. DI MARCO. (2007) Oral mucosa of coeliac disease patients produces antiendomysial and antitransglutaminase antibodies: the diagnostic usefulness of an in vitro culture system. Alimentary Pharmacology & Therapeutics 25:12, pages 1471-1477.
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T. T. SALMI, P. COLLIN, O. JARVINEN, K. HAIMILA, J. PARTANEN, K. LAURILA, I. R. KORPONAY-SZABO, H. HUHTALA, T. REUNALA, M. MAKI & K. KAUKINEN. (2006) Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming coeliac disease. Alimentary Pharmacology and Therapeutics 24:3, pages 541-552.
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Katri Kaukinen, Markku Maki & Pekka Collin. (2006) Immunohistochemical Features in Antiendomysium Positive Patients with Normal Villous Architecture. The American Journal of Gastroenterology 101:3, pages 675-676.
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Natalia Periolo & Alejandra C. Cherñavsky. (2006) Coeliac disease. Autoimmunity Reviews 5:3, pages 202-208.
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Frits Koning, Detlef Schuppan, Nadine Cerf-Bensussan & Ludvig M. Sollid. (2005) Pathomechanisms in celiac disease. Best Practice & Research Clinical Gastroenterology 19:3, pages 373-387.
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Pekka Collin, Peter J Wahab & Joseph Anthony Murray. (2005) Intraepithelial lymphocytes and coeliac disease. Best Practice & Research Clinical Gastroenterology 19:3, pages 341-350.
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J Kokkonen, K Holm, TJ Karttunen & M Mäki. (2007) Enhanced local immune response in children with prolonged gastrointestinal symptoms. Acta Paediatrica 93:12, pages 1601-1607.
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Renata Auricchio, Francesco Paparo, Maria Maglio, Adriana Franzese, Francesca Lombardi, Giuliana Valerio, Gerardo Nardone, Selvaggia Percopo, Luigi Greco & Riccardo Troncone. (2004) In Vitro–Deranged Intestinal Immune Response to Gliadin in Type 1 Diabetes. Diabetes 53:7, pages 1680-1683.
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S. Iltanen, M. Maki, P. Collin, K. Mustalahti, K. Kaukinen, J. Partanen, J. Hulkkonen, M. Hurme & J. Aittoniemi. (2003) The association between mannan-binding lectin gene alleles and celiac disease. The American Journal of Gastroenterology 98:12, pages 2808-2809.
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Markku Mäki, Kirsi Mustalahti, Jorma Kokkonen, Petri Kulmala, Mila Haapalahti, Tuomo Karttunen, Jorma Ilonen, Kaija Laurila, Ingrid Dahlbom, Tony Hansson, Peter Höpfl & Mikael Knip. (2003) Prevalence of Celiac Disease among Children in Finland. New England Journal of Medicine 348:25, pages 2517-2524.
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Jorma Kokkonen, Tarja Ruuska, Tuomo J. Karttunen & Markku Maki. (2002) Lymphonodular hyperplasia of the terminal ileum associated with colitis shows an increased gammadelta+ T-cell density in children. The American Journal of Gastroenterology 97:3, pages 667-672.
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S ILTANEN, K HOLM, M ASHORN, T RUUSKA, P LAIPPALA & M MÄKI. (1999) Changing jejunal γδ T cell receptor (TCR)-bearing intraepithelial lymphocyte density in coeliac disease. Clinical and Experimental Immunology 117:1, pages 51-55.
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Antonio Carroccio, Francesca Cavataio, Giuseppe Montalto, Francesco Paparo, Riccardo Troncone & Giuseppe Iacono. (2001) Treatment of giardiasis reverses ‘active’ coeliac disease to ‘latent’ coeliac disease. European Journal of Gastroenterology & Hepatology 13:9, pages 1101-1105.
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