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Research Article

Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4

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Pages 768-778 | Received 16 Nov 2011, Accepted 02 Jan 2012, Published online: 03 Feb 2012

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Read on this site (4)

Xiao-yuan Zheng, Shi-ming Yang, Rong Zhang, Su-min Wang, Guo-bing Li & Shi-wen Zhou. (2019) Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes. Drug Design, Development and Therapy 13, pages 3171-3180.
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Shuifang Chen, Zeying Zhang & Jianli Zhang. (2019) Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo. Drug Design, Development and Therapy 13, pages 1145-1153.
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Franziska Trautmann, Monica Cojoc, Ina Kurth, Nicolas Melin, Laure C. Bouchez, Anna Dubrovska & Claudia Peitzsch. (2014) CXCR4 as biomarker for radioresistant cancer stem cells. International Journal of Radiation Biology 90:8, pages 687-699.
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Shailendra Kapoor. (2013) Emodin: inhibitory effects on growth in malignant tumors. Immunopharmacology and Immunotoxicology 35:2, pages 307-307.
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Articles from other publishers (32)

Priyanka S. Lande, Vaibhav S. Adhao, Jaya P. Ambhore, Kiran P. Gaikwad, Chanchal S. Chandak & Leena P. Joge. (2023) Anticancer action of naturally occurring emodin for the controlling of cervical cancer. Exploration of Targeted Anti-tumor Therapy, pages 690-698.
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Na Young Kim, Young Yun Jung, Min Hee Yang, Jae-Young Um, Gautam Sethi & Kwang Seok Ahn. (2022) Isoimperatorin down-regulates epithelial mesenchymal transition through modulating NF-κB signaling and CXCR4 expression in colorectal and hepatocellular carcinoma cells. Cellular Signalling 99, pages 110433.
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Ana Dácil Marrero, Ana R. Quesada, Beatriz Martínez-Poveda & Miguel Ángel Medina. (2022) Antiangiogenic Phytochemicals Constituent of Diet as Promising Candidates for Chemoprevention of Cancer. Antioxidants 11:2, pages 302.
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Ruchi Badoni Semwal, Deepak Kumar Semwal, Sandra Combrinck & Alvaro Viljoen. (2021) Emodin - A natural anthraquinone derivative with diverse pharmacological activities. Phytochemistry 190, pages 112854.
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Esra Küpeli Akkol, Iffet Irem Tatlı, Gökçe Şeker Karatoprak, Osman Tuncay Ağar, Çiğdem Yücel, Eduardo Sobarzo-Sánchez & Raffaele Capasso. (2021) Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin. Cancers 13:11, pages 2733.
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Ho-Sung Lee, In-Hee Lee, Kyungrae Kang, Sang-In Park, Tae-Wook Kwon & Dae-Yeon Lee. (2021) Uncovering the Anti-Lung-Cancer Mechanisms of the Herbal Drug FDY2004 by Network Pharmacology. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-15.
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Premlata K. Ambre, Chandan Rajendra Gupta, Elvis A.F. Martis & Evans C. Coutinho. 2021. Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications. Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications 151 189 .
Yuanshuo Alice Wang, John Sfakianos, Ashutosh K. Tewari, Carlos Cordon-cardo & Natasha Kyprianou. (2020) Molecular tracing of prostate cancer lethality. Oncogene 39:50, pages 7225-7238.
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Young Yun Jung, Jae-Young Um, Acharan S. Narula, Ojas A. Namjoshi, Bruce E. Blough, Alan Prem Kumar & Kwang Seok Ahn. (2020) Identification of Matrine as a Novel Regulator of the CXCR4 Signaling Axis in Tumor Cells. International Journal of Molecular Sciences 21:13, pages 4731.
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Hua-Zhong Ying, Chen-Huan Yu, Hao-Kun Chen, Huan-Huan Zhang, Jie Fang, Fang Wu & Wen-Ying Yu. (2020) Quinonoids: Therapeutic Potential for Lung Cancer Treatment. BioMed Research International 2020, pages 1-13.
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Juan Gu, Chang-fu Cui, Li Yang, Ling Wang & Xue-hua Jiang. (2019) Emodin Inhibits Colon Cancer Cell Invasion and Migration by Suppressing Epithelial‐Mesenchymal Transition via the Wnt/β-Catenin Pathway. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 27:2, pages 193-202.
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Nuno Bernardes & Arsenio Fialho. (2018) Perturbing the Dynamics and Organization of Cell Membrane Components: A New Paradigm for Cancer-Targeted Therapies. International Journal of Molecular Sciences 19:12, pages 3871.
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Guo‑Hua Shi & Lin Zhou. (2018) Emodin suppresses angiogenesis and metastasis in anaplastic thyroid cancer by affecting TRAF6‑mediated pathways in�vivo and in�vitro. Molecular Medicine Reports.
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Naseer Ullah Khan, Hua He, Xiaojuan Wang, Baosheng Ge, Qian Wang, Xu Liu, Jun Lao, Yanan Wang, Jiqiang Li, Zhencai Wang, Shitan Zhou & Fang Huang. (2018) A two-color fluorescence enhanced dot-blot assay for revealing co-operative expression of chemokine receptors in cells. Chemical Communications 54:7, pages 778-781.
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Jin Su, Yan Yan, Jingkun Qu, Xuewen Xue, Zi Liu & Hui Cai. (2017) Emodin induces apoptosis of lung cancer cells through ER stress and the TRIB3/NF-κB pathway. Oncology Reports.
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Qiaomei Zheng, Ying Xu, Jingjing Lu, Jing Zhao, Xuan Wei & Peishu Liu. (2016) Emodin Inhibits Migration and Invasion of Human Endometrial Stromal Cells by Facilitating the Mesenchymal–Epithelial Transition Through Targeting ILK. Reproductive Sciences 23:11, pages 1526-1535.
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Jui-Wen Ma, Chao-Ming Hung, Ying-Chao Lin, Chi-Tang Ho, Jung-Yie Kao & Tzong-Der Way. (2016) Aloe-emodin inhibits HER-2 expression through the downregulation of Y-box binding protein-1 in HER-2-overexpressing human breast cancer cells. Oncotarget 7:37, pages 58915-58930.
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Ashraf Bakkar, Mohammed Alshalalfa, Lars F. Petersen, Hatem Abou-Ouf, Amal Al-Mami, Samar A. Hegazy, Felix Feng, Reda Alhajj, Krikor Bijian, Moulay A. Alaoui-Jamali & Tarek A. Bismar. (2016) microRNA 338-3p exhibits tumor suppressor role and its down-regulation is associated with adverse clinical outcome in prostate cancer patients. Molecular Biology Reports 43:4, pages 229-240.
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B. Anu Monisha, Niraj Kumar & Ashu Bhan Tiku. 2016. Anti-inflammatory Nutraceuticals and Chronic Diseases. Anti-inflammatory Nutraceuticals and Chronic Diseases 47 73 .
Jie-yu Xing, Gao-peng Song, Jun-peng Deng, Ling-zhi Jiang, Ping Xiong, Bin-jie Yang & Shan-shan Liu. (2015) Antitumor Effects and Mechanism of Novel Emodin Rhamnoside Derivatives against Human Cancer Cells In Vitro. PLOS ONE 10:12, pages e0144781.
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Pooja Chandrakant Thacker & Devarajan Karunagaran. (2015) Curcumin and Emodin Down-Regulate TGF-β Signaling Pathway in Human Cervical Cancer Cells. PLOS ONE 10:3, pages e0120045.
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Thacker Pooja & Devarajan Karunagaran. (2014) Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620. European Journal of Pharmacology 742, pages 55-64.
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Richard Schroeder, Cheryl Stevens & Jayalakshmi Sridhar. (2014) Small Molecule Tyrosine Kinase Inhibitors of ErbB2/HER2/Neu in the Treatment of Aggressive Breast Cancer. Molecules 19:9, pages 15196-15212.
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Kathleen L. Arnolds & Juliet V. Spencer. (2014) CXCR4: A virus’s best friend?. Infection, Genetics and Evolution 25, pages 146-156.
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SONGPING XIE, WENHUI ZENG, GUOHUA FAN, JIE HUANG, GANJUN KANG, QING GENG, BANGCHANG CHENG, WEI WANG & PING DONG. (2014) Effect of CXCL12/CXCR4 on increasing the metastatic potential of non-small cell lung cancer in vitro is inhibited through the downregulation of CXCR4 chemokine receptor expression. Oncology Letters 7:4, pages 941-947.
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Jietao Ma, Jiahe Zheng, Yaoyong Li, Shuling Zhang, Dongmei Bai, Huawei Zou & Chengbo Han. (2013) CXCL12 induces lung cancer cell migration by polarized mtDNA redistribution. Human Cell 27:1, pages 22-28.
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WEI-TIAN WEI, SHENG-ZHANG LIN, DIAN-LEI LIU & ZHAO-HONG WANG. (2013) The distinct mechanisms of the antitumor activity of emodin in different types of cancer (Review). Oncology Reports 30:6, pages 2555-2562.
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Deepti Shrimali, Muthu K. Shanmugam, Alan Prem Kumar, Jingwen Zhang, Benny K.H. Tan, Kwang Seok Ahn & Gautam Sethi. (2013) Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer. Cancer Letters 341:2, pages 139-149.
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Kanjoormana Aryan Manu, Muthu K. Shanmugam, Tina H. Ong, Aruljothi Subramaniam, Kodappully Sivaraman Siveen, Ekambaram Perumal, Ramar Perumal Samy, Pradeep Bist, Lina H. K. Lim, Alan Prem Kumar, Kam M. Hui & Gautam Sethi. (2013) Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular Carcinoma. PLoS ONE 8:3, pages e57015.
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Jean de Dieu Tamokou, Jean Rodolphe Chouna, Eva Fischer-Fodor, Gabriela Chereches, Otilia Barbos, Grigore Damian, Daniela Benedec, Mihaela Duma, Alango Pépin Nkeng Efouet, Hippolyte Kamdem Wabo, Jules Roger Kuiate, Augustin Mot & Radu Silaghi-Dumitrescu. (2013) Anticancer and Antimicrobial Activities of Some Antioxidant-Rich Cameroonian Medicinal Plants. PLoS ONE 8:2, pages e55880.
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Barbara Mognetti, Giuseppe La Montagna, Maria Giulia Perrelli, Pasquale Pagliaro & Claudia Penna. (2013) Bone marrow mesenchymal stem cells increase motility of prostate cancer cells via production of stromal cell-derived factor-1 α . Journal of Cellular and Molecular Medicine 17:2, pages 287-292.
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Ean-Jeong Seo, Victor Kuete, Onat Kadioglu, Benjamin Krusche, Sven Schröder, Henry Johannes Greten, Joachim Arend, Ik-Soo Lee & Thomas Efferth. (2013) Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-13.
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