Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4

References

• Steeg, P.S. Metastasis suppressors alter the signal transduction of cancer cells. Nat Rev Cancer 2003, 3, 55–63.
   PubMed Web of Science ®Google Scholar
• Richmond, A. Nf-kappa B, chemokine gene transcription and tumour growth. Nat Rev Immunol 2002, 2, 664–674.
   PubMed Web of Science ®Google Scholar
• Balkwill, F. Cancer and the chemokine network. Nat Rev Cancer 2004, 4, 540–550.
   PubMed Web of Science ®Google Scholar
• Kruizinga, R.C.,Bestebroer, J., Berghuis, P., de Haas, C.J.,Links, T.P., de Vries, E.G., Walenkamp, A.M. Role of chemokines and their receptors in cancer. Curr Pharm Des 2009, 15, 3396–3416.
   PubMed Web of Science ®Google Scholar
• Lazennec, G., Richmond, A. Chemokines and chemokine receptors: new insights into cancer-related inflammation. Trends Mol Med 2010, 16, 133–144.
   PubMed Web of Science ®Google Scholar
• Teicher, B.A., Fricker, S.P. CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 2010, 16, 2927–2931.
   PubMed Web of Science ®Google Scholar
• Kucia, M., Jankowski, K., Reca, R., Wysoczynski, M., Bandura, L., Allendorf, D.J., Zhang, J., Ratajczak, J., Ratajczak, M.Z. CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol 2004, 35, 233–245.
   PubMed Web of Science ®Google Scholar
• Kucia, M., Reca, R., Miekus, K., Wanzeck, J., Wojakowski, W., Janowska-Wieczorek, A., Ratajczak, J., Ratajczak, M.Z. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells 2005, 23, 879–894.
   PubMed Web of Science ®Google Scholar
• Taichman, R.S., Cooper, C., Keller, E.T., Pienta, K.J., Taichman, N.S., McCauley, L.K. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res 2002, 62, 1832–1837.
   PubMed Web of Science ®Google Scholar
• Phillips, R.J., Burdick, M.D., Lutz, M., Belperio, J.A., Keane, M.P., Strieter, R.M. The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am J Respir Crit Care Med 2003, 167, 1676–1686.
   PubMed Web of Science ®Google Scholar
• Andre, F., Cabioglu, N., Assi, H., Sabourin, J.C., Delaloge, S., Sahin, A., Broglio, K., Spano, J.P., Combadiere, C., Bucana, C., Soria, J.C., Cristofanilli, M.. Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer. Ann Oncol 2006, 17, 945–951.
   PubMed Web of Science ®Google Scholar
• Marchesi, F., Monti, P., Leone, B.E., Zerbi, A., Vecchi, A., Piemonti, L., Mantovani, A., Allavena, P. Increased survival, proliferation, and migration in metastati c human pancreatic tumor cells expressing functional CXCR4. Cancer Res 2004, 64, 8420–8427.
   PubMed Web of Science ®Google Scholar
• Porcile, C., Bajetto, A., Barbero, S., Pirani, P., Schettini, G. CXCR4 activation induces epidermal growth factor receptor transactivation in an ovarian cancer cell line. Ann N Y Acad Sci 2004, 1030, 162–169.
   PubMedGoogle Scholar
• Hernandez, P.A., Gorlin, R.J., Lukens, J.N., Taniuchi, S., Bohinjec, J., Francois, F., Klotman, M.E., Diaz, G.A. Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease. Nat Genet 2003, 34, 70–74.
   PubMed Web of Science ®Google Scholar
• Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S., Kitamura, Y., Yoshida, N., Kikutani, H., Kishimoto, T. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1996, 382, 635–638.
   PubMed Web of Science ®Google Scholar
• Knaut, H., Werz, C., Geisler, R., Nüsslein-Volhard, C.; Tübingen 2000 Screen Consortium. A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor. Nature 2003, 421, 279–282.
   PubMed Web of Science ®Google Scholar
• Kunwar, P.S., Lehmann, R. Developmental biology: Germ-cell attraction. Nature 2003, 421, 226–227.
   Google Scholar
• Connor, R.I., Sheridan, K.E., Ceradini, D., Choe, S., Landau, N.R. Change in coreceptor use correlates with disease progression in HIV-1–infected individuals. J Exp Med 1997, 185, 621–628.
   PubMed Web of Science ®Google Scholar
• Scarlatti, G., Tresoldi, E., Björndal, A., Fredriksson, R., Colognesi, C., Deng, H.K., Malnati, M.S., Plebani, A., Siccardi, A.G., Littman, D.R., Fenyö, E.M., Lusso, P. In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression. Nat Med 1997, 3, 1259–1265.
   PubMed Web of Science ®Google Scholar
• Li, Y.M., Pan, Y., Wei, Y., Cheng, X., Zhou, B.P., Tan, M., Zhou, X., Xia, W., Hortobagyi, G.N., Yu, D., Hung, M.C. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell 2004, 6, 459–469.
   PubMed Web of Science ®Google Scholar
• Zeelenberg, I.S., Ruuls-Van Stalle, L., Roos, E. The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. Cancer Res 2003, 63, 3833–3839.
   PubMed Web of Science ®Google Scholar
• Proudfoot, A.E. Chemokine receptors: multifaceted therapeutic targets. Nat Rev Immunol 2002, 2, 106–115.
   PubMed Web of Science ®Google Scholar
• Goel, R.K., Das Gupta, G., Ram, S.N., Pandey, V.B. Antiulcerogenic and anti-inflammatory effects of emodin, isolated from Rhamnus triquerta wall. Indian J Exp Biol 1991, 29, 230–232.
   PubMed Web of Science ®Google Scholar
• Kumar, A., Dhawan, S., Aggarwal, B.B. Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells. Oncogene 1998, 17, 913–918.
   PubMed Web of Science ®Google Scholar
• Lin, M.L., Lu, Y.C., Chung, J.G., Li, Y.C., Wang, S.G., N.G, S.H., Wu, C.Y., Su, H.L., Chen, S.S. Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway. Cancer Lett 2010, 291, 46–58.
   PubMed Web of Science ®Google Scholar
• Ko, J.C., Su, Y.J., Lin, S.T., Jhan, J.Y., Ciou, S.C., Cheng, C.M., Lin, Y.W. Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells. Biochem Pharmacol 2010, 79, 655–664.
   PubMed Web of Science ®Google Scholar
• Lu, G.D., Shen, H.M., Chung, M.C., Ong, C.N. Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells. Carcinogenesis 2007, 28, 1937–1945.
   Google Scholar
• Xue, J., Ding, W., Liu, Y. Anti-diabetic effects of emodin involved in the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice. Fitoterapia 2010, 81, 173–177.
   PubMed Web of Science ®Google Scholar
• Lu, Y., Yang, J.H., Li, X., Hwangbo, K., Hwang, S.L., Taketomi, Y., Murakami, M., Chang, Y.C., Kim, C.H., Son, J.K., Chang, H.W. Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. Biochem Pharmacol 2011, 82, 1700–1708.
   PubMed Web of Science ®Google Scholar
• Ahn, K.S., Sethi, G., Chao, T.H., Neuteboom, S.T., Chaturvedi, M.M., Palladino, M.A., Younes, A., Aggarwal, B.B. Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products. Blood 2007, 110, 2286–2295.
   PubMed Web of Science ®Google Scholar
• Su, Y.T., Chang, H.L., Shyue, S.K., Hsu, S.L. Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Biochem Pharmacol 2005, 70, 229–241.
   PubMed Web of Science ®Google Scholar
• Chen, R.S., Jhan, J.Y., Su, Y.J., Lee, W.T., Cheng, C.M., Ciou, S.C., Lin, S.T., Chuang, S.M., Ko, J.C., Lin, Y.W. Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation. Exp Cell Res 2009, 315, 2658–2672.
   PubMedGoogle Scholar
• Su, Y.J., Tsai, M.S., Kuo, Y.H., Chiu, Y.F., Cheng, C.M., Lin, S.T., Lin, Y.W. Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells. Mol Pharmacol 2010, 77, 633–643.
   Google Scholar
• Fernandis, A.Z., Prasad, A., Band, H., Klösel, R., Ganju, R.K. Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells. Oncogene 2004, 23, 157–167.
   PubMed Web of Science ®Google Scholar
• Chinni, S.R., Yamamoto, H., Dong, Z., Sabbota, A., Bonfil, R.D., Cher, M.L. CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone. Mol Cancer Res 2008, 6, 446–457.
   PubMed Web of Science ®Google Scholar
• Gangadhar, T., Nandi, S., Salgia, R. The role of chemokine receptor CXCR4 in lung cancer. Cancer Biol Ther 2010, 9, 409–416.
   PubMedGoogle Scholar
• Marchese, A., Benovic, J.L. Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting. J Biol Chem 2001, 276, 45509–45512.
   PubMed Web of Science ®Google Scholar
• Bhandari, D., Trejo, J., Benovic, J.L., Marchese, A. Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. J Biol Chem 2007, 282, 36971–36979.
   PubMed Web of Science ®Google Scholar
• Kukreja, P., Abdel-Mageed, A.B., Mondal, D., Liu, K., Agrawal, K.C. Up-regulation of CXCR4 expression in PC-3 cells by stromal-derived factor-1alpha (CXCL12) increases endothelial adhesion and transendothelial migration: role of MEK/ERK signaling pathway-dependent NF-kappaB activation. Cancer Res 2005, 65, 9891–9898.
   PubMed Web of Science ®Google Scholar
• Shanmugam, M.K., Rajendran, P., Li, F., Nema, T., Vali, S., Abbasi, T., Kapoor, S., Sharma, A., Kumar, A.P., Ho, P.C., Hui, K.M., Sethi, G. Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. J Mol Med 2011, 89, 713–727.
   PubMed Web of Science ®Google Scholar
• Lee, B.C., Lee, T.H., Avraham, S., Avraham, H.K. Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells. Mol Cancer Res 2004, 2, 327–338.
   PubMed Web of Science ®Google Scholar
• Murphy, P.M. Chemokines and the molecular basis of cancer metastasis. N Engl J Med 2001, 345, 833–835.
   PubMed Web of Science ®Google Scholar
• Uchida, D., Begum, N.M., Almofti, A., Nakashiro, K., Kawamata, H., Tateishi, Y., Hamakawa, H., Yoshida, H., Sato, M. Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma. Exp Cell Res 2003, 290, 289–302.
   PubMedGoogle Scholar
• Gschwind, A., Prenzel, N., Ullrich, A. Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation. Cancer Res 2002, 62, 6329–6336.
   PubMed Web of Science ®Google Scholar
• Schioppa, T., Uranchimeg, B., Saccani, A., Biswas, S.K., Doni, A., Rapisarda, A., Bernasconi, S., Saccani, S., Nebuloni, M., Vago, L., Mantovani, A., Melillo, G., Sica, A. Regulation of the chemokine receptor CXCR4 by hypoxia. J Exp Med 2003, 198, 1391–1402.
   PubMed Web of Science ®Google Scholar
• Helbig, G., Christopherson, K.W. 2nd, Bhat-Nakshatri, P., Kumar, S., Kishimoto, H., Miller, K.D., Broxmeyer, H.E., Nakshatri, H. NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem 2003, 278, 21631–21638.
   PubMed Web of Science ®Google Scholar
• Bachelder, R.E., Wendt, M.A., Mercurio, A.M. Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res 2002, 62, 7203–7206.
   PubMed Web of Science ®Google Scholar
• Castellone, M.D., Guarino, V., De Falco, V., Carlomagno, F., Basolo, F., Faviana, P., Kruhoffer, M., Orntoft, T., Russell, J.P., Rothstein, J.L., Fusco, A., Santoro, M., Melillo, R.M. Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas. Oncogene 2004, 23, 5958–5967.
   PubMed Web of Science ®Google Scholar
• Tomescu, O., Xia, S.J., Strezlecki, D., Bennicelli, J.L., Ginsberg, J., Pawel, B., Barr, F.G. Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression. Lab Invest 2004, 84, 1060–1070.
   PubMed Web of Science ®Google Scholar
• Roes, J., Choi, B.K., Cazac, B.B. Redirection of B cell responsiveness by transforming growth factor beta receptor. Proc Natl Acad Sci USA 2003, 100, 7241–7246.
   Google Scholar
• Staller, P., Sulitkova, J., Lisztwan, J., Moch, H., Oakeley, E.J., Krek, W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003, 425, 307–311.
   PubMed Web of Science ®Google Scholar
• Zhou, B.P., Hu, M.C., Miller, S.A., Yu, Z., Xia, W., Lin, S.Y., Hung, M.C. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway. J Biol Chem 2000, 275, 8027–8031.
   PubMedGoogle Scholar
• Huang, Q., Shen, H.M., Ong, C.N. Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB. Biochem Pharmacol 2004, 68, 361–371.
   PubMed Web of Science ®Google Scholar
• Cabioglu, N., Sahin, A., Doucet, M., Yavuz, E., Igci, A., O Yildirim, E., Aktas, E., Bilgic, S., Kiran, B., Deniz, G., Price, J.E. Chemokine receptor CXCR4 expression in breast cancer as a potential predictive marker of isolated tumor cells in bone marrow. Clin Exp Metastasis 2005, 22, 39–46.
   PubMedGoogle Scholar
• Kang, H., Watkins, G., Douglas-Jones, A., Mansel, R.E., Jiang, W.G. The elevated level of CXCR4 is correlated with nodal metastasis of human breast cancer. Breast 2005, 14, 360–367.
   PubMed Web of Science ®Google Scholar
• Jung, S.J., Kim, C.I., Park, C.H., Chang, H.S., Kim, B.H., Choi, M.S., Jung, H.R. Correlation between Chemokine Receptor CXCR4 Expression and Prognostic Factors in Patients with Prostate Cancer. Korean J Urol 2011, 52, 607–611.
   Google Scholar
• Otsuka, S., Klimowicz, A.C., Kopciuk, K., Petrillo, S.K., Konno, M., Hao, D., Muzik, H., Stolte, E., Boland, W., Morris, D., Magliocco, A.M., Bebb, D.G. CXCR4 overexpression is associated with poor outcome in females diagnosed with stage IV non-small cell lung cancer. J Thorac Oncol 2011, 6, 1169–1178.
   PubMed Web of Science ®Google Scholar
• Chun-Guang, W., Jun-Qing, Y., Bei-Zhong, L., Dan-Ting, J., Chong, W., Liang, Z., Dan, Z., Yan, W. Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo. Eur J Pharmacol 2010, 627, 33–41.
   Google Scholar