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Immunopharmacology and Immunotoxicology Volume 34, 2012 - Issue 5
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Research Article

PEGylation is effective in reducing immunogenicity, immunotoxicity, and hepatotoxicity of α-momorcharin in vivo

Jue-cun Zheng
,
Ning LeiDepartment of Chemical and Pharmaceutical Engineering, Chengdu University of Technology, Chengdu, PR China
,
Qian-chuan HeSchool of Public Health, University of North Carolina at Chapel Hill, NC, USA
,
Wei HuDepartment of Internal Medicine, Hospital of Wuhan University, Wuhan, PR China
,
Ja-Gui JinSchool of Medical Laboratory Science, Chengdu Medical College, Chengdu, PR China
,
Yao MengSchool of Medical Laboratory Science, Chengdu Medical College, Chengdu, PR China
,
Nian-hua DengSchool of Medical Laboratory Science, Chengdu Medical College, Chengdu, PR China
,
Yan-Fa MengKey Laboratory of Bio-Resources and Eco-Environment Ministry of Education/Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, PR China
,
Chong-Jie ZhangDepartment of Immunology, College of Preclinical and Forensic Medicine, Sichuan University, Chengdu, PR China
&
Fu-bing ShenSchool of Medical Laboratory Science, Chengdu Medical College, Chengdu, PR ChinaCorrespondence[email protected] [email protected] [email protected]
 show all
Pages 866-873 | Received 17 Dec 2011, Accepted 13 Feb 2012, Published online: 23 Mar 2012

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Nianhua Deng, Yun Sun, Mengling Liu, Qianchuan He, Ling Wang, Yu Zhang, Wenkui Sun, Ning Lei, Yang Liu, Yingxia Luo & Fubing Shen. (2019) Alpha-momorcharin regulates cytokine expression and induces apoptosis in monocytes. Immunopharmacology and Immunotoxicology 41:2, pages 258-266.
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Nian-hua Deng, Ling Wang, Qian-chuan He, Jue-cun Zheng, Yao Meng, Yan-Fa Meng, Chong-Jie Zhang & Fu-bing Shen. (2016) PEGylation alleviates the non-specific toxicities of Alpha-Momorcharin and preserves its antitumor efficacy in vivo. Drug Delivery 23:1, pages 95-100.
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Yushu Chen, Li Gong, Ning Gao, Jichun Liao, Jiayu Sun, Yuqing Wang, Lei Wang, Pengjin Zhu, Qing Fan, Yongqiang Andrew Wang, Wen Zeng, Hui Mao, Lily Yang & Fabao Gao. (2015) Preclinical evaluation of a urokinase plasminogen activator receptor-targeted nanoprobe in rhesus monkeys. International Journal of Nanomedicine 10, pages 6689-6698.
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Bryan D. Fleming & Mitchell Ho. (2020) Development of Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer: An Update. Biomolecules 10:6, pages 934.
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Ching-Dong Chang, Ping-Yuan Lin, Yo-Chia Chen, Han-Hsiang Huang & Wen-Ling Shih. (2017) Novel purification method and antibiotic activity of recombinant Momordica charantia MAP30. 3 Biotech 7:1.
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Ling Wang, Fubing Shen, Min Zhang, Qianchuan He, Hui Zhao, Xiaoping Yu, Shuxia Yang, Yang Liu, Nianhua Deng, Juecun Zheng, Lixia Zhu & Xiaolan Liu. (2016) Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endocytosis and JNK activation. Toxicology 357-358, pages 33-43.
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Shuzhen Wang, Zhiliang Li, Shiming Li, Rong Di, Chi-Tang Ho & Guliang Yang. (2016) Ribosome-inactivating proteins (RIPs) and their important health promoting property. RSC Advances 6:52, pages 46794-46805.
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Marianela González, Victoria A. Vaillard & Santiago E. Vaillard. 2015. Handbook of Polymers for Pharmaceutical Technologies. Handbook of Polymers for Pharmaceutical Technologies 51 99 .
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Qimeng Mu, Tao Hu & Jingkai Yu. (2013) Molecular Insight into the Steric Shielding Effect of PEG on the Conjugated Staphylokinase: Biochemical Characterization and Molecular Dynamics Simulation. PLoS ONE 8:7, pages e68559.
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