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Research Article

PEGylation is effective in reducing immunogenicity, immunotoxicity, and hepatotoxicity of α-momorcharin in vivo

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Pages 866-873 | Received 17 Dec 2011, Accepted 13 Feb 2012, Published online: 23 Mar 2012

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Nianhua Deng, Yun Sun, Mengling Liu, Qianchuan He, Ling Wang, Yu Zhang, Wenkui Sun, Ning Lei, Yang Liu, Yingxia Luo & Fubing Shen. (2019) Alpha-momorcharin regulates cytokine expression and induces apoptosis in monocytes. Immunopharmacology and Immunotoxicology 41:2, pages 258-266.
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Nian-hua Deng, Ling Wang, Qian-chuan He, Jue-cun Zheng, Yao Meng, Yan-Fa Meng, Chong-Jie Zhang & Fu-bing Shen. (2016) PEGylation alleviates the non-specific toxicities of Alpha-Momorcharin and preserves its antitumor efficacy in vivo. Drug Delivery 23:1, pages 95-100.
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Yushu Chen, Li Gong, Ning Gao, Jichun Liao, Jiayu Sun, Yuqing Wang, Lei Wang, Pengjin Zhu, Qing Fan, Yongqiang Andrew Wang, Wen Zeng, Hui Mao, Lily Yang & Fabao Gao. (2015) Preclinical evaluation of a urokinase plasminogen activator receptor-targeted nanoprobe in rhesus monkeys. International Journal of Nanomedicine 10, pages 6689-6698.
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Shuzhen Wang, Qian Liu, Ting Zeng, Jianfeng Zhan, Hui Zhao, Chi-Tang Ho, Yunli Xiao & Shiming Li. (2022) Immunomodulatory effects and associated mechanisms of Momordica charantia and its phytochemicals . Food & Function 13:23, pages 11986-11998.
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Bryan D. Fleming & Mitchell Ho. (2020) Development of Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer: An Update. Biomolecules 10:6, pages 934.
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Jia-Qi Lu, Zhen-Ning Zhu, Yong-Tang Zheng & Pang-Chui Shaw. (2020) Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties. Toxins 12:3, pages 167.
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Lisandra Herrera Belén, Carlota de Oliveira Rangel-Yagui, Jorge F. Beltrán Lissabet, Brian Effer, Manuel Lee-Estevez, Adalberto Pessoa, Rodrigo L. Castillo & Jorge G. Farías. (2019) From Synthesis to Characterization of Site-Selective PEGylated Proteins. Frontiers in Pharmacology 10.
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Ying-Jie Chen, Jia-Qian Zhu, Xiu-Qiong Fu, Tao Su, Ting Li, Hui Guo, Pei-Li Zhu, Sally Kin-Wah Lee, Hua Yu, Anfernee Kai-Wing Tse & Zhi-Ling Yu. (2019) Ribosome-Inactivating Protein α-Momorcharin Derived from Edible Plant Momordica charantia Induces Inflammatory Responses by Activating the NF-kappaB and JNK Pathways. Toxins 11:12, pages 694.
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Karen T. Valencia-Rivero, Juan C. Cruz, Nicolle Wagner-Gutierrez, Antonio D’Amore, Maria C. Miranda, Rocío López, Albert Guerrero, William Wagner, Néstor Sandoval & Juan C. Briceño. (2019) Evaluation of Microscopic Structure−Function Relationships of PEGylated Small Intestinal Submucosa Vascular Grafts for Arteriovenous Connection. ACS Applied Bio Materials 2:9, pages 3706-3721.
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Bryan J. Jones, Advitiya Mahajan & Alptekin Aksan. (2019) Dextranol: An inert xeroprotectant. PLOS ONE 14:9, pages e0222006.
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A. R. Satvik Iyengar & Abhay H. Pande. (2019) Is Human Paraoxonase 1 the Saviour Against the Persistent Threat of Organophosphorus Nerve Agents?. Protein & Peptide Letters 26:7, pages 471-478.
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Navneet Kaur, Prakash Kumar Sinha & Girish Sahni. (2019) Site-specific PEGylation of micro-plasmin for improved thrombolytic therapy through engineering enhanced resistance against serpin mediated inhibition. PLOS ONE 14:5, pages e0217234.
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Eun Seo Choi, Jihyeon Song, Yoon Young Kang & Hyejung Mok. (2019) Mannose‐Modified Serum Exosomes for the Elevated Uptake to Murine Dendritic Cells and Lymphatic Accumulation. Macromolecular Bioscience, pages 1900042.
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Weijia Han, Qiao Wu, Xiaohui Zhang & Zhongping Duan. (2019) Innovation for hepatotoxicity in vitro research models: A review. Journal of Applied Toxicology 39:1, pages 146-162.
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Wenkui Sun, Jinghui Sun, Haowen Zhang, Yanfa Meng, Linli Li, Gangrui Li, Xu Zhang & Yao Meng. (2018) Chemosynthesis and characterization of site-specific N-terminally PEGylated Alpha-momorcharin as apotential agent. Scientific Reports 8:1.
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Takashi Imada, Koji Moriya, Masahiko Uchiyama, Naoto Inukai, Mitsuhiro Hitotsuyanagi, Akiko Masuda, Takehiro Suzuki, Shotaro Ayukawa, Yo-ichi Tagawa, Naoshi Dohmae, Michinori Kohara, Masayuki Yamamura & Daisuke Kiga. (2018) A Highly Bioactive Lys-Deficient IFN Leads to a Site-Specific Di-PEGylated IFN with Equivalent Bioactivity to That of Unmodified IFN-α2b. ACS Synthetic Biology 7:11, pages 2537-2546.
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Ching-Dong Chang, Ping-Yuan Lin, Yo-Chia Chen, Han-Hsiang Huang & Wen-Ling Shih. (2017) Novel purification method and antibiotic activity of recombinant Momordica charantia MAP30. 3 Biotech 7:1.
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Saumya Roy, Jun Y. Axup, Jane S. Forsyth, Rajib K. Goswami, Benjamin M. Hutchins, Krishna M. Bajuri, Stephanie A. Kazane, Vaughn V. Smider, Brunhilde H. Felding & Subhash C. Sinha. (2017) SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth. Chemical Communications 53:30, pages 4234-4237.
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Ling Wang, Fubing Shen, Min Zhang, Qianchuan He, Hui Zhao, Xiaoping Yu, Shuxia Yang, Yang Liu, Nianhua Deng, Juecun Zheng, Lixia Zhu & Xiaolan Liu. (2016) Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endocytosis and JNK activation. Toxicology 357-358, pages 33-43.
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Shuzhen Wang, Zhiliang Li, Shiming Li, Rong Di, Chi-Tang Ho & Guliang Yang. (2016) Ribosome-inactivating proteins (RIPs) and their important health promoting property. RSC Advances 6:52, pages 46794-46805.
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Marianela González, Victoria A. Vaillard & Santiago E. Vaillard. 2015. Handbook of Polymers for Pharmaceutical Technologies. Handbook of Polymers for Pharmaceutical Technologies 51 99 .
Dongliang Cao, Yun Sun, Ling Wang, Qianchuan He, Juecun Zheng, Fei Deng, Shanshan Deng, ShuChing Chang, XiaoPing Yu, Minhui Li, Yao Meng, Jiagui Jin & Fubing Shen. (2015) Alpha-momorcharin (α-MMC) exerts effective anti-human breast tumor activities but has a narrow therapeutic window in vivo. Fitoterapia 100, pages 139-149.
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Qimeng Mu, Tao Hu & Jingkai Yu. (2013) Molecular Insight into the Steric Shielding Effect of PEG on the Conjugated Staphylokinase: Biochemical Characterization and Molecular Dynamics Simulation. PLoS ONE 8:7, pages e68559.
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