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Short Communication

Biologically relevant doses of mixed aflatoxins B and G up-regulate MyD88, TLR2, TLR4 and CD14 transcripts in human PBMCs

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Pages 528-532 | Received 09 Mar 2013, Accepted 06 May 2013, Published online: 21 Jun 2013

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Jalil Mehrzad, Taghi Zahraei Salehi, Alireza Khosravi, Saman Hosseinkhani, Yaser Tahamtani, Ensiyeh Hajizadeh-Saffar, Maedeh Moazenchi & Amir Mohammad Malvandi. (2023) Environmentally occurring aflatoxins B1 and M1 notifyably harms pancreatic islets. Toxin Reviews 42:1, pages 51-60.
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Sajad Najafi, Gholamreza Mohammadi, Mehrdad Mohri, Saman Hosseinkhani & Jalil Mehrzad. (2020) Colostrum fails to prevent bovine/camelid neonatal neutrophil damage from AFB1. Journal of Immunotoxicology 17:1, pages 43-50.
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Masumeh Taheri, Jalil Mehrzad, Reza Afshari, Massoud Saleh-Moghaddam & Mohamad Hosein Mahmudy Gharaie. (2016) Inorganic arsenic can be potent granulotoxin in mammalian neutrophils in vitro. Journal of Immunotoxicology 13:5, pages 686-693.
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Abbas Bahari, Jalil Mehrzad, Mahmoud Mahmoudi, Mohammad Reza Bassami & Hesam Dehghani. (2015) GST-M1 is transcribed moreso than AKR7A2 in AFB1-exposed human monocytes and lymphocytes. Journal of Immunotoxicology 12:2, pages 194-198.
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Jalil Mehrzad, Bert Devriendt, Kim Baert & Eric Cox. (2015) Aflatoxins of type B and G affect porcine dendritic cell maturation in vitro. Journal of Immunotoxicology 12:2, pages 174-180.
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Abbas Bahari, Jalil Mehrzad, Mahmoud Mahmoudi, Mohammad Reza Bassami & Hesam Dehghani. (2014) Cytochrome P450 isoforms are differently up-regulated in aflatoxin B1-exposed human lymphocytes and monocytes. Immunopharmacology and Immunotoxicology 36:1, pages 1-10.
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Jalil Mehrzad, Mojgan Milani & Mahmoud Mahmoudi. (2013) Naturally occurring level of mixed aflatoxins B and G stimulate toll-like receptor-4 in bovine mononuclear cells. Veterinary Quarterly 33:4, pages 186-190.
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Articles from other publishers (23)

Jing Zhang, Yong Fang, Yutong Fu, Sangita Jalukar, Jinglin Ma, Yanrong Liu, Yongpeng Guo, Qiugang Ma, Cheng Ji & Lihong Zhao. (2023) Yeast polysaccharide mitigated oxidative injury in broilers induced by mixed mycotoxins via regulating intestinal mucosal oxidative stress and hepatic metabolic enzymes. Poultry Science 102:9, pages 102862.
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Liwen Zhang, Dong Cheng, Jing Zhang, Hui Tang, Fenghua Li, Yi Peng, Xinglan Duan, En Meng, Cuili Zhang, Tao Zeng, Fuyong Song, Jia-Sheng Wang, Xiulan Zhao & Jun Zhou. (2023) Role of macrophage AHR/TLR4/STAT3 signaling axis in the colitis induced by non-canonical AHR ligand aflatoxin B1. Journal of Hazardous Materials 452, pages 131262.
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Hongwei Guo, Ping Wang, Chaoqi Liu, Ting Zhou, Juan Chang, Qingqiang Yin, Lijun Wang, Sanjun Jin, Qun Zhu & Fushan Lu. (2022) Effects of Compound Mycotoxin Detoxifier on Alleviating Aflatoxin B1-Induced Inflammatory Responses in Intestine, Liver and Kidney of Broilers. Toxins 14:10, pages 665.
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Silvia Iori, Marianna Pauletto, Irene Bassan, Federico Bonsembiante, Maria Elena Gelain, Anisa Bardhi, Andrea Barbarossa, Anna Zaghini, Mauro Dacasto & Mery Giantin. (2022) Deepening the Whole Transcriptomics of Bovine Liver Cells Exposed to AFB1: A Spotlight on Toll-like Receptor 2. Toxins 14:7, pages 504.
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Amir Mohammad Malvandi, Sara Shahba, Jalil Mehrzad & Giovanni Lombardi. (2022) Metabolic Disruption by Naturally Occurring Mycotoxins in Circulation: A Focus on Vascular and Bone Homeostasis Dysfunction. Frontiers in Nutrition 9.
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Hong-Wei Guo, Juan Chang, Ping Wang, Qing-Qiang Yin, Chao-Qi Liu, Xiao-Xiang Xu, Xiao-Wei Dang, Xiao-Fei Hu & Quan-Liang Wang. (2021) Effects of compound probiotics and aflatoxin-degradation enzyme on alleviating aflatoxin-induced cytotoxicity in chicken embryo primary intestinal epithelium, liver and kidney cells. AMB Express 11:1.
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Xingyao Pei, Wenjuan Zhang, Haiyang Jiang, Dingkuo Liu, Xinyu Liu, Liuan Li, Cun Li, Xilong Xiao, Shusheng Tang & Daowen Li. (2021) Food-Origin Mycotoxin-Induced Neurotoxicity: Intend to Break the Rules of Neuroglia Cells. Oxidative Medicine and Cellular Longevity 2021, pages 1-14.
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Rahim Khan, Farinazleen Mohamad Ghazali, Nor Ainy Mahyudin & Nik Iskandar Putra Samsudin. (2021) Aflatoxin Biosynthesis, Genetic Regulation, Toxicity, and Control Strategies: A Review. Journal of Fungi 7:8, pages 606.
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Sara Shahba, Jalil Mehrzad & Amir Mohammad Malvandi. (2021) Neuroimmune disruptions from naturally occurring levels of mycotoxins. Environmental Science and Pollution Research 28:25, pages 32156-32176.
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Ling Zhao, Jiang Deng, Li-Bao Ma, Wan-Po Zhang, Mahmoud Mohamed Khalil, Niel Alexander Karrow, De-Sheng Qi & Lv-Hui Sun. (2021) Dietary Se deficiency dysregulates metabolic and cell death signaling in aggravating the AFB1 hepatotoxicity of chicks. Food and Chemical Toxicology 149, pages 111938.
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Jalil Mehrzad. 2021. Toxicology. Toxicology 165 179 .
Nahid Vatanpour, Javad Feizy, Hossein Hedayati Talouki, Zarrin Es’haghi, Laura Scesi & Amir Mohammad Malvandi. (2020) The high levels of heavy metal accumulation in cultivated rice from the Tajan river basin: Health and ecological risk assessment. Chemosphere 245, pages 125639.
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Noreddine Benkerroum. (2020) Chronic and Acute Toxicities of Aflatoxins: Mechanisms of Action. International Journal of Environmental Research and Public Health 17:2, pages 423.
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Amir Mohammad Malvandi, Cristian Loretelli, Moufida Ben Nasr, Gian Vincenzo Zuccotti & Paolo Fiorina. (2019) Sitagliptin favorably modulates immune-relevant pathways in human beta cells. Pharmacological Research 148, pages 104405.
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P. Vahidi-FerdowsiJ. MehrzadA.M. MalvandiS. Hosseinkhani. (2018) Bioluminescence-based detection of astrocytes apoptosis and ATP depletion induced by biologically relevant level aflatoxin B 1 . World Mycotoxin Journal 11:4, pages 589-598.
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Jalil Mehrzad, Abbas Bahari, Mohammad Reza Bassami, Mahmoud Mahmoudi & Hesam Dehghani. (2018) Immunobiologically relevant level of aflatoxin B1 alters transcription of key functional immune genes, phagocytosis and survival of human dendritic cells. Immunology Letters 197, pages 44-52.
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Fengyuan Wang, Zhicai Zuo, Kejie Chen, Caixia Gao, Zhuangzhi Yang, Song Zhao, Jianzhen Li, Hetao Song, Xi Peng, Jing Fang, Hengmin Cui, Ping Ouyang, Yi Zhou, Gang Shu & Bo Jing. (2018) Histopathological Injuries, Ultrastructural Changes, and Depressed TLR Expression in the Small Intestine of Broiler Chickens with Aflatoxin B1. Toxins 10:4, pages 131.
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Jalil Mehrzad, Saman Hosseinkhani & Amir Mohammad  Malvandi. (2018) Human Microglial Cells Undergo Proapoptotic Induction and Inflammatory Activation upon in vitro Exposure to a Naturally Occurring Level of Aflatoxin B<sub>1</sub>. Neuroimmunomodulation 25:3, pages 176-183.
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Jalil Mehrzad, Amir Mohammad Malvandi, Mohsen Alipour & Saman Hosseinkhani. (2017) Environmentally relevant level of aflatoxin B 1 elicits toxic pro-inflammatory response in murine CNS-derived cells. Toxicology Letters 279, pages 96-106.
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Saleh A. Bakheet, Sabry M. Attia, Mohammad Y. Alwetaid, Mushtaq Ahmad Ansari, Khairy M.A. Zoheir, Ahmed Nadeem, Othman A. Al-Shabanah, Mohammed M. Al-Harbi & Sheikh Fayaz Ahmad. (2016) β-1,3-Glucan reverses aflatoxin B1-mediated suppression of immune responses in mice. Life Sciences 152, pages 1-13.
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Rosita Accardi, Henri Gruffat, Cécilia Sirand, Floriane Fusil, Tarik Gheit, Hector Hernandez-Vargas, Florence Le Calvez-Kelm, Alexandra Traverse-Glehen, François-Loïc Cosset, Evelyne Manet, Christopher P. Wild & Massimo Tommasino. (2015) The mycotoxin aflatoxin B1 stimulates Epstein–Barr virus-induced B-cell transformation in in vitro and in vivo experimental models . Carcinogenesis 36:11, pages 1440-1451.
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Jalil Mehrzad, Majid Shajari, Massoud Saleh-moghaddam & Mohammad Sarmad-Nabavi. (2015) Stressed (acute) mice display neuroimmunodysregulation and defective innate immune response against coliform infection. International Immunopharmacology 28:1, pages 168-174.
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Azam Mohammadi, Jalil Mehrzad, Mahmoud Mahmoudi & Marion Schneider. (2014) Environmentally Relevant Level of Aflatoxin B 1 Dysregulates Human Dendritic Cells Through Signaling on Key Toll-Like Receptors . International Journal of Toxicology 33:3, pages 175-186.
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