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Immunopharmacology and Immunotoxicology Volume 36, 2014 - Issue 1
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Research Article

Cytochrome P450 isoforms are differently up-regulated in aflatoxin B1-exposed human lymphocytes and monocytes

Abbas BahariDepartment of Pathobiology, Section Immunology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad MashhadIran;Veterinary Biotechnology Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad MashhadIran
,
Jalil MehrzadDepartment of Pathobiology, Section Immunology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad MashhadIran;Veterinary Biotechnology Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad MashhadIranCorrespondence[email protected]
,
Mahmoud MahmoudiImmunology Research Center, Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences MashhadIran
,
Mohammad Reza BassamiVeterinary Biotechnology Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad MashhadIran;Department of Clinical Science
&
Hesam DehghaniDepartment of Basic Science, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad MashhadIran;Embryonic and Stem Cell Biology and Biotechnology Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad MashhadIran
Pages 1-10 | Received 14 May 2013, Accepted 27 Sep 2013, Published online: 30 Oct 2013

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Jalil Mehrzad, Taghi Zahraei Salehi, Alireza Khosravi, Saman Hosseinkhani, Yaser Tahamtani, Ensiyeh Hajizadeh-Saffar, Maedeh Moazenchi & Amir Mohammad Malvandi. (2023) Environmentally occurring aflatoxins B1 and M1 notifyably harms pancreatic islets. Toxin Reviews 42:1, pages 51-60.
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Ali Rassouli, Basim Shihmani, Jalil Mehrzad & Sara Shokrpoor. (2022) The immunomodulatory effect of minocycline on gene expression of inflammation related cytokines in lipopolysaccharide-treated human peripheral blood mononuclear cells. Animal Biotechnology 0:0, pages 1-7.
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Sajad Najafi, Gholamreza Mohammadi, Mehrdad Mohri, Saman Hosseinkhani & Jalil Mehrzad. (2020) Colostrum fails to prevent bovine/camelid neonatal neutrophil damage from AFB1. Journal of Immunotoxicology 17:1, pages 43-50.
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Zhi-Xu He, Xiao-Wu Chen, Zhi-Wei Zhou & Shu-Feng Zhou. (2015) Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine. Drug Metabolism Reviews 47:4, pages 470-519.
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Jalil Mehrzad, Bert Devriendt, Kim Baert & Eric Cox. (2015) Aflatoxins of type B and G affect porcine dendritic cell maturation in vitro. Journal of Immunotoxicology 12:2, pages 174-180.
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Jalil Mehrzad, Mojgan Milani & Mahmoud Mahmoudi. (2013) Naturally occurring level of mixed aflatoxins B and G stimulate toll-like receptor-4 in bovine mononuclear cells. Veterinary Quarterly 33:4, pages 186-190.
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Articles from other publishers (37)

Przemysław J. Danek & Władysława A. Daniel. (2023) The Novel Atypical Antipsychotic Lurasidone Affects Cytochrome P450 Expression in the Liver and Peripheral Blood Lymphocytes. International Journal of Molecular Sciences 24:23, pages 16796.
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Vahideh Sabbaghi, Mehran Mehri & Mehravar Mehri. (2023) Response surface model to illustrate the benefits of tryptophan, melatonin, and N,N-dimethylglycine in quail chicks exposed to aflatoxin B1. Poultry Science 102:8, pages 102803.
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Basim Shihmani, Ali Rassouli, Jalil Mehrzad & Sara Shokrpoor. (2023) The anti-inflammatory effects of minocycline on lipopolysaccharide-induced paw oedema in rats: a histopathological and molecular study. Inflammopharmacology 31:4, pages 1913-1928.
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Yuhang Sun, Yuqi Song, Miao Long & Shuhua Yang. (2023) Immunotoxicity of Three Environmental Mycotoxins and Their Risks of Increasing Pathogen Infections. Toxins 15:3, pages 187.
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Yuhang Sun, Zhaoran Yao, Miao Long, Ying Zhang, Kehe Huang & Lin Li. (2023) Alveolar Macrophages Participate in the Promotion of Influenza Virus Infection by Aflatoxin B1 at an Early Stage. Toxins 15:1, pages 67.
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Yuting Chen, Zhaohong Lu, Boxin Li, Huanhuan Wang, Tikeng Jiang, Mei Xuan, Hui Yang, Jialong Chen, Xiaoshan Liu, Hairong Liang, Yungang Liu & Huanwen Tang. (2023) Human CYP1B1 enzyme-mediated, AhR enhanced activation of aflatoxin B1 for its genotoxicity in human cells. Toxicology Letters 373, pages 132-140.
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Amir Mohammad Malvandi, Sara Shahba, Jalil Mehrzad & Giovanni Lombardi. (2022) Metabolic Disruption by Naturally Occurring Mycotoxins in Circulation: A Focus on Vascular and Bone Homeostasis Dysfunction. Frontiers in Nutrition 9.
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Sara Shahba, Jalil Mehrzad & Amir Mohammad Malvandi. (2021) Neuroimmune disruptions from naturally occurring levels of mycotoxins. Environmental Science and Pollution Research 28:25, pages 32156-32176.
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Slobodan P. Rendic & F. Peter Guengerich. (2021) Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update. Archives of Toxicology 95:2, pages 395-472.
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Jalil Mehrzad. 2021. Toxicology. Toxicology 165 179 .
Maria Löfgren, Pia Larsson, Ronny Lindberg, Katarina Hörnaeus & Eva Tydén. (2020) Expression of xenobiotic metabolising enzymes in lungs of horses with or without histological evidence of lower airway inflammation. Veterinary Medicine and Science 7:1, pages 16-24.
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Abbas Bahari, Iman Shahabi-Ghahfarrokhi & Davoud Koolivand. (2020) Kefiran ameliorates malfunctions in primary and functional immune cells caused by lipopolysaccharides. International Journal of Biological Macromolecules 165, pages 619-624.
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Nadia Fattahi, Abbas Bahari, Ali Ramazani & Davoud Koolivand. (2020) In vitro immunobiological assays of methotrexate-stearic acid conjugate in human PBMCs. Immunobiology 225:5, pages 151984.
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Marianna Pauletto, Roberta Tolosi, Mery Giantin, Giorgia Guerra, Andrea Barbarossa, Anna Zaghini & Mauro Dacasto. (2020) Insights into Aflatoxin B1 Toxicity in Cattle: An In Vitro Whole-Transcriptomic Approach. Toxins 12:7, pages 429.
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Ruiqi Su, Xuemei Tang, Lu Feng, Guang-long Yao & Jian Chen. (2020) Development of quantitative magnetic beads-based flow cytometry fluorescence immunoassay for aflatoxin B1. Microchemical Journal 155, pages 104715.
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Lingqiao Wang, Lixiong He, Hui Zeng, Wenjuan Fu, Jia Wang, Yao Tan, Chuanfen Zheng, Zhiqun Qiu, Jiaohua Luo, Chen Lv, Yujing Huang & Weiqun Shu. (2020) Low-dose microcystin-LR antagonizes aflatoxin B1 induced hepatocarcinogenesis through decreasing cytochrome P450 1A2 expression and aflatoxin B1-DNA adduct generation. Chemosphere 248, pages 126036.
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Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean‐Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Doris Marko, Isabelle P Oswald, Aldert Piersma, Michael Routledge, Josef Schlatter, Katleen Baert, Petra Gergelova & Heather Wallace. (2020) Risk assessment of aflatoxins in food. EFSA Journal 18:3.
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Sunwoo Park, Jin-Young Lee, Seungkwon You, Gwonhwa Song & Whasun Lim. (2020) Neurotoxic effects of aflatoxin B1 on human astrocytes in vitro and on glial cell development in zebrafish in vivo. Journal of Hazardous Materials 386, pages 121639.
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Jalil Mehrzad, Fatemeh Fazel, Nazaninzeynam Pouyamehr, Saman Hosseinkhani & Hesam Dehghani. (2019) Naturally Occurring Level of Aflatoxin B 1 Injures Human, Canine and Bovine Leukocytes Through ATP Depletion and Caspase Activation . International Journal of Toxicology 39:1, pages 30-38.
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Haixing Li & Jed N. Lampe. (2019) Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism. Archives of Biochemistry and Biophysics 673, pages 108078.
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Ke Guan, Hang Li, Zhicai Zuo, Fengyuan Wang, Ping Hu, Xi Peng, Jing Fang, Hengmin Cui, Gang Shu & Ping Ouyang. (2018) The Molecular Mechanisms of Protective Role of Se on the G0/G1 Phase Arrest Caused by AFB1 in Broiler’s Thymocytes. Biological Trace Element Research 189:2, pages 556-566.
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Hang Li, Ke Guan, Zhicai Zuo, Fengyuan Wang, Xi Peng, Jing Fang, Hengmin Cui, Yi Zhou, Ping Ouyang, Gang Su & Zhengli Chen. (2019) Effects of aflatoxin B<sub>1</sub> on the cell cycle distribution of splenocytes in chickens. Journal of Toxicologic Pathology 32:1, pages 27-36.
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Jalil Mehrzad, Abbas Bahari, Mohammad Reza Bassami, Mahmoud Mahmoudi & Hesam Dehghani. (2018) Data on environmentally relevant level of aflatoxin B1-induced human dendritic cells' functional alteration. Data in Brief 18, pages 1576-1580.
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Jalil Mehrzad, Abbas Bahari, Mohammad Reza Bassami, Mahmoud Mahmoudi & Hesam Dehghani. (2018) Immunobiologically relevant level of aflatoxin B1 alters transcription of key functional immune genes, phagocytosis and survival of human dendritic cells. Immunology Letters 197, pages 44-52.
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Laetitia Dou, Stéphane Poitevin, Marion Sallée, Tawfik Addi, Bertrand Gondouin, Nathalie McKay, Michael S. Denison, Noémie Jourde-Chiche, Ariane Duval-Sabatier, Claire Cerini, Philippe Brunet, Françoise Dignat-George & Stéphane Burtey. (2018) Aryl hydrocarbon receptor is activated in patients and mice with chronic kidney disease. Kidney International 93:4, pages 986-999.
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Ping Hu, Zhicai Zuo, Hang Li, Fengyuan Wang, Xi Peng, Jing Fang, Hengmin Cui, Caixia Gao, Hetao Song, Yi Zhou & Zhengli Chen. (2018) The molecular mechanism of cell cycle arrest in the Bursa of Fabricius in chick exposed to Aflatoxin B 1. Scientific Reports 8:1.
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Jalil Mehrzad, Saman Hosseinkhani & Amir Mohammad  Malvandi. (2018) Human Microglial Cells Undergo Proapoptotic Induction and Inflammatory Activation upon in vitro Exposure to a Naturally Occurring Level of Aflatoxin B<sub>1</sub>. Neuroimmunomodulation 25:3, pages 176-183.
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Jing Fang, Heng Yin, Zhixiang Zheng, Panpan Zhu, Xi Peng, Zhicai Zuo, Hengmin Cui, Yi Zhou, Ping Ouyang, Yi Geng & Junliang Deng. (2017) The Molecular Mechanisms of Protective Role of Se on the G2/M Phase Arrest of Jejunum Caused by AFB1. Biological Trace Element Research 181:1, pages 142-153.
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Xiaohong Yang, Wenyi Liu, Hui Lin, Hui Zeng, Renping Zhang, Chaowen Pu, Lingqiao Wang, Chuanfen Zheng, Yao Tan, Yang Luo, Xiaobin Feng, Yingqiao Tian, Guosheng Xiao, Jia Wang, Yujing Huang, Jiaohua Luo, Zhiqun Qiu, Ji-an Chen, Liping Wu, Lixiong He & Weiqun Shu. (2017) Interaction Effects of AFB1 and MC-LR Co-exposure with Polymorphism of Metabolic Genes on Liver Damage: focusing on SLCO1B1 and GSTP1. Scientific Reports 7:1.
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Yanhui Li, Yuhong Li, Guoying Zheng, Lingyan Zhu, Jishun Wang, Shasha Mu, Qi Ren & Fumin Feng. (2017) Cytochrome P450 1A1 and 1B1 promoter CpG island methylation regulates rat liver injury induced by isoniazid. Molecular Medicine Reports.
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Jalil Mehrzad, Amir Mohammad Malvandi, Mohsen Alipour & Saman Hosseinkhani. (2017) Environmentally relevant level of aflatoxin B 1 elicits toxic pro-inflammatory response in murine CNS-derived cells. Toxicology Letters 279, pages 96-106.
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Abbas Bahari & Vahid Salmani. (2017) Environmentally relevant dose of arsenic interferes in functions of human monocytes derived dendritic cells. Toxicology Letters 275, pages 118-122.
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Mario Bauer, Beate Fink, Loreen Thürmann, Markus Eszlinger, Gunda Herberth & Irina Lehmann. (2016) Tobacco smoking differently influences cell types of the innate and adaptive immune system—indications from CpG site methylation. Clinical Epigenetics 8:1.
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Vlad Simon Luca, Anca Miron & Ana Clara Aprotosoaie. (2016) The antigenotoxic potential of dietary flavonoids. Phytochemistry Reviews 15:4, pages 591-625.
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Jikai Wen, Peiqiang Mu & Yiqun Deng. (2016) Mycotoxins: cytotoxicity and biotransformation in animal cells. Toxicology Research 5:2, pages 377-387.
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Rosita Accardi, Henri Gruffat, Cécilia Sirand, Floriane Fusil, Tarik Gheit, Hector Hernandez-Vargas, Florence Le Calvez-Kelm, Alexandra Traverse-Glehen, François-Loïc Cosset, Evelyne Manet, Christopher P. Wild & Massimo Tommasino. (2015) The mycotoxin aflatoxin B1 stimulates Epstein–Barr virus-induced B-cell transformation in in vitro and in vivo experimental models . Carcinogenesis 36:11, pages 1440-1451.
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Azam Mohammadi, Jalil Mehrzad, Mahmoud Mahmoudi & Marion Schneider. (2014) Environmentally Relevant Level of Aflatoxin B 1 Dysregulates Human Dendritic Cells Through Signaling on Key Toll-Like Receptors . International Journal of Toxicology 33:3, pages 175-186.
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