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Immunopharmacology and Immunotoxicology Volume 36, 2014 - Issue 2
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Research Article

Ginsenoside metabolite compound K attenuates inflammatory responses of adjuvant-induced arthritis rats

Huaxun WuInstitute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education HefeiChina
,
Jingyu ChenInstitute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education HefeiChina
,
Qingtong WangInstitute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education HefeiChina
,
Xiaoyi JiaInstitute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education HefeiChina
,
Shasha SongInstitute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education HefeiChina
,
Pingfan YuanInstitute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education HefeiChina
,
Kangkang LiuInstitute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education HefeiChina
,
Lihua LiuInstitute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education HefeiChina
,
Yunfang ZhangInstitute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education HefeiChina
,
Aiwu ZhouInstitute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education HefeiChina
&
Wei WeiInstitute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education HefeiChinaCorrespondence[email protected]
 show all
Pages 124-129 | Received 28 Oct 2013, Accepted 03 Jan 2014, Published online: 23 Jan 2014

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Yating Wang, Xiurong Bao, Hao Xian, Fang Wei, Yining Song, Siyu Zhao, Yujie Zhang, Yumeng Wang & Ying Wang. (2023) Glucocorticoid receptors involved in ginsenoside compound K ameliorate adjuvant arthritis by inhibiting the glycolysis of fibroblast-like synoviocytes via the NF-κB/HIF-1α pathway. Pharmaceutical Biology 61:1, pages 1162-1174.
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Jingyu Chen, Wu Wang, Mengya Jiang, Mei Yang & Wei Wei. (2020) Combination therapy of ginsenoside compound K and methotrexate was efficient in elimination of anaemia and reduction of disease activity in adjuvant-induced arthritis rats. Pharmaceutical Biology 58:1, pages 1140-1148.
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Li Cai, Wei-Na Chen, Rong Li, Cheng-Mu Hu, Chao Lei & Chun-Mei Li. (2018) Therapeutic effect of acetazolamide, an aquaporin 1 inhibitor, on adjuvant-induced arthritis in rats by inhibiting NF-κB signal pathway. Immunopharmacology and Immunotoxicology 40:2, pages 117-125.
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Kyung-Chul Shin & Deok-Kun Oh. (2016) Classification of glycosidases that hydrolyze the specific positions and types of sugar moieties in ginsenosides. Critical Reviews in Biotechnology 36:6, pages 1036-1049.
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Jingyu Chen, Qingtong Wang, Huaxun Wu, Kangkang Liu, Yujing Wu, Yan Chang & Wei Wei. (2016) The ginsenoside metabolite compound K exerts its anti-inflammatory activity by downregulating memory B cell in adjuvant-induced arthritis. Pharmaceutical Biology 54:7, pages 1280-1288.
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Keqiang Zhang & Yuwei Li. (2016) Effects of ginsenoside compound K combined with cisplatin on the proliferation, apoptosis and epithelial mesenchymal transition in MCF-7 cells of human breast cancer. Pharmaceutical Biology 54:4, pages 561-568.
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Articles from other publishers (20)

Yixin Wang, Qin Han, Shuxia Zhang, Xiaoyan Xing & Xiaobo Sun. (2023) New perspective on the immunomodulatory activity of ginsenosides: Focus on effective therapies for post-COVID-19. Biomedicine & Pharmacotherapy 165, pages 115154.
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Susanna Choi & Taesoo Kim. (2023) Compound K - An immunomodulator of macrophages in inflammation. Life Sciences 323, pages 121700.
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Pingping Wang, Jiali Wang, Guoping Zhao, Xing Yan & Zhihua Zhou. (2021) Systematic optimization of the yeast cell factory for sustainable and high efficiency production of bioactive ginsenoside compound K. Synthetic and Systems Biotechnology 6:2, pages 69-76.
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Mengshi Tang, Xi Xie, Yongyu Yang & Fen Li. (2021) Ginsenoside compound K- a potential drug for rheumatoid arthritis. Pharmacological Research 166, pages 105498.
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Eunju Choi, Eunji Kim, Ji Hye Kim, Keejung Yoon, Sunggyu Kim, Jongsung Lee & Jae Youl Cho. (2019) AKT1-targeted proapoptotic activity of compound K in human breast cancer cells. Journal of Ginseng Research 43:4, pages 692-698.
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Jingyu Chen, Min Si, Ying Wang, Lihua Liu, Yunfang Zhang, Aiwu Zhou & Wei Wei. (2018) Ginsenoside metabolite compound K exerts anti-inflammatory and analgesic effects via downregulating COX2. Inflammopharmacology 27:1, pages 157-166.
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Chenhao Pan, Haojie Shan, Tianyi Wu, Wei Liu, Yiwei Lin, Wenyang Xia, Feng Wang, Zubin Zhou & Xiaowei Yu. (2019) 20(S)-Protopanaxadiol Inhibits Titanium Particle-Induced Inflammatory Osteolysis and RANKL-Mediated Osteoclastogenesis via MAPK and NF-κB Signaling Pathways. Frontiers in Pharmacology 9.
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Da-lun Lv, Lei Chen, Wei Ding, Wei Zhang, He–li Wang, Shuai Wang & Wen-bei Liu. (2018) Ginsenoside G-Rh2 synergizes with SMI-4a in anti-melanoma activity through autophagic cell death. Chinese Medicine 13:1.
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Lulu Chen, Luping Zhou, Jie Huang, Yaqin Wang, Guoping Yang, Zhirong Tan, Yicheng Wang, Gan Zhou, Jianwei Liao & Dongsheng Ouyang. (2018) Single- and Multiple-Dose Trials to Determine the Pharmacokinetics, Safety, Tolerability, and Sex Effect of Oral Ginsenoside Compound K in Healthy Chinese Volunteers. Frontiers in Pharmacology 8.
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Lulu Chen, Luping Zhou, Yaqin Wang, Guoping Yang, Jie Huang, Zhirong Tan, Yicheng Wang, Gan Zhou, Jianwei Liao & Dongsheng Ouyang. (2017) Food and Sex-Related Impacts on the Pharmacokinetics of a Single-Dose of Ginsenoside Compound K in Healthy Subjects. Frontiers in Pharmacology 8.
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Priyanka Singh, Hina Singh, Verónica Castro-Aceituno, Sungeun Ahn, Yeon Ju Kim, Mohamed El-Agamy Farh & Deok Chun Yang. (2017) Engineering of mesoporous silica nanoparticles for release of ginsenoside CK and Rh2 to enhance their anticancer and anti-inflammatory efficacy: in vitro studies. Journal of Nanoparticle Research 19:7.
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Meng Wang, Shi-Ju Yan, Hong-Tao Zhang, Nan Li, Tao Liu, Ying-Long Zhang, Xiao-Xiang Li, Qiong Ma, Xiu-Chun Qiu, Qing-Yu Fan & Bao-An Ma. (2017) Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model. Oncology Letters 13:2, pages 681-685.
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Priyanka Singh, Hina Singh, Verónica Castro-Aceituno, Sungeun Ahn, Yeon Ju Kim & Deok Chun Yang. (2017) Bovine serum albumin as a nanocarrier for the efficient delivery of ginsenoside compound K: preparation, physicochemical characterizations and in vitro biological studies. RSC Advances 7:25, pages 15397-15407.
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Jun Ho Kim, Jeong Hoon Pan, Hyung Taek Cho & Young Jun Kim. (2016) Black Ginseng Extract Counteracts Streptozotocin-Induced Diabetes in Mice. PLOS ONE 11:1, pages e0146843.
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Ying Wang, Jingyu Chen, Xuexia Luo, Ying Zhang, Ming Si, Huaxun Wu, Chang Yan & Wei Wei. (2016) Ginsenoside metabolite compound K exerts joint-protective effect by interfering with synoviocyte function mediated by TNF-α and Tumor necrosis factor receptor type 2. European Journal of Pharmacology 771, pages 48-55.
Crossref
Kyung-Chul Shin, Seung-Hye Hong, Min-Ju Seo & Deok-Kun Oh. (2015) An amino acid at position 512 in β-glucosidase from Clavibacter michiganensis determines the regioselectivity for hydrolyzing gypenoside XVII. Applied Microbiology and Biotechnology 99:19, pages 7987-7996.
Crossref
Jingyu Chen, Huaxun Wu, Qingtong Wang, Yan Chang, Kangkang Liu & Wei Wei. (2015) Ginsenoside Metabolite Compound K Suppresses T-Cell Priming via Modulation of Dendritic Cell Trafficking and Costimulatory Signals, Resulting in Alleviation of Collagen-Induced Arthritis. Journal of Pharmacology and Experimental Therapeutics 353:1, pages 71-79.
Crossref
Yun Jong LeeKye Yong SongEun Young LeeHeun Soo KangYeong Wook Song. (2015) Compound K, a Metabolite of Ginsenosides, Attenuates Collagen-induced Arthritis in Mice. Journal of Rheumatic Diseases 22:3, pages 154.
Crossref
Xi-Ding Yang, Yong-Yu Yang, Dong-Sheng Ouyang & Guo-Ping Yang. (2015) A review of biotransformation and pharmacology of ginsenoside compound K. Fitoterapia 100, pages 208-220.
Crossref
Jingyu Chen, Huaxun Wu, Qingtong Wang, Yan Chang, Kangkang Liu, Shasha Song, Pingfan Yuan, Jingjing Fu, Wuyi Sun, Qiong Huang, Lihua Liu, Yujing Wu, Yunfang Zhang, Aiwu Zhou & Wei Wei. (2014) Ginsenoside Metabolite Compound K Alleviates Adjuvant-Induced Arthritis by Suppressing T Cell Activation. Inflammation 37:5, pages 1608-1615.
Crossref

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