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Immunopharmacology and Immunotoxicology Volume 10, 1988 - Issue 2
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Research Article

Effects of Lentinan on Cytotoxic Functions of Human Lymphocytes

Gergely Péater Second Department of Medicine and First Department of Surgery, Semmelweis University, Budapest, Hungary, Pharmaceuticals and Development Department, Ajinomoto Co., Inc., Tokyo, Japan
,
Vallent Káaroly Second Department of Medicine and First Department of Surgery, Semmelweis University, Budapest, Hungary, Pharmaceuticals and Development Department, Ajinomoto Co., Inc., Tokyo, Japan
,
BodÓA Imre Second Department of Medicine and First Department of Surgery, Semmelweis University, Budapest, Hungary, Pharmaceuticals and Development Department, Ajinomoto Co., Inc., Tokyo, Japan
,
FehÉAr Jáanos Second Department of Medicine and First Department of Surgery, Semmelweis University, Budapest, Hungary, Pharmaceuticals and Development Department, Ajinomoto Co., Inc., Tokyo, Japan
&
Yutaro Kaneko Second Department of Medicine and First Department of Surgery, Semmelweis University, Budapest, Hungary, Pharmaceuticals and Development Department, Ajinomoto Co., Inc., Tokyo, Japan
Pages 157-163 | Published online: 28 Sep 2008

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Gunnar Heuser & Aristo Vojdani. (1997) Enhancement of Natural Killer Cell Activity and T and B Cell Function by Buffered Vitamin C In Patients Exposed to Toxic Chemicals: The Role of Protein Kinase-C. Immunopharmacology and Immunotoxicology 19:3, pages 291-312.
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Articles from other publishers (27)

Beata Kaleta, Aleksander Roszczyk, Michał Zych, Monika Kniotek, Radosław Zagożdżon, Marzenna Klimaszewska, Eliza Malinowska, Michał Pac & Jadwiga Turło. (2021) Selective Biological Effects of Selenium-Enriched Polysaccharide (Se-Le-30) Isolated from Lentinula edodes Mycelium on Human Immune Cells. Biomolecules 11:12, pages 1777.
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Xiucong Wu, Ziming Zheng, Tingting Guo, Kaiping Wang & Yu Zhang. (2021) Molecular dynamics simulation of lentinan and its interaction with the innate receptor dectin-1. International Journal of Biological Macromolecules 171, pages 527-538.
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Zheng Xiao, Yuan Jiang, Xiao-Fan Chen, Cheng-Qiong Wang, Xiao-Tian Zheng, Wei-hong Xu, Xing-Xia Zou, Jia-Mei Zhou, Ya-Hui Yang, Shan-Shan Hu, Li-Jing Shan, Qing-Yong Cai, Yu-Hong Tang, Ji-Hong Feng & Xue Xiao. (2020) Intrathoracic infusion therapy with Lentinan and chemical irritants for malignant pleural effusion: a systematic review and meta-analysis of 65 randomized controlled trials. Phytomedicine 76, pages 153260.
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Meng Zhang, Yiran Zhang, Lijuan Zhang & Qingwu Tian. 2019. Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part B. Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part B 297 328 .
Yiran Zhang, Meng Zhang, Yifei Jiang, Xiulian Li, Yanli He, Pengjiao Zeng, Zhihua Guo, Yajing Chang, Heng Luo, Yong Liu, Cui Hao, Hua Wang, Guoqing Zhang & Lijuan Zhang. (2018) Lentinan as an immunotherapeutic for treating lung cancer: a review of 12 years clinical studies in China. Journal of Cancer Research and Clinical Oncology 144:11, pages 2177-2186.
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Hao Wu, Ning Tao, Xiaoman Liu, Xiao Li, Jian Tang, Chungwah Ma, Xiaofei Xu, Haitao Shao, Baidong Hou, Hui Wang & Zhihai Qin. (2012) Polysaccharide from Lentinus edodes Inhibits the Immunosuppressive Function of Myeloid-Derived Suppressor Cells. PLoS ONE 7:12, pages e51751.
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Jerry T. Thornthwaite, Hare Shah, Pashupati Shah & Henry Respess. (2012) The Natural Killer Cell: A Historical Perspective and the Use of Supplements to Enhance NKC Activity. Journal of Immune Based Therapies, Vaccines and Antimicrobials 01:03, pages 21-51.
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Xiaojuan Xu, Michiko Yasuda, Sachiko Nakamura-Tsuruta, Masashi Mizuno & Hitoshi Ashida. (2012) β-Glucan from Lentinus edodes Inhibits Nitric Oxide and Tumor Necrosis Factor-α Production and Phosphorylation of Mitogen-activated Protein Kinases in Lipopolysaccharide-stimulated Murine RAW 264.7 Macrophages. Journal of Biological Chemistry 287:2, pages 871-878.
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Xiaojuan Xu, Chen Pan, Lina Zhang & Hitoshi Ashida. (2011) Immunomodulatory β-Glucan from Lentinus edodes Activates Mitogen-activated Protein Kinases and Nuclear Factor-κB in Murine RAW 264.7 Macrophages. Journal of Biological Chemistry 286:36, pages 31194-31198.
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Yangyang Zhang, Sheng Li, Xiaohua Wang, Lina Zhang & Peter C.K. Cheung. (2011) Advances in lentinan: Isolation, structure, chain conformation and bioactivities. Food Hydrocolloids 25:2, pages 196-206.
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Robert K. Oldham. 2009. Principles of Cancer Biotherapy. Principles of Cancer Biotherapy 101 145 .
Yangyang Zhang, Xiaojuan Xu & Lina Zhang. (2008) Gel formation and low-temperature intramolecular conformation transition of a triple-helical polysaccharide lentinan in water. Biopolymers 89:10, pages 852-861.
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Yangyang Zhang, Xiaojuan Xu & Lina Zhang. (2008) Dynamic viscoelastic behavior of triple helical Lentinan in water: Effect of temperature. Carbohydrate Polymers 73:1, pages 26-34.
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HL Chen, DF Li, BY Chang, LM Gong, XS Piao, GF Yi & JX Zhang. (2003) Effects of lentinan on broiler splenocyte proliferation, interleukin-2 production, and signal transduction. Poultry Science 82:5, pages 760-766.
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Robert K. Oldham. 2003. Principles of Cancer Biotherapy. Principles of Cancer Biotherapy 111 161 .
Raymond Chang. (2002) Bioactive Polysaccharides from Traditional Chinese Medicine Herbs as Anticancer Adjuvants. The Journal of Alternative and Complementary Medicine 8:5, pages 559-565.
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Tsutomu Nakada, Kenji Watanabe, Guang-Bi Jin, Kazuo Toriizuka & Toshihiko Hanawa. (2012) Effect of Ninjin-Youei-To on T h 1/T h 2 Type Cytokine Production in Different Mouse Strains . The American Journal of Chinese Medicine 30:02n03, pages 215-223.
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Masashi MIZUNO, Ken-ichiro MINATO, Sachiko KAWAKAMI, Shigenobu TATSUOKA, Yutaka DENPO & Hironobu TSUCHIDA. (2001) Contents of Anti-Tumor Polysaccharides in Certain Mushrooms and Their Immunomodulating Activities.. Food Science and Technology Research 7:1, pages 31-34.
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Robert K. Oldham. 1997. Principles of Cancer Biotherapy. Principles of Cancer Biotherapy 93 140 .
W. Blaschek, R. Hänsel, K. Keller, J. Reichling, H. Rimpler & G. Schneider. 1998. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 1 145 .
Csilla KerÉkgyártó, Lászó Virág, László Tankó, Goro Chihara & József Fachet. (1996) Strain differences in the cytotoxic activity and TNF production of murine macrophages stimulated by lentinan. International Journal of Immunopharmacology 18:6-7, pages 347-353.
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C K Wong, K N Leung, K P Fung & Y M Choy. (2016) Immunomodulatory and Anti-Tumour Polysaccharides from Medicinal Plants. Journal of International Medical Research 22:6, pages 299-312.
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Andrea Ladányi, József Tímár & Károly Lapis. (1993) Effect of lentinan on macrophage cytotoxicity against metastatic tumor cells. Cancer Immunology Immunotherapy 36:2, pages 123-126.
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Youichi Mizutani, Yoshinori Nio & Osamu Yoshida. (1992) Effect of PSK and its Subfractions on Peripheral Blood Lymphocytes Mediated Cytotoxicity against Urinary Bladder Tumor Cells. Journal of Urology 148:5 Part 1, pages 1571-1576.
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Shinya Arinaga, Nobuya Karimine, Kiyoshi Takamuku, Shigeru Nanbara, Hiroshi Inoue, Masaaki Nagamatsu, Hiroaki Ueo & Tsuyoshi Akiyoshi. (1992) Enhanced induction of lymphokine-activated killer activity after lentinan administration in patients with gastric carcinoma. International Journal of Immunopharmacology 14:4, pages 535-539.
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