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Immunopharmacology and Immunotoxicology Volume 14, 1992 - Issue 3
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Research Article

Immunotoxic Effects of Mercuric Compounds on Human Lymphocytes and Monocytes. I. Suppression of T-Cell Activation

B. J. Shenker Department of Pathology, University of Pennsylvania School of Dental Medicine, 4010 Locust Street, Philadelphia, PA, 19104
,
C. Rooney Department of Pathology, University of Pennsylvania School of Dental Medicine, 4010 Locust Street, Philadelphia, PA, 19104
,
L. Vitale Department of Pathology, University of Pennsylvania School of Dental Medicine, 4010 Locust Street, Philadelphia, PA, 19104
&
I. M. Shapiro Department of Biochemistry, University of Pennsylvania School of Dental Medicine, 4010 Locust Street, Philadelphia, PA, 19104
Pages 539-553 | Published online: 28 Sep 2008

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Suhendan Mol, Ozkan Ozden & Saadet Karakulak. (2012) Levels of Selected Metals in Albacore (Thunnus alalunga, Bonnaterre, 1788) from the Eastern Mediterranean. Journal of Aquatic Food Product Technology 21:2, pages 111-117.
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Silbergeld Ek, Sacci Jb & Azad Af. (2000) Mercury Exposure and Murine Response to Plasmodium Yoelii Infection and Immunization. Immunopharmacology and Immunotoxicology 22:4, pages 685-695.
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Libia Vega, Patricia Ostrosky-Wegman, Teresa I. Fortou1, Cinthya Díaz, Vicente Madrid & Rafael Saavedra. (1999) Sodium Arsenite Reduces Proliferation of Human Activated T-Cells by Inhibition of the Secretion of Interleukin-2. Immunopharmacology and Immunotoxicology 21:2, pages 203-220.
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Sa Thompson, Kl Roellich, A Grossmann, Sg Gilbert & Tj Kavanagh. (1998) Alterations in Immune Parameters Associated with Low Level Methylmercury Exposure in Mice. Immunopharmacology and Immunotoxicology 20:2, pages 299-314.
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B. J. Shenker, C. Rooney, L. Vitale And, J. S. Mayro & I. M. Shapiro. (1993) Immunotoxic Effects of Mercuric Compounds on Human Lymphocytes and Monocytes. IV. Alterations in Cellular Glutathione Content. Immunopharmacology and Immunotoxicology 15:2-3, pages 273-290.
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Victória dos Santos Chemelo, Leonardo Oliveira Bittencourt, Walessa Alana Bragança Aragão, Sávio Monteiro dos Santos, Renata Duarte Souza-Rodrigues, Carolina Heitmann Mares Azevedo Ribeiro, Marta Chagas Monteiro & Rafael Rodrigues Lima. (2020) Long-Term Exposure to Inorganic Mercury Leads to Oxidative Stress in Peripheral Blood of Adult Rats. Biological Trace Element Research 199:8, pages 2992-3000.
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Lixin Yang, Yuanyuan Zhang, Feifei Wang, Zidie Luo, Shaojuan Guo & Uwe Strähle. (2020) Toxicity of mercury: Molecular evidence. Chemosphere 245, pages 125586.
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Angélica dos Santos Vianna, Elisabete Pedra de Matos, Iracina Maura de Jesus, Carmen Ildes Rodrigues Fróes Asmus & Volney de Magalhães Câmara. (2019) Human exposure to mercury and its hematological effects: a systematic review. Cadernos de Saúde Pública 35:2.
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Huijeong Ahn, Jeongeun Kim, Seung Goo Kang, Sung-il Yoon, Hyun-Jeong Ko, Pyeung-Hyeun Kim, Eui-Ju Hong, Beum-Soo An, Eunsong Lee & Geun-Shik Lee. (2018) Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation. Scientific Reports 8:1.
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Velid Unsal. (2018) Natural Phytotherapeutic Antioxidants in the Treatment of Mercury Intoxication-A Review. Advanced Pharmaceutical Bulletin 8:3, pages 365-376.
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Kimberley W. J. van der Sloot, Marzyeh Amini, Vera Peters, Gerard Dijkstra & Behrooz Z. Alizadeh. (2017) Inflammatory Bowel Diseases. Inflammatory Bowel Diseases 23:9, pages 1499-1509.
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Aurélie Dupont, Marie-Claire De Pauw-Gillet, Joseph Schnitzler, Ursula Siebert & Krishna Das. (2015) Effects of Methylmercury on Harbour Seal Peripheral Blood Leucocytes In Vitro Studied by Electron Microscopy. Archives of Environmental Contamination and Toxicology 70:1, pages 133-142.
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Renee M. Gardner & Jennifer F. Nyland. 2016. Environmental Influences on the Immune System. Environmental Influences on the Immune System 273 302 .
Xuan Li, Daqiang Yin, Jiaoyang Yin, Qiqing Chen & Rui Wang. (2014) Dietary selenium protect against redox-mediated immune suppression induced by methylmercury exposure. Food and Chemical Toxicology 72, pages 169-177.
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Xuan Li, Daqiang Yin, Jiang Li & Rui Wang. (2014) Protective Effects of Selenium on Mercury Induced Immunotoxic Effects in Mice by Way of Concurrent Drinking Water Exposure. Archives of Environmental Contamination and Toxicology 67:1, pages 104-114.
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Nancy N. Maserejian, Peter Shrader, Olivia A. Brown, Felicia L. Trachtenberg, Jennifer Soncini, Russ Hauser & Bruce J. Shenker. (2014) Dental sealants and composite restorations and longitudinal changes in immune function markers in children. International Journal of Paediatric Dentistry 24:3, pages 215-225.
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Bong-Hwa Kim, Pyong-Gon Moon, Jeong-Eun Lee, Soyoung Lee, Sook-Kyung Kim, Jong Kwon Lee, Sang-Hyun Kim & Moon-Chang Baek. (2013) Identification of Potential Serum Biomarkers in Mercury-Treated Mice Using a Glycoproteomic Approach. International Journal of Toxicology 32:5, pages 368-375.
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Kaeko Murota, Mai Yoshida, Nana Ishibashi, Hideo Yamazaki & Takeshi Minami. (2011) Direct Absorption of Methyl Mercury by Lymph. Biological Trace Element Research 145:3, pages 349-354.
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Blake C. Ellis, Sebastiano Gattoni-Celli & Mark S. Kindy. (2010) The impact of methylmercury on 1,25-dihydroxyvitamin D3-induced transcriptomic responses in dolphin skin cells. Biological Chemistry 391:2-3, pages 245-258.
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Dana M. Hawley, Kelly K. Hallinger & Daniel A. Cristol. (2009) Compromised immune competence in free-living tree swallows exposed to mercury. Ecotoxicology 18:5, pages 499-503.
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Mary Trang Le, Jürgen Gailer & Elmar J. Prenner. (2008) Hg2+ and Cd2+ interact differently with biomimetic erythrocyte membranes. BioMetals 22:2, pages 261-274.
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Bruce J. Shenker, Nancy N. Maserejian, Annie Zhang & Sonja McKinlay. (2008) Immune Function Effects of Dental Amalgam in Children. The Journal of the American Dental Association 139:11, pages 1496-1505.
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N Y A Hemdan, I Lehmann, G Wichmann, J Lehmann, F Emmrich & U Sack. (2007) Immunomodulation by mercuric chloride in vitro : application of different cell activation pathways . Clinical and Experimental Immunology 148:2, pages 325-337.
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Anshu Agrawal, Poonam Kaushal, Sudhanshu Agrawal, Sastry Gollapudi & Sudhir Gupta. (2007) Thimerosal induces TH2 responses via influencing cytokine secretion by human dendritic cells. Journal of Leukocyte Biology 81:2, pages 474-482.
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Teresa Coccini, Giovanna Randine, Anna F. Castoldi, Davide Acerbi & Luigi Manzo. (2007) Methylmercury interaction with lymphocyte cholinergic muscarinic receptors in developing rats. Environmental Research 103:2, pages 229-237.
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Said Havarinasab, Erik Björn, Jimmy Ekstrand & Per Hultman. (2007) Dose and Hg species determine the T-helper cell activation in murine autoimmunity. Toxicology 229:1-2, pages 23-32.
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Said Havarinasab & Per Hultman. (2005) Organic mercury compounds and autoimmunity. Autoimmunity Reviews 4:5, pages 270-275.
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S. Havarinasab, B. Häggqvist, E. Björn, K.M. Pollard & P. Hultman. (2005) Immunosuppressive and autoimmune effects of thimerosal in mice. Toxicology and Applied Pharmacology 204:2, pages 109-121.
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Bo Häggqvist, Said Havarinasab, Erik Björn & Per Hultman. (2005) The immunosuppressive effect of methylmercury does not preclude development of autoimmunity in genetically susceptible mice. Toxicology 208:1, pages 149-164.
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Myrian Colombo, Claudine Hamelin, Edouard Kouassi, Michel Fournier & Jacques Bernier. (2004) Differential effects of mercury, lead, and cadmium on IL-2 production by Jurkat T cells. Clinical Immunology 111:3, pages 311-322.
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Saeko Araragi, Masuo Kondoh, Masaki Kawase, Sayaka Saito, Minoru Higashimoto & Masao Sato. (2003) Mercuric chloride induces apoptosis via a mitochondrial-dependent pathway in human leukemia cells. Toxicology 184:1, pages 1-9.
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Gregory G. Miller, Leonard I. Sweet, Jean V. Adams, Geneva M. Omann, Dora R. Passino-Reader & Peter G. Meier. (2002) In vitro toxicity and interactions of environmental contaminants (Arochlor 1254 and mercury) and immunomodulatory agents (lipopolysaccharide and cortisol) on thymocytes from lake trout (Salvelinus namaycush). Fish & Shellfish Immunology 13:1, pages 11-26.
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Bruce J. Shenker, Lisa Pankoski, Ali Zekavat & Irving M. Shapiro. (2002) Mercury-Induced Apoptosis in Human Lymphocytes: Caspase Activation Is Linked to Redox Status. Antioxidants & Redox Signaling 4:3, pages 379-389.
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Xiaoli Shen, Kyeongeun Lee & Rolf König. (2001) Effects of heavy metal ions on resting and antigen-activated CD4+ T cells. Toxicology 169:1, pages 67-80.
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Xiaohui Rausch-Fan, Andreas Schedle, Alexander Franz, Andreas Spittler, Alexander Gornikiewicz, Erika Jensen-Jarolim, Wolfgang Sperr & George Boltz-Nitulescu. (2000) Influence of dental amalgam and heavy metal cations onin vitro interleukin-1? production by human peripheral blood mononuclear cells. Journal of Biomedical Materials Research 51:1, pages 88-95.
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Tai Liang Guo, Mark A. Miller, Irving M. Shapiro & Bruce J. Shenker. (1998) Mercuric Chloride Induces Apoptosis in Human T Lymphocytes: Evidence of Mitochondrial Dysfunction. Toxicology and Applied Pharmacology 153:2, pages 250-257.
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