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Inhalation Toxicology
International Forum for Respiratory Research
Volume 22, 2010 - Issue 7
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Research Article

Delayed low-dose supplemental oxygen improves survival following phosgene-induced acute lung injury

C. GraingeInstitute of Naval Medicine, Alverstoke, UK
,
B. J. JuggBiomedical Sciences Department, Dstl Porton Down, Salisbury, UK
,
A. J. SmithBiomedical Sciences Department, Dstl Porton Down, Salisbury, UKCorrespondence[email protected]
,
R. F. R. BrownBiomedical Sciences Department, Dstl Porton Down, Salisbury, UK
,
J. JennerBiomedical Sciences Department, Dstl Porton Down, Salisbury, UK
,
D.A. ParkhouseAnaesthetic Department, St Andrews Centre for Plastic Surgery and Burns, Broomfield Hospital, Chelmsford, UK
&
P. RiceBiomedical Sciences Department, Dstl Porton Down, Salisbury, UK
 show all
Pages 552-560 | Received 04 Aug 2009, Accepted 18 Dec 2009, Published online: 13 Apr 2010

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Stephen T. Hobson, Richard A. Richieri & Missag H. Parseghian. (2021) Phosgene: toxicology, animal models, and medical countermeasures. Toxicology Mechanisms and Methods 31:4, pages 293-307.
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Stephen T. Hobson, Robert P. Casillas, Richard A. Richieri, Robert N. Nishimura, Richard H. Weisbart, Rick Tuttle, Glenn T. Reynolds & Missag H. Parseghian. (2019) Development of an acute, short-term exposure model for phosgene. Toxicology Mechanisms and Methods 29:8, pages 604-615.
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B. Jugg, S. Fairhall, A. Smith, S. Rutter, T. Mann, R. Perrott, J. Jenner, J. Salguero, J. Shute & A. M. Sciuto. (2013) N-acetyl-L-cysteine protects against inhaled sulfur mustard poisoning in the large swine. Clinical Toxicology 51:4, pages 216-224.
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Christopher Grainge & Paul Rice. (2010) Management of phosgene-induced acute lung injury. Clinical Toxicology 48:6, pages 497-508.
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Articles from other publishers (17)

Jun He, Yue Zhao, Zhenli Fu, Li Chen, Kongzhen Hu, Xiaoyan Lin, Ning Wang, Weijian Huang, Qi Xu, Shuhua He, Ying He, Linliang Song, Mei xia Fang, Jie Zheng, Biying Chen, Qiuyan Cai, Jiangnan Fu & Jin Su. (2023) A novel tree shrew model of lipopolysaccharide-induced acute respiratory distress syndrome. Journal of Advanced Research.
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Chao Cao, Lin Zhang & Jie Shen. (2022) Phosgene-Induced acute lung injury: Approaches for mechanism-based treatment strategies. Frontiers in Immunology 13.
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Qianying Lu, Siyu Huang, Xiangyan Meng, Jianfeng Zhang, Sifan Yu, Junfeng Li, Mingyu Shi, Haojun Fan & Yanmei Zhao. (2021) Mechanism of Phosgene-Induced Acute Lung Injury and Treatment Strategy. International Journal of Molecular Sciences 22:20, pages 10933.
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Juergen Pauluhn. (2021) Phosgene inhalation toxicity: Update on mechanisms and mechanism-based treatment strategies. Toxicology 450, pages 152682.
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Stuart Graham, Sarah Fairhall, Steve Rutter, Philippa Auton, Rachel Rendell, Adam Smith, Rosi Perrott, Tim Nicholson Roberts & Bronwen Jugg. (2018) Continuous positive airway pressure: An early intervention to prevent phosgene-induced acute lung injury. Toxicology Letters 293, pages 120-126.
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Rachel Rendell, Sarah Fairhall, Stuart Graham, Steve Rutter, Philippa Auton, Adam Smith, Rosi Perrott & Bronwen Jugg. (2018) Assessment of N -acetylcysteine as a therapy for phosgene-induced acute lung injury. Toxicology Letters 290, pages 145-152.
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Eleanor M. Summerhill, Gary W. Hoyle, Sven-Eric Jordt, Bronwen J. Jugg, James G. Martin, Sadis Matalon, Steven E. Patterson, David J. Prezant, Alfred M. Sciuto, Erik R. Svendsen, Carl W. White & Livia A. Veress. (2017) An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness. Annals of the American Thoracic Society 14:6, pages 1060-1072.
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Shahaf Katalan, Reut Falach, Amir Rosner, Michael Goldvaser, Tal Brosh-Nissimov, Ayana Dvir, Avi Mizrachi, Orr Goren, Barak Cohen, Yoav Gal, Anita Sapoznikov, Sharon Ehrlich, Tamar Sabo & Chanoch Kronman. (2017) Novel swine model of ricin-induced acute respiratory distress syndrome. Disease Models & Mechanisms.
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Helen Rice, Tom M. Mann, Stuart J. Armstrong, Matthew E. Price, A. Chris Green & John E.H. Tattersall. (2016) The potential role of bioscavenger in the medical management of nerve-agent poisoned casualties. Chemico-Biological Interactions 259, pages 175-181.
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Missag H. Parseghian, Stephen T. Hobson & Richard A. Richieri. (2016) Targeted heat shock protein 72 for pulmonary cytoprotection. Annals of the New York Academy of Sciences 1374:1, pages 78-85.
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David K. Meyerholz, Allyn M. Lambertz, Leah R. Reznikov, Georgina K. Ofori-Amanfo, Phil H. Karp, Paul B. McCrayJrJr, Michael J. Welsh & David A. Stoltz. (2015) Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans. Toxicologic Pathology 44:3, pages 434-441.
Crossref
Wenli Li, Martin Rosenbruch & Jürgen Pauluhn. (2015) Effect of PEEP on phosgene-induced lung edema: Pilot study on dogs using protective ventilation strategies. Experimental and Toxicologic Pathology 67:2, pages 109-116.
Crossref
Lewis S. HardisonJr.Jr., Edward Wright & Anthony F. Pizon. (2013) Phosgene Exposure: A Case of Accidental Industrial Exposure. Journal of Medical Toxicology 10:1, pages 51-56.
Crossref
Fangfang Liu, Jürgen Pauluhn, Hubert Trübel & Chen Wang. (2014) Single high-dose dexamethasone and sodium salicylate failed to attenuate phosgene-induced acute lung injury in rats. Toxicology 315, pages 17-23.
Crossref
George D. Leikauf & Daniel R. Prows. 2001. Patty's Toxicology. Patty's Toxicology 949 1032 .
B. J. A. Jugg, A. J. Smith, S. J. Rudall & P. Rice. (2011) The injured lung: clinical issues and experimental models. Philosophical Transactions of the Royal Society B: Biological Sciences 366:1562, pages 306-309.
Crossref
C. Grainge, A. Smith, B. Jugg, S. Fairhall, T. Mann, R. Perrott, J. Jenner, T. Millar & P. Rice. (2010) Furosemide in the Treatment of Phosgene Induced Acute Lung Injury. Journal of the Royal Army Medical Corps 156:4, pages 245-250.
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