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Inhalation Toxicology
International Forum for Respiratory Research
Volume 23, 2011 - Issue 14
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Research Article

Assessing the impact of the duration and intensity of inhalation exposure on the magnitude of the variability of internal dose metrics in children and adults

Mathieu ValckeCorrespondence[email protected]
&
Kannan KrishnanDépartement de santé environnementale et de santé au travail, Université de Montréal, Montreal, QC, Canada
Pages 863-877 | Received 22 Jun 2011, Accepted 29 Jul 2011, Published online: 15 Nov 2011

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Yejin Esther Yun & Andrea N. Edginton. (2019) Model qualification of the PK-Sim® pediatric module for pediatric exposure assessment of CYP450 metabolized compounds. Journal of Toxicology and Environmental Health, Part A 82:14, pages 789-814.
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M.I. Banton, J.S. Bus, J.J. Collins, E. Delzell, H.-P. Gelbke, J.E. Kester, M.M. Moore, R. Waites & S.S. Sarang. (2019) Evaluation of potential health effects associated with occupational and environmental exposure to styrene – an update. Journal of Toxicology and Environmental Health, Part B 22:1-4, pages 1-130.
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Honesty Tohon, Andy Nong, Marjory Moreau, Mathieu Valcke & Sami Haddad. (2018) Reverse dosimetry modeling of toluene exposure concentrations based on biomonitoring levels from the Canadian health measures survey. Journal of Toxicology and Environmental Health, Part A 81:20, pages 1066-1082.
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Virunya S. Bhat, M.E. (Bette) Meek, Mathieu Valcke, Caroline English, Alan Boobis & Richard Brown. (2017) Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance. Critical Reviews in Toxicology 47:9, pages 733-753.
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Mathieu Valcke & Sami Haddad. (2015) Assessing Human Variability in Kinetics for Exposures to Multiple Environmental Chemicals: A Physiologically Based Pharmacokinetic Modeling Case Study with Dichloromethane, Benzene, Toluene, Ethylbenzene, and m-Xylene. Journal of Toxicology and Environmental Health, Part A 78:7, pages 409-431.
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Articles from other publishers (12)

Kristal Pech, Norma Pérez-Herrera, Ángel Antonio Vértiz-Hernández, Martín Lajous & Paulina Farías. (2023) Health Risk Assessment in Children Occupationally and Para-Occupationally Exposed to Benzene Using a Reverse-Translation PBPK Model. International Journal of Environmental Research and Public Health 20:3, pages 2275.
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Chia-Chen Wu, Jessica R. Blount, Alex Haimbaugh, Samantha Heldman, Jeremiah N. Shields & Tracie R. Baker. (2022) Evaluating Phenotypic and Transcriptomic Responses Induced by Low-Level VOCs in Zebrafish: Benzene as an Example. Toxics 10:7, pages 351.
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Honesty Tohon, Mathieu Valcke, Rocio Aranda-Rodriguez, Andy Nong & Sami Haddad. (2021) Estimation of toluene exposure in air from BMA (S-benzylmercapturic acid) urinary measures using a reverse dosimetry approach based on physiologically pharmacokinetic modeling. Regulatory Toxicology and Pharmacology 120, pages 104860.
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Carol J. Miller, Melissa Runge-Morris, Andrea E. Cassidy-Bushrow, Jennifer K. Straughen, Timothy M. Dittrich, Tracie R. Baker, Michael C. Petriello, Gil Mor, Douglas M. Ruden, Brendan F. O’Leary, Sadaf Teimoori, Chandra M. Tummala, Samantha Heldman, Manisha Agarwal, Katherine Roth, Zhao Yang & Bridget B. Baker. (2020) A Review of Volatile Organic Compound Contamination in Post-Industrial Urban Centers: Reproductive Health Implications Using a Detroit Lens. International Journal of Environmental Research and Public Health 17:23, pages 8755.
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Cleo Tebby, Hilko van der Voet, Georges de Sousa, Emiel Rorije, Vikas Kumar, Waldo de Boer, Johannes W. Kruisselbrink, Frédéric Y. Bois, Moosa Faniband, Angelo Moretto & Céline Brochot. (2020) A generic PBTK model implemented in the MCRA platform: Predictive performance and uses in risk assessment of chemicals. Food and Chemical Toxicology 142, pages 111440.
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Honesty Tohon, Mathieu Valcke & Sami Haddad. (2019) An assessment of the impact of multi‐route co‐exposures on human variability in toxicokinetics: A case study with binary and quaternary mixtures of volatile drinking water contaminants. Journal of Applied Toxicology 39:7, pages 974-991.
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J.W. Fisher, J. Wang, P. Duan & X. Yang. 2018. Comprehensive Toxicology. Comprehensive Toxicology 34 62 .
Lynne T. Haber, Reena Sandhu, Angela Li-Muller, Asish Mohapatra, Sanya Petrovic & M. E. Bette Meek. (2016) Framework for human health risk assessment of non-cancer effects resulting from short-duration and intermittent exposures to chemicals. Journal of Applied Toxicology 36:9, pages 1077-1089.
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Anna-Karin Mörk, Fredrik Jonsson & Gunnar Johanson. (2014) Adjustment factors for toluene, styrene and methyl chloride by population modeling of toxicokinetic variability. Regulatory Toxicology and Pharmacology 69:1, pages 78-90.
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Mathieu Valcke & Kannan Krishnan. (2014) Characterization of the human kinetic adjustment factor for the health risk assessment of environmental contaminants. Journal of Applied Toxicology 34:3, pages 227-240.
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Mathieu Valcke & Kannan Krishnan. (2013) Assessing the impact of child/adult differences in hepatic first-pass effect on the human kinetic adjustment factor for ingested toxicants. Regulatory Toxicology and Pharmacology 65:1, pages 126-134.
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Kannan Krishnan, Brooks McPhail, Weihsueh Chiu & Paul White. 2013. Computational Toxicology. Computational Toxicology 45 66 .

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