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Inhalation Toxicology
International Forum for Respiratory Research
Volume 24, 2012 - Issue 14
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Research Article

Deposition behavior of inhaled nanostructured TiO2 in rats: fractions of particle diameter below 100 nm (nanoscale) and the slicing bias of transmission electron microscopy

Peter MorfeldCorrespondence[email protected]
,
Silke TreumannExperimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany
,
Lan Ma-HockExperimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany
,
Joachim Bruch
&
Robert LandsiedelExperimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany
Pages 939-951 | Received 10 Aug 2012, Accepted 05 Oct 2012, Published online: 10 Dec 2012

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Jody Morgan, Robin Bell & Alison L. Jones. (2020) Endogenous doesn’t always mean innocuous: a scoping review of iron toxicity by inhalation. Journal of Toxicology and Environmental Health, Part B 23:3, pages 107-136.
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Takami Okada, Byeong Woo Lee, Akira Ogami, Takako Oyabu & Toshihiko Myojo. (2019) Inhalation of titanium dioxide (P25) nanoparticles to rats and changes in surfactant protein (SP-D) levels in bronchoalveolar lavage fluid and serum. Nanotoxicology 13:10, pages 1396-1408.
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Viviana Marzaioli, Juan Antonio Aguilar-Pimentel, Ingrid Weichenmeier, Georg Luxenhofer, Martin Wiemann, Robert Landsiedel, Wendel Wohlleben, Stefanie Eiden, Martin Mempel, Heidrun Behrendt, Carsten Schmidt-Weber, Jan Gutermuth & Francesca Alessandrini. (2014) Surface modifications of silica nanoparticles are crucial for their inert versus proinflammatory and immunomodulatory properties. International Journal of Nanomedicine 9, pages 2815-2832.
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P. Morfeld, S. Treumann, L. Ma-Hock, J. Bruch & R. Landsiedel. (2013) Particle diameter estimates of Creutzenberg et al. (2012) are distorted due to the slicing bias of transmission electron microscopy. Inhalation Toxicology 25:1, pages 63-64.
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Ahmed A. H. Abdellatif, Riaz A. Khan, Ahmad H. Alhowail, Abdulmajeed Alqasoumi, Sultan M. Sajid, Ahmed M. Mohammed, Mansour Alsharidah, Osamah Al Rugaie & Ayman M. Mousa. (2021) Octreotide-conjugated silver nanoparticles for active targeting of somatostatin receptors and their application in a nebulized rat model. Nanotechnology Reviews 11:1, pages 266-283.
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Qiqi Wang, Qiong Wang, Ziyue Zhao, Jingbo Fan, Linghan Qin, David B. Alexander, Hiroyuki Tsuda, Dahai Zhao & Jiegou Xu. (2021) Surfactant Proteins A/D–CD14 on Alveolar Macrophages Is a Common Pathway Associated With Phagocytosis of Nanomaterials and Cytokine Production. Frontiers in Immunology 12.
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Natalie D. Keirstead, Evan B. Janovitz, James T. Meehan, Bruce E. LeRoy, John R. Megill, Richard A. Peterson, Regis G. Masson & Heike A. Marxfeld. (2019) Scientific and Regulatory Policy Committee Points to Consider*: Review of Scientific and Regulatory Policy Committee Points to Consider: Review of Current Practices for Ultrastructural Pathology Evaluations in Support of Nonclinical Toxicology Studies. Toxicologic Pathology 47:4, pages 461-468.
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Ruth J. Bevan, Reinhard Kreiling, Leonard S. Levy & David B. Warheit. (2018) Toxicity testing of poorly soluble particles, lung overload and lung cancer. Regulatory Toxicology and Pharmacology 100, pages 80-91.
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Frank S. Bierkandt, Lars Leibrock, Sandra Wagener, Peter Laux & Andreas Luch. (2018) The impact of nanomaterial characteristics on inhalation toxicity. Toxicology Research 7:3, pages 321-346.
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Robert Landsiedel, Lan Ma-Hock, Karin Wiench, Wendel Wohlleben & Ursula G. Sauer. (2017) Safety assessment of nanomaterials using an advanced decision-making framework, the DF4nanoGrouping. Journal of Nanoparticle Research 19:5.
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Peter Laux, Christian Riebeling, Andy M. Booth, Joseph D. Brain, Josephine Brunner, Cristina Cerrillo, Otto Creutzenberg, Irina Estrela-Lopis, Thomas Gebel, Gunnar Johanson, Harald Jungnickel, Heiko Kock, Jutta Tentschert, Ahmed Tlili, Andreas Schäffer, Adriënne J.A.M. Sips, Robert A. Yokel & Andreas Luch. (2017) Biokinetics of nanomaterials: The role of biopersistence. NanoImpact 6, pages 69-80.
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Robert Landsiedel, Ursula G. Sauer & Wim H. de Jong. 2017. Adverse Effects of Engineered Nanomaterials. Adverse Effects of Engineered Nanomaterials 189 222 .
Steven E. Mischler, Emanuele G. Cauda, Michelangelo Di Giuseppe, Linda J. McWilliams, Claudette St. Croix, Ming Sun, Jonathan Franks & Luis A. Ortiz. (2016) Differential activation of RAW 264.7 macrophages by size-segregated crystalline silica. Journal of Occupational Medicine and Toxicology 11:1.
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Lingling Ou, Bin Song, Huimin Liang, Jia Liu, Xiaoli Feng, Bin Deng, Ting Sun & Longquan Shao. (2016) Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms. Particle and Fibre Toxicology 13:1.
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Martin Wiemann, Antje Vennemann, Ursula G. Sauer, Karin Wiench, Lan Ma-Hock & Robert Landsiedel. (2016) An in vitro alveolar macrophage assay for predicting the short-term inhalation toxicity of nanomaterials. Journal of Nanobiotechnology 14:1.
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Elena Maser, Markus Schulz, Ursula G. Sauer, Martin Wiemann, Lan Ma-Hock, Wendel Wohlleben, Andrea Hartwig & Robert Landsiedel. (2015) In vitro and in vivo genotoxicity investigations of differently sized amorphous SiO2 nanomaterials. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 794, pages 57-74.
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Alexandra Noël & Ginette Truchon. (2015) Inhaled Titanium Dioxide Nanoparticles: A Review of Their Pulmonary Responses with Particular Focus on the Agglomeration State. Nano LIFE 05:01, pages 1450008.
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Josje H.E. Arts, Mackenzie Hadi, Muhammad-Adeel Irfan, Athena M. Keene, Reinhard Kreiling, Delina Lyon, Monika Maier, Karin Michel, Thomas Petry, Ursula G. Sauer, David Warheit, Karin Wiench, Wendel Wohlleben & Robert Landsiedel. (2015) A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping). Regulatory Toxicology and Pharmacology 71:2, pages S1-S27.
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Anja Silge, Katharina Bräutigam, Thomas Bocklitz, Petra Rösch, Antje Vennemann, Inge Schmitz, Jürgen Popp & Martin Wiemann. (2015) ZrO 2 nanoparticles labeled via a native protein corona: detection by fluorescence microscopy and Raman microspectroscopy in rat lungs . The Analyst 140:15, pages 5120-5128.
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T. Smijs & S. Pavel. 2015. Nanoengineering. Nanoengineering 375 423 .
Anna G. Cattaneo, Rosalba Gornati, Giovanni Bernardini, Enrico Sabbioni, Luigi Manzo & Mario Di Gioacchino. 2014. Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology. Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology 3 34 .
Ju Du, Ping Du & Hugh DC Smyth. (2013) Hydrogels for controlled pulmonary delivery. Therapeutic Delivery 4:10, pages 1293-1305.
Crossref
Robert Landsiedel. 2013. Nanomaterials. Nanomaterials 43 48 .

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