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Inhalation Toxicology
International Forum for Respiratory Research
Volume 2, 1990 - Issue 1
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Research Article

Nitric Oxide and Nitrogen Dioxide as Inducers of Acute Pulmonary Injury when Inhaled at Relatively High Concentrations for Brief Periods

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Pages 53-67 | Received 11 Apr 1989, Accepted 21 Jun 1989, Published online: 27 Sep 2008

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James H. Stuhmiller, Diane W. Long & Louise M. Stuhmiller. (2006) An Internal Dose Model of Incapacitation and Lethality Risk from Inhalation of Fire Gases. Inhalation Toxicology 18:5, pages 347-364.
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R KUHLEN, T BUSCH, U KAISERS, H GERLACH, D PAPPERT, K FALKE & R ROSSAINT. (1997) Evaluation of two prototypes for inhalation of nitric oxide during mechanical ventilation with different tidal volumes. Clinical Intensive Care 8:4, pages 171-177.
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. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 37 .
Ruixue Wang, Geli Li, Yongqiang Dong, Yuwu Chi & Guonan Chen. (2013) Carbon Quantum Dot-Functionalized Aerogels for NO 2 Gas Sensing . Analytical Chemistry 85:17, pages 8065-8069.
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George D. Leikauf & Daniel R. Prows. 2003. Patty's Toxicology. Patty's Toxicology 949 1032 .
A. Ghaffari, C.C. Miller, B. McMullin & A. Ghahary. (2006) Potential application of gaseous nitric oxide as a topical antimicrobial agent. Nitric Oxide 14:1, pages 21-29.
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Soraisham Amuchou Singh, Thowfique Ibrahim, Deborah Jane Clark, Richard Scott Taylor & David Hilles George. (2005) Persistent pulmonary hypertension of newborn due to congenital capillary alveolar dysplasia. Pediatric Pulmonology 40:4, pages 349-353.
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George D. Leikauf & Daniel R. Prows. 2003. Patty's Toxicology. Patty's Toxicology.
Gerald Bushman. (2016) Essentials of Nitric Oxide for the Pediatric (Cardiac) Anesthesiologist. Seminars in Cardiothoracic and Vascular Anesthesia 5:1, pages 79-90.
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S Göthberg, KE Edberg, SF Tang, S Michelsen, P Winberg, D Holmgren, O Miller, E Thaulow & P‐A Lönnqvist. (2007) Residual pulmonary hypertension in children after treatment with inhaled nitric oxide: a follow‐up study regarding cardiopulmonary and neurological symptoms. Acta Paediatrica 89:12, pages 1414-1419.
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T. SAITO, H. NINOMIYA, I. OHTSU, M. INOUE, Y. UCHIDA & S. HASEGAWA. (2000) A demand valve device decreases exhaust nitric oxide and nitrogen dioxide by nitric oxide inhalation with a nasal cannula in the human. Respiratory Medicine 94:6, pages 542-548.
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Khalid Al-Hathlol, Susan Phillips, Mary M.K Seshia, Oscar Casiro, Ruben E Alvaro & Henrique Rigatto. (2000) Alveolar capillary dysplasia. Early Human Development 57:2, pages 85-94.
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D. Keh, H. Gerlach & K. Falke. 2000. Nitric Oxide. Nitric Oxide 399 441 .
Peter Schenk, Christoph Mittermayer & Klaus Ratheiser. (1999) Inhaled nitric oxide in a patient with severe pulmonary embolism. Annals of Emergency Medicine 33:6, pages 710-714.
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Adam A. Rosenberg. (1998) Inhaled nitric oxide in the premature infant with severe hypoxemic respiratory failure: A time for caution. The Journal of Pediatrics 133:6, pages 720-722.
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Leif D Nelin, Stephen E Welty, James F Morrisey, Christine Gotuaco & Christopher A Dawson. (1998) Nitric Oxide Increases the Survival of Rats with a High Oxygen Exposure. Pediatric Research 43:6, pages 727-732.
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Simon C. Body & Stanton K. Shernan. (2016) The Utility of Nitric Oxide in the Postoperative Period. Seminars in Cardiothoracic and Vascular Anesthesia 2:1, pages 4-30.
Crossref
Johannes Breuer, Wolfgang Prein, Sabine Gebhardt, Ralf Knies, Ludger Sieverding, Winfried Baden & Juergen Apitz. (1998) Inhaled nitric oxide treatment of children with pulmonary hypertension after cardiac surgery. Progress in Pediatric Cardiology 9:2, pages 73-83.
Crossref
Christophe Adrie, Fumito Ichinose, Alexandra Holzmann, Larry Keefer, William E. Hurford & Warren M. Zapol. (1998) Pulmonary vasodilation by nitric oxide gas and prodrug aerosols in acute pulmonary hypertension. Journal of Applied Physiology 84:2, pages 435-441.
Crossref
Jutta Berger. 1998. Monitoring in Anästhesie und Intensivmedizin. Monitoring in Anästhesie und Intensivmedizin 406 413 .
M. Sydow, J. Zinserling & S. J. Allen. 1998. Yearbook of Intensive Care and Emergency Medicine 1998. Yearbook of Intensive Care and Emergency Medicine 1998 561 568 .
E. Steil, L. Sieverding, J. Apitz, F. Kuhn-Regnier, E. R. de Vivie, J. Breuer & W. Baden. 1998. Pädiatrische Kardiologie. Pädiatrische Kardiologie 561 636 .
B Thébaud & J.C Mercier. (1997) Le monoxyde d'azote inhalé: un traitement plus physiologique de l'hypertension artérielle pulmonaire persistante du nouveau-né. Archives de Pédiatrie 4:10, pages 988-1003.
Crossref
Neil N. Finer & Keith J. Barrington. (1997) Nitric oxide in respiratory failure in the newborn infant. Seminars in Perinatology 21:5, pages 426-440.
Crossref
John P. Kinsella & Steven H. Abman. (1997) Inhaled nitric oxide in the premature infant: Animal models and clinical experience. Seminars in Perinatology 21:5, pages 418-425.
Crossref
Michael Sydow, Frank Bristow, Jörg Zinserling & Steven J. Allen. (1997) Flow-Proportional Administration of Nitric Oxide With a New Delivery System*. Chest 112:2, pages 496-504.
Crossref
Anne P. M. C. De Jaegere, Frans I. M. Jacobs, Nico G. C. Laheij & John N. van den Anker. (1997) Variation of inhaled nitric oxide concentration with the use of a continuous flow ventilator. Critical Care Medicine 25:6, pages 995-1002.
Crossref
David A. Fullerton, James Jaggers, Mary M. Wollmering, Fran Piedalue, Frederick L. Grover & Robert C. McIntyreJrJr. (1997) Variable response to inhaled nitric oxide after cardiac surgery. The Annals of Thoracic Surgery 63:5, pages 1251-1256.
Crossref
Peter Q. Eichacker. (1997) Inhaled nitric oxide in adult respiratory distress syndrome. Critical Care Medicine 25:4, pages 563-565.
Crossref
Robin H. Steinhorn, Peter N. Cox, Jeffrey R. Fineman, Neil N. Finer, Ellen M. Rosenberg, Meredith M. Silver, Juzer Tyebkhan, Maurice S. Zwass & Frederick C. MorinIIIIII. (1997) Inhaled nitric oxide enhances oxygenation but not survival in infants with alveolar capillary dysplasia. The Journal of Pediatrics 130:3, pages 417-422.
Crossref
George M. Hoffman, Gerald A. Ross, Susan E. Day, Thomas B. Rice & Leif D. Nelin. (1997) Inhaled nitric oxide reduces the utilization of extracorporeal membrane oxygenation in persistent pulmonary hypertension of the newborn. Critical Care Medicine 25:2, pages 352-359.
Crossref
Duncan J. Macrae. (1997) Drug therapy in persistent pulmonary hypertension of the newborn. Seminars in Neonatology 2:1, pages 49-58.
Crossref
David A. Fullerton, James Jaggers, Fran Piedalue, Frederick L. Grover & Robert C. McIntyreJr.Jr.. (1997) Effective control of refractory pulmonary hypertension after cardiac operations. The Journal of Thoracic and Cardiovascular Surgery 113:2, pages 363-370.
Crossref
F.J. Baud. (1996) Toxicologie du monoxyde d'azote. Réanimation Urgences 5:6, pages 51s-58s.
Crossref
Mikko Hallman & Kristina Bry. (1996) Nitric oxide and lung surfactant. Seminars in Perinatology 20:3, pages 173-185.
Crossref
Michael J. Antunes, Jay S. Greenspan & Ksenia Zukowsky. (1996) ADVANCED VENTILATION IN THE NEONATE. Nursing Clinics of North America 31:2, pages 405-422.
Crossref
David A. Fullerton & Robert C. McIntyreJrJr. (1996) Inhaled nitric oxide: Therapeutic applications in cardiothoracic surgery. The Annals of Thoracic Surgery 61:6, pages 1856-1864.
Crossref
Hiroshi Date, Anastosios N. Triantafillou, Elbert P. Trulock, Mary S. Pohl, Joel D. Cooper & G.Alexander Patterson. (1996) Inhaled nitric oxide reduces human lung allograft dysfunction. The Journal of Thoracic and Cardiovascular Surgery 111:5, pages 913-919.
Crossref
Klaus Lewandowski & Konrad J. Falke. (1996) 9 Acute respiratory distress syndrome. Baillière's Clinical Anaesthesiology 10:1, pages 181-214.
Crossref
David A. Fullerton, Stephen D. Jones, James Jaggers, Fran Piedalue, Frederick L. Grover & Robert C. McIntyreJr.Jr.. (1996) Effective control of pulmonary vascular resistance with inhaled nitric oxide after cardiac operation. The Journal of Thoracic and Cardiovascular Surgery 111:4, pages 753-763.
Crossref
Geoffrey N. Morris, George F. Rich & Roger A. Johns. (1996) Exogenous inhaled nitric oxide as a selective pulmonary vasodilator. Seminars in Anesthesia, Perioperative Medicine and Pain 15:1, pages 47-60.
Crossref
Ronald W. Day, Margarita Guarin, Joanna M. Lynch, Donald D. Vernon & J. Michael Dean. (1996) Inhaled nitric oxide in children with severe lung disease. Critical Care Medicine 24:2, pages 215-221.
Crossref
L. Puybasset & J. J. Rouby. 1996. Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine 434 465 .
Jean-Jacques Rouby. 1996. Vascular Endothelium. Vascular Endothelium 181 203 .
S.C. Body, P.M. Hartigan, S.K. Shernan, V. Formanek & W.E. Hurford. (1995) Nitric oxide: Delivery, measurement, and clinical application. Journal of Cardiothoracic and Vascular Anesthesia 9:6, pages 748-763.
Crossref
Young-Kyoo Choi, Hidekazu Yukioka, Tokuhiro Yamada, Masanori Hayashi & Mitsugu Fujimori. (1995) Evaluation of a delivery system and monitors for ventilator administration of nitric oxide. Journal of Anesthesia 9:4, pages 318-323.
Crossref
S J Brett & T W Evans. (1995) Inhaled vasodilator therapy in acute lung injury: first, do NO harm?. Thorax 50:8, pages 821-823.
Crossref
Robin H. Steinhorn, Susan L. Millard & Frederick C. MorinIIIIII. (1995) Persistent Pulmonary Hypertension of the Newborn: Role of Nitric Oxide and Endothelin in Pathophysiology and Treatment. Clinics in Perinatology 22:2, pages 405-428.
Crossref
John P. Kinsella & Steven H. Abman. (1995) Recent developments in the pathophysiology and treatment of persistent pulmonary hypertension of the newborn. The Journal of Pediatrics 126:6, pages 853-864.
Crossref
Eddie Weitzberg, Anders Rudehill, Agnes Modin & Jan M. Lundberg. (1995) Effect of combined nitric oxide inhalation and N sup G-nitro-L-arginine infusion in porcine endotoxin shock. Critical Care Medicine 23:5, pages 909-918.
Crossref
U. Schedin, C. Frostell, M. G. Persson, J. Jakobsson, G. Andersson & L. E. Gustafsson. (2008) Contribution from upper and lower airways to exhaled endogenous nitric oxide in humans. Acta Anaesthesiologica Scandinavica 39:3, pages 327-332.
Crossref
George F. Rich. (1995) 3 Inhaled nitric oxide. Baillière's Clinical Anaesthesiology 9:1, pages 37-49.
Crossref
Claes G. Frostell & Warren M. Zapol. 1995. Nitric Oxide - Biochemistry, Molecular Biology, and Therapeutic Implications. Nitric Oxide - Biochemistry, Molecular Biology, and Therapeutic Implications 439 456 .
J. C. Mercier, A. T. Dinh-Xuan & S. H. Abman. 1995. Role of Nitric Oxide in Sepsis and ADRS. Role of Nitric Oxide in Sepsis and ADRS 355 379 .
C. G. Frostell. 1995. Role of Nitric Oxide in Sepsis and ADRS. Role of Nitric Oxide in Sepsis and ADRS 342 354 .
W. M. Zapol & W. E. Hurford. 1995. Role of Nitric Oxide in Sepsis and ADRS. Role of Nitric Oxide in Sepsis and ADRS 323 341 .
L. Puybasset & J. J. Rouby. 1995. Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine 331 357 .
W. M. Zapol & W. E. Hurford. 1995. Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine 323 330 .
John C. Ring & Gregory L. Stidham. (1994) Novel Therapies for acute Respiratory Failure. Pediatric Clinics of North America 41:6, pages 1325-1363.
Crossref
Richard N. Channick, John W. Newhart, F. Wayne Johnson & Kenneth M. Moser. (1994) Inhaled Nitric Oxide Reverses Hypoxic Pulmonary Vasoconstriction in Dogs. Chest 105:6, pages 1842-1847.
Crossref
P. Winberg, B. P. Lundell & L. E. Gustafsson. (1994) Effect of inhaled nitric oxide on raised pulmonary vascular resistance in children with congenital heart disease.. Heart 71:3, pages 282-286.
Crossref
Anthony David Milner. (1994) Nitric oxide. European Journal of Pediatrics 153:S2, pages S7-S11.
Crossref
O I Miller, D S Celermajer, J E Deanfield & D J Macrae. (1994) Guidelines for the safe administration of inhaled nitric oxide.. Archives of Disease in Childhood - Fetal and Neonatal Edition 70:1, pages F47-F49.
Crossref
Warren M. Zapol & William E. Hurford. 1994. 513 530 .
J. Tibballs, M. Hochmann, B. Carter & A. Osborne. (2019) An Appraisal of Techniques for Administration of Gaseous Nitric Oxide. Anaesthesia and Intensive Care 21:6, pages 844-847.
Crossref
J. Tibballs. (2019) The Role of Nitric Oxide (Formerly Endothelium-Derived Relaxing Factor-EDRF) in Vasodilatation and Vasodilator Therapy. Anaesthesia and Intensive Care 21:6, pages 759-773.
Crossref
Michel Zayek, Linda Wild, Jesse D. Roberts & Frederick C. MorinIIIIII. (1993) Effect of nitric oxide on the survival rate and incidence of lung injury in newborn lambs with persistent pulmonary hypertension. The Journal of Pediatrics 123:6, pages 947-952.
Crossref
D L WesselI AdatiaT M GigliaJ E ThompsonT J Kulik. (1993) Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass.. Circulation 88:5, pages 2128-2138.
Crossref
Jesse D. RobertsJr.Jr. & Philip W. Shaul. (1993) Advances in the Treatment of Persistent Pulmonary Hypertension of the Newborn. Pediatric Clinics of North America 40:5, pages 983-1004.
Crossref
J. Meulenbelt, J.A.M.A. Dormans, L. van Bree, P.J.A. Rombout & B. Sangster. (2016) Desferrioxamine Treatment Reduces Histological Evidence of Lung Damage in Rats after Acute Nitrogen Dioxide (NO2) intoxication. Human & Experimental Toxicology 12:5, pages 389-395.
Crossref
Michel Zayek, David Cleveland & Frederick C. MorinIIIIII. (1993) Treatment of persistent pulmonary hypertension in the newborn lamb by inhaled nitric oxide. The Journal of Pediatrics 122:5, pages 743-750.
Crossref
Bruce E. Lehnert. 1993. Handbook of Hazardous Materials. Handbook of Hazardous Materials 475 489 .
G. Ganesh Konduri & Laine L. Woodard. (1992) Reply. The Journal of Pediatrics 120:6, pages 1004-1005.
Crossref
J. Meulenbelt, J.A.M.A. Dormans, M. Marra, P.J.A. Rombout & B. Sangster. (2016) Rat Model to Investigate the Treatment of Acute Nitrogen Dioxide Intoxication. Human & Experimental Toxicology 11:3, pages 179-187.
Crossref
C. G. Frostell. 1992. Yearbook of Intensive Care and Emergency Medicine 1992. Yearbook of Intensive Care and Emergency Medicine 1992 233 237 .
. (1991) Nitric oxide in the clinical arena. The Lancet 338:8782-8783, pages 1560-1562.
Crossref
C FrostellM D FratacciJ C WainR JonesW M Zapol. (1991) Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction.. Circulation 83:6, pages 2038-2047.
Crossref

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